Novel Allogeneic Granulocyte-Macrophage Colony-Stimulating Factor–Secreting Tumor Vaccine for Pancreatic Cancer: A Phase I Trial of Safety and Immune Activation

Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial.

1997 • 5,683 citations

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

The Central Role of CD4+ T Cells in the Antitumor Immune Response

1998 • 1,332 citations

Role of Bone Marrow-Derived Cells in Presenting MHC Class I-Restricted Tumor Antigens

1994 • 1,185 citations

Design and Analysis of Phase I Clinical Trials

1989 • 882 citations

Human tumor antigens recognized by T lymphocytes.

1996 • 860 citations

Granulocyte Colony-Stimulating Factor and Granulocyte-Macrophage Colony-Stimulating Factor

1992 • 841 citations

Cancer statistics, 1991

1991 • 625 citations

Pancreaticoduodenectomy for Pancreatic Adenocarcinoma: Postoperative Adjuvant Chemoradiation Improves Survival

1997 • 600 citations

Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte–macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma

1998 • 586 citations

Measurement of Delayed Skin-Test Responses

1975 • 516 citations

Induction of immunity to prostate cancer antigens: results of a clinical trial of vaccination with irradiated autologous prostate tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor using ex vivo gene transfer.

1999 • 468 citations

Immunodepression after major surgery in normal patients.

1975 • 424 citations

The influence of surgical operations on components of the human immune system

1985 • 407 citations

Pancreaticoduodenectomy With or Without Extended Retroperitoneal Lymphadenectomy for Periampullary Adenocarcinoma

1999 • 365 citations

Granulocyte Colony-Stimulating Factor and Granulocyte-Macrophage Colony-Stimulating Factor

1992 • 364 citations

Identification of HLA-A2–Restricted T-Cell Epitopes Derived From the MUC1 Tumor Antigen for Broadly Applicable Vaccine Therapies

1999 • 301 citations

Treatment of metastatic melanoma with an autologous tumor-cell vaccine: clinical and immunologic results in 64 patients.

1990 • 300 citations

Induction of cell-mediated immunity to autologous melanoma cells and regression of metastases after treatment with a melanoma cell vaccine preceded by cyclophosphamide.

1986 • 255 citations

Phase I Trial of Twice-Weekly Gemcitabine and Concurrent Radiation in Patients With Advanced Pancreatic Cancer

1999 • 243 citations

In Vivo Cross-Priming of MHC Class I–Restricted Antigens Requires the TAP Transporter

1996 • 225 citations

Dendritic cells and immune-based therapies.

1996 • 180 citations

Cancer Vaccines

1999 • 120 citations

Delayed cutaneous hypersensitivity reactions to membrane extracts of human tumour cells.

1971 • 108 citations

Transient Acantholytic Dermatosis

1977 • 103 citations

Transient acantholytic dermatosis (Grover's disease): A global perspective

1996 • 103 citations

Development and characterization of a cytokine-secreting pancreatic adenocarcinoma vaccine from primary tumors for use in clinical trials.

1998 • 100 citations

Renal cell carcinoma treated by vaccines for active specific immunotherapy: Correlation of survival with skin testing by autologous tumor cells

1990 • 98 citations

Delayed cutaneous hypersensitivity to autologous tumor cells in colorectal cancer patients immunized with an autologous tumor cell: Bacillus Calmette-Guérin vaccine.

1984 • 96 citations

Grover's Disease: Clinicopathologic Review of 72 Cases

1999 • 96 citations

Protective antitumor immunity induced by immunization with completely allogeneic tumor cells.

1996 • 89 citations

Generation of Stable CD4+and CD8+T Cell Lines from Patients Immunized withrasOncogene-Derived Peptides Reflecting Codon 12 Mutations

1997 • 88 citations

Enhanced Tumor Protection by Granulocyte-Macrophage Colony-Stimulating Factor Expression at the Site of an Allogeneic Vaccine

1998 • 84 citations

A Phase I Clinical Trial of Lethally Irradiated Allogeneic Pancreatic Tumor Cells Transfected with the GM-CSF Gene for the Treatment of Pancreatic Adenocarcinoma. The Johns Hopkins Oncology Center, Baltimore, Maryland

1998 • 83 citations

Identification of the Genes Encoding Cancer Antigens: Implications for Cancer Immunotherapy

1996 • 75 citations

Enhanced Immune Priming with Spatial Distribution of Paracrine Cytokine Vaccines

1996 • 67 citations

Adjuvant Therapy with Chemotherapy and Radiation Therapy in the Management of Carcinoma of the Pancreatic Head

1995 • 28 citations

Partial recovery of lymphocyte activity in patients with colorectal carcinoma after curative surgical treatment and return of plasma glutamate concentrations to normal levels

1990 • 19 citations

Potential role of tumor vaccines in GI malignancies.

2000 • 9 citations

Vaccination with recombinant adenoviruses encoding tumor-derived CTL-epitopes in a string-of-bead fashion induces protective anti-tumor immunity

1997 • 3 citations

Cancer Vaccines

1997 • 1 citations

Deleted Work

1955 • 0 citations