T‐Cell Recognition of Antigen

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.

1991 • 1,132 citations

The Basis for the Immunoregulatory Role of Macrophages and Other Accessory Cells

1987 • 1,040 citations

The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes.

1988 • 716 citations

The structure of HLA-B27 reveals nonamer self-peptides bound in an extended conformation

1991 • 687 citations

Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

1989 • 671 citations

A binding site for the T-cell co-receptor CD8 on the α3 domain of HLA-A2

1990 • 527 citations

Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor

1992 • 501 citations

The dynamic regulation of integrin adhesiveness

1994 • 456 citations

Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness.

1994 • 431 citations

Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands

1993 • 414 citations

MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8

1992 • 368 citations

Low Affinity Interaction of Peptide-MHC Complexes with T Cell Receptors

1991 • 366 citations

T Cell Receptor-MHC Class I Peptide Interactions: Affinity, Kinetics, and Specificity

1994 • 292 citations

Identification of a CD4 binding site on the β2 domain of HLA-DR molecules

1992 • 272 citations

Kinetics and affinity of reactions between an antigen-specific T cell receptor and peptide-MHC complexes

1994 • 253 citations

The binary logic of antigen processing and presentation to T cells

1990 • 235 citations

Intercellular Communication and Cell-Cell Adhesio n

1992 • 230 citations

Expression of T Cell Antigen Receptor Heterodimers in a Lipid-Linked Form

1990 • 224 citations

Specific low-affinity recognition of major histocompatibility complex plus peptide by soluble T-cell receptor

1992 • 221 citations

Transient intercellular adhesion: the importance of weak protein-protein interactions

1994 • 213 citations

Human Cell-Adhesion Molecule CD2 Binds CD58 (LFA-3) with a Very Low Affinity and an Extremely Fast Dissociation Rate but Does Not Bind CD48 or CD59

1994 • 204 citations

High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins.

1994 • 200 citations

Substitution at residue 227 of H–2 class I molecules abrogates recognition by CD8-dependent, but not CD8-independent, cytotoxic T lymphocytes

1989 • 198 citations

Direct evidence for two affinity states for lymphocyte function-associated antigen 1 on activated T cells.

1993 • 195 citations

Binary and ternary complexes between T-cell receptor, class II MHC and superantigen in vitro

1994 • 182 citations

Expression of a class II major histocompatibility complex (MHC) heterodimer in a lipid-linked form with enhanced peptide/soluble MHC complex formation at low pH.

1991 • 143 citations

Affinity and kinetic analysis of the interaction of the cell adhesion molecules rat CD2 and CD48.

1993 • 115 citations

Correlation of CD2 binding and functional properties of multimeric and monomeric lymphocyte function-associated antigen 3.

1989 • 85 citations

Structural and binding analysis of a two domain extracellular CD2 molecule.

1989 • 61 citations

Mouse CD4 binds MHC class II with extremely low affinity

1993 • 60 citations

Formation of functional peptide complexes of class II major histocompatibility complex proteins from subunits produced in Escherichia coli.

1993 • 58 citations