Combination Immunotherapy of B16 Melanoma Using Anti–Cytotoxic T Lymphocyte–Associated Antigen 4 (Ctla-4) and Granulocyte/Macrophage Colony-Stimulating Factor (Gm-Csf)-Producing Vaccines Induces Rejection of Subcutaneous and Metastatic Tumors Accompanied by Autoimmune Depigmentation

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

1998 • 2,615 citations

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1998 • 2,373 citations

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

1998 • 2,106 citations

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.

1995 • 2,090 citations

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

The Central Role of CD4+ T Cells in the Antitumor Immune Response

1998 • 1,332 citations

Tumor Antigens Recognized by T Lymphocytes

1994 • 1,238 citations

Role of Bone Marrow-Derived Cells in Presenting MHC Class I-Restricted Tumor Antigens

1994 • 1,185 citations

Tumor Rejection After Direct Costimulation of CD8 ⁺ T Cells by B7-Transfected Melanoma Cells

1993 • 1,154 citations

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

1992 • 1,076 citations

Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection.

1994 • 921 citations

Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules.

1997 • 837 citations

Induction of Peripheral T Cell Tolerance In Vivo Requires CTLA-4 Engagement

1997 • 736 citations

Induction of antigen-specific T cell anergy: An early event in the course of tumor progression

1998 • 710 citations

The Emerging Role of CTLA-4 as an Immune Attenuator

1997 • 637 citations

gp100/pmel 17 Is a Murine Tumor Rejection Antigen: Induction of “Self”-reactive, Tumoricidal T Cells Using High-affinity, Altered Peptide Ligand

1998 • 490 citations

High Frequency of Skin-homing Melanocyte-specific Cytotoxic T Lymphocytes in Autoimmune Vitiligo

1998 • 446 citations

Low avidity recognition of self-antigen by T cells permits escape from central tolerance

1995 • 415 citations

Identification of Tyrosinase-related Protein 2 as a Tumor Rejection Antigen for the B16 Melanoma

1997 • 405 citations

Cancer vaccines based on the identification of genes encoding cancer regression antigens

1997 • 395 citations

Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer

1997 • 383 citations

Vaccination with a recombinant vaccinia virus encoding a “self” antigen induces autoimmune vitiligo and tumor cell destruction in mice: Requirement for CD4⁺T lymphocytes

1999 • 383 citations

The selection and characterization of an invasive variant of the B16 melanoma.

1979 • 376 citations

CTLA-4 blockade synergizes with tumor-derived granulocyte– macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma

1998 • 375 citations

Vitiligo in Patients with Melanoma

1996 • 335 citations

CD28-B7 interactions in T-cell activation

1994 • 315 citations

Sequential chemoimmunotherapy in the treatment of metastatic melanoma.

1992 • 258 citations

Activation of Low Avidity CTL Specific for a Self Epitope Results in Tumor Rejection But Not Autoimmunity

1998 • 248 citations

Tumor immunity and autoimmunity induced by immunization with homologous DNA.

1998 • 233 citations

Enhanced induction of antitumor T-cell responses by cytotoxic T lymphocyte-associated molecule-4 blockade: the effect is manifested only at the restricted tumor-bearing stages.

1997 • 197 citations

In vivo priming of two distinct antitumor effector populations: the role of MHC class I expression.

1994 • 196 citations

Implicating a role for immune recognition of self in tumor rejection: passive immunization against the brown locus protein.

1995 • 186 citations

A reassessment of the role of B7-1 expression in tumor rejection.

1995 • 178 citations

Immune response to a differentiation antigen induced by altered antigen: A study of tumor rejection and autoimmunity

1996 • 163 citations

Viral and Bacterial Infections Interfere with Peripheral Tolerance Induction and Activate CD8+ T Cells to Cause Immunopathology

1998 • 161 citations

In vivoblockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance

1999 • 157 citations

Anti-Tyrosinase-Related Protein-2 Immune Response in Vitiligo Patients and Melanoma Patients Receiving Active-Specific Immunotherapy

1998 • 134 citations

Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Can Regulate Dendritic Cell–induced Activation and Cytotoxicity of CD8+ T Cells Independently of CD4+T Cell Help

1999 • 69 citations

Cytotoxic cells : basic mechanisms and medical applications

2000 • 34 citations

Tolerance is overcome in beef insulin‐transgenic mice by activation of low‐affinity autoreactive T cells

1996 • 32 citations

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