Optimization of epitope processing enhances immunogenicity of multiepitope DNA vaccines

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

Direct Visualization of Antigen-specific CD8+T Cells during the Primary Immune Response to Epstein-Barr Virus In Vivo

1998 • 902 citations

The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes.

1994 • 838 citations

Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara

1998 • 663 citations

Nine major HLA class I supertypes account for the vast preponderance of HLA-A and -B polymorphism

1999 • 619 citations

A New Era for Cancer Immunotherapy Based on the Genes that Encode Cancer Antigens

1999 • 578 citations

Development of a lipopeptide-based therapeutic vaccine to treat chronic HBV infection. I. Induction of a primary cytotoxic T lymphocyte response in humans.

1995 • 332 citations

Analysis of the HLA-restricted influenza-specific cytotoxic T lymphocyte response in transgenic mice carrying a chimeric human-mouse class I major histocompatibility complex.

1991 • 330 citations

Effective Induction of Simian Immunodeficiency Virus-Specific Cytotoxic T Lymphocytes in Macaques by Using a Multiepitope Gene and DNA Prime-Modified Vaccinia Virus Ankara Boost Vaccination Regimen

1999 • 312 citations

Delivery of Multiple CD8 Cytotoxic T Cell Epitopes by DNA Vaccination

1998 • 169 citations

Utilization of MHC Class I Transgenic Mice for Development of Minigene DNA Vaccines Encoding Multiple HLA-Restricted CTL Epitopes

1999 • 166 citations

CTL responses of HLA-A2.1-transgenic mice specific for hepatitis C viral peptides predict epitopes for CTL of humans carrying HLA-A2.1.

1995 • 165 citations

The induction of virus-specific CTL as a function of increasing epitope expression: responses rise steadily until excessively high levels of epitope are attained.

1999 • 155 citations

An algorithm for the prediction of proteasomal cleavages

2000 • 154 citations

Variations in the number of peptide-MHC class I complexes required to activate cytotoxic T cell responses.

1995 • 148 citations

The Induction of Virus-Specific CTL as a Function of Increasing Epitope Expression: Responses Rise Steadily Until Excessively High Levels of Epitope Are Attained

1999 • 144 citations

Minimal epitopes expressed in a recombinant polyepitope protein are processed and presented to CD8+ cytotoxic T cells: implications for vaccine design.

1995 • 142 citations

T lymphocyte responses in HIV-1 infection: implications for vaccine development

1999 • 116 citations

Flanking residues alter antigenicity and immunogenicity of multi-unit CTL epitopes.

1996 • 102 citations

Identification of Novel HLA-A2-Restricted Human Immunodeficiency Virus Type 1-Specific Cytotoxic T-Lymphocyte Epitopes Predicted by the HLA-A2 Supertype Peptide-Binding Motif

2001 • 98 citations

An HLA-A2 Polyepitope Vaccine for Melanoma Immunotherapy

1999 • 85 citations

Immunodominance Among EBV-Derived Epitopes Restricted by HLA-B27 Does Not Correlate with Epitope Abundance in EBV-Transformed B-Lymphoblastoid Cell Lines

2000 • 80 citations

CD8+ T cell recognition of an endogenously processed epitope is regulated primarily by residues within the epitope.

1992 • 79 citations

The specificity of proteasomes: impact on MHC class I processing and presentation of antigens

1999 • 76 citations

Identification of A2-restricted hepatitis C virus-specific cytotoxic T lymphocyte epitopes from conserved regions of the viral genome

1996 • 69 citations

Immunogenicity of a Human Immunodeficiency Virus (HIV) Polytope Vaccine Containing Multiple HLA A2 HIV CD8⁺Cytotoxic T-Cell Epitopes

1999 • 63 citations

Influenza A-specific, HLA-A2.1-restricted cytotoxic T lymphocytes from HLA-A2.1 transgenic mice recognize fragments of the M1 protein.

1991 • 62 citations

Presentation of endogenous peptide/MHC class I complexes is profoundly influenced by specific C-terminal flanking residues.

1995 • 57 citations

Functional analysis of amino acid residues encompassing and surrounding two neighboring H-2Db-restricted cytotoxic T-lymphocyte epitopes in simian virus 40 tumor antigen

1995 • 29 citations

Effect of epitope flanking residues on the presentation of N-terminal cytotoxic T lymphocyte epitopes

1999 • 28 citations

Characterization of an in situ IFN-γ ELISA assay which is able to detect specific peptide responses from freshly isolated splenocytes induced by DNA minigene immunization

2000 • 26 citations