Relationship Between myc Oncogene Activation and MHC Class I Expression

A Progress Report on the Treatment of 157 Patients with Advanced Cancer Using Lymphokine-Activated Killer Cells and Interleukin-2 or High-Dose Interleukin-2 Alone

1987 • 2,769 citations

In search of the ‘missing self’: MHC molecules and NK cell recognition

1990 • 2,600 citations

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

1987 • 2,403 citations

Use of Tumor-Infiltrating Lymphocytes and Interleukin-2 in the Immunotherapy of Patients with Metastatic Melanoma

1988 • 2,196 citations

Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy

1986 • 2,102 citations

Association of Multiple Copies of the N-mycOncogene with Rapid Progression of Neuroblastomas

1985 • 1,989 citations

Molecular themes in oncogenesis

1991 • 1,663 citations

Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with Myc

1991 • 1,650 citations

Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour

1983 • 1,407 citations

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

1983 • 1,358 citations

Cellular Oncogenes and Multistep Carcinogenesis

1983 • 1,154 citations

Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements

1988 • 984 citations

Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes

1989 • 970 citations

Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis.

1989 • 961 citations

Biology and clinical relevance of human natural killer cells

1990 • 930 citations

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2

1990 • 910 citations

Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes

1984 • 906 citations

The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product

1990 • 900 citations

Sequence-Specific DNA Binding by the c-Myc Protein

1990 • 893 citations

Cloning of the p50 DNA binding subunit of NF-κB: Homology to rel and dorsal

1990 • 870 citations

Identification of self peptides bound to purified HLA-B27

1991 • 844 citations

Cooperation between oncogenes

1991 • 792 citations

Tumor suppressor genes

1991 • 775 citations

Identification of cooperating oncogenes in Eμ-myc transgenic mice by provirus tagging

1991 • 765 citations

Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells

1984 • 729 citations

Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters

1990 • 717 citations

THE myc ONCOGENE: ITS ROLE IN TRANSFORMATION AND DIFFERENTIATION

1986 • 714 citations

STRUCTURE, FUNCTION, AND DIVERSITY OF CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULES

1990 • 693 citations

The structure of HLA-B27 reveals nonamer self-peptides bound in an extended conformation

1991 • 687 citations

Molecular cloning of an enhancer binding protein:Isolation by screening of an expression library with a recognition site DNA

1988 • 677 citations

Specificity pockets for the side chains of peptide antigens in HLA-Aw68

1989 • 664 citations

L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer

1985 • 652 citations

Decreased expression of N-myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma

1985 • 644 citations

Methylation-Sensitive Sequence-Specific DNA Binding by the c-Myc Basic Region

1991 • 596 citations

Expression of class I major histocompatibility antigens switched off by highly oncogenic adenovirus 12 in transformed rat cells

1983 • 586 citations

Association of Myn, the murine homolog of Max, with c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation

1991 • 576 citations

Differential expression of myc family genes during murine development

1986 • 542 citations

Differential expression of cellular oncogenes during pre- and postnatal development of the mouse

1982 • 540 citations

Specific chromosomal translocations and the genesis of B-cell-derived tumors in mice and men

1983 • 517 citations

Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in Eμ-myc transgenic mice

1991 • 516 citations

Tumor-specific cytolysis by lymphocytes infiltrating human melanomas.

1989 • 511 citations

Assembly of MHC class I molecules analyzed in vitro

1990 • 491 citations

Identification of specific cytolytic immune responses against autologous tumor in humans bearing malignant melanoma.

1987 • 478 citations

MHC Class I Deficiency: Susceptibility to Natural Killer (NK) Cells and Impaired NK Activity

1991 • 474 citations

Transport Protein Genes in the Murine MHC: Possible Implications for Antigen Processing

1990 • 438 citations

NK susceptibility varies inversely with target cell class I HLA antigen expression.

1987 • 433 citations

Consequences of widespread deregulation of the c-myc gene in transgenic mice: Multiple neoplasms and normal development

1986 • 427 citations

A proteasome-related gene between the two ABC transporter loci in the class II region of the human MHC

1991 • 427 citations

MHC class II region encoding proteins related to the muKidrug resistance family of transmembrane transporters

1990 • 426 citations

Secondary Cancers after Bone Marrow Transplantation for Leukemia or Aplastic Anemia

1989 • 425 citations

Rejection of class I MHC-deficient haemopoietic cells by irradiated MHC-matched mice

1991 • 419 citations

Direct binding of peptide to empty MHC class I molecules on intact cells and in vitro

1990 • 418 citations

Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter

1991 • 413 citations

Genetic alteration of the c-myc protooncogene (MYC) in human primary breast carcinomas.

1986 • 413 citations

Abrogation of metastatic properties of tumour cells by de novo expression of H–2K antigens following H–2 gene transfection

1985 • 410 citations

An adenovirus type 2 glycoprotein blocks cell surface expression of human histocompatibility class I antigens

1985 • 405 citations

Detailed analysis of the mouse H-2Kb promoter: Enhancer-like sequences and their role in the regulation of class I gene expression

1986 • 395 citations

Nuclear Proto-Oncogenes Fos and Jun

1990 • 392 citations

Reversal of Oncogenesis by the Expression of a Major Histocompatibility Complex Class I Gene

1985 • 375 citations

An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes.

1990 • 368 citations

Rejection of transplantable AKR leukaemia cells following MHC DNA-mediated cell transformation

1984 • 359 citations

Markedly decreased expression of class I histocompatibility antigens, protein, and mRNA in human small-cell lung cancer.

1985 • 358 citations

Close link between reduction of c-myc expression by interferon and G0/G1 arrest

1985 • 358 citations

Tumorigenicity of cells transformed by adenovirus type 12 by evasion of T-cell immunity

1983 • 353 citations

PECULIAR IMMUNOBIOLOGY OF BONE MARROW ALLOGRAFTS

1971 • 349 citations

PECULIAR IMMUNOBIOLOGY OF BONE MARROW ALLOGRAFTS

1971 • 343 citations

Human major histocompatibility complex contains genes for the major heat shock protein HSP70.

1989 • 336 citations

New light on Myc and Myb. Part I. Myc.

1990 • 325 citations

Impaired intracellular transport of class I MHC antigens as a possible means for adenoviruses to evade immune surveillance

1985 • 322 citations

Structural and serological similarity of MHC-linked LMP and proteasome (multicatalytic proteinase) complexes

1991 • 310 citations

Two transcription factors, NF-kappa B and H2TF1, interact with a single regulatory sequence in the class I major histocompatibility complex promoter.

1988 • 308 citations

The gene coding for a major tumor rejection antigen of tumor P815 is identical to the normal gene of syngeneic DBA/2 mice.

1991 • 306 citations

Lack of HLA class I antigen expression by cultured melanoma cells FO-1 due to a defect in B2m gene expression.

1991 • 304 citations

Eradication of adenovirus E1-induced tumors by E1A-specific cytotoxic T lymphocytes

1989 • 300 citations

N-myc amplification causes down-modulation of MHC class I antigen expression in neuroblastoma

1986 • 297 citations

Structure of the gene of tum− transplantation antigen P91A: The mutated exon encodes a peptide recognized with Ld by cytolytic T cells

1989 • 296 citations

Human small-cell lung cancers show amplification and expression of the N-myc gene.

1986 • 293 citations

Definition of multiple, functionally distinct TATA elements, one of which is a target in the hsp70 promoter for E1A regulation

1988 • 292 citations

Human N-myc gene contributes to neoplastic transformation of mammalian cells in culture

1985 • 288 citations

Evolution of Class-I MHC Genes and Proteins: From Natural Selection to Thymic Selection

1990 • 286 citations

Tumor Eradication by Adoptive Transfer of Cytototic T Lymphocytes

1992 • 281 citations

TNF stimulates expression of mouse MHC class I genes by inducing an NF kappa B-like enhancer binding activity which displaces constitutive factors.

1989 • 275 citations

Behavior of myc and ras oncogenes in transformation of rat embryo fibroblasts.

1986 • 272 citations

NF-κB, KBF1, dorsal, and related matters

1990 • 267 citations

Striking paucity of HLA-A, B, C and beta 2-microglobulin on human neuroblastoma cell lines.

1983 • 257 citations

Immunotherapy of cancer using interleukin 2: current status and future prospects

1988 • 256 citations

Peptide selection by MHC class I molecules

1991 • 253 citations

Interferon response sequence potentiates activity of an enhancer in the promoter region of a mouse H–2 gene

1986 • 252 citations

A DNA-binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence.

1990 • 249 citations

c-myc down-regulates class I HLA expression in human melanomas.

1988 • 248 citations

Tumor necrosis factor enhances HLA-A,B,C and HLA-DR gene expression in human tumor cells.

1987 • 248 citations

A New Cluster of Genes Within the Human Major Histocompatibility Complex

1989 • 247 citations

ras oncogenes: their role in neoplasia

1990 • 244 citations

Binding of a nuclear factor to a regulatory sequence in the promoter of the mouse H-2Kb class I major histocompatibility gene.

1987 • 244 citations

Reversal of natural killing susceptibility in target cells expressing transfected class I HLA genes.

1989 • 241 citations

Recognition of HLA-B27 and related antigen by a monoclonal antibody

1982 • 240 citations

Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence.

1986 • 232 citations

Lysis of human melanoma cells by autologous cytolytic T cell clones. Identification of human histocompatibility leukocyte antigen A2 as a restriction element for three different antigens.

1989 • 223 citations

Peptide-induced conformational change of the class I heavy chain

1991 • 221 citations

"E3/19K" protein of adenovirus type 2 inhibits lysis of cytolytic T lymphocytes by blocking cell-surface expression of histocompatibility class I antigens.

1987 • 215 citations

Fibroblast lines expressing activated c-myc oncogenes are tumorigenic in nude mice and syngeneic animals

1984 • 212 citations

Human T lymphocytes recognize a peptide of single point-mutated, oncogenic ras proteins.

1991 • 208 citations

Autocrine β-related interferon controls c-myc suppression and growth arrest during hematopoietic cell differentiation

1986 • 206 citations

The melanoma antigen gp75 is the human homologue of the mouse b (brown) locus gene product.

1990 • 203 citations

Increased rate of degradation of c-myc mRNA in interferon-treated Daudi cells.

1985 • 203 citations

Role of the Major Histocompatibility Complex Class I Antigens in Tumor Growth and Metastasis

1988 • 201 citations

Nucleotide sequence of the human N-myc gene.

1986 • 190 citations

Cytolytic T-cell clones against an autologous human melanoma: specificity study and definition of three antigens by immunoselection.

1989 • 188 citations

Mouse major histocompatibility class I gene expression begins at midsomite stage and is inducible in earlier-stage embryos by interferon.

1985 • 185 citations

Immunological Surveillance of Tumors in the Context of Major Histocompatibility Complex Restriction of T Cell Function

1984 • 185 citations

Purification of KBF1, a common factor binding to both H-2 and beta 2-microglobulin enhancers.

1987 • 184 citations

Loss of MHC class‐I expression in cervical carcinomas

1990 • 184 citations

Presence on a human melanoma of multiple antigens recognized by autologous CTL

1989 • 180 citations

Oncogenes and the molecular origins of cancer

1990 • 177 citations

Expression of N-myc in teratocarcinoma stem cells and mouse embryos

1985 • 173 citations

Phenotypic dynamics of tumor progression in human malignant melanoma

1985 • 172 citations

Interferon-induced transcription of a major histocompatibility class I gene accompanies binding of inducible nuclear factors to the interferon consensus sequence.

1988 • 170 citations

A common positive trans-acting factor binds to enhancer sequences in the promoters of mouse H-2 and beta 2-microglobulin genes.

1987 • 169 citations

An improved biochemical method for the analysis of HLA-class I antigens. Definition of new HLA-class I subtypes

1986 • 167 citations

Histocompatibility Antigens on Murine Tumors

1985 • 164 citations

Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B.

1989 • 164 citations

Intracellular leucine zipper interactions suggest c-Myc hetero-oligomerization.

1991 • 161 citations

Cytotoxic T cell clones isolated from ovarian tumor-infiltrating lymphocytes recognize multiple antigenic epitopes on autologous tumor cells.

1991 • 159 citations

Distribution of HLA class 1 antigens in normal human tissue and in mammary cancer.

1981 • 153 citations

Amplification of the c-myc oncogene in one of five human breast carcinoma cell lines.

1984 • 152 citations

The raf Oncogene Is Associated with a Radiation-Resistant Human Laryngeal Cancer

1987 • 150 citations

Immunohistochemical analysis of malignant melanomas and nevocellular nevi with monoclonal antibodies to distinct monomorphic determinants of HLA antigens.

1984 • 149 citations

Structure of the gene of tum- transplantation antigen P198: a point mutation generates a new antigenic peptide.

1990 • 149 citations

Interferon regulates c-myc gene expression in Daudi cells at the post-transcriptional level.

1985 • 149 citations

A nonpolymorphic class I gene in the murine major histocompatibility complex

1984 • 146 citations

Identification of a subset of murine natural killer cells that mediates rejection of Hh-1d but not Hh-1b bone marrow grafts.

1989 • 144 citations

A large protein containing zinc finger domains binds to related sequence elements in the enhancers of the class I major histocompatibility complex and kappa immunoglobulin genes.

1990 • 144 citations

Antigenic heterogeneity of surgically removed primary and autologous metastatic human melanoma lesions.

1983 • 144 citations

Oncogenes and the molecular origins of cancer

1991 • 142 citations

Natural killer susceptibility of human cells may be regulated by genes in the HLA region on chromosome 6.

1986 • 141 citations

Down-regulation of LFA-1 Adhesion Receptors by C-mycOncogene in Human B Lymphoblastoid Cells

1990 • 136 citations

Loss of HLA‐A,B,C and de novo expression of HLA‐D in colorectal cancer

1986 • 136 citations

Regulation of Gene Expression by Interferons: Control of H-2 Promoter Responses

1988 • 136 citations

Level of HLA antigens in locoregional metastases and clinical course of the disease in patients with melanoma.

1988 • 136 citations

Demonstration by class I gene transfer that reduced susceptibility of human cells to natural killer cell‐mediated lysis is inversely correlated with HLA class I antigen expression

1989 • 133 citations

The HLA system: structure and function.

1987 • 131 citations

Excess β2 microglobulin promoting functional peptide association with purified soluble class I MHC molecules

1991 • 129 citations

Class I-induced resistance to natural killing: identification of nonpermissive residues in HLA-A2.

1991 • 128 citations

A Stereospecific Cyclization Catalyzed by an Antibody

1987 • 128 citations

HLA class I gene expression on human primary tumours and autologous metastases: demonstration of selective losses of HLA antigens on colorectal, gastric and laryngeal carcinomas

1989 • 127 citations

T cell recognition of transforming proteins encoded by mutated ras proto-oncogenes.

1991 • 126 citations

Heterogeneity in the expression of HLA and tumor-associated antigens by surgically removed and cultured breast carcinoma cells.

1983 • 125 citations

Perspectives on the Role of Mhc Antigens in Normal and Malignant Cell Development

1989 • 124 citations

Negative regulation of the major histocompatibility class I gene in undifferentiated embryonal carcinoma cells.

1986 • 123 citations

Effect of herpes simplex virus types 1 and 2 on surface expression of class I major histocompatibility complex antigens on infected cells

1985 • 122 citations

DEFICIENT GROWTH OF C57BL MARROW CELLS TRANSPLANTED IN F1 HYBRID MICE. ASSOCIATION WITH THE HISTOCOMPATIBILITY-2 LOCUS.

1964 • 120 citations

Loss of HLA-A,B,C allele products and lymphocyte function-associated antigen 3 in colorectal neoplasia.

1989 • 119 citations

Immunohistologic Characterization of Major Histocompatibility Antigens and Inflammatory Cellular Infiltrate in Human Breast Cancer<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1983 • 119 citations

The E3/19K protein of adenovirus type 2 binds to the domains of histocompatibility antigens required for CTL recognition.

1987 • 117 citations

The Human myc Gene Family

1986 • 116 citations

MHC-restricted recognition of autologous melanoma by tumor-specific cytotoxic T cells. Evidence for restriction by a dominant HLA-A allele.

1991 • 116 citations

Interferon increases HLA synthesis in melanoma cells: interferon-resistant and -sensitive cell lines.

1982 • 115 citations

Developmental activation of the H-2K gene is correlated with an increase in DNA methylation

1983 • 115 citations

Molecular cloning of an activated human oncogene, homologous to v-raf, from primary stomach cancer.

1985 • 113 citations

A gamma-interferon-induced factor that binds the interferon response sequence of the MHC class I gene, H-2Kb.

1989 • 113 citations

Loss of growth factor dependence and conversion of transforming growth factor-beta 1 inhibition to stimulation in metastatic H-ras-transformed murine fibroblasts.

1988 • 113 citations

Suppression of class I human histocompatibility leukocyte antigen by c-myc is locus specific.

1989 • 112 citations

Expression of histocompatibility antigens H-2K, -D, and -L is reduced in adenovirus-12-transformed mouse cells and is restored by interferon gamma.

1985 • 111 citations

Human tumor infiltrating lymphocytes. Analysis of lymphokine mRNA expression and relevance to cancer immunotherapy.

1989 • 111 citations

Differential regulation of interferon‐induced mRNAs and c‐myc mRNA by α‐ and γ‐interferons

1985 • 110 citations

Tumor necrosis factor and immune interferon synergistically increase transcription of HLA class I heavy- and light-chain genes in vascular endothelium.

1990 • 109 citations

Expression of major histocompatibility antigens and leucocyte infiltration in benign and malignant human breast disease

1984 • 109 citations

Tumor Necrosis Factor Reduces c- myc Expression and Cooperates with Interferon-γ in HeLa Cells

1986 • 109 citations

Interferon gamma induces lung colonization by intravenously inoculated B16 melanoma cells in parallel with enhanced expression of class I major histocompatibility complex antigens.

1987 • 107 citations

DNA replication origin and transcriptional enhancer in c-myc gene share the c-myc protein binding sequences.

1989 • 106 citations

Increased resistance to non-MHC-restricted cytotoxicity related to HLA A, B expression. Direct demonstration using beta 2-microglobulin-transfected Daudi cells.

1988 • 106 citations

Modulation of the tumorigenicity of human adenovirus-12-transformed cells by interferon

1985 • 105 citations

Interferons increase transcription of a major histocompatibility class I gene via a 5' interferon consensus sequence.

1987 • 105 citations

Cytotoxic T lymphocyte clones from peripheral blood and from tumor site detect intratumor heterogeneity of melanoma cells. Analysis of specificity and mechanisms of interaction.

1989 • 104 citations

Reconstitution by MHC-restricted peptides of HLA-A2 heavy chain with β2-microglobulin, in vitro

1991 • 104 citations

Detection of three protein binding sites in the serum-regulated promoter of the human gene encoding the 70-kDa heat shock protein.

1987 • 102 citations

Selective loss of HLA-A or HLA-B antigen expression in colon carcinoma.

1989 • 101 citations

Adenoviruses of subgenera B, C, D, and E modulate cell-surface expression of major histocompatibility complex class I antigens.

1986 • 100 citations

‘Nonspecific’ MHC-unrestricted killer cells and their receptors

1987 • 98 citations

Tumor cytolysis by lymphocytes infiltrating ovarian malignant ascites.

1991 • 95 citations

Increased synthesis and expression of H-2 antigens on thymocytes as a result of radiation leukemia virus infection: a possible mechanism for H-2 linked control of virus-induced neoplasia.

1978 • 95 citations

Retrovirus-induced changes in major histocompatibility complex antigen expression influence susceptibility to lysis by cytotoxic T lymphocytes.

1985 • 95 citations

The alpha 1/alpha 2 domains of class I HLA molecules confer resistance to natural killing.

1989 • 95 citations

Suppression of MHC class I gene expression by N-myc through enhancer inactivation.

1989 • 94 citations

Domains of human c-myc protein required for autosuppression and cooperation with ras oncogenes are overlapping.

1990 • 94 citations

Specific recognition of human CD3-CD16+ natural killer cells requires the expression of an autosomic recessive gene on target cells.

1990 • 92 citations

Defective expression of MHC class I antigens is frequent in B‐cell lymphomas of high‐grade malignancy

1987 • 88 citations

Loss of β2 microglobulin from the cell surface of cutaneous malignant and premalignant lesions

1981 • 87 citations

Expression of major histocompatibility complex class I antigens as a strategy for the potentiation of immune recognition of tumor cells.

1986 • 87 citations

Reversal of the metastatic phenotype in Lewis lung carcinoma cells after transfection with syngeneic H-2Kb gene.

1988 • 86 citations

CD4+ T cell clones specific for the human p97 melanoma-associated antigen can eradicate pulmonary metastases from a murine tumor expressing the p97 antigen.

1991 • 86 citations

Developmental and tissue-specific expression of nuclear proteins that bind the regulatory element of the major histocompatibility complex class I gene.

1989 • 84 citations

Adenovirus type 12 E1A gene represses accumulation of MHC class I mRNAs at the level of transcription

1988 • 83 citations

Class II histocompatibility antigen expression in human melanocytes transformed by Harvey murine sarcoma virus (Ha-MSV) and Kirsten MSV retroviruses.

1986 • 81 citations

Reduced expression of HLA class I and II antigens in colon cancer.

1990 • 80 citations

The influence of major histocompatibility complex class I antigens on tumor growth and metastasis

1987 • 80 citations

Generation of human autologous melanoma-specific cytotoxic T-cells using HLA-A2-matched allogeneic melanomas.

1990 • 80 citations

C-MYC: evidence for multiple regulatory functions.

1990 • 79 citations

Structure of the gene of tum- transplantation antigen P35B: presence of a point mutation in the antigenic allele.

1990 • 76 citations

In vivo ultraviolet-exposed human epidermal cells activate T suppressor cell pathways that involve CD4+CD45RA+ suppressor-inducer T cells.

1990 • 76 citations

Expression of MHC products and leucocyte differentiation antigens in gynaecological neoplasms: An immunohistological analysis of the tumour cells and infiltrating leucocytes

1985 • 71 citations

Adenovirus type 12 early region 1A proteins repress class I HLA expression in transformed human cells.

1986 • 71 citations

Lung colonization and metastasis by disseminated b16 melanoma cells: H‐2 associated control at the level of the host and the tumor cell

1985 • 71 citations

A new cell line (8701-BC) from primary ductal infiltrating carcinoma of human breast

1989 • 71 citations

Influence of major histocompatibility complex class I and II antigens on survival in colorectal carcinoma.

1991 • 70 citations

HLA antigens in colorectal tumours — low expression of HLA class I antigens in mucinous colorectal carcinomas

1987 • 69 citations

Regulation of major histocompatibility class I gene expression at the level of transcription in highly oncogenic adenovirus transformed rat cells.

1988 • 67 citations

A complex regulatory DNA element associated with a major histocompatibility complex class I gene consists of both a silencer and an enhancer.

1991 • 67 citations

Myc meets its max

1991 • 66 citations

Susceptibility to Natural Killer Cell-Mediated Cytolysis Is Independent of the Level of Target Cell Class I HLA-A Expression1

2015 • 66 citations

Characterisation of breast cancer infiltrates using monoclonal antibodies to human leucocyte antigens

1984 • 66 citations

Susceptibility or resistance to lysis by alloreactive natural killer cells is governed by a gene in the human major histocompatibility complex between BF and HLA-B.

1990 • 65 citations

Two purified factors bind to the same sequence in the enhancer of mouse MHC class I genes: one of them is a positive regulator induced upon differentiation of teratocarcinoma cells

1989 • 65 citations

Reduction in susceptibility to natural killer cell-mediated lysis of human FO-1 melanoma cells after induction of HLA class I antigen expression by transfection with B2m gene.

1991 • 65 citations

Identification of negative and positive regulatory elements associated with a class I major histocompatibility complex gene.

1988 • 65 citations

Differential expression of c-myc gene and c-fos gene in premalignant and malignant tissues from patients with familial polyposis coli.

1988 • 65 citations

Adenovirus E1A-mediated regulation of class I MHC expression.

1986 • 65 citations

H‐2K^b TRANSFECTION OF B16 MELANOMA CELLS RESULTS IN REDUCED TUMOURIGENICITY AND METASTATIC COMPETENCE

1989 • 63 citations

Lack of MHC class I antigens and tumour aggressiveness of the squamous cell carcinoma of the larynx

1990 • 63 citations

Structure and expression of B-myc, a new member of the myc gene family.

1988 • 63 citations

Transcriptional suppression of cellular gene expression by c-Myc.

1991 • 62 citations

The leucine zipper of c-Myc is required for full inhibition of erythroleukemia differentiation.

1990 • 61 citations

Antigenic heterogeneity of a human melanoma tumor detected by autologous CTL clones

1988 • 60 citations

c-myc reverses neu-induced transformed morphology by transcriptional repression.

1991 • 59 citations

HLA non-A,B,C class I genes: Their structure and expression

1990 • 59 citations

aberrant expression of HLA Class‐I antigens in burkitt lymphoma cells

1991 • 59 citations

Aggressive subtypes of human colorectal tumors frequently exhibit amplification of the c-myc gene.

1991 • 59 citations

Absence of human leukocyte antigen molecules in skin tumors and some cutaneous appendages: Evidence using monoclonal antibodies

1983 • 58 citations

The murine cellular immune response to adenovirus type 5

1989 • 57 citations

Increased MHC H–2K gene transcription in cultured mouse embryo cells after adenovirus infection

1985 • 56 citations

Stimulation of HLA-A,B,C by IFN-alpha. The derivation of Molt 4 variants and the differential expression of HLA-A,B,C subsets.

1985 • 56 citations

N-myc disrupts protein kinase C-mediated signal transduction in neuroblastoma.

1991 • 56 citations

Selective loss of beta 2-microglobulin mRNA in human colon carcinoma.

1989 • 56 citations

RAS residues that are distant from the GDP binding site play a critical role in dissociation factor-stimulated release of GDP.

1992 • 55 citations

Oncogene cooperation in lymphocyte transformation: malignant conversion of E mu-myc transgenic pre-B cells in vitro is enhanced by v-H-ras or v-raf but not v-abl.

1989 • 55 citations

The biological consequences of altered MHC expression on tumours

1987 • 55 citations

Immunoregulation of Carcinogenesis: Past, Present, and Future1

1988 • 54 citations

Prognostic value of c-myc proto-oncogene overexpression in early invasive carcinoma of the cervix.

1990 • 53 citations

DNA binding of regulatory factors interacting with MHC-class-I gene enhancer correlates with MHC-class-I transcriptional level in class-I-defective cell lines

1991 • 53 citations

H-2Kb antigen expression has no effect on natural killer susceptibility and tumorigenicity of a murine hepatoma.

1988 • 52 citations

Identification of sequences responsible for positive and negative regulation by E1A in the promoter of H-2Kbm1 class I MHC gene.

1990 • 52 citations

Antisense inhibition of single copy N-myc expression results in decreased cell growth without reduction of c-myc protein in a neuroepithelioma cell line.

1990 • 52 citations

A Burst of c-fos Gene Expression in the Mouse Occurs at Birth

1987 • 51 citations

On a Possible Protective Effect of HLA-A11 Against Skin Cancer and Keratotic Skin Lesions in Renal Transplant Recipients

1991 • 51 citations

Lysis of a lung carcinoma by poly I:C-induced natural killer cells is independent of the expression of class I histocompatibility antigens.

1988 • 50 citations

Lacking prognostic significance of β2-microglobulin, MHC class I and class II antigen expression in breast carcinomas

1990 • 50 citations

Natural resistance of lethally irradiated F1 hybrid mice to parental marrow grafts is a function of H-2/Hh-restricted effectors.

1984 • 50 citations

High expression of the c-myc oncogene renders melanoma cells prone to lysis by natural killer cells.

1989 • 49 citations

Susceptibility to natural killer cell-mediated cytolysis is independent of the level of target cell class I HLA expression.

1989 • 49 citations

Adenovirus Proteins And Mhc Expression

1989 • 48 citations

Lymphokine-activated killer (LAK) cells. IV. Characterization of murine LAK effector subpopulations.

1990 • 48 citations

Gamma interferon and 5-azacytidine cause transcriptional elevation of class I major histocompatibility complex gene expression in K562 leukemia cells in the absence of differentiation.

1986 • 48 citations

Suppression of MHC class I RNA in highly oncogenic cells occurs at the level of transcription initiation.

1989 • 48 citations

An experimental analysis of cancer: role of ras oncogenes in multistep carcinogenesis.

1990 • 48 citations

Gene Amplification in Human Lung Cancer: ThemycFamily Genes and Other Proto-oncogenes and Growth Factor Genes

1990 • 47 citations

Natural killer susceptibility is independent of HLA class I antigen expression on cell lines obtained from human solid tumors

1990 • 46 citations

A burst of c-fos gene expression in the mouse occurs at birth.

1987 • 46 citations

Two genes encode factors with NF-kappa B- and H2TF1-like DNA-binding properties.

1990 • 46 citations

Target cell expression of MHC antigens is not (always) a turn-off signal to natural killer cells.

1988 • 46 citations

Lack of correlation between levels of MHC class I antigen and susceptibility to lysis of small cellular lung carcinoma (SCLC) by natural killer cells

1990 • 46 citations

Reconstitution of H‐2 class I expression by gene transfection decreases susceptibility to natural killer cells of an EL4 class I loss variant

1990 • 46 citations

Increased N-myc expression following progressive growth of human neuroblastoma.

1986 • 45 citations

Fine peptide specificity of cytotoxic T lymphocytes directed against adenovirus-induced tumours and peptide-mhc binding

1991 • 44 citations

NK sensitivity and lung clearance of MHC‐class‐I‐deficient cells within a heterogeneous fibrosarcoma

1989 • 44 citations

Antiproliferative effects of antisense oligonucleotides directed to the RNA ofc-myconcogene

1991 • 44 citations

Negative regulation of the major histocompatibility complex class I promoter in embryonal carcinoma cells.

1991 • 43 citations

Afferent and efferent cellular interactions in natural resistance directed against MHC class I deficient tumor grafts.

1988 • 43 citations

Tumorigenicity of adenovirus-transformed rat cells and expression of class I major histocompatibility antigen

1984 • 43 citations

Target lysis by human lak cells is critically dependent upon target binding properties, but LFA‐1, LFA‐3 AND ICAM‐1 are not the major adhesion ligands on targets

1991 • 41 citations

Lack of correlation between levels of MHC class I antigen and susceptibility to lysis of small cellular lung carcinoma (SCLC) by natural killer cells.

1989 • 40 citations

Studies of sublines selected for loss of HLA expression from an EBV-transformed lymphoblastoid cell line. Changes in sensitivity to cytotoxic T cells activated by allostimulation and natural killer cells activated by IFN or IL-2.

1989 • 40 citations

Adenovirus type 12 E1A down regulates expression of a transgene under control of a major histocompatibility complex class I promoter: evidence for transcriptional control

1989 • 38 citations

Differential regulation of HLA class I genes by interferon

1990 • 38 citations

Loss of Membrane B2 Microglobulin in Eccrine Porocarcinoma

1984 • 38 citations

Defective HLA class II expression in a regulatory mutant is partially complemented by activated ras oncogenes.

1987 • 37 citations

Lessons from T cell responses to virus induced tumours for cancer eradication in general.

1992 • 36 citations

Autocrine interferon and the suppression of the c-myc nuclear oncogene.

1987 • 36 citations

IMPAIRED H‐2 EXPRESSION IN B 16 MELANOMA VARIANTS

1983 • 36 citations

Multiple enhancer-like sequences in the HLA-B7 gene.

1989 • 36 citations

CpG islands and HTF islands in the HLA class I region: investigation of the methylation status of class I genes leads to precise physical mapping of the HLA-B and -C genes

1988 • 36 citations

Loss of polymorphic A and B locus HLA antigens in colon carcinoma

1988 • 36 citations

Quantitation of MHC antigen expression on colorectal tumours and its association with tumour progression

1987 • 36 citations

Hematopoietic Histoincompatibility Reactions by NK Cells in Vitro: Model for Genetic Resistance to Marrow Grafts

1985 • 36 citations

Immunohistochemical detection of major histocompatibility complex antigens and quantitative analysis of tumour-infiltrating mononuclear cells in renal cell cancer

1990 • 35 citations

A transcription factor interacting with the class I gene enhancer is inactive in tumorigenic cell lines which suppress major histocompatibility complex class I genes.

1990 • 35 citations

Expression of class I histocompatibility antigens in neuroectodermal tumors is independent of the expression of a transfected neuroblastoma myc gene.

1989 • 34 citations

Murine retroviruses control class I major histocompatibility antigen gene expression via a trans effect at the transcriptional level.

1987 • 34 citations

Suppression of MHC gene expression in cancer cells

1987 • 33 citations

Expression of HLA-A, -B, -C, -DR, -DP, -DQ, and of HLA-D-associated invariant chain (Ii) in non-neoplastic mammary epithelium, fibroadenoma, adenoma, and carcinoma of the breast.

1989 • 33 citations

Differential expression and interferon response of HLA class I genes in thymocyte lines and response variants

1988 • 33 citations

Reduced tumorigenicity of a spontaneous mouse lung carcinoma following H-2 gene transfection.

1987 • 33 citations

Use of anti-HLA antibodies to mask major histocompatibility complex gene products on tumor cells can enhance susceptibility of these cells to lysis by natural killer cells.

1989 • 32 citations

Selective and non-selective loss of immunoregulatory molecules (HLA-A,B,C antigens and LFA-3) in transitional cell carcinoma

1990 • 30 citations

Inhibition of HLA class I antigen and mRNA expression induced by Rous sarcoma virus in transformed human fibroblasts.

1988 • 29 citations

Sensitivity of melanoma cell lines to natural killer cells: a role for oncogene-modulated HLA class I expression?

1991 • 29 citations

Altered regulation of MHC class I genes in different tumor cell lines is reflected by distinct sets of DNase I hypersensitive sites.

1989 • 28 citations

HLA class I and beta 2-microglobulin expression in frozen and formaldehyde-fixed paraffin sections of neuroblastoma tumors.

1985 • 28 citations

Association in the expression of Kirsten-ras oncogene and the major histocompatibility complex class I antigens in fibrosarcoma tumor cell variants exhibiting different metastatic capabilities.

1987 • 27 citations

N-myc Expression Switched Off and Class I Human Leukocyte Antigen Expression Switched On after Somatic Cell Fusion of Neuroblastoma Cells

1990 • 27 citations

Partial suppression of anchorage-independent growth and tumorigenicity in immunodeficient mice by transfection of the H-2 class I gene H-2Ld into a human colon cancer cell line (HCT).

1988 • 26 citations

Potentiation of interferon induction of class I major histocompatibility complex antigen expression by human tumor necrosis factor in small cell lung cancer cell lines.

1989 • 26 citations

The c-fos proto-oncogene in murine 3LL carcinoma clones controls the expression of MHC genes.

1988 • 26 citations

N-myc oncogene expression and amplification in metastatic lesions of stage IV-S neuroblastoma

1990 • 24 citations

N-myc expression switched off and class I human leukocyte antigen expression switched on after somatic cell fusion of neuroblastoma cells.

1990 • 24 citations

In vitro modulation and relationship between N-myc and HLA class I RNA steady-state levels in human neuroblastoma cells.

1990 • 24 citations

IMMUNOGENICITY OF H‐2 POSITIVE AND H‐2 NEGATIVE CLONES OF A MOUSE TUMOUR, GR9

1986 • 23 citations

Major histocompatibility complex class I genes in murine fibrosarcoma IC9 are down regulated at the level of the chromatin structure.

1989 • 23 citations

Metastatic potential of cloned murine melanoma cells transfected with activated c-Ha-ras.

1989 • 23 citations

Anti-adenovirus type 5 cytotoxic T lymphocytes: immunodominant epitopes are encoded by the E1A gene

1991 • 23 citations

Altered growth of a human neuroendocrine carcinoma line after transfection of a major histocompatibility complex class I gene.

1989 • 22 citations

Variation in HLA Expression on Tumors: An Escape from Immune Response

1989 • 22 citations

C-terminal domain of the adenovirus E1A oncogene product is required for induction of cytotoxic T lymphocytes and tumor-specific transplantation immunity

1989 • 22 citations

Malignant transformation of an infinite life span human fibroblast cell strain by transfection with v-Ki-ras.

1990 • 22 citations

Regulation of IFN-gamma-induced host cell MHC antigen expression by Kirsten MSV and MLV. II. Effects on class II antigen expression.

1989 • 21 citations

Expression of the N-myc oncogene in Wilms' tumour and related tissues.

1988 • 20 citations

Modulation of major histocompatibility complex (MHC) class I genes in adenovirus 12 transformed cells: interferon-gamma increases class I expression by a mechanism that circumvents E1A induced-repression and tumor necrosis factor enhances the effect of interferon-gamma.

1989 • 20 citations

Antigens recognized on a melanoma cell line by autologous cytolytic T lymphocytes are also expressed on freshly collected tumor cells

1990 • 20 citations

Paired tumour infiltrating lymphocyte (TIL) and tumour cell line from bladder cancer: a new approach to study tumour immunology in vitro

1991 • 20 citations

Introduction of the activated N-ras oncogene into human fibroblasts by retroviral vector induces morphological transformation and tumorigenicity

1990 • 19 citations

Regulation of HLA class I transcription in T cells.

1989 • 19 citations

Proportion of antigenic variants induced by in vitro UV irradiation differs in clones derived from a single tumor.

1988 • 18 citations

Increased sensitivity to MHC-nonrestricted lysis of BL6 melanoma cells by transfection with class I H-2Kb gene.

1990 • 18 citations

K‐ras mutations (codon 12) are not involved in down‐regulation of mhc class‐i genes in colon carcinomas

1990 • 18 citations

Expression of major histocompatibility class I genes in differentiating leukemic cells is temporally related to activation of c-fos proto-oncogene.

1987 • 17 citations

Adenovirus type 5 E3 gene products interfere with the expression of the cytolytic T cell immunodominant E1 a antigen

1991 • 17 citations

Acquisition of tumorigenic potential in the human myoepithelial HBL100 cell line is associated with decreased expression of HLA class I, class II and integrin β3 and increased expression of c‐myc

1989 • 17 citations

Association of expression between N-myc gene and major histocompatibility complex class I gene in surgically resected human neuroblastoma

1991 • 17 citations

Downregulation of c-myc RNA is not a prerequisite for reduced cell proliferation, but is associated with G1 arrest in B-lymphoid cell lines

1987 • 16 citations

Locus-specific regulation of Kd, Dd, and Ld class I genes in the BALB/c S49 lymphoma sublines.

1989 • 15 citations

Cis-acting elements determine the locus-specific shutoff of class I major histocompatibility genes in murine S49 lymphoma sublines.

1989 • 14 citations

c‐fos transfection of 3LL tumor cells turns on MHC gene expression and consequently reduces their metastatic competence

1990 • 14 citations

Modulation of the transformed and neoplastic phenotype of rat fibroblasts by MHC-I gene expression.

1989 • 14 citations

Site-specific mutagenesis of the class I regulatory element the Q10 gene allows expression in non-liver tissues.

1989 • 14 citations

Tumorigenicity, metastasis and suppression of MHC class-I expression in murine fibroblasts transformed by mutantv-ras deficient in GTP binding

1991 • 13 citations

Immunosurveillance of Virus-induced Tumors

1989 • 13 citations

Differential induction of H-2K versus H-2D class I major histocompatibility antigens by recombinant gamma interferon. Lack of Kk augmentation in a leukemia virus-induced tumor is due to a cis-dominant effect.

1988 • 13 citations

POST‐TRANSCRIPTIONAL DOWNREGULATION OF MHC CLASS I EXPRESSION IN ONCOGENE‐TRANSFORMED CELLS IS REVERTED BY IFN‐GAMMA AND TNF‐ALPHA

1989 • 13 citations

Structure and expression of polypeptides encoded in the mouseQa region

1987 • 13 citations

Comparative action of myc and bcl-2 in B-cell malignancy.

1991 • 12 citations

Distinct mechanisms of interferon‐gamma and tumor necrosis factor‐alpha action in oncogene‐transformed mouse fibroblasts

1988 • 12 citations

A Short, Highly Repetitive Element in Intron -1 of the Human c-Ha-ras Gene Acts as a Block to Transcriptional Readthrough by a Viral Promoter

1990 • 12 citations

NK and LAK Susceptibility Varies Inversely with Target Cell MHC Class I Antigen Expression in a Rat Epithelial Tumour System

1991 • 11 citations

Induction of c-ets and c-fos gene expression upon antigenic stimulation of a T cell hybridoma with inducible cytolytic capacity.

1987 • 11 citations

Differential enhancement of HLA-B27 by interferon

1990 • 10 citations

The level of expression of class‐I MHC antigens in adenovirus‐transformed human cell lines

1987 • 10 citations

Partial Suppression of Metastatic Potential of Malignant Cells in Immunodeficient Mice Caused by Transfection of H-2Kb Gene

1990 • 10 citations

Regulation of c-mycRNA and Its Proteins in Daudi Cells by Interferon-β

1987 • 10 citations

A short, highly repetitive element in intron -1 of the human c-Ha-ras gene acts as a block to transcriptional readthrough by a viral promoter.

1990 • 10 citations

The role of major histocompatibility complex class I antigens in tumorigenesis: future applications in cancer therapy

1989 • 10 citations

Negative and Positive Regulation of Human Leukocyte Antigen Class I Gene Transcription in K562 Leukemia Cells

1987 • 9 citations

Role of major histocompatibility complex class-I molecules in tumor rejection

1990 • 9 citations

Alteration and Enhanced Expression of the c-myc Oncogene in Human Colorectal Carcinomas

1990 • 8 citations

The regulation of exogenous and endogenous class I MHC genes in a human tumor cell line, K562

1990 • 8 citations

MHC class‐I antigen deficiency, malignancy and susceptibility of P815 mastocytoma to NK and macrophage killing

1990 • 8 citations

NK SENSITIVITY, H‐2 EXPRESSION AND METASTATIC POTENTIAL: ANALYSIS OF H‐2D^k GENE TRANSFECTED FIBROSARCOMA CELLS

1989 • 8 citations

Rat natural killer cell and cytotoxic T cell lysis of H‐2‐negative murine embryonal carcinoma cells

1985 • 8 citations

Differential expression of the HLA-B7 and the HLA-A2 gene in transfected mouse L(tk−) cells after Stimulation by mouse interferon

1987 • 8 citations

The tumor progression‐associated human melanoma antigen P3.58 mediates monocyte‐lymphocyte interactions in vitro

1988 • 7 citations

Molecular and cellular biology of Wilms' tumour.

1989 • 7 citations

Correlation between chromosome 5q deletions and different mechanisms of c-myc overexpression in human colorectal cancer

1991 • 7 citations

Application of isoelectric focusing for studies of major histocompatibility complex class I antigen expression on human carcinomas and sarcomas

1991 • 7 citations

Identification of locus-specific DNA-binding factors for the regulation of HLA class-I genes in human colorectal cancer

1991 • 7 citations

Expression of major histocompatibility complex class I antigens in normal and transformed rat thyroid epithelial cell lines.

1987 • 7 citations

Down-regulation of MHC class I antigens is not a general mechanism for the increased tumorigenicity caused by c-myc amplification.

1990 • 7 citations

Differential transcription inducibility by interferon of the HLA-A3 and HLA-B7 class-I genes

1991 • 7 citations

Reduced HLA-A,B,C expression in tumourigenic v-raf transfected human urothelial cells

1990 • 7 citations

Regulatory elements involved in the liver-specific expression of the mouse MHC class I Q10 gene: characterization of a new TATA-binding factor

1990 • 7 citations

Interferon-γ regulation of major histocompatibility class i gene expression in rat cells containing the adenovirus 12 E1 a oncogene

1990 • 6 citations

Regulation of HLA class I gene expression in human colorectal carcinoma.

1991 • 6 citations

beta2 Microglobulin Expression in Normal Melanocytes, Nevocellular Nevi, and Malignant Melanomas.

1989 • 6 citations

Comparison of the promoter regions of H-2K^band H-2K^bm1class I MHC genes

1990 • 6 citations

HEMOPOIETIC HISTOCOMPATIBILITY (Hh-1) REGULATORY AND STRUCTURAL GENES OF THE f HAPLOTYPE MAP TO H-2

1990 • 6 citations

High proliferative capacity and specific antiautologous melanoma cytotoxicity of a human t-lymphocyte clone derived from tumor-infiltrating lymphocytes

1990 • 5 citations

Negative and positive regulation of human leukocyte antigen class I gene transcription in K562 leukemia cells.

1987 • 5 citations

The relationship of modulation of major histocompatibility complex class I antigens to retrovirus transformation in rat cell lines.

1988 • 4 citations

Oncogenes in Cancer diagnosis

1991 • 3 citations

ALTERED EXPRESSION OF HLA‐A,B SPECIFICITIES ON ACUTE LYMPHOID AND MYELOID LEUKAEMIA BLASTS

1990 • 3 citations

Oncogenes in Cancer Diagnosis

1990 • 2 citations

Deleted Work

1955 • 0 citations

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