Role of antigen, CD8, and cytotoxic T lymphocyte (CTL) avidity in high dose antigen induction of apoptosis of effector CTL.

Solid Phase Peptide Synthesis

1976 • 1,798 citations

The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides

1986 • 1,723 citations

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

1993 • 1,219 citations

Induction of apoptosis in mature T cells by tumour necrosis factor

1995 • 1,139 citations

lnterleukin-2 programs mouse αβ T lymphocytes for apoptosis

1991 • 1,027 citations

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity.

1993 • 801 citations

Peripheral deletion of antigen-reactive T cells in oral tolerance

1995 • 775 citations

Peripheral Selection of the T Cell Repertoire

1991 • 666 citations

T Cell Deletion in High Antigen Dose Therapy of Autoimmune Encephalomyelitis

1994 • 530 citations

Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy.

1996 • 520 citations

An immunodominant epitope of the human immunodeficiency virus envelope glycoprotein gp160 recognized by class I major histocompatibility complex molecule-restricted murine cytotoxic T lymphocytes.

1988 • 417 citations

The thymus selects the useful, neglects the useless and destroys the harmful

1989 • 378 citations

Death of mature T cells by separate ligation of CD4 and the T-cell receptor for antigen

1990 • 375 citations

Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood T cells.

1993 • 341 citations

Receptor-stimulated death pathway is opened by antigen in mature T cells.

1991 • 255 citations

Rapid quantitation of apoptosis in pure and heterogeneous cell populations using flow cytometry

1994 • 245 citations

Profound deletion of mature T cells in vivo by chronic exposure to exogenous superantigen.

1993 • 241 citations

Cell growth cycle block of T cell hybridomas upon activation with antigen.

1987 • 235 citations

T cell priming versus T cell tolerance induced by synthetic peptides.

1995 • 230 citations

Levels of Peripheral T Cell Tolerance Induced by Different Doses of Tolerogen

1994 • 229 citations

Peripheral Clonal Elimination of Functional T Cells

1990 • 213 citations

Protease inhibitors selectively block T cell receptor-triggered programmed cell death in a murine T cell hybridoma and activated peripheral T cells.

1993 • 198 citations

T cell receptor/CD3-signaling induces death by apoptosis in human T cell receptor gamma delta + T cells.

1991 • 167 citations

Self‐Ignorance in the Peripheral T‐Cell Pool

1993 • 124 citations

CD8+ T lymphocytes of patients with AIDS maintain normal broad cytolytic function despite the loss of human immunodeficiency virus-specific cytotoxicity.

1990 • 120 citations

Activation-driven T cell death. II. Quantitative differences alone distinguish stimuli triggering nontransformed T cell proliferation or death.

1992 • 120 citations

Correlation between CD8 dependency and determinant density using peptide-induced, Ld-restricted cytotoxic T lymphocytes.

1991 • 117 citations

Serum angiotensin-1 converting enzyme activity processes a human immunodeficiency virus 1 gp160 peptide for presentation by major histocompatibility complex class I molecules.

1992 • 110 citations

Discrepancy between in vitro measurable and in vivo virus neutralizing cytotoxic T cell reactivities. Low T cell receptor specificity and avidity sufficient for in vitro proliferation or cytotoxicity to peptide-coated target cells but not for in vivo protection.

1992 • 107 citations

Broad recognition of cytotoxic T cell epitopes from the HIV-1 envelope protein with multiple class I histocompatibility molecules.

1992 • 97 citations

Antigen-induced suppression of the proliferative response of T cell clones.

1988 • 96 citations

Cognate peptides induce self-destruction of CD8+ cytolytic T lymphocytes.

1990 • 96 citations

Peripheral deletion of mature CD8+ antigen-specific T cells after in vivo exposure to male antigen.

1992 • 84 citations

Cognate peptide-induced destruction of CD8+ cytotoxic T lymphocytes is due to fratricide.

1993 • 68 citations

Inactivation of human immunodeficiency virus (HIV)-1 envelope-specific CD8+ cytotoxic T lymphocytes by free antigenic peptide: a self-veto mechanism?

1996 • 52 citations

Sensitivity of T cells to anti‐CD3‐stimulated suicide is independent of functional phenotype

1992 • 51 citations

Peripheral tolerance in mice expressing a liver-specific class I molecule: inactivation/deletion of a T-cell subpopulation.

1990 • 40 citations

Parameters controlling the programmed death of mature mouse T lymphocytes in high-dose suppression

1995 • 34 citations

Effects of cognate peptides on cytolytic and proliferative activities of cloned cytotoxic T lymphocytes

1992 • 23 citations

Consequences of self-presentation of peptide antigen by cytolytic T lymphocytes.

1989 • 21 citations

Antigen as a positive and negative regulator of proliferation in cytotoxic lymphocytes. A model for the differential regulation of proliferation and lytic activity.

1988 • 12 citations

Deleted Work

1955 • 0 citations