Evidence that a Single Peptide–MHC Complex on a Target Cell Can Elicit a Cytolytic T Cell Response

Serial triggering of many T-cell receptors by a few peptide–MHC complexes

1995 • 1,143 citations

Monoclonal Antibodies for Analysis of the HLA System

1979 • 745 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation

1990 • 468 citations

Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness.

1994 • 431 citations

GENERATION, TRANSLOCATION, AND PRESENTATION OF MHC CLASS I-RESTRICTED PEPTIDES

1995 • 428 citations

The Minimal Number of Class II MHC-Antigen Complexes Needed for T Cell Activation

1990 • 410 citations

A pentapeptide as minimal antigenic determinant for MHC class I-restricted T lymphocytes

1989 • 339 citations

Peptide binding to class I MHC on living cells and quantitation of complexes required for CTL lysis

1991 • 336 citations

Monoclonal antibodies to mouse MHC antigens. II. Antibodies to the H-2Ld antigen, the products of a third polymorphic locus of the mouse major histocompatibility complex.

1980 • 306 citations

Importance of Peptide Amino and Carboxyl Termini to the Stability of MHC Class I Molecules

1994 • 294 citations

T Cell Receptor-MHC Class I Peptide Interactions: Affinity, Kinetics, and Specificity

1994 • 292 citations

A naturally occurring peptide recognized by alloreactive CD8+ cytotoxic T lymphocytes in association with a class I MHC protein

1992 • 286 citations

Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx

1985 • 282 citations

Kinetics and affinity of reactions between an antigen-specific T cell receptor and peptide-MHC complexes

1994 • 253 citations

Naturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by human immunodeficiency virus type 1.

1994 • 221 citations

The minimum peptide epitope from the influenza virus matrix protein. Extra and intracellular loading of HLA-A2.

1991 • 214 citations

Major antigen-induced domain rearrangements in an antibody

1993 • 206 citations

High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins.

1994 • 200 citations

Split Anergy in a CD8 ⁺ T Cell: Receptor-dependent Cytolysis in the Absence of Interleukin-2 Production

1991 • 199 citations

Immunoprecipitation of cell surface structures of cloned cytotoxic T lymphocytes by clone-specific antisera.

1984 • 183 citations

Crystal Structure of the V _α Domain of a T Cell Antigen Receptor

1995 • 178 citations

Peptide ligand-induced conformation and surface expression of the Ld class I MHC molecule

1990 • 155 citations

Variations in the number of peptide-MHC class I complexes required to activate cytotoxic T cell responses.

1995 • 148 citations

Cytolytic lymphocytes induce both apoptosis and necrosis in target cells.

1991 • 145 citations

Differential transport requirements of HLA and H-2 class I glycoproteins

1989 • 143 citations

A ubiquitous protein is the source of naturally occurring peptides that are recognized by a CD8+ T-cell clone.

1993 • 129 citations

Identification of the nonamer peptide from influenza A matrix protein and the role of pockets of HLA‐A2 in its recognition by cytotoxic T lymphocytes

1992 • 114 citations

The law of mass action governs antigen-stimulated cytolytic activity of CD8+ cytotoxic T lymphocytes.

1995 • 106 citations

The biologic activity of anti-T cell receptor V region monoclonal antibodies is determined by the epitope recognized.

1988 • 86 citations

Minimal requirements for peptide mediated activation of CD8+ CTL

1994 • 71 citations

Inhibition or activation of human T cell receptor transfectants is controlled by defined, soluble antigen arrays.

1992 • 44 citations

Stoichiometric Labeling of Peptides by Iodination on Tyrosyl or Histidyl Residues

1993 • 37 citations

Effects of cognate peptides on cytolytic and proliferative activities of cloned cytotoxic T lymphocytes

1992 • 23 citations

T cell activation through TCR/-CD3 complex. IL-2 production of T cell clones stimulated with anti-CD3 without cross-linkage.

1992 • 22 citations

In Vitro Radiolabeling of Peptides and Proteins

1995 • 20 citations