Human Tumor Antigens

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Observations on the Systemic Administration of Autologous Lymphokine-Activated Killer Cells and Recombinant Interleukin-2 to Patients with Metastatic Cancer

1985 • 2,616 citations

DEMONSTRATION OF TUMOR-SPECIFIC ANTIGENS IN HUMAN COLONIC CARCINOMATA BY IMMUNOLOGICAL TOLERANCE AND ABSORPTION TECHNIQUES

1965 • 2,318 citations

Glycosphingolipids in Cellular Interaction, Differentiation, and Oncogenesis

1981 • 1,650 citations

CHROMATOGRAPHlC SEPARATION OF HUMAN BRAIN GANGLIOSIDES*

1963 • 1,644 citations

Colorectal carcinoma antigens detected by hybridoma antibodies

1979 • 1,342 citations

The Biochemistry of Glycoproteins and Proteoglycans

1980 • 1,231 citations

Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are onco-developmental antigens

1985 • 1,184 citations

T and Tn, General Carcinoma Autoantigens

1984 • 998 citations

Monoclonal antibody to a plasma membrane antigen of neurons.

1979 • 965 citations

Aberrant glycosylation in cancer cell membranes as focused on glycolipids: overview and perspectives.

1985 • 809 citations

Tumorigenicity of virus-transformed cells in nude mice is correlated specifically with anchorage independent growth in vitro.

1975 • 747 citations

Tumor-Associated Carbohydrate Antigens

1984 • 622 citations

PRODUCTION OF EMBRYONAL α-GLOBULIN BY TRANSPLANTABLE MOUSE HEPATOMAS

1963 • 601 citations

Specific Antigen in Serum of Patients with Colon Carcinoma

1981 • 583 citations

Glycosphingolipids as Tumor-Associated and Differentiation Markers<xref ref-type="fn" rid="FN5">5</xref><xref ref-type="fn" rid="FN6">6</xref>

1983 • 580 citations

GD3, a prominent ganglioside of human melanoma. Detection and characterisation by mouse monoclonal antibody.

1982 • 579 citations

Mouse monoclonal IgG3 antibody detecting GD3 ganglioside: a phase I trial in patients with malignant melanoma.

1985 • 566 citations

Cell surface antigens of human malignant melanoma: definition of six antigenic systems with mouse monoclonal antibodies.

1980 • 522 citations

Ganglioside-mediated modulation of cell growth, growth factor binding, and receptor phosphorylation.

1984 • 501 citations

Studies on the Chemical and Enzymatic Modification of Glycoproteins

1971 • 498 citations

Hybrid hybridomas and their use in immunohistochemistry

1983 • 497 citations

Determination of cellular shape by the extracellular matrix and its correlation with the control of cellular growth.

1978 • 487 citations

Detection of gangliosides that bind cholera toxin: Direct binding of 125I-labeled toxin to thin-layer chromatograms

1980 • 480 citations

Cell surface antigens of human malignant melanoma: mixed hemadsorption assays for humoral immunity to cultured autologous melanoma cells.

1976 • 442 citations

Effect of ethanol on liver 8-aminolaevulinate synthetase in rats.

1968 • 430 citations

Gangliosides as membrane receptors for tetanus toxin, cholera toxin and serotonin

1974 • 391 citations

A Monosialoganglioside Is a Monoclonal Antibody-Defined Antigen of Colon Carcinoma

1981 • 375 citations

Detection of ganglioside GD2 in tumor tissues and sera of neuroblastoma patients.

1984 • 364 citations

Contactual lysis of antibody-coated chicken erythrocytes by purified lymphocytes

1970 • 363 citations

THE NATURE OF BENCE-JONES PROTEINS

1962 • 353 citations

Study of antibodies against human melanoma produced by somatic cell hybrids.

1978 • 349 citations

Contact-Induced Cytotoxicity by Lymphoid Cells Containing Foreign Isoantigens

1965 • 327 citations

PHASE-I CLINICAL TRIAL OF MONOCLONAL ANTIBODY IN TREATMENT OF GASTROINTESTINAL TUMOURS

1982 • 317 citations

Morphological appearance, growth behavior and migratory activity of human tumor cells maintained on extracellular matrix versus plastic

1980 • 312 citations

Unique glycoprotein-proteoglycan complex defined by monoclonal antibody on human melanoma cells.

1982 • 305 citations

Disialogangliosides GD2 and GD3 are involved in the attachment of human melanoma and neuroblastoma cells to extracellular matrix proteins.

1986 • 305 citations

Human melanoma-associated antigen p97 is structurally and functionally related to transferrin

1982 • 288 citations

Distribution and molecular characterization of a cell‐surface and a cytoplasmic antigen detectable in human melanoma cells with monoclonal antibodies

1981 • 269 citations

REMOVAL OF NEUROBLASTOMA CELLS FROM BONE MARROW WITH MONOCLONAL ANTIBODIES CONJUGATED TO MAGNETIC MICROSPHERES

1984 • 262 citations

Specific gangliosides function as host cell receptors for Sendai virus.

1981 • 262 citations

Identification of a cell surface protein, p97, in human melanomas and certain other neoplasms.

1980 • 259 citations

Ganglioside inhibition of fibronectin-mediated cell adhesion to collagen.

1979 • 259 citations

Molecular recognition and the future of monoclonal antibodies

1982 • 251 citations

Quantitative analysis of melanoma-associated antigen p97 in normal and neoplastic tissues.

1981 • 250 citations

Identification of a human neuroectodermal tumor antigen (OFA-I-2) as ganglioside GD2.

1982 • 242 citations

Fibronectin and proteoglycans as determinants of cell‐substratum adhesion

1979 • 240 citations

O -Acetylation of Disialoganglioside GD ₃ by Human Melanoma Cells Creates a Unique Antigenic Determinant

1984 • 237 citations

GQlb, a Bioactive Ganglioside that Exhibits Novel Nerve Growth Factor (NGF)Like Activities in the Two Neuroblastoma Cell Lines

1983 • 232 citations

Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence.

1986 • 232 citations

Inhibition of growth of colorectal carcinoma in nude mice by monoclonal antibody.

1980 • 230 citations

A monoclonal antibody recognizes an O-acylated sialic acid in a human melanoma-associated ganglioside.

1984 • 222 citations

Characterization of a human melanoma-associated ganglioside antigen defined by a monoclonal antibody, 4.2.

1982 • 217 citations

Initial clinical evaluation of an immunoradiometric assay for CA 19‐9 using the nci serum bank

1984 • 212 citations

Thyrotropin-ganglioside interactions and their relationship to the structure and function of thyrotropin receptors.

1976 • 208 citations

Monoclonal antibody therapy of malignant melanoma: in vivo localization in cutaneous metastasis after intravenous administration.

1984 • 203 citations

Structural characterization of human melanoma-associated antigen p97 with monoclonal antibodies.

1981 • 203 citations

Human Macrophages Armed with Murine Immunoglobulin G2a Antibodies to Tumors Destroy Human Cancer Cells

1983 • 199 citations

Cyclosporin in renal transplantation: a guide to management.

1984 • 198 citations

Localization of the gangliosides GD2 and GD3 in adhesion plaques and on the surface of human melanoma cells.

1984 • 198 citations

Organizational difference of cell surface “hematoside” in normal and virally transformed cells

1968 • 191 citations

Cell Density-Dependent Changes of Glycolipid Concentrations in Fibroblasts, and Loss of This Response in Virus-Transformed Cells

1970 • 190 citations

Production and Characterization of Monoclonal Antibody to a Melanoma Specific Glycoprotein

1981 • 179 citations

Characterization of N-glycolylneuraminic acid-containing gangliosides as tumor-associated Hanganutziu-Deicher antigen in human colon cancer.

1985 • 176 citations

Ganglioside GM2 as a human tumor antigen (OFA-I-1).

1983 • 174 citations

Syngeneic monoclonal antibody against melanoma antigen with interspecies cross-reactivity recognizes GM3, a prominent ganglioside of B16 melanoma.

1985 • 171 citations

Binding of interferon to gangliosides

1974 • 171 citations

Calcium/Ganglioside‐Dependent Protein Kinase Activity in Rat Brain Membrane

1985 • 170 citations

Factors affecting expression of glycolipid tumor antigens: influence of ceramide composition and coexisting glycolipid on the antigenicity of gangliotriaosylceramide in murine lymphoma cells.

1983 • 169 citations

Hybridomas in Cancer Diagnosis and Treatment

1982 • 161 citations

Lipid Composition of Human Malignant Melanoma Tumors at Various Levels of Malignant Growth

1979 • 156 citations

Occurrence of Sialic Acids

1982 • 155 citations

N-Acetylneuraminyllactosylceramide, GM3-NeuAc, a new influenza A virus receptor which mediates the adsorption-fusion process of viral infection. Binding specificity of influenza virus A/Aichi/2/68 (H3N2) to membrane-associated GM3 with different molecular species of sialic acid.

1985 • 152 citations

Monoclonal antibodies in cell‐mediated cytotoxicity against human melanoma and colorectal carcinoma

1979 • 147 citations

Human melanoma antigen AH is an autoantigenic ganglioside related to GD2.

1982 • 140 citations

An autosomal dominant gene regulates the extent of 9-O-acetylation of murine erythrocyte sialic acids. A probable explanation for the variation in capacity to activate the human alternate complement pathway.

1980 • 132 citations

Proton NMR and fast-atom bombardment mass spectrometry analysis of the melanoma-associated ganglioside 9-O-acetyl-GD3.

1985 • 128 citations

MONOCLONAL ANTIBODIES AND CANCER

1982 • 123 citations

Composition and distribution of glycosaminoglycans in cultures of human normal and malignant glial cells

1978 • 119 citations

Competition for receptors for immunoglobulin on cytotoxic lymphocytes.

1972 • 117 citations

Monoclonal antibody and an antibody-toxin conjugate to a cell surface proteoglycan of melanoma cells suppress in vivo tumor growth.

1983 • 117 citations

Inhibition of human melanoma cell growth in vitro by monoclonal anti-GD3-ganglioside antibody.

1984 • 114 citations

Studies of a high molecular weight human melanoma-associated antigen.

1983 • 111 citations

Direct Evidence That Endogenous G _M1 Ganglioside Can Mediate Thymocyte Proliferation

1985 • 110 citations

The D1.1 antigen: a cell surface marker for germinal cells of the central nervous system

1984 • 108 citations

Biosynthetic studies of proteoglycans in human melanoma cells with a monoclonal antibody to a core glycoprotein of chondroitin sulfate proteoglycans.

1984 • 104 citations

Cell contact-dependent ganglioside changes in mouse 3T3 fibroblasts and a suppressed sialidase activity on cell contact

1975 • 103 citations

Glycolipids: Receptors for fibronectin?

1981 • 102 citations

Characterization of Monoclonal Antibodies to Human Melanoma-Associated Antigens<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref><xref ref-type="fn" rid="FN4">4</xref>

1981 • 102 citations

Ganglioside GD2 specificity of monoclonal antibodies to human neuroblastoma cell

1985 • 102 citations

A 94,OOO-Dalton Glycoprotein Expressed by Human Melanoma and Carcinoma Cells<xref ref-type="fn" rid="fn2">2</xref>

1982 • 96 citations

Neuroblastoma: Clinical Perspectives, Monoclonal Antibodies, and Retinoic Acid

1982 • 96 citations

Disialoganglioside GD3 on human melanoma serves as a relevant target antigen for monoclonal antibody-mediated tumor cytolysis.

1985 • 95 citations

Disialoganglioside GD2 distributes preferentially into substrate-associated microprocesses on human melanoma cells during their attachment to fibronectin.

1986 • 94 citations

Monoclonal antibody detection of a circulating tumor-associated antigen. II. A longitudinal evaluation of patients with colorectal cancer

1982 • 93 citations

Exogenous gangliosides enhance the interaction of fibronectin with ganglioside-deficient cells

1983 • 91 citations

Organization of glycolipids and glycoproteins in surface membranes: Dependency on cell cycle and on transformation

1974 • 91 citations

Synthesis of 9-O-Acetyl- and 4,9-Di-O-Acetyl Derivatives of the Methyl Ester of N-Acetyl-β-D-Neuraminic Acid Methylglycoside. Their Use as Models in Periodate Oxidation Studies

1975 • 85 citations

Studies of Methotrexate-Monoclonal Antibody Conjugates for Immunotherapy

1985 • 85 citations

Biochemical characterization of human melanoma cell surfaces: dissection with monoclonal antibodies.

1980 • 82 citations

Glycosphingolipids in detergent-insoluble substrate attachment matrix (DISAM) prepared from substrate attachment material (SAM)

1984 • 82 citations

Gangliosides as receptors for fibronectin?

1982 • 80 citations

A monoclonal antibody directed to N-acetylneuraminosyl-alpha 2 leads to 6-galactosyl residue in gangliosides and glycoproteins.

1983 • 80 citations

Reactivity of monoclonal anti‐melanoma antibodies with melanoma cells freshly isolated from primary and metastatic melanoma

1979 • 76 citations

Analysis of normal neoplastic human tissues for the tumor‐associated protein p97

1981 • 73 citations

Tissue distribution, molecular profile, and shedding of a cytoplasmic antigen identified by the monoclonal antibody 465.12S to human melanoma cells.

1982 • 72 citations

Possible Role of Gangliosides in Regulating an Adenylate Cyclase‐Linked 5‐Hydroxytryptamine (5‐HT₁) Receptor

1985 • 72 citations

Incorporation of fluorescent gangliosides into human fibroblasts: mobility, fate, and interaction with fibronectin.

1984 • 72 citations

Immunohistochemical localization of ganglioside GD3 in human malignant melanoma, epithelial tumors, and normal tissues.

1985 • 71 citations

Monoclonal antibodies and cancer therapy

1985 • 71 citations

Undersulfated proteoglycans are secreted by cultured chondrocytes in the presence of the ionophore monensin.

1980 • 69 citations

Clonal variation in expression of a human melanoma antigen defined by a monoclonal antibody.

1981 • 69 citations

Eradication of neuroblastoma cells in vitro by monoclonal antibody and human complement: method for purging autologous bone marrow.

1985 • 69 citations

Eradication of established human melanoma tumors in nude mice by antibody-directed effector cells.

1985 • 66 citations

Monoclonal antibody-directed effector cells selectively lyse human melanoma cells in vitro and in vivo.

1983 • 66 citations

Activation of human peripheral blood mononuclear cells by anti-T3: killing of tumor target cells coated with anti-target-anti-T3 conjugates.

1986 • 63 citations

Isolation and chemical characterization of a melanoma-associated proteoglycan antigen

1983 • 60 citations

Tumor-associated antigens in spent medium of human melanoma cells: immunochemical characterization with xenoantisera.

1981 • 59 citations

Isolation and characterization of anti-monosialoganglioside monoclonal antibody 19-9 class-switch variants.

1985 • 59 citations

Monoclonal antibodies to two determinants of melanoma-antigen p97 act synergistically in complement-dependent cytotoxicity.

1981 • 55 citations

Gene-Regulated Expression of Glycolipids: Appearance of GD3 Ganglioside in Rat Cells on Transfection with Transforming Gene E1 of Human Adenovirus Type 12 DNA and Its Transcriptional Subunits1

1984 • 55 citations

Characterization of monoclonal antibody 155.8 and partial characterization of its proteoglycan antigen on human melanoma cells.

1984 • 55 citations

Cytotoxicity of human lymphocytes induced by rabbit antibodies to chicken erythrocytes. Inhibition by normal IgG and by human myeloma proteins of different IgG subclasses.

1973 • 52 citations

The diagnostic dilemma of the “small round cell neoplasm”: Catecholamine fluorescence and tissue culture morphology as markers for neuroblastoma

1981 • 47 citations

Monoclonal anticolon carcinoma antibodies in complement‐dependent cytotoxicity

1981 • 44 citations

Monoclonal antibody to ganglioside gq discriminates between haemopoietic cells and infiltrating neuroblastoma tumour cells in bone marrow

1981 • 42 citations

Structural characterization of the ‘melanoma-specific’ antigen detected by monoclonal antibody 691I5Nu-4-B

1981 • 38 citations

Extracellular matrix: Structure and function

1986 • 38 citations

A ganglioside antigen on the rat pancreatic B cell surface identified by monoclonal antibody R2D6.

1984 • 37 citations

Ammonium chloride interferes with a distinct step in the biosynthesis and cell surface expression of human melanoma-type chondroitin sulfate proteoglycan.

1986 • 33 citations

Ex vivo perfusion of human colon with monoclonal anticolorectal cancer antibodies

1982 • 32 citations

Inhibition of post-translational modification and surface expression of a melanoma-associated chondroitin sulfate proteoglycan by diethylcarbamazine or ammonium chloride.

1986 • 29 citations

Monoclonal antibody (1116 NS 19‐9) defined monosialoganglioside (GICA) in colorectal carcinoma in relation to stage, histopathology and DNA flow cytometry

1983 • 29 citations

Glycolipid affinity purification of migration inhibitory factor

1982 • 28 citations

Serological and Biochemical Analyses of Monoclonal Antibodies to Human Melanoma-Associated Antigens

1982 • 27 citations

Class‐specific antibodies (Igg and Iga) to membrane antigens of herpes simplex type‐2 infected cells in patients with cervical dysplasia and neoplasia

1981 • 26 citations

Lymphocyte‐dependent antibodies to antigen 3.1, a cell‐surface antigen expressed by a subgroup of human melanomas

1981 • 26 citations

Biochemical analysis of a 130,000 molecular weight glycoprotein on human melanoma cells.

1983 • 25 citations

Melanoma antigens and antibodies

1983 • 24 citations

Human melanoma-associated antigens: role of carbohydrate in shedding and cell surface expression.

1981 • 21 citations

Comparative Study of the Binding Characteristics of Monoclonal Antimelanoma Antibodies

1982 • 20 citations

Immunochemical and Biosynthetic Analysis of Monoclonal Antibody-Defined Melanoma-Associated Antigen

1982 • 19 citations

Antibody-dependent cell-mediated cytolysis (ADCC) with antibody-coated effectors: new methods for enhancing antibody binding and cytolysis.

1980 • 18 citations

Neuroblastoma simulating acute leukemia

1976 • 18 citations

Glycosaminoglycans Synthesized by Tumorigenic and Nontumorigenic Mouse Melanoma Cells in Culture<xref ref-type="fn" rid="fn2">2</xref>

1980 • 13 citations

Human tumor-associated antigens defined by monoclonal antibodies.

1984 • 11 citations

Directed effector cells selectively lyse human tumour cells

1982 • 11 citations

Lack of Association of Serologically Detectable Human Melanoma-Associated Antigens With Beta2 Microglobulin: Serologic and Immunochemical Evidence23

1980 • 5 citations

Progress of Cancer Research

1960 • 3 citations