The Th1–Th2 hypothesis of HIV infection: new insights

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1989 • 1,739 citations

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

1994 • 1,549 citations

A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor.

1989 • 1,436 citations

A TH1→TH2 switch is a critical step in the etiology of HIV infection

1993 • 1,403 citations

IL-4 directs the development of Th2-like helper effectors.

1990 • 1,261 citations

Human TH1 and TH2 subsets: doubt no more

1991 • 1,103 citations

Quantitation of Human Immunodeficiency Virus Type 1 in the Blood of Infected Persons

1989 • 1,090 citations

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.

1992 • 1,029 citations

Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individuals.

1992 • 907 citations

Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells

1994 • 888 citations

Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni.

1991 • 777 citations

Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, human immunodeficiency virus-seropositive patients. Independence of CD4+ cell numbers and clinical staging.

1989 • 637 citations

IL-12: Initiation Cytokine for Cell-Mediated Immunity

1993 • 583 citations

Cell dysfunction and depletion in AIDS: the programmed cell death hypothesis

1991 • 548 citations

Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals.

1993 • 484 citations

Ability of HIV to Promote a T _H 1 to T _H 0 Shift and to Replicate Preferentially in T _H 2 and T _H 0 Cells

1994 • 482 citations

Role of T‐Cell Derived Cytokines in the Downregulation of Immune Responses in Parasitic and Retroviral Infection

1992 • 473 citations

Pathogenesis of human immunodeficiency virus infection.

1993 • 455 citations

Impaired interleukin 12 production in human immunodeficiency virus-infected patients.

1994 • 435 citations

Lack of Evidence for the Dichotomy of T_H1 and T_H2 Predominance in HIV-Infected Individuals

1994 • 434 citations

Tuberculosis: Pathogenesis, protection, and control

1995 • 409 citations

Restoration of HIV-Specific Cell-Mediated Immune Responses by Interleukin-12 in Vitro

1993 • 397 citations

Role of interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus.

1994 • 393 citations

Cell-Mediated Immune Response to Human Immunodeficiency Virus (HIV) Type 1 in Seronegative Homosexual Men with Recent Sexual Exposure to HIV-1

1992 • 392 citations

Cytokine production at the site of disease in human tuberculosis

1993 • 379 citations

Cytokine patterns in the pathogenesis of human leishmaniasis.

1993 • 372 citations

Contrasting effects of glucocorticoids on the capacity of T cells to produce the growth factors interleukin 2 and interleukin 4

1989 • 372 citations

HIV-specific cytotoxic T-cell activity in an HIV-exposed but uninfected infant

1993 • 368 citations

In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma.

1993 • 345 citations

Switch of CD8 T Cells to Noncytolytic CD8 ^- CD4 ^- Cells that Make T _H 2 Cytokines and Help B Cells

1993 • 343 citations

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1993 • 337 citations

Gamma interferon activates human macrophages to become tumoricidal and leishmanicidal but enhances replication of macrophage-associated mycobacteria

1985 • 315 citations

Hormones, peripherally activated prohormones and regulation of the Th1/Th2 balance

1994 • 286 citations

Th2-like CD8+ T cells showing B cell helper function and reduced cytolytic activity in human immunodeficiency virus type 1 infection.

1994 • 276 citations

Infection with Schistosoma mansoni alters Th1/Th2 cytokine responses to a non-parasite antigen.

1992 • 256 citations

Human immunodeficiency virus (HIV) nef-specific cytotoxic T lymphocytes in noninfected heterosexual contact of HIV-infected patients.

1994 • 238 citations

HIV Disease and the Endocrine System

1992 • 225 citations

Unidirectional Coupling of Gap Junctions Between Neuroglia

1993 • 224 citations

Cytotoxic T lymphocyte responses in the peripheral blood of children born to human immunodeficiency virus‐1‐infected mothers

1992 • 221 citations

A diffusible lymphokine produced by CD8+ T lymphocytes suppresses HIV replication.

1989 • 221 citations

A1, Cw7, B8, DR3 HLA antigen combination associated with rapid decline of T-helper lymphocytes in HIV-1 infection

1990 • 210 citations

A Strategy for Prophylactic Vaccination Against HIV

1993 • 203 citations

HIV-Specific T-Helper Activity in Seronegative Health Care Workers Exposed to Contaminated Blood

1994 • 201 citations

Interleukin-12: A bridge between innate resistance and adaptive immunity with a role in infection and acquired immunodeficiency

1994 • 189 citations

TH1 and TH2 cytokine production by peripheral blood mononuclear cells from HIV-infected patients

1994 • 164 citations

Elevation of IgE in HIV-infected subjects: A marker of poor prognosis

1992 • 135 citations

Serum IgE and human immunodeficiency virus (HIV) infection

1990 • 135 citations

Cellular immune factors associated with mother-to-infant transmission of HIV

1993 • 115 citations

Interleukin 13 inhibits human immunodeficiency virus type 1 production in primary blood-derived human macrophages in vitro.

1993 • 106 citations

Exposure to Human Immunodeficiency Virus Type I-Specific T Helper Cell Responses before Detection of Infection by Polymerase Chain Reaction and Serum Antibodies

1991 • 93 citations

CD4+CD7-CD57+ T cells: a new T-lymphocyte subset expanded during human immunodeficiency virus infection

1992 • 90 citations

Non-cytotoxic, IL-4, IL-5, IL-10 producing CD8+ T cells: their activation and effector functions

1994 • 89 citations

Interleukin 10

1991 • 87 citations

T-cell response towards HIV in infected individuals with and without zidovudine therapy, and in HIV-exposed sexual partners

1989 • 86 citations

Atopic manifestations in the acquired immune deficiency syndrome: response to recombinant interferon gamma.

1987 • 85 citations

Human Immunodeficiency Virus Infection in the US Air Force: Seroconversions, Clinical Staging, and Assessment of a T Helper Cell Functional Assay to Predict Change in CD4+ T Cell Counts

1991 • 84 citations

Increased levels of interferon-gamma (IFN-γ), IL-4 and transforming growth factor-beta (TGF-β) mRNA expressing blood mononuclear cells in human HIV infection

1994 • 80 citations

T Helper Cell Immune Dysfunction in Asymptomatic, HIV-1-Seropositive Individuals: The Role of TH1-TH2 Cross-Regulation

1992 • 76 citations

Decreased Serum Dehydroepiandrosterone Is Associated with an Increased Progression of Human Immunodeficiency Virus Infection in Men with CD4 Cell Counts of 200-499

1991 • 75 citations

The Th1/Th2-like switch in syphilitic infection: is it detrimental?

1992 • 70 citations

IL-12 transiently induces IFN-_γ transcription and protein synthesis in human CD4 ⁺ allergen-specific T_h2 T cell clones

1994 • 68 citations

Dehydroepiandrosterone as Predictor for Progression to AIDS in Asymptomatic Human Immunodeficiency Virus-Infected Men

1992 • 66 citations

Prospective study of cytotoxic T lymphocyte responses to influenza and antibodies to human T lymphotropic virus-III in homosexual men. Selective loss of an influenza-specific, human leukocyte antigen-restricted cytotoxic T lymphocyte response in human T lymphotropic virus-III positive individuals with symptoms of acquired immunodeficiency syndrome and in a patient with acquired immunodeficiency syndrome.

1985 • 60 citations

Pleuritis as a manifestation of reactivation tuberculosis

1990 • 56 citations

Lymphocyte Proliferative Responses to HIV-1 Envelope and Core Antigens by Infected and Uninfected Adults and Children

1990 • 55 citations

Immunization with subunit human immunodeficiency virus vaccine generates stronger T helper cell immunity than natural infection

1991 • 43 citations

Immunoglobulins and hypersensitivity in human immunodeficiency virus (HIV) infection

1989 • 36 citations

Detection of HIV-1 DNA in different subsets of human peripheral blood mononuclear cells using the polymerase chain reaction

1989 • 33 citations

Dehydroepiandrosterone regulation of the hepatic glucocorticoid receptor in the zucker rat. The obesity research program

1993 • 32 citations

Circumvention of defective CD4 T helper cell function in HIV-infected individuals by stimulation with HLA alloantigens.

1990 • 24 citations

Cell-mediated immunity in HIV infection

1993 • 19 citations

Hypereosinophilia Secondary to Immunodysregulation in Patients With HIV-1 Disease

1994 • 9 citations