Translational Mini-Review Series on Type 1 Diabetes: Systematic analysis of T cell epitopes in autoimmune diabetes

Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

1990 • 1,955 citations

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

Insulin Antibodies in Insulin-Dependent Diabetics Before Insulin Treatment

1983 • 1,078 citations

Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

2005 • 744 citations

Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation

1993 • 670 citations

β-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial

2001 • 513 citations

Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health

2004 • 482 citations

Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes.

1994 • 452 citations

Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library

1999 • 442 citations

Cytotoxic T Cells

2005 • 430 citations

Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes.

1996 • 428 citations

Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope

2005 • 417 citations

Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23).

1996 • 415 citations

The role of T-cells in the pathogenesis of Type 1 diabetes: From cause to cure

2003 • 410 citations

Identification of the β cell antigen targeted by a prevalent population of pathogenic CD8⁺T cells in autoimmune diabetes

2003 • 378 citations

Spontaneous Autoimmune Diabetes in Monoclonal T Cell Nonobese Diabetic Mice

1997 • 359 citations

Epitope specificity, cytokine production profile and diabetogenic activity of insulin‐specific T cell clones isolated from NOD mice

1995 • 359 citations

Progression of autoimmune diabetes driven by avidity maturation of a T-cell population

2000 • 344 citations

Autoreactive CD8 T cells associated with β cell destruction in type 1 diabetes

2005 • 275 citations

Relationship of the 37,000- and 40,000-M(r) tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512).

1995 • 257 citations

Acceleration of type 1 diabetes mellitus in proinsulin 2–deficient NOD mice

2003 • 221 citations

The insulin A-chain epitope recognized by human T cells is posttranslationally modified

2005 • 220 citations

T-Cell Epitopes in Type 1 Diabetes Autoantigen Tyrosine Phosphatase IA-2: Potential for Mimicry with Rotavirus and Other Environmental Agents

1998 • 213 citations

Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood

2003 • 210 citations

A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin

2001 • 210 citations

Peptide therapy for diabetes in NOD mice

1994 • 205 citations

Cytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase

2001 • 201 citations

Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse

2003 • 201 citations

Detection of GAD65-Specific T-Cells by Major Histocompatibility Complex Class II Tetramers in Type 1 Diabetic Patients and At-Risk Subjects

2002 • 198 citations

Auto- and alloimmune reactivity to human islet allografts transplanted into type 1 diabetic patients.

1999 • 183 citations

T-cell clones from a type-1 diabetes patient respond to insulin secretory granule proteins

1990 • 179 citations

Cytotoxic T cells specific for glutamic acid decarboxylase in autoimmune diabetes.

1995 • 173 citations

A comprehensive guide to antibody and T‐cell responses in type 1 diabetes

2003 • 166 citations

T-Cell Responses to Autoantigens in IDDM: The Search for the Holy Grail

1996 • 164 citations

GAD-reactive CD4+ Th1 cells induce diabetes in NOD/SCID mice.

1998 • 160 citations

Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4

1999 • 159 citations

Evidence for the role of CD8+ cytotoxic T cells in the destruction of pancreatic beta-cells in nonobese diabetic mice.

1994 • 157 citations

Identification of naturally processed T cell epitopes from glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients.

1997 • 148 citations

Prevention of diabetes by manipulation of anti-IGRP autoimmunity: high efficiency of a low-affinity peptide

2005 • 144 citations

Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401.

1996 • 139 citations

T Cell Proliferative Responses of Type 1 Diabetes Patients and Healthy Individuals to Human hsp60 and its Peptides

1999 • 135 citations

Recognition of a subregion of human proinsulin by class I-restricted T cells in type 1 diabetic patients

2005 • 122 citations

Individual Nonobese Diabetic Mice Exhibit Unique Patterns of CD8+ T Cell Reactivity to Three Islet Antigens, Including the Newly Identified Widely Expressed Dystrophia Myotonica Kinase

2004 • 121 citations

Evidence That a Peptide Spanning the B-C Junction of Proinsulin Is an Early Autoantigen Epitope in the Pathogenesis of Type 1 Diabetes

2001 • 116 citations

T cell epitopes of insulin defined in HLA-DR4 transgenic mice are derived from preproinsulin and proinsulin

1998 • 116 citations

HLA-A*0201-Restricted T Cells from Humanized NOD Mice Recognize Autoantigens of Potential Clinical Relevance to Type 1 Diabetes

2006 • 115 citations

Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(α1*0101,β1*0401) transgenic mice

1997 • 111 citations

Tracking the Recruitment of Diabetogenic CD8+ T-Cells to the Pancreas in Real Time

2004 • 109 citations

Islet-Specific Glucose-6-Phosphatase Catalytic Subunit-Related Protein-Reactive CD4+ T Cells in Human Subjects

2006 • 105 citations

Similar peptides from two beta cell autoantigens, proinsulin and glutamic acid decarboxylase, stimulate T cells of individuals at risk for insulin-dependent diabetes.

1995 • 103 citations

Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide

2003 • 98 citations

Identification and modulation of a naturally processed T cell epitope from the diabetes-associated autoantigen human glutamic acid decarboxylase 65 (hGAD65)

2001 • 93 citations

NOD Mouse Diabetes: The Ubiquitous Mouse Hsp60 is a β-Cell Target Antigen of Autoimmune T Cells

1996 • 90 citations

The role of MHC class II molecules in susceptibility to type I diabetes: Identification of peptide epitopes and characterization of the T cell repertoire

1999 • 90 citations

Identification of a β-Cell-Specific HLA Class I Restricted Epitope in Type 1 Diabetes

2003 • 87 citations

Molecular mimicry in type 1 diabetes mellitus revisited: T-cell clones to GAD65 peptides with sequence homology to Coxsackie or proinsulin peptides do not crossreact with homologous counterpart

2001 • 86 citations

Analysis of T-Cell Assays to Measure Autoimmune Responses in Subjects With Type 1 Diabetes

2006 • 86 citations

Similar Peptides from Two β Cell Autoantigens, Proinsulin and Glutamic Acid Decarboxylase, Stimulate T Cells of Individuals at Risk for Insulin-Dependent Diabetes

1995 • 86 citations

CD4+ T Cells from Glutamic Acid Decarboxylase (GAD)65-specific T Cell Receptor Transgenic Mice Are Not Diabetogenic and Can Delay Diabetes Transfer

2002 • 84 citations

Major Histocompatibility Complex

2000 • 82 citations

T-cell reactivity to GAD65 peptide sequences shared with coxsackie virus protein in recent-onset IDDM, post-onset IDDM patients and control subjects

1997 • 81 citations

Targeted Disruption of the IA-2β Gene Causes Glucose Intolerance and Impairs Insulin Secretion but Does Not Prevent the Development of Diabetes in NOD Mice

2004 • 80 citations

T cell Clones to Epitopes of Glutamic Acid Decarboxylase 65 Raised from Normal Subjects and Patients with Insulin-dependent Diabetes

1996 • 79 citations

Identification of Naturally Processed HLA-A2—Restricted Proinsulin Epitopes by Reverse Immunology

2005 • 78 citations

L-Glutamate Decarboxylase

1979 • 78 citations

T cell Autoreactivity to Proinsulin Epitopes in Diabetic Patients and Healthy Subjects

1999 • 76 citations

T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes.

2000 • 74 citations

Glutamate Decarboxylase and GABA in Pancreatic Islets: Lessons from Knock-Out Mice

1999 • 72 citations

T Cells and autoantibodies to human HSP70 in Type 1 diabetes in children

2003 • 71 citations

Treatment of NOD Diabetes with a Novel Peptide of the hsp60 Molecule Induces Th2-type Antibodies

1997 • 68 citations

Transgenic Insulin (B:9-23) T-Cell Receptor Mice Develop Autoimmune Diabetes Dependent Upon RAG Genotype, H-2g7 Homozygosity, and Insulin 2 Gene Knockout

2006 • 68 citations

Development of autoimmune diabetes in glutamic acid decarboxylase 65 (GAD65) knockout NOD mice

2004 • 64 citations

Cloned T Cells from a Recent Onset IDDM Patient Reactive with Insulin B-chain

1998 • 62 citations

Identification of immunogenic epitopes of GAD 65 presented by A g7 in non-obese diabetic mice

1997 • 61 citations

Pro- and anti-inflammatory cytokine production by autoimmune T cells against preproinsulin in HLA-DRB1*04, DQ8 Type 1 diabetes

2004 • 61 citations

T Cell Response to Preproinsulin I and II in the Nonobese Diabetic Mouse

2002 • 60 citations

T cell clones

1981 • 59 citations

Antigen‐specific immunotherapy for autoimmune disease: fighting fire with fire?

2001 • 59 citations

Major DQ8-restricted T-cell epitopes for human GAD65 mapped using human CD4, DQA1*0301, DQB1*0302 transgenic IA(null) NOD mice.

1999 • 59 citations

Detection of glutamic acid decarboxylase-activated T cells with I-A^g7tetramers

2000 • 57 citations

High Affinity Presentation of an Autoantigenic Peptide in Type I Diabetes by an HLA Class II Protein Encoded in a Haplotype Protecting From Disease

1997 • 55 citations

Major Histocompatibility Complex Class I–Restricted Infiltration and Destruction of Pancreatic Islets by NOD Mouse-Derived β-Cell Cytotoxic CD8+ T-Cell Clones In Vivo

1996 • 54 citations

Dense Core Vesicle Proteins IA-2 and IA-2β

2005 • 52 citations

Determination of Glutamic Acid Decarboxylase 65 Peptides Presented by the Type I Diabetes-Associated HLA-DQ8 Class II Molecule Identifies an Immunogenic Peptide Motif

1999 • 52 citations

GAD65-Reactive T cells in a Non-diabetic Stiff-man Syndrome Patient

1999 • 51 citations

T cell activation and anergy to islet cell antigen in type I diabetes.

1995 • 51 citations

Characterization of self-glutamic acid decarboxylase 65-reactive CD4+ T-cell clones established from Japanese patients with insulin-dependent diabetes mellitus

1998 • 49 citations

Predominantly Recognized ProInsulin T Helper Cell Epitopes in Individuals With and Without Islet Cell Autoimmunity

2002 • 48 citations

TGF- signaling is required for the function of insulin-reactive T regulatory cells

2006 • 46 citations

Early Autoimmune Destruction of Islet Grafts Is Associated with a Restricted Repertoire of IGRP-Specific CD8+ T Cells in Diabetic Nonobese Diabetic Mice

2006 • 45 citations

Characterization of Novel T-cell Epitopes on 65kDa and 67kDa Glutamic Acid Decarboxylase Relevant in Autoimmune Responses in NOD Mice

1998 • 45 citations

Identification of CD4+ T Cell-Specific Epitopes of Islet-Specific Glucose-6-Phosphatase Catalytic Subunit-Related Protein: A Novel β Cell Autoantigen in Type 1 Diabetes

2005 • 44 citations

MHC Class I-Restricted Determinants on the Glutamic Acid Decarboxylase 65 Molecule Induce Spontaneous CTL Activity

2001 • 44 citations

T Cell Recognition of Human Pre-Proinsulin Peptides Depends on the Polymorphism at HLA DQ Locus: A Study Using HLA DQ8 and DQ6 Transgenic Mice

1997 • 41 citations

Loss of Self-Tolerance to ICA69 in Nonobese Diabetic Mice

1997 • 37 citations

Glutamic acid decarboxylase T lymphocyte responses associated with susceptibility or resistance to type I diabetes: analysis in disease discordant human twins, non-obese diabetic mice and HLA-DQ transgenic mice.

1998 • 37 citations

Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide

2003 • 36 citations

Prevention of type I diabetes transfer by glutamic acid decarboxylase 65 peptide 206-220-specific T cells

2004 • 34 citations

Humoral and cellular immune responses to proinsulin in adults with newly diagnosed type 1 diabetes

2002 • 33 citations

Cytotoxic T Cells to an Epitope in the Islet Autoantigen IA-2 Are Not Disease-Specific

2001 • 32 citations

ICA69null Nonobese Diabetic Mice Develop Diabetes, but Resist Disease Acceleration by Cyclophosphamide

2002 • 31 citations

Autoreactive T cells in human type 1 diabetes

2004 • 29 citations

An islet-homing NOD CD8+cytotoxic T cell clone recognizes GAD65and causes insulitis

2003 • 24 citations

HLA-DQ8 transgenic and NOD mice recognize different epitopes within the cytoplasmic region of the tyrosine phosphatase-like molecule, IA-2

2001 • 22 citations

T-Cell Epitope Analysis on the Autoantigen Phogrin (IA-2β) in the Nonobese Diabetic Mouse

2001 • 21 citations

The search for the Holy Grail

2007 • 20 citations

Peptide-specific cytotoxicity of T lymphocytes against glutamic acid decarboxylase and insulin in type 1 diabetes mellitus

2001 • 17 citations

T cell reactivity to DR^*0401- and DQ^*0302-binding peptides of the putative autoantigen IA-2 in type 1 diabetes

2009 • 12 citations

Generation and maintenance of autoantigen-specific CD8+ T cell clones isolated from NOD mice

1999 • 12 citations

Proliferative responses to selected peptides of IA-2 in identical twins discordant for Type 1 diabetes

2000 • 7 citations

HLA-DR53 molecules restrict glutamic acid decarboxylase peptide presentation to T cells of a Type I diabetes patient: specification of the trimolecular HLA-peptide/T-cell receptor complex

2001 • 6 citations

Secondary measures of immunologic efficacy in clinical trials

2006 • 4 citations