Progression of autoimmune diabetes driven by avidity maturation of a T-cell population

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

MHC ligands and peptide motifs: first listing

1995 • 1,674 citations

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1993 • 962 citations

The Nonobese Diabetic Mouse as a Model of Autoimmune Diabetes: Immune Dysregulation Gets the NOD

1997 • 685 citations

T-cell-receptor affinity and thymocyte positive selection

1996 • 620 citations

A Kinetic Basis For T Cell Receptor Repertoire Selection during an Immune Response

1999 • 515 citations

Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library

1999 • 442 citations

Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness.

1994 • 431 citations

A TCR Binds to Antagonist Ligands with Lower Affinities and Faster Dissociation Rates Than to Agonists

1996 • 430 citations

Spontaneous Autoimmune Diabetes in Monoclonal T Cell Nonobese Diabetic Mice

1997 • 359 citations

High- and Low-Potency Ligands with Similar Affinities for the TCR

1998 • 322 citations

Major Histocompatibility Complex Class I-Deficient NOD-B2mnull Mice are Diabetes and Insulitis Resistant

1994 • 301 citations

β2-Microglobulin–Deficient NOD Mice Do Not Develop Insulitis or Diabetes

1994 • 241 citations

Ligand-specific oligomerization of T-cell receptor molecules

1997 • 232 citations

Major histocompatibility complex class I molecules are required for the development of insulitis in non‐obese diabetic mice

1993 • 201 citations

Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor α chain gene rearrangement

1998 • 179 citations

Evidence for the role of CD8+ cytotoxic T cells in the destruction of pancreatic beta-cells in nonobese diabetic mice.

1994 • 157 citations

Prevalent CD8⁺T cell response against one peptide/MHC complex in autoimmune diabetes

1999 • 153 citations

Acceleration of spontaneous diabetes in TCR-beta-transgenic nonobese diabetic mice by beta-cell cytotoxic CD8+ T cells expressing identical endogenous TCR-alpha chains.

1996 • 130 citations

Beta-cell-cytotoxic CD8+ T cells from nonobese diabetic mice use highly homologous T cell receptor alpha-chain CDR3 sequences.

1995 • 93 citations

The immune response to islets in experimental diabetes and insulin-dependent diabetes mellitus

1996 • 25 citations