Autoreactive CD8 T cells associated with β cell destruction in type 1 diabetes

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

2005 • 744 citations

Prominent role of secondary anchor residues in peptide binding to HLA-A2.1 molecules

1993 • 630 citations

High White Blood Cell Count Is Associated With a Worsening of Insulin Sensitivity and Predicts the Development of Type 2 Diabetes

2002 • 560 citations

Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis.

1994 • 539 citations

Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health

2004 • 482 citations

Endoplasmic Reticulum Stress and the Development of Diabetes

2002 • 455 citations

Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes.

1996 • 428 citations

Combined use of autoantibodies (IA-2 autoantibody, GAD autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies) in type 1 diabetes: Combinatorial Islet Autoantibody Workshop.

1998 • 424 citations

Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope

2005 • 417 citations

Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23).

1996 • 415 citations

The role of T-cells in the pathogenesis of Type 1 diabetes: From cause to cure

2003 • 410 citations

Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein.

1991 • 384 citations

Epitope specificity, cytokine production profile and diabetogenic activity of insulin‐specific T cell clones isolated from NOD mice

1995 • 359 citations

CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.

1996 • 349 citations

Major Histocompatibility Complex Class I-Deficient NOD-B2mnull Mice are Diabetes and Insulitis Resistant

1994 • 301 citations

Insulin‐specific T cells are a predominant component of islet infiltrates in pre‐diabetic NOD mice

1994 • 279 citations

Efficient Identification of Novel Hla-A*0201–Presented Cytotoxic T Lymphocyte Epitopes in the Widely Expressed Tumor Antigen Prame by Proteasome-Mediated Digestion Analysis

2001 • 268 citations

Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes–prone mice

1996 • 266 citations

β2-Microglobulin–Deficient NOD Mice Do Not Develop Insulitis or Diabetes

1994 • 241 citations

Autoreactive CD8 T Cells in Organ-Specific Autoimmunity

2002 • 204 citations

Detection of GAD65-Specific T-Cells by Major Histocompatibility Complex Class II Tetramers in Type 1 Diabetic Patients and At-Risk Subjects

2002 • 198 citations

Auto- and alloimmune reactivity to human islet allografts transplanted into type 1 diabetic patients.

1999 • 183 citations

T-cell clones from a type-1 diabetes patient respond to insulin secretory granule proteins

1990 • 179 citations

Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor α chain gene rearrangement

1998 • 179 citations

Cytotoxic T cells specific for glutamic acid decarboxylase in autoimmune diabetes.

1995 • 173 citations

Induction of Glutamic Acid Decarboxylase 65-Specific Th2 Cells and Suppression of Autoimmune Diabetes at Late Stages of Disease Is Epitope Dependent

1999 • 173 citations

Implantation of standardized beta-cell grafts in a liver segment of IDDM patients: graft and recipient characteristics in two cases of insulin-independence under maintenance immunosuppression for prior kidney graft

1998 • 156 citations

Major differences in transporter associated with antigen presentation (TAP)-dependent translocation of MHC class I-presentable peptides and the effect of flanking sequences.

1995 • 155 citations

Distinct Proteolytic Processes Generate the C and N Termini of MHC Class I-Binding Peptides

1999 • 144 citations

The cleavage preference of the proteasome governs the yield of antigenic peptides.

1995 • 117 citations

A gene in the HLA class I region contributes to susceptibility to IDDM in the Finnish population

1994 • 101 citations

Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide

2003 • 98 citations

Abrogation of CTL Epitope Processing by Single Amino Acid Substitution Flanking the C-Terminal Proteasome Cleavage Site

2000 • 95 citations

An HLA class I peptide-binding assay based on competition for binding to class I molecules on intact human B cells

1995 • 91 citations

Identification of a β-Cell-Specific HLA Class I Restricted Epitope in Type 1 Diabetes

2003 • 87 citations

Altered immune response to insulin in newly diagnosed compared to insulin-treated diabetic patients and healthy control subjects

1997 • 78 citations

Functional evidence for the mediation of diabetogenic T cell responses by HLA-A2.1 MHC class I molecules through transgenic expression in NOD mice

2002 • 76 citations

Treatment of NOD Diabetes with a Novel Peptide of the hsp60 Molecule Induces Th2-type Antibodies

1997 • 68 citations

Pro- and anti-inflammatory cytokine production by autoimmune T cells against preproinsulin in HLA-DRB1*04, DQ8 Type 1 diabetes

2004 • 61 citations

Identification of Children with Early Onset and High Incidence of Anti-islet Autoantibodies

2002 • 59 citations

Detailed motifs for peptide binding to HLA-A∗0201 derived from large random sets of peptides using a cellular binding assay

1995 • 39 citations

Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide

2003 • 36 citations

A sensitive fluorometric assay for quantitatively measuring specific peptide binding to HLA class I and class II molecules

1997 • 32 citations

Precursor frequencies of T-cells reactive to insulin in recent onset type 1 diabetes mellitus

2004 • 26 citations