Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide

SYFPEITHI: database for MHC ligands and peptide motifs

1999 • 2,307 citations

The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes

1997 • 931 citations

The antigenic identity of peptide-MHC complexes: A comparison of the conformations of five viral peptides presented by HLA-A2

1993 • 681 citations

Double-Blind Pilot Trial of Oral Tolerization with Myelin Antigens in Multiple Sclerosis

1993 • 592 citations

Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library

1999 • 442 citations

Oral Tolerance: Mechanisms and Therapeutic Applications

1999 • 318 citations

Induction of Autoimmune Diabetes by Oral Administration of Autoantigen

1996 • 261 citations

A Structural Framework for Deciphering the Link Between I-A ^g7 and Autoimmune Diabetes

2000 • 256 citations

Transgenic Expression of Mouse Proinsulin II Prevents Diabetes in Nonobese Diabetic Mice

1997 • 248 citations

Crystal Structure of I-Ak in Complex with a Dominant Epitope of Lysozyme

1998 • 245 citations

Oral insulin administration and residual (β-cell function in recent-onset type 1 diabetes: a multicentre randomised controlled trial

2000 • 239 citations

T-Cell Epitopes in Type 1 Diabetes Autoantigen Tyrosine Phosphatase IA-2: Potential for Mimicry with Rotavirus and Other Environmental Agents

1998 • 213 citations

No effect of oral insulin on residual beta-cell function in recent-onset Type I diabetes (the IMDIAB VII)

2000 • 211 citations

Structural Basis of Peptide Binding and Presentation by the Type I Diabetes-Associated MHC Class II Molecule of NOD Mice

2000 • 197 citations

Peptide-specific prevention of experimental allergic encephalomyelitis. Neonatal tolerance induced to the dominant T cell determinant of myelin basic protein.

1989 • 152 citations

Evidence That a Peptide Spanning the B-C Junction of Proinsulin Is an Early Autoantigen Epitope in the Pathogenesis of Type 1 Diabetes

2001 • 116 citations

Orally administered myelin basic protein in neonates primes for immune responses and enhances experimental autoimmune encephalomyelitis in adult animals

1994 • 114 citations

Antigen-specific therapy for autoimmune disease

2000 • 107 citations

Similar peptides from two beta cell autoantigens, proinsulin and glutamic acid decarboxylase, stimulate T cells of individuals at risk for insulin-dependent diabetes.

1995 • 103 citations

A Peptide-binding Motif for I-Ag7, the Class II Major Histocompatibility Complex (MHC) Molecule of NOD and Biozzi AB/H Mice

1997 • 90 citations

Enhanced Intracellular Dissociation of Major Histocompatibility Complex Class I–associated Peptides: A Mechanism for Optimizing the Spectrum of Cell Surface–Presented Cytotoxic T Lymphocyte Epitopes

1997 • 89 citations

RIP-beta 2-microglobulin transgene expression restores insulitis, but not diabetes, in beta 2-microglobulin null nonobese diabetic mice.

1996 • 88 citations

Similar Peptides from Two β Cell Autoantigens, Proinsulin and Glutamic Acid Decarboxylase, Stimulate T Cells of Individuals at Risk for Insulin-Dependent Diabetes

1995 • 86 citations

Class III Alleles of the Variable Number of Tandem Repeat Insulin Polymorphism Associated with Silencing of Thymic Insulin Predispose to Type 1 Diabetes

2001 • 86 citations

Revisiting Tolerance Induced by Autoantigen in Incomplete Freund’s Adjuvant

2000 • 85 citations

Systemic antigen in the treatment of T-cell-mediated autoimmune diseases

1997 • 85 citations

Up-regulation of MHC class I by flavivirus-induced peptide translocation into the endoplasmic reticulum

1995 • 76 citations

Lack of efficacy of oral bovine type II collagen added to existing therapy in rheumatoid arthritis

1999 • 69 citations

Potential risk of oral insulin with adjuvant for the prevention of Type I diabetes: a protocol effective in NOD mice may exacerbate disease in BB rats

1998 • 61 citations

Analysis of structure and function relationships of an autoantigenic peptide of insulin bound to H-2K^dthat stimulates CD8 T cells in insulin-dependent diabetes mellitus

2002 • 61 citations

Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice

1997 • 55 citations

Mucosal Antigen Primes Diabetogenic Cytotoxic T-Lymphocytes Regardless of Dose or Delivery Route

2001 • 53 citations

INDUCTION OF CHRONIC AUTOIMMUNE ARTHRITIS IN DBA/1 MICE BY ORAL ADMINISTRATION OF TYPE II COLLAGEN AND ESCHERICHIA COLl LIPOPOLYSACCHARIDE

1996 • 52 citations

Immunomodulation of Experimental Autoimmune Diseases via Oral Tolerance

2000 • 50 citations

MHC Class I-Restricted Determinants on the Glutamic Acid Decarboxylase 65 Molecule Induce Spontaneous CTL Activity

2001 • 44 citations

Binding of Longer Peptides to the H-2Kb Heterodimer Is Restricted to Peptides Extended at Their C Terminus: Refinement of the Inherent MHC Class I Peptide Binding Criteria

1999 • 40 citations

Transient blockade of CD40 ligand dissociates pathogenic from protective mucosal immunity

2002 • 38 citations

Transient blockade of CD40 ligand dissociates pathogenic from protective mucosal immunity

2002 • 37 citations

Cytotoxic T Cells to an Epitope in the Islet Autoantigen IA-2 Are Not Disease-Specific

2001 • 32 citations

Systemic Administration of Agonist Peptide Blocks the Progression of Spontaneous CD8-Mediated Autoimmune Diabetes in Transgenic Mice Without Bystander Damage

2000 • 26 citations

Modelling of the MHC II allele I-A g7 of NOD mouse: pH-dependent changes in specificity at pockets 9 and 6 explain several of the unique properties of this molecule

2000 • 19 citations

Class III Alleles of the Variable Number of Tandem Repeat Insulin Polymorphism Associated with Silencing of Thymic Insulin Predispose to Type 1 Diabetes

2001 • 18 citations