Detection of glutamic acid decarboxylase-activated T cells with I-A^g7tetramers

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors.

1979 • 1,301 citations

Insulin-Dependent Diabetes Mellitus

1996 • 1,171 citations

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1993 • 962 citations

Type-I Diabetes: A Chronic Autoimmune Disease of Human, Mouse, and Rat

1990 • 650 citations

The NOD mouse model of type 1 diabetes: As good as it gets?

1999 • 592 citations

Use of Peptide Libraries to Map the Substrate Specificity of a Peptide-Modifying Enzyme: A 13 Residue Consensus Peptide Specifies Biotinylation in Escherichia coli

1993 • 586 citations

Genetic Control of Autoimmune Diabetes in the Nod Mouse

1995 • 586 citations

AN IMPROVED METHOD FOR ISOLATION OF MOUSE PANCREATIC ISLETS

1985 • 548 citations

Phenotypic analysis of antigen-specific T lymphocytes. Science. 1996. 274: 94-96.

2011 • 539 citations

MHC Class-II Molecules and Autoimmunity

1991 • 521 citations

A Kinetic Basis For T Cell Receptor Repertoire Selection during an Immune Response

1999 • 515 citations

Detection of Antigen-Specific T Cells with Multivalent Soluble Class II MHC Covalent Peptide Complexes

1998 • 465 citations

Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library

1999 • 442 citations

Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes.

1996 • 428 citations

The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique.

1987 • 402 citations

Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A β-chain or normal I-E α-chain

1990 • 334 citations

Production of soluble MHC class II proteins with covalently bound single peptides

1994 • 302 citations

Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes–prone mice

1996 • 266 citations

An inverse relationship between T cell receptor affinity and antigen dose during CD4⁺T cell responsesin vivoandin vitro

1999 • 259 citations

A Structural Framework for Deciphering the Link Between I-A ^g7 and Autoimmune Diabetes

2000 • 256 citations

Control of Autoimmune Diabetes in NOD Mice by GAD Expression or Suppression in β Cells

1999 • 248 citations

Induction of Rapid T Cell Activation and Tolerance by Systemic Presentation of an Orally Administered Antigen

1998 • 219 citations

The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders.

1996 • 217 citations

An explanation for the protective effect of the MHC class II I–E molecule in murine diabetes

1989 • 216 citations

Prevention of diabetes in non-obese diabetic I-Ak transgenic mice

1990 • 204 citations

A Mechanism for the Major Histocompatibility Complex–linked Resistance to Autoimmunity

1997 • 202 citations

Structural Basis of Peptide Binding and Presentation by the Type I Diabetes-Associated MHC Class II Molecule of NOD Mice

2000 • 197 citations

Transgenic plants expressing autoantigens fed to mice to induce oral immune tolerance

1997 • 180 citations

GAD-reactive CD4+ Th1 cells induce diabetes in NOD/SCID mice.

1998 • 160 citations

The natural history of lymphocyte subsets infiltrating the pancreas of NOD mice

1989 • 146 citations

Use of soluble peptide–DR4 tetramers to detect synovial T cells specific for cartilage antigens in patients with rheumatoid arthritis

2000 • 138 citations

Immunization With the Larger Isoform of Mouse Glutamic Acid Decarboxylase (GAD67) Prevents Autoimmune Diabetes in NOD Mice

1994 • 128 citations

Diabetogenic T-Cell Clones

1996 • 127 citations

Complexes generated by the binding of free peptides to class II MHC molecules are antigenically diverse compared with those generated by intracellular processing.

1996 • 120 citations

Autoreactivity of T cells from nonobese diabetic mice: An I-A^g7-dependent reaction

1998 • 115 citations

Major Histocompatibility Complex Class II Molecules Can Protect from Diabetes by Positively Selecting T Cells with Additional Specificities

1998 • 109 citations

Breaking self-tolerance in nonobese diabetic mice.

1996 • 88 citations

Introduction

1997 • 87 citations

Aspartate at position 57 of nonobese diabetic I-Ag7 beta-chain diminishes the spontaneous incidence of insulin-dependent diabetes mellitus.

1995 • 85 citations

pH-dependent Peptide Binding Properties of the Type I Diabetes–associated I-Ag7 Molecule: Rapid Release of CLIP at an Endosomal pH

1999 • 79 citations

Infectious Th1 and Th2 autoimmunity in diabetes‐prone mice

1998 • 65 citations

Identification of immunogenic epitopes of GAD 65 presented by A g7 in non-obese diabetic mice

1997 • 61 citations

Following Antigen Challenge, T Cells Up-Regulate Cell Surface Expression of CD4 In Vitro and In Vivo

1998 • 61 citations

Induction of insulitis by glutamic acid decarboxylase peptide-specific and HLA-DQ8-restricted CD4(+) T cells from human DQ transgenic mice.

1998 • 56 citations

Selection of Antigen-specific T Cells by a Single IEk Peptide Combination

1997 • 52 citations

The role of CD4 and CD8 T cells in type I diabetes in the NOD mouse

1997 • 49 citations

Pancreatic Islet Allograft Immunity and Tolerance: the Two‐Signal Hypothesis Revisited

1996 • 42 citations

Two Mechanisms for the Non-MHC-Linked Resistance to Spontaneous Autoimmunity

1999 • 35 citations

Glutamic acid decarboxylase and other autoantigens in IDDM

1995 • 26 citations

Isolation of leukocytes infiltrating the islets of Langerhans of diabetes-prone mice for flow cytometric analysis

1995 • 23 citations

Endogenous Immune Response to Glutamic Acid Decarboxylase (GAD67) in NOD Mice is Modulated by Adjuvant Immunotherapy

1998 • 20 citations

Insights into the chemistry and biology of the I-Ag7 class II molecule

1997 • 11 citations