Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4

Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein

1995 • 1,528 citations

MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation

1994 • 1,448 citations

Sequence analysis of peptides bound to MHC class II molecules

1991 • 1,071 citations

Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles.

1993 • 900 citations

CAPTURE AND PROCESSING OF EXOGENOUS ANTIGENS FOR PRESENTATION ON MHC MOLECULES

1997 • 779 citations

Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size

1992 • 763 citations

The role of CD4+ T cell responses in antitumor immunity

1998 • 678 citations

Type-I Diabetes: A Chronic Autoimmune Disease of Human, Mouse, and Rat

1990 • 650 citations

Detection of Antigen-Specific T Cells with Multivalent Soluble Class II MHC Covalent Peptide Complexes

1998 • 465 citations

Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes.

1994 • 452 citations

Low avidity recognition of self-antigen by T cells permits escape from central tolerance

1995 • 415 citations

Susceptibility to type I diabetes: HLA-DQ and DR revisited

1996 • 324 citations

Precise prediction of major histocompatibility complex class II-peptide interaction based on peptide side chain scanning.

1994 • 304 citations

Relationship of the 37,000- and 40,000-M(r) tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512).

1995 • 257 citations

Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes

1993 • 247 citations

Autoantigens IA-2 and GAD in Type I (insulin-dependent) diabetes

1999 • 223 citations

Purification and characterization of class II histocompatibility antigens from a homozygous human B cell line.

1987 • 222 citations

T-Cell Epitopes in Type 1 Diabetes Autoantigen Tyrosine Phosphatase IA-2: Potential for Mimicry with Rotavirus and Other Environmental Agents

1998 • 213 citations

Neural network-based prediction of candidate T-cell epitopes

1998 • 180 citations

T Cell Receptor Recognition of MHC Class II–Bound Peptide Flanking Residues Enhances Immunogenicity and Results in Altered TCR V Region Usage

1997 • 174 citations

Autoreactive epitopes defined by diabetes-associated human monoclonal antibodies are localized in the middle and C-terminal domains of the smaller form of glutamate decarboxylase.

1993 • 172 citations

Comparison of peptides bound to spleen and thymus class II.

1993 • 168 citations

Association between HLA class II genotype and spontaneous clearance of hepatitis C viraemia

1998 • 164 citations

Identification of naturally processed T cell epitopes from glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients.

1997 • 148 citations

Antibodies to Islet 37k Antigen, But Not to Glutamate Decarboxylase, Discriminate Rapid Progression to IDDM in Endocrine Autoimmunity

1994 • 134 citations

HLA class II region sequences, 1998

1998 • 111 citations

Characterization of a naturally processed MHC class II-restricted T-cell determinant of hen egg lysozyme

1989 • 111 citations

Arginine at positions 13 or 70-71 in pocket 4 of HLA-DRB1 alleles is associated with susceptibility to tuberculoid leprosy.

1996 • 102 citations

Immunodominant epitopes of glutamic acid decarboxylase 65 and 67 in insulin-dependent diabetes mellitus

1994 • 91 citations

Mitogenic lectins bind to the antigen receptor on human lymphocytes

1989 • 83 citations

HLA Class II Peptide Binding Specificity and Autoimmunity

1997 • 78 citations

Minute quantities of a single immunodominant foreign epitope are presented as large nested sets by major histocompatibility complex class II molecules

1993 • 73 citations

HLA‐associated inverse correlation between T cell and antibody responsiveness to islet autoantigen in recent‐onset insulin‐dependent diabetes mellitus

1996 • 66 citations

Reverse immunogenetics: from HLA-disease associations to vaccine candidates

1996 • 59 citations

Human B Cells Secreting Immunoglobulin G to Glutamic Acid Decarboxylase-65 from a Nondiabetic Patient with Multiple Autoantibodies and Graves’ Disease: A Comparison with Those Present in Type 1 Diabetes¹

1997 • 50 citations

Evaluation of Islet Cell Antigen (ICA) 512/IA-2 Autoantibody Radioassays Using Overlapping ICA512/IA-2 Constructs¹

1997 • 49 citations

HLA-DP2: self peptide sequences and binding properties.

1997 • 49 citations

Sequence‐specific priming and exonuclease‐released fluorescence detection of HLA‐DQB1 alleles

1996 • 47 citations

Scanning a DRB3*0101 (DR52a)-Restricted Epitope Cross-Presented by DR3: Overlapping Natural and Artificial Determinants in the Human Acetylcholine Receptor

1999 • 44 citations

Direct Identification of Naturally Processed Autoantigen-derived Peptides Bound to HLA-DR15

1996 • 40 citations

Immunoregulation of Th cells by naturally processed peptide antagonists.

1999 • 25 citations

HLA DR4 Is Associated with the Development of Multiple Basal Cell Carcinomas and Malignant Melanoma

1993 • 25 citations

Altered peptide ligand design: altering immune responses to class I MHC/peptide complexes

1998 • 24 citations

Cutting Edge: Immunoregulation of Th Cells by Naturally Processed Peptide Antagonists

1999 • 20 citations

T Cell Clones Generated from Patients with Type 1 Diabetes Using Interleukin-2 Proliferate to Human Islet Antigens

1994 • 17 citations

Pillars Article: Sequence Analysis of Peptides Bound to MHC Class II Molecules. Nature. 1991. 353: 622-627.

2016 • 17 citations

N-terminal elongation of a peptide determinant beyond the first primary anchor improves binding to H-2 I-Ad and HLA-DR1 by backbone-dependent and aromatic side chain-dependent interactions, respectively

1999 • 16 citations

T cell reactivity to DR^*0401- and DQ^*0302-binding peptides of the putative autoantigen IA-2 in type 1 diabetes

2009 • 12 citations

Spontaneous T-cell proliferation in the non-obese diabetic mouse to a peptide from the unique class II MHC molecule, I-A g7 , which is also protective against the development of autoimmune diabetes

1999 • 11 citations

Enhanced T cell proliferation and increased responder frequency following delivery of antigen to the antigen-presenting cell; B cell dependency and use in detection of autoreactive T cells

1998 • 9 citations

Deleted Work

1955 • 0 citations