Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope

Type I Diabetes Mellitus

1986 • 1,615 citations

A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes

2004 • 1,392 citations

The Pathogenesis of Insulin-Dependent Diabetes Mellitus

1994 • 1,077 citations

Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

2005 • 744 citations

Following a diabetogenic T cell from genesis through pathogenesis

1993 • 708 citations

Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study.

1999 • 633 citations

The accelerator hypothesis: weight gain as the missing link between Type I and Type II diabetes

2001 • 607 citations

Environmental Triggers and Determinants of Type 1 Diabetes

2005 • 485 citations

Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library

1999 • 442 citations

Initiation of Autoimmune Diabetes by Developmentally Regulated Presentation of Islet Cell Antigens in the Pancreatic Lymph Nodes

1999 • 426 citations

A functional variant of SUMO4, a new IκBα modifier, is associated with type 1 diabetes

2004 • 399 citations

Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases.

1985 • 387 citations

Genetic heterogeneity, modes of inheritance, and risk estimates for a joint study of Caucasians with insulin-dependent diabetes mellitus.

1988 • 371 citations

Epitope specificity, cytokine production profile and diabetogenic activity of insulin‐specific T cell clones isolated from NOD mice

1995 • 359 citations

Feasibility of genetic and immunological prediction of Type I diabetes in a population-based birth cohort

2001 • 336 citations

Insulin‐specific T cells are a predominant component of islet infiltrates in pre‐diabetic NOD mice

1994 • 279 citations

Control of Autoimmune Diabetes in NOD Mice by GAD Expression or Suppression in β Cells

1999 • 248 citations

Pancreatic islet-specific T-cell clones from nonobese diabetic mice.

1989 • 246 citations

Temporal changes in the frequencies of HLA genotypes in patients with Type 1 diabetes—indication of an increased environmental pressure?

2003 • 243 citations

Comparison of Continuous Subcutaneous Insulin Infusion and Multiple Daily Injection Regimens in Children With Type 1 Diabetes: A Randomized Open Crossover Trial

2003 • 239 citations

Predominance of T lymphocytes in pancreatic islets and spleen of pre-diabetic non-obese diabetic (NOD) mice: a longitudinal study.

1985 • 237 citations

The First Signs of β-Cell Autoimmunity Appear in Infancy in Genetically Susceptible Children from the General Population: The Finnish Type 1 Diabetes Prediction and Prevention Study

2001 • 215 citations

Persistence of collagen type II-specific T-cell clones in the synovial membrane of a patient with rheumatoid arthritis.

1989 • 215 citations

T-Cell Responses to Autoantigens in IDDM: The Search for the Holy Grail

1996 • 164 citations

Distinct molecular forms of human T cell receptor gamma/delta detected on viable T cells by a monoclonal antibody.

1988 • 161 citations

Identification of naturally processed T cell epitopes from glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients.

1997 • 148 citations

Autoantigen recognition by thyroid-infiltrating T cells in Graves disease.

1991 • 148 citations

Determinant Spreading of T Helper Cell 2 (Th2) Responses to Pancreatic Islet Autoantigens

1997 • 134 citations

Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes

2004 • 133 citations

Oligoclonal T lymphocytes in the cerebrospinal fluid of patients with multiple sclerosis.

1988 • 132 citations

T cell receptor V gene usage of islet beta cell-reactive T cells is not restricted in non-obese diabetic mice.

1991 • 130 citations

Diazoxide Treatment at Onset Preserves Residual Insulin Secretion in Adults with Autoimmune Diabetes

1996 • 108 citations

Islet-specific T-cell clones from nonobese diabetic mice express heterogeneous T-cell receptors.

1991 • 107 citations

Cotherapy with recombinant human insulin-like growth factor I and insulin improves glycemic control in type 1 diabetes. RhIGF-I in IDDM Study Group.

1999 • 89 citations

Comparison of cytokine ELISpot assay formats for the detection of islet antigen autoreactive T cells

2003 • 82 citations

Characterization of Preparations of GAD65, Proinsulin, and the Islet Tyrosine Phosphatase IA-2 for Use in Detection of Autoreactive T-Cells in Type 1 Diabetes

2001 • 79 citations

Restricted islet-cell reactive T cell repertoire of early pancreatic islet infiltrates in NOD mice

2002 • 78 citations

Islet-reactive T cells are a marker of preclinical insulin-dependent diabetes.

1992 • 67 citations

Rapid screening of T‐cell receptor (TCR) variable gene usage by multiplex PCR: Application for assessment of clonal composition

1999 • 58 citations

Insulin autoimmunity: prediction/precipitation/prevention type 1A diabetes

2002 • 55 citations

Continuous Subcutaneous Insulin Infusion versus Multiple Daily Injections in Adolescents with Type I Diabetes Mellitus: A Randomized Open Crossover Trial

2003 • 53 citations

Invariant or highly conserved TCR alpha are expressed on double-negative (CD3+CD4-CD8-) and CD8+ T cells.

1999 • 52 citations

Invariant or Highly Conserved TCR α Are Expressed on Double-Negative (CD3+CD4−CD8−) and CD8+ T Cells

1999 • 40 citations

Cross-Reactive TCR Responses to Self Antigens Presented by Different MHC Class II Molecules

2004 • 26 citations

Promiscuous binding of proinsulin peptides to Type 1 diabetes-permissive and -protective HLA class II molecules

2003 • 23 citations

Lack of Association of PAX4 Gene With Type 1 Diabetes in the Finnish and Hungarian Populations

2005 • 20 citations

The Role of Class II Molecules in Development of Insulin-Dependent Diabetes Mellitus in Mice, Rats and Humans

1990 • 18 citations

Development of new strategies to prevent type 1 diabetes: the role of animal models

2003 • 15 citations

Deleted Work

1955 • 0 citations