Pro- and anti-inflammatory cytokine production by autoimmune T cells against preproinsulin in HLA-DRB1*04, DQ8 Type 1 diabetes

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

Phenotypic and Functional Separation of Memory and Effector Human CD8+ T Cells

1997 • 1,391 citations

Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases

1995 • 1,120 citations

Prediction of Type I Diabetes in First-Degree Relatives Using a Combination of Insulin, GAD, and ICA512bdc/IA-2 Autoantibodies

1996 • 788 citations

Early expression of antiinsulin autoantibodies of humans and the NOD mouse: Evidence for early determination of subsequent diabetes

2000 • 456 citations

Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice.

1988 • 455 citations

Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes.

1996 • 428 citations

Combined Analysis of Autoantibodies Improves Prediction of IDDM in Islet Cell Antibody-Positive Relatives

1994 • 360 citations

Epitope specificity, cytokine production profile and diabetogenic activity of insulin‐specific T cell clones isolated from NOD mice

1995 • 359 citations

A Novel Micro-assay for Insulin Autoantibodies

1997 • 238 citations

A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin

2001 • 210 citations

HLA‐DR, DO AND DP TYPING USING PCR AMPLIFICATION AND IMMOBILIZED PROBES

1991 • 197 citations

Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokines

2002 • 194 citations

Determinant Spreading of T Helper Cell 2 (Th2) Responses to Pancreatic Islet Autoantigens

1997 • 134 citations

Cellular Immune Response to Diverse Islet Cell Antigens in IDDM

1996 • 123 citations

T cell epitopes of insulin defined in HLA-DR4 transgenic mice are derived from preproinsulin and proinsulin

1998 • 116 citations

T cell autoreactivity to insulin in diabetic and related non-diabetic individuals.

1988 • 100 citations

Regulatory Th2-type T cell Lines Against Insulin and GAD Peptides Derived from Orally- and Nasally-Treated NOD Mice Suppress Diabetes

1999 • 94 citations

Intermolecular Antigen Spreading Occurs During the Preclinical Period of Human Type 1 Diabetes

2001 • 93 citations

Karlsburg Type I diabetes risk study of a general population: frequencies and interactions of the four major Type I diabetes-associated autoantibodies studied in 9419 schoolchildren

1999 • 92 citations

HLA-DQ polymorphisms are highly selective for peptide binding interactions.

1995 • 83 citations

Characterization of Preparations of GAD65, Proinsulin, and the Islet Tyrosine Phosphatase IA-2 for Use in Detection of Autoreactive T-Cells in Type 1 Diabetes

2001 • 79 citations

Altered immune response to insulin in newly diagnosed compared to insulin-treated diabetic patients and healthy control subjects

1997 • 78 citations

Regulatory and Effector CD4 T Cells in Nonobese Diabetic Mice Recognize Overlapping Determinants on Glutamic Acid Decarboxylase and Use DistinctVβGenes

2001 • 74 citations

Characterization of Insulin Autoantibodies in Relatives of Patients With Type I Diabetes

1993 • 74 citations

HLA-DR binding analysis of peptides from islet antigens in IDDM.

1998 • 63 citations

Cellular immunity to human insulin in individuals at high risk for the development of Type I diabetes mellitus

1990 • 62 citations

Cloned T Cells from a Recent Onset IDDM Patient Reactive with Insulin B-chain

1998 • 62 citations

Specific Association of HLA-DR4 With Increased Prevalence and Level of Insulin Autoantibodies in First-Degree Relatives of Patients With Type I Diabetes

1991 • 61 citations

Increased Numbers ofin vivoActivated T cells in Patients with Recent Onset Insulin-dependent Diabetes Mellitus

1996 • 53 citations

A Study of Identical Twins

1963 • 53 citations

HLA-Associated Insulin Autoantibody Formation in Newly Diagnosed Type I Diabetic Patients

1991 • 51 citations

Proinsulin autoantibodies are more closely associated with Type 1 (insulin-dependent) diabetes mellitus than insulin autoantibodies

1991 • 48 citations

Induction of Autoimmune Diabetes Through Insulin (but Not GAD65) DNA Vaccination in Nonobese Diabetic and in RIP-B7.1 Mice

2002 • 48 citations

Predominantly Recognized ProInsulin T Helper Cell Epitopes in Individuals With and Without Islet Cell Autoimmunity

2002 • 48 citations

Increase in Simultaneous Coexpression of Naive and Memory Lymphocyte Markers at Diagnosis of IDDM

1993 • 45 citations

Autoreactive and immunoregulatory T-cell subsets in insulindependent diabetes mellitus

1999 • 43 citations

The Karlsburg Type 1 Diabetes Risk Study of a Normal Schoolchild Population: Association of β-Cell Autoantibodies and Human Leukocyte Antigen-DQB1 Alleles in Antibody-Positive Individuals

2002 • 41 citations

HLA-DQ-Restricted, Islet-Specific T-Cell Clones of a Type I Diabetic Patient: T-Cell Receptor Sequence Similarities to Insulitis-Inducing T-Cells of Nonobese Diabetic Mice

1994 • 40 citations

Insulin selectively primes Th2 responses and induces regulatory tolerance to insulin in pre-diabetic mice

1998 • 33 citations

Abnormalities within CD4 and CD8 T lymphocyte subsets in type 1 (insulin-dependent) diabetes

1991 • 32 citations

Heterophile antibodies segregate in families and are associated with protection from type 1 diabetes

1999 • 24 citations

Cellular immune responses against proinsulin: no evidence for enhanced reactivity in individuals with IDDM.

1999 • 23 citations

Increased Expression of T-Cell Markers of Immunological Memory Associated with Protection from Type I Diabetes: A study of Identical Twins

1994 • 19 citations

Recombinant human preproinsulin expression, purification and reaction with insulin autoantibodies in sera from patients with insulin-dependent diabetes mellitus

1993 • 13 citations

Mapping of antigenic epitopes within the recombinant human preproinsulin related to insulin‐dependent diabetes mellitus

1994 • 1 citations