Humoral and cellular immune responses to proinsulin in adults with newly diagnosed type 1 diabetes

Phototyping: comprehensive DNA typing for HLA‐A, B, C, DRB1, DRB3, DRB4, DRB5 & DQB1 by PCR with 144 primer mixes utilizing sequence‐specific primers (PCR‐SSP)

1995 • 1,018 citations

Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study.

1999 • 633 citations

Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis.

1994 • 539 citations

Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library

1999 • 442 citations

Prediction of IDDM in the General Population: Strategies Based on Combinations of Autoantibody Markers

1997 • 425 citations

Combined use of autoantibodies (IA-2 autoantibody, GAD autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies) in type 1 diabetes: Combinatorial Islet Autoantibody Workshop.

1998 • 424 citations

Transgenic Expression of Mouse Proinsulin II Prevents Diabetes in Nonobese Diabetic Mice

1997 • 248 citations

A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin

2001 • 210 citations

Concentration of Insulin Autoantibodies at Onset of Type I Diabetes: Inverse Log-Linear Correlation With Age

1988 • 185 citations

Self-antigen–presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs

2001 • 171 citations

Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4

1999 • 159 citations

Correlates of Insulin Antibodies in Newly Diagnosed Children with Insulin-dependent Diabetes Before Insulin Therapy

1985 • 126 citations

T cell epitopes of insulin defined in HLA-DR4 transgenic mice are derived from preproinsulin and proinsulin

1998 • 116 citations

Research, Development, Production, and Safety of Biosynthetic Human Insulin

1993 • 113 citations

Antigen-specific therapy for autoimmune disease

2000 • 107 citations

Similar peptides from two beta cell autoantigens, proinsulin and glutamic acid decarboxylase, stimulate T cells of individuals at risk for insulin-dependent diabetes.

1995 • 103 citations

Epidemiology, Clinical Aspects, and Biology of IDDM Patients Under Age 40 Years: Comparison of data from Antwerp with complete ascertainment with data from Belgium with 40% ascertainment. The Belgian Diabetes Registry

1997 • 97 citations

Can Islet Cell Antibodies Predict IDDM in the General Population?

1993 • 92 citations

Optimized autoantibody-based risk assessment in family members. Implications for future intervention trials.

1999 • 92 citations

A Peptide-binding Motif for I-Ag7, the Class II Major Histocompatibility Complex (MHC) Molecule of NOD and Biozzi AB/H Mice

1997 • 90 citations

Similar Peptides from Two β Cell Autoantigens, Proinsulin and Glutamic Acid Decarboxylase, Stimulate T Cells of Individuals at Risk for Insulin-Dependent Diabetes

1995 • 86 citations

Altered immune response to insulin in newly diagnosed compared to insulin-treated diabetic patients and healthy control subjects

1997 • 78 citations

T cell Autoreactivity to Proinsulin Epitopes in Diabetic Patients and Healthy Subjects

1999 • 76 citations

Evidence of IgG Autoantibodies Against Human Proinsulin in Patients With IDDM Before Insulin Treatment

1988 • 73 citations

Persistent T Cell Anergy in Human Type 1 Diabetes

1999 • 66 citations

Correlates of insulin antibodies in newly diagnosed children with insulin-dependent diabetes before insulin therapy

1985 • 51 citations

Proinsulin autoantibodies are more closely associated with Type 1 (insulin-dependent) diabetes mellitus than insulin autoantibodies

1991 • 48 citations

Intranasal Administration of Insulin Peptide B: 9–23 Protects NOD Mice from Diabetes

1996 • 45 citations

Autoreactive and immunoregulatory T-cell subsets in insulindependent diabetes mellitus

1999 • 43 citations

Sex Differences in Incidence of IDDM in Age-Group 15-29 yr: Higher risk in males in Province of Turin, Italy

1993 • 42 citations

T Cell Recognition of Human Pre-Proinsulin Peptides Depends on the Polymorphism at HLA DQ Locus: A Study Using HLA DQ8 and DQ6 Transgenic Mice

1997 • 41 citations

Evidence of IgG autoantibodies against human proinsulin in patients with IDDM before insulin treatment

1988 • 41 citations

T-cell response to proinsulin and insulin in type 1 and pretype 1 diabetes.

1999 • 39 citations

HLA class II typing of whole genome amplified mouth swab DNA

2000 • 36 citations

The Relationship between Peripheral T Cell Reactivity to Insulin, Clinical Remissions and Cytokine Production in Type 1 (Insulin-Dependent) Diabetes Mellitus¹

1999 • 33 citations

Experimental autoimmune insulitis. Induction by T lymphocytes specific for a peptide of proinsulin.

1995 • 31 citations

Cellular immune responses against proinsulin: no evidence for enhanced reactivity in individuals with IDDM.

1999 • 23 citations

Insulin Autoantibodies: More Specific than Proinsulin Autoantibodies for Prediction of Type 1 Diabetes

1999 • 21 citations

Autoantibodies to Insulin and to Proinsulin in Type 1 Diabetic Patients and in At-Risk Probands Differentiate Only Little between Both Antigens

1995 • 20 citations

Attenuation of Inducible Th2 Immunity with Autoimmune Disease Progression

1998 • 18 citations

The Relationship between Peripheral T Cell Reactivity to Insulin, Clinical Remissions and Cytokine Production in Type 1 (Insulin-Dependent) Diabetes Mellitus

1999 • 17 citations

Autoimmune Endocrinopathies

1999 • 15 citations

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