Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(α1*0101,β1*0401) transgenic mice

HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

1987 • 2,045 citations

MHC ligands and peptide motifs: first listing

1995 • 1,674 citations

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo

1994 • 967 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1993 • 962 citations

Mice lacking MHC class II molecules

1991 • 869 citations

T Helper Cell Subsets in Insulin-Dependent Diabetes

1995 • 600 citations

The classification of amino acid conservation

1986 • 559 citations

MHC Class-II Molecules and Autoimmunity

1991 • 521 citations

Promiscuous and allele-specific anchors in HLA-DR-binding peptides

1993 • 383 citations

Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes.

1987 • 319 citations

Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes–prone mice

1996 • 266 citations

Glutamate decarboxylase-, insulin-, and islet cell-antibodies and HLA typing to detect diabetes in a general population-based study of Swedish children.

1995 • 255 citations

Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes

1993 • 247 citations

Several mechanisms can account for defective E alpha gene expression in different mouse haplotypes.

1983 • 245 citations

HLA class II alleles and susceptibility and resistance to insulin dependent diabetes mellitus in Mexican-American families

1993 • 186 citations

Peptides determine the lifespan of MHC class II molecules in the antigen-presenting cell

1994 • 175 citations

HLA-Encoded Genetic Predisposition in IDDM: DR4 Subtypes May Be Associated With Different Degrees of Protection

1997 • 150 citations

Identification of naturally processed T cell epitopes from glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients.

1997 • 148 citations

Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401.

1996 • 139 citations

Specificity of an HLA‐DRB1*0401‐restricted T cell response to type II collagen

1996 • 115 citations

The distribution of DR4 haplotypes in sardinia suggests a primary association of type I diabetes with DRB1 and DQB1 loci

1995 • 96 citations

Immunodominant epitopes of glutamic acid decarboxylase 65 and 67 in insulin-dependent diabetes mellitus

1994 • 91 citations

Expression of HLA-DR4 and human CD4 transgenes in mice determines the variable region beta-chain T-cell repertoire and mediates an HLA-DR-restricted immune response.

1994 • 90 citations

T cell Clones to Epitopes of Glutamic Acid Decarboxylase 65 Raised from Normal Subjects and Patients with Insulin-dependent Diabetes

1996 • 79 citations

DRB1*0403 Protects Against IDDM in Caucasians With the High-Risk Heterozygous DQA1*0301-DQB1*0302/DQA1*0501-DQB1*0201 Genotype

1995 • 75 citations

Natural ligand motifs of closely related HLA-DR4 molecules predict features of rheumatoid arthritis associated peptides

1996 • 64 citations

Glutamic acid decarboxylase and other autoantigens in IDDM

1995 • 26 citations