CD4+ T-Cell Induction and Effector Functions: A Comparison of Immunity against Soluble Antigens and Viral Infections

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

1995 • 4,310 citations

HIV-1 Dynamics in Vivo: Virion Clearance Rate, Infected Cell Life-Span, and Viral Generation Time

1996 • 3,496 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Approaching the Asymptote? Evolution and Revolution in Immunology

1989 • 3,079 citations

Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes.

1989 • 2,118 citations

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

The ubiquitin-proteasome proteolytic pathway

1994 • 1,778 citations

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

CTLA-4 is a second receptor for the B cell activation antigen B7.

1991 • 1,662 citations

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

Hepatitis B Virus Immunopathogenesis

1995 • 1,568 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.

1989 • 1,462 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

The Role of the CD28 Receptor During T Cell Responses to Antigen

1993 • 1,320 citations

IL-4 directs the development of Th2-like helper effectors.

1990 • 1,261 citations

The CD40 Antigen and its Ligand

1994 • 1,259 citations

Three-Dimensional Structure of Poliovirus at 2.9 Å Resolution

1985 • 1,253 citations

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

1993 • 1,219 citations

The Immunopathogenesis of Human Immunodeficiency Virus Infection

1993 • 1,194 citations

CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection

1994 • 1,161 citations

Induction of Bystander T Cell Proliferation by Viruses and Type I Interferon in Vivo

1996 • 1,077 citations

Sequence analysis of peptides bound to MHC class II molecules

1991 • 1,071 citations

The Biochemistry and Cell Biology of Antigen Processing and Presentation

1993 • 1,022 citations

Recombinant human interleukin 5 is a selective activator of human eosinophil function.

1988 • 976 citations

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo

1994 • 967 citations

Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones.

1987 • 966 citations

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

1990 • 904 citations

Interleukin-4: a prototypic immunoregulatory lymphokine

1991 • 878 citations

Signals and signs for lymphocyte responses

1994 • 868 citations

Two types of mouse helper T-cell clone

1987 • 813 citations

pppA2'p5'A2'p5'A: an inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells.

1978 • 787 citations

The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model.

1995 • 768 citations

T Cell-Dependent B Cell Activation

1993 • 727 citations

Tumour necrosis factors α and β inhibit virus replication and synergize with interferons

1986 • 726 citations

The Th1–Th2 hypothesis of HIV infection: new insights

1994 • 708 citations

Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells.

1995 • 699 citations

HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loading

1995 • 684 citations

Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ.

1990 • 670 citations

Theiler's virus infection in mice: an unusual biphasic disease process leading to demyelination

1975 • 615 citations

Molecular Mechanisms of Lymphocyte-Mediated Cytotoxicity and Their Role in Immunological Protection and Pathogenesis In Vivo

1996 • 614 citations

Receptor-Mediated Antigen Uptake and its Effect on Antigen Presentation to Class II-Restricted T Lymphocytes

1990 • 605 citations

The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3

1995 • 583 citations

B Cells Turn Off Virgin But Not Memory T Cells

1992 • 578 citations

MHC class II-associated invariant chain contains a sorting signal for endosomal compartments

1990 • 565 citations

The Virology and Immunobiology of Lymphocytic Choriomeningitis Virus Infection

1980 • 554 citations

T Cell Deletion in High Antigen Dose Therapy of Autoimmune Encephalomyelitis

1994 • 530 citations

Transfer of specific cytotoxic T lymphocytes protects mice inoculated with influenza virus

1978 • 528 citations

The Biochemistry, Biology, and Role of Interleukin 2 in the Induction of Cytotoxic T Cell and Antibody-Forming B Cell Responses

1982 • 524 citations

Essential Role for Cathepsin S in MHC Class II–Associated Invariant Chain Processing and Peptide Loading

1996 • 523 citations

Cellular immune response to hepatitis B virus-encoded antigens in acute and chronic hepatitis B virus infection.

1990 • 503 citations

Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals.

1993 • 484 citations

Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand

1995 • 476 citations

NEUTRALIZING ANTIVIRAL B CELL RESPONSES

1997 • 467 citations

T cell genetic background determines default T helper phenotype development in vitro.

1995 • 466 citations

Clonal anergy induced in mature Vβ6+ T lymphocytes on immunizing Mls-1b mice with Mls-1a expressing cells

1989 • 462 citations

Mechanisms of class I restricted immunopathology. A transgenic mouse model of fulminant hepatitis.

1993 • 454 citations

Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes

1994 • 442 citations

Induction of immunological paralysis in two zones of dosage

1964 • 439 citations

Reversibility of T helper 1 and 2 populations is lost after long-term stimulation.

1996 • 437 citations

Small B cells as antigen-presenting cells in the induction of tolerance to soluble protein antigens.

1992 • 435 citations

CD8-positive T lymphocytes specific for murine cytomegalovirus immediate-early antigens mediate protective immunity

1987 • 432 citations

IgG2a restriction of murine antibodies elicited by viral infections.

1987 • 429 citations

Isolation and characterization of the intracellular MHC class II compartment

1994 • 426 citations

Requirement for CD40 Ligand in Costimulation Induction, T Cell Activation, and Experimental Allergic Encephalomyelitis

1996 • 425 citations

CD40 ligand-transduced co-stimulation of T cells in the development of helper function

1995 • 425 citations

Cytokine-mediated regulation of chronic intestinal helminth infection.

1994 • 425 citations

Helper T‐Cell Subsets: Phenotype, Function and the Role of Lymphokines in Regulating their Development

1991 • 423 citations

CD40 Ligand-Dependent T Cell Activation: Requirement of B7-CD28 Signaling Through CD40

1996 • 421 citations

Interstitial murine cytomegalovirus pneumonia after irradiation: characterization of cells that limit viral replication during established infection of the lungs

1985 • 417 citations

Heterosubtypic immunity to influenza type A virus in mice. Effector mechanisms and their longevity.

1994 • 400 citations

Role of cytokines in determining T-lymphocyte function

1994 • 396 citations

Role of interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus.

1994 • 393 citations

IL-10: a novel cytotoxic T cell differentiation factor.

1991 • 391 citations

Mice lacking the MHC class II-associated invariant chain

1993 • 385 citations

Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge.

1992 • 381 citations

Virus-specific major MHC class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection

1998 • 380 citations

Clearance of influenza virus respiratory infection in mice lacking class I major histocompatibility complex-restricted CD8+ T cells.

1991 • 372 citations

Pathogenesis of Infectious Disease

1978 • 371 citations

The Nucleocapsid of Hepatitis B Virus Is Both a T-Cell-Independent and a T-Cell-Dependent Antigen

1986 • 363 citations

Cytotoxic T lymphocytes recognize an HLA-A2-restricted epitope within the hepatitis B virus nucleocapsid antigen.

1991 • 363 citations

In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39.

1993 • 354 citations

Interferon-Induced Proteins and the Antiviral State

1990 • 353 citations

Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion.

1996 • 349 citations

Cellular events in the lymph node and lung of mice with influenza. Consequences of depleting CD4+ T cells.

1990 • 340 citations

Mice Lacking H2-M Complexes, Enigmatic Elements of the MHC Class II Peptide-Loading Pathway

1996 • 337 citations

HLA A2 restricted cytotoxic T lymphocyte responses to multiple hepatitis B surface antigen epitopes during hepatitis B virus infection.

1993 • 333 citations

CD40 Ligand Is Required for Protective Cell-Mediated Immunity to Leishmania major

1996 • 332 citations

Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression.

1993 • 326 citations

Article

1995 • 325 citations

New Concepts in the Immunopathogenesis of HIV Infection

1995 • 323 citations

Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice

1994 • 321 citations

Antibody production to the nucleocapsid and envelope of the hepatitis B virus primed by a single synthetic T cell site

1987 • 319 citations

Brefeldin A implicates egress from endoplasmic reticulum in class I restricted antigen presentation

1989 • 317 citations

Disruption of CD40–CD40 Ligand Interactions Results in an Enhanced Susceptibility to Leishmania amazonensis Infection

1996 • 311 citations

Origin of Thy-1+ dendritic epidermal cells of adult mice from fetal thymic precursors

1990 • 306 citations

Flow cytometric determination of cytokines in activated murine T helper lymphocytes: Expression of interleukin‐10 in interferon‐γ and in interleukin‐4‐expressing cells

1994 • 305 citations

Induction of cytotoxic T-cell responses in vivo in the absence of CD4 helper cells

1987 • 304 citations

B lymphocytes can be competent antigen-presenting cells for priming CD4+ T cells to protein antigens in vivo.

1995 • 303 citations

Protective Role of CD40 in Leishmania major Infection at Two Distinct Phases of Cell-Mediated Immunity

1996 • 302 citations

CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response.

1996 • 300 citations

Transgenic mice susceptible to poliovirus.

1991 • 293 citations

Natural killer (NK) cells as a responder to interleukin 2 (IL 2). II. IL 2-induced interferon gamma production.

1983 • 288 citations

CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge

1996 • 287 citations

The roles of perforin‐ and Fas‐dependent cytotoxicity in protection against cytopathic and noncytopathic viruses

1995 • 286 citations

T cell priming in vivo: a major role for B cells in presenting antigen to T cells in lymph nodes.

1987 • 286 citations

Successful T cell priming in B cell-deficient mice.

1995 • 284 citations

Influenza virus-specific CD4+ T helper type 2 T lymphocytes do not promote recovery from experimental virus infection.

1994 • 283 citations

Current Status of Immunological Adjuvants

1986 • 283 citations

Immunological Unresponsiveness

1973 • 278 citations

Concepts in Viral Pathogenesis

1984 • 272 citations

Costimulatory requirements of naive CD4+ T cells. ICAM-1 or B7-1 can costimulate naive CD4 T cell activation but both are required for optimum response.

1995 • 271 citations

Antigen Presentation and T Cell Development in H2-M-Deficient Mice

1996 • 263 citations

On the complexity of self

1991 • 261 citations

MHC class II—Restricted presentation of intracellular antigen

1991 • 260 citations

Resistance to Leishmania major Induced by Tolerance to a Single Antigen

1996 • 258 citations

The structure of influenza virus

1970 • 247 citations

Theiler's Virus-Induced Demyelination: Prevention by Immunosuppression

1976 • 242 citations

Polarized expression of cytokines in cell conjugates of helper T cells and splenic B cells.

1991 • 241 citations

The ups and downs of T cell costimulation

1994 • 240 citations

The B cell is the initiating antigen-presenting cell in peripheral lymph nodes.

1987 • 240 citations

Delayed clearance of Sendai virus in mice lacking class I MHC-restricted CD8+ T cells.

1992 • 237 citations

Different Roles for L3T4+ and Lyt 2+ T Cell Subsets in the Control of an Acute Herpes Simplex Virus Infection of the Skin and Nervous System

1987 • 236 citations

Virus-triggered acquired immunodeficiency by cytotoxic T-cell-dependent destruction of antigen-presenting cells and lymph follicle structure.

1991 • 231 citations

Efficient cell surface expression of class II MHC molecules in the absence of associated invariant chain.

1986 • 226 citations

HLA-A31- and HLA-Aw68-restricted cytotoxic T cell responses to a single hepatitis B virus nucleocapsid epitope during acute viral hepatitis.

1993 • 224 citations

Expression and function of the murine B7 antigen, the major costimulatory molecule expressed by peritoneal exudate cells.

1992 • 220 citations

A case for cytokines as effector molecules in the resolution of virus infection

1993 • 216 citations

Antigen-pulsed dendritic cells can efficiently induce an antibody response in vivo.

1992 • 215 citations

B lymphocytes in vivo fail to prime naive T cells but can stimulate antigen-experienced T lymphocytes.

1993 • 210 citations

The influence of virus structure on antibody responses and virus serotype formation

1996 • 205 citations

T4+ T helper cell function in vivo: differential requirement for induction of antiviral cytotoxic T-cell and antibody responses

1988 • 205 citations

Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes

1990 • 205 citations

Immune response against lymphocytic choriomeningitis virus infection in mice without CD8 expression.

1991 • 201 citations

Processing pathways for presentation of cytosolic antigen to MHC class II-restricted T cells

1992 • 201 citations

Functional analysis of influenza-specific helper T cell clones in vivo. T cells specific for internal viral proteins provide cognate help for B cell responses to hemagglutinin.

1986 • 199 citations

The role of antigen-presenting B cells in T cell priming in vivo. Studies of B cell-deficient mice.

1988 • 199 citations

Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple compartments

1995 • 198 citations

T Cell Response to Viral and Bacterial Infection

1974 • 197 citations

Superantigens of Mouse Mammary Tumor Virus

1995 • 196 citations

Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis.

1996 • 196 citations

Can B cells turn on virgin T cells?

1988 • 192 citations

Superantigen-induced immune stimulation amplifies mouse mammary tumor virus infection and allows virus transmission

1993 • 189 citations

An endogenous processing pathway in vaccinia virus-infected cells for presentation of cytoplasmic antigens to class II-restricted T cells.

1990 • 188 citations

Role of Lymphoid Organs in the Pathogenesis of Human Immunodeficiency Virus (HIV) Infection

1994 • 188 citations

Exhaustion of CTL memory and recrudescence of viremia in lymphocytic choriomeningitis virus-infected MHC class II-deficient mice and B cell-deficient mice.

1996 • 185 citations

Mechanism of recovery from acute virus infection: treatment of lymphocytic choriomeningitis virus-infected mice with monoclonal antibodies reveals that Lyt-2+ T lymphocytes mediate clearance of virus and regulate the antiviral antibody response

1987 • 185 citations

A role of la-associated invariant chains in antigen processing and pressentation

1989 • 184 citations

Poxvirus pathogenesis.

1991 • 183 citations

Host Defenses Against Influenza Virus: The Role of Anti-Hemagglutinin Antibody

1975 • 183 citations

Protein-Specific Helper T-Lymphocyte Formation Initiated by Dendritic Cells

1985 • 181 citations

Human T cell response to the surface antigen of hepatitis B virus (HBsAg). Endosomal and nonendosomal processing pathways are accessible to both endogenous and exogenous antigen.

1988 • 180 citations

Mice can recover from pulmonary influenza virus infection in the absence of class I-restricted cytotoxic T cells.

1992 • 174 citations

Rabies pathogenesis

1977 • 169 citations

Cell biology of antigen presentation

1993 • 166 citations

Different roles for CD4+ and CD8+ T lymphocytes and macrophage subsets in the control of a generalized virus infection

1996 • 165 citations

Role of dendritic cells in the priming of CD4+ T lymphocytes to peptide antigen in vivo.

1993 • 164 citations

LCMV-Specific, Class II-Restricted Cytotoxic T Cells in β2-Microglobulin-Deficient Mice

1992 • 164 citations

Antiviral protection by virus-immune cytotoxic T cells: infected target cells are lysed before infectious virus progeny is assembled.

1977 • 161 citations

Beta 2-microglobulin-, CD8+ T-cell-deficient mice survive inoculation with high doses of vaccinia virus and exhibit altered IgG responses.

1992 • 160 citations

The Effect of L3T4 T Cell Depletion on the Pathogenesis of Theiler's Murine Encephalomyelitis Virus Infection in CBA Mice

1987 • 155 citations

Activation of cytokine genes in T cells during primary and secondary murine influenza pneumonia.

1993 • 150 citations

CD40-CD40 ligand interactions are critical in T-B cooperation but not for other anti-viral CD4+ T cell functions.

1996 • 149 citations

Protection of Mice from Fatal Herpes Simplex Virus Type 1 Infection by Adoptive Transfer of Cloned Virus-specific and H-2-restricted Cytotoxic T Lymphocytes

1983 • 149 citations

Rabies pathogenesis. Brief review.

1977 • 148 citations

Antigen Uptake and Accumulation in Antigen‐Specific B Cells

1987 • 148 citations

Acquisition of specific cytotoxic activity by human T4+ T lymphocytes in culture

1984 • 147 citations

Importance of interferons in recovery from mousepox

1993 • 146 citations

Invariant chain targets HLA class II molecules to acidic endosomes containing internalized influenza virus.

1991 • 146 citations

Interferon inhibits Viral Protein Synthesis in L Cells infected with Vaccinia Virus

1972 • 145 citations

Thymus dependence of viral antigens

1975 • 145 citations

Characterization of endogenous peptides bound to purified HLA-DR molecules and their absence from invariant chain-associated alpha beta dimers.

1993 • 145 citations

Cooperation between cytotoxic and helper T lymphocytes in protection against lethal Sendai virus infection. Protection by T cells is MHC-restricted and MHC-regulated; a model for MHC-disease associations.

1986 • 139 citations

Demyelinative myelopathy in mice induced by the DA virus

1976 • 139 citations

Human poliovirus receptor gene expression and poliovirus tissue tropism in transgenic mice

1992 • 137 citations

Selective expansion of cytotoxic T lymphocytes with a CD4+CD56+ surface phenotype and a T helper type 1 profile of cytokine secretion in the liver of patients chronically infected with Hepatitis B virus.

1994 • 136 citations

Superantigen-reactive CD4+ T cells are required to stimulate B cells after infection with mouse mammary tumor virus.

1993 • 136 citations

Expression of Cytokines by Recombinant Vaccinia Viruses: A Model for Studying Cytokines in Virus Infections in vivo

1992 • 135 citations

Concurrent production of interleukin-2, interleukin-10, and gamma interferon in the regional lymph nodes of mice with influenza pneumonia

1994 • 134 citations

Impairment and delay of neutralizing antiviral antibody responses by virus-specific cytotoxic T cells.

1993 • 134 citations

Antigenic specificities of human CD4+ T-cell clones recovered from recurrent genital herpes simplex virus type 2 lesions

1994 • 134 citations

Protection against lethal viral infection by neutralizing and nonneutralizing monoclonal antibodies: distinct mechanisms of action in vivo

1984 • 133 citations

A quantitative analysis of antigen-presenting cell function: activated B cells stimulate naive CD4 T cells but are inferior to dendritic cells in providing costimulation.

1994 • 133 citations

Virus-induced autoantibody response to a transgenic viral antigen

1990 • 130 citations

B cell activation: Three steps and their variations

1984 • 130 citations

Microbial induction of co-stimulatory activity for CD4 T-cell growth

1991 • 130 citations

Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus-induced demyelinating disease. VI. Potentiation of demyelination with and characterization of an immunopathologic CD4+ T cell line specific for an immunodominant VP2 epitope.

1994 • 128 citations

Peptide and protein antigens require distinct antigen-presenting cell subsets for the priming of CD4+ T cells.

1995 • 127 citations

How HLA-DM edits the MHC class II peptide repertoire: survival of the fittest?

1997 • 127 citations

T cells primed by influenza virion internal components can cooperate in the antibody response to haemagglutinin

1979 • 125 citations

Adoptive immunotherapy of murine cytomegalovirus adrenalitis in the immunocompromised host: CD4-helper-independent antiviral function of CD8-positive memory T lymphocytes derived from latently infected donors

1988 • 124 citations

Selection of a Broad Repertoire of CD4+ T Cells in H-2Ma0/0 Mice

1997 • 122 citations

Poliovirus-specific CD4+ Th1 clones with both cytotoxic and helper activity mediate protective humoral immunity against a lethal poliovirus infection in transgenic mice expressing the human poliovirus receptor.

1995 • 121 citations

Regulatory Mechanisms in the Immune Response to Cell-surface Antigens

1977 • 118 citations

Characteristics of the influenza virus-specific CD8+ T cell response in mice homozygous for disruption of the H-2lAb gene.

1995 • 118 citations

Roles of different T-cell subsets in control of herpes simplex virus infection determined by using T-cell-deficient mouse-models

1995 • 117 citations

Immunodeficient mice recover from infection with vaccinia virus expressing interferon‐γ

1990 • 117 citations

Diversity of Endogenous Epitopes Bound to MHC Class II Molecules Limited by Invariant Chain

1994 • 116 citations

Failure in generating hemopoietic stem cells is the primary cause of death from cytomegalovirus disease in the immunocompromised host.

1988 • 115 citations

Role of T_H1/T_H2 Cytokines in HIV Infection

1994 • 114 citations

Recognition of pre-processed endogenous antigen by class I but not class II MHC-restricted T cells

1989 • 113 citations

Two processing pathways for the MHC class II-restricted presentation of exogenous influenza virus antigen.

1994 • 113 citations

Class I‐deficient resistant mice intracerebrally inoculated with Theiler's virus show an increased T cell response to viral antigens and susceptibility to demyelination

1993 • 112 citations

Interferon gamma is involved in the recovery of athymic nude mice from recombinant vaccinia virus/interleukin 2 infection.

1990 • 110 citations

Gene-targeted B-deficient mice reveal a critical role for B cells in the CD4 T cell response

1995 • 109 citations

Cytotoxic T cell recognition of an endogenous class I HLA peptide presented by a class II HLA molecule.

1990 • 109 citations

Recognition of hepatitis B surface antigen by human T lymphocytes. Proliferative and cytotoxic responses to a major antigenic determinant defined by synthetic peptides.

1988 • 107 citations

Presentation of endogenous viral proteins in association with major histocompatibility complex class II: On the role of intracellular compartmentalization, invariant chain and the TAP transporter system

1995 • 106 citations

The predominance of CD8+ T cells after infection with measles virus suggests a role for CD8+ class I MHC-restricted cytotoxic T lymphocytes (CTL) in recovery from measles. Clonal analyses of human CD8+ class I MHC-restricted CTL.

1990 • 105 citations

CD4+ T cell activation and tolerance induction in B cell knockout mice.

1996 • 103 citations

Interferon-mediated, double-stranded RNA-dependent protein kinase is inhibited in extracts from vaccinia virus-infected cells

1984 • 101 citations

Defective induction of antigen‐reactive proliferating T cells in B cell‐deprived mice

1981 • 99 citations

Dendritic cells but not B cells present antigenic complexes to class II-restricted T cells after administration of protein in adjuvant.

1996 • 99 citations

Antiviral protection by CD8+ versus CD4+ T cells. CD8+ T cells correlating with cytotoxic activity in vitro are more efficient in antivaccinia virus protection than CD4-dependent IL.

1991 • 95 citations

Absence of an antigen‐specific helper T cell required for the expression of the Tn 15 idiotype in mice treated with anti‐μ antibody

1980 • 92 citations

Rapid recovery of lung histology correlates with clearance of influenza virus by specific CD8+ cytotoxic T cells.

1989 • 91 citations

T cell-dependent IFN-gamma exerts an antiviral effect in the central nervous system but not in peripheral solid organs.

1993 • 88 citations

Administration of anti-IFN-gamma antibody to beta 2-microglobulin-deficient mice delays influenza virus clearance but does not switch the response to a T helper cell 2 phenotype.

1994 • 86 citations

Patterns of cytokine secretion in murine leishmaniasis: correlation with disease progression or resolution

1990 • 86 citations

Beta 2-microglobulin-deficient mice can be protected against influenza A infection by vaccination with vaccinia-influenza recombinants expressing hemagglutinin and neuraminidase.

1993 • 84 citations

MHC class II antigen processing: biology of invariant chain

1994 • 83 citations

Tolerogenicity of resting and activated B cells.

1994 • 83 citations

CELLULAR IMMUNITY IN VACCINIA INFECTION OF MICE

1968 • 80 citations

Vaccination with recombinant vaccinia viruses expressing ICP27 induces protective immunity against herpes simplex virus through CD4+ Th1+ T cells

1995 • 78 citations

Chemistry and functional role of the invariant chain

1992 • 76 citations

Peripheral T cell activation and deletion induced by transfer of lymphocyte subsets expressing endogenous or exogenous mouse mammary tumor virus.

1993 • 75 citations

Peptide transporter‐independent, stress protein‐mediated endosomal processing of endogenous protein antigens for major histocompatibility complex class I presentation

1994 • 73 citations

Fas-dependent CD4⁺cytotoxic T-cell-mediated pathogenesis during virus infection

1996 • 72 citations

IMMUNE RESPONSES TO INFLUENZA VIRUS IN THE MOUSE, AND THEIR ROLE IN CONTROL OF THE INFECTION

1979 • 69 citations

Hepatitis B virus-reactive human T lymphocyte clones: antigen specificity and helper function for antibody synthesis.

1984 • 66 citations

Role of antigen‐presenting cells in the polarized development of helper T cell subsets: evidence for differential cytokine production by Th0 cells in response to antigen presentation by B cells and macrophages

1994 • 66 citations

Host response to Sendai virus in mice lacking class II major histocompatibility complex glycoproteins

1995 • 65 citations

Processing of an endogenous protein can generate MHC class II-restricted T cell determinants distinct from those derived from exogenous antigen.

1991 • 60 citations

PROSPECTIVE STUDY OF CELLULAR IMMUNITY TO HEPATITIS-B-VIRUS ANTIGENS FROM THE EARLY INCUBATION PHASE OF ACUTE HEPATITIS B

1987 • 60 citations

Cytotoxic T-memory cells in virus infection and the specificity of helper T cells.

1982 • 58 citations

Impaired Generation of Anti‐Viral Cytotoxicity against Lymphocytic Choriomeningitis and Vaccinia Virus in Mice Treated with CD4‐Specific Monoclonal Antibody

1989 • 56 citations

Evidence that cytotoxic T cells are part of the host's response to influenza pneumonia.

1978 • 55 citations

Antiviral Immune Responses of Mice Lacking MHC Class II or Its Associated Invariant Chain

1996 • 55 citations

Activity of CD4+ T-cell clones of type 1 and type 2 in generation of influenza virus-specific cytotoxic responses in vitro

1991 • 54 citations

Do L3T4+ T cells act as effector cells in protection against influenza virus infection.

1987 • 53 citations

Enhanced Virus Clearance by Early Inducible Lymphocytic Choriomeningitis Virus-Neutralizing Antibodies in Immunoglobulin-Transgenic Mice

1998 • 50 citations

Primary antibody responses to a well-defined and unique hapten are not enhanced by preimmunization with carrier: analysis in a viral model.

1986 • 50 citations

Anchor sequence-dependent endogenous processing of human immunodeficiency virus 1 envelope glycoprotein gp160 for CD4+ T cell recognition.

1990 • 49 citations

CD4+ T cells are essential in overcoming experimental murine measles encephalitis.

1994 • 45 citations

Enhancement of disease by neutralizing antiviral antibodies in the absence of primed antiviral cytotoxic T cells

1993 • 42 citations

Strong priming of T cells adoptively transferred into scid mice.

1991 • 42 citations

Theiler's virus infection: a model for multiple sclerosis.

1985 • 40 citations

Lymphocytes in congenital immunological deficiency diseases.

1968 • 39 citations

Nature and mode of action of vaccinia virus products that block activation of the interferon-mediated ppp(A2′p)nA-synthetase

1984 • 38 citations

CD4+ T cells control measles virus infection of the central nervous system.

1992 • 38 citations

Fewer protective cytotoxic T-cell epitopes than T-helper-cell epitopes on vesicular stomatitis virus

1993 • 37 citations

Cytolytic T lymphocytes from the BALB/c-H-2dm2 mouse recognize the vesicular stomatitis virus glycoprotein and are restricted by class II MHC antigens.

1990 • 33 citations

Cell cooperation in antibody responses to influenza virus. I. Priming of helper T cells by internal components of the virion

1980 • 33 citations

Formation of complexes between self-peptides and MHC class II molecules in cells defective for presentation of exogenous protein antigens.

1992 • 31 citations

Antigenic sequences of poliovirus recognized by T cells: serotype-specific epitopes on VP1 and VP3 and cross-reactive epitopes on VP4 defined by using CD4+ T-cell clones

1992 • 31 citations

Study of the mechanisms by which CD4+ T cells contribute to protection in Theiler's murine encephalomyelitis.

1993 • 31 citations

Functional in vivo MHC class II loading by endogenously synthesized glycoprotein during viral infection.

1997 • 28 citations

Cross-protection against lymphocytic choriomeningitis virus mediated by a CD4+ T-cell clone specific for an envelope glycoprotein epitope of Lassa virus

1993 • 28 citations

Binding of T cell receptor to major histocompatibility complex class II‐peptide complexes at the single‐cell level results in the induction of antigen unresponsiveness (anergy)

1992 • 28 citations

Antigen presentation by dendritic cells provides optimal stimulation for the production of interleukin (IL) 2, IL 4 and interferon‐γ by allogeneic T cells

1991 • 27 citations

Antigen processing for presentation to CD4+ T cells.

1992 • 27 citations

A Role for Early Cytotoxic T Cells in Resistance to Ectromelia Virus Infection in Mice

1987 • 26 citations

The complementary roles of cellular and humoral immunity in resistance to re-infection with LCM virus.

1988 • 24 citations

Class II‐restricted IgG2a^b‐specific T cells recognize a signal‐minus form of the V‐CH3^b antigen

1991 • 22 citations

Cellular interactions involved in T-dependent B-cell activation

1982 • 22 citations

Regulatory role of IL4 and other cytokines in T helper cell development in an αβ TCR transgenic mouse system

1993 • 17 citations

B-lymphocyte requirement for vaccine-mediated protection from Theiler's murine encephalomyelitis virus-induced central nervous system disease

1995 • 16 citations

Pathogenetic aspects of persistent measles virus infections in brain tissue

1991 • 11 citations

Molecular aspects of immune recognition of cytomegalovirus.

1991 • 11 citations

T-lymphocyte effects on murine cytomegalovirus pulmonary infection.

1990 • 8 citations

Structure of Influenza Virus

1974 • 5 citations