Protective Role of CD40 in Leishmania major Infection at Two Distinct Phases of Cell-Mediated Immunity

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

1993 • 1,704 citations

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.

1989 • 1,462 citations

Altered immune responses in mice lacking inducible nitric oxide synthase

1995 • 1,296 citations

Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis.

1981 • 1,281 citations

The Regulation of Immunity to Leishmania Major

1995 • 1,265 citations

The CD40 Antigen and its Ligand

1994 • 1,259 citations

The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation

1994 • 1,099 citations

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.

1993 • 991 citations

B70 antigen is a second ligand for CTLA-4 and CD28

1993 • 907 citations

The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome

1993 • 840 citations

CD40 Ligand Gene Defects Responsible for X-Linked Hyper-IgM Syndrome

1993 • 836 citations

Recombinant interleukin 12 cures mice infected with Leishmania major.

1993 • 776 citations

Mice deficient for the CD40 ligand

1994 • 753 citations

Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from L-arginine.

1990 • 751 citations

Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM

1993 • 739 citations

Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response.

1993 • 738 citations

CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM

1993 • 719 citations

Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism.

1990 • 629 citations

CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40.

1993 • 593 citations

B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4

1995 • 577 citations

Humoral immune responses in CD40 ligand-deficient mice.

1994 • 541 citations

Production of interferon gamma, interleukin 2, interleukin 4, and interleukin 10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis.

1991 • 528 citations

A limiting dilution assay for quantifying Leishmania major in tissues of infected mice

1985 • 508 citations

Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand

1995 • 476 citations

Prevention of Collagen-Induced Arthritis with an Antibody to gp39, the Ligand for CD40

1993 • 471 citations

Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones.

1994 • 438 citations

Activated T cells induce interleukin‐12 production by monocytes via CD40‐CD40 ligand interaction

1995 • 427 citations

CD40 ligand-transduced co-stimulation of T cells in the development of helper function

1995 • 425 citations

CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major.

1994 • 397 citations

Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells.

1994 • 379 citations

Administration of monoclonal anti-IFN-gamma antibodies in vivo abrogates natural resistance of C3H/HeN mice to infection with Leishmania major.

1989 • 374 citations

B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells.

1994 • 347 citations

Standardization of mRNA titration using a polymerase chain reaction method involving co-amplification with a multispecific internal control.

1992 • 342 citations

Immunology of Leishmaniasis

1993 • 337 citations

Selective induction of B7/BB-1 on interferon-γ stimulated monocytes: A potential mechanism for amplification of T cell activation through the CD28 pathway

1991 • 325 citations

Immunodeficiency with hyper-IgM (HIM).

1992 • 318 citations

CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation.

1994 • 245 citations

IL-12 induces the production of IFN-gamma by neonatal human CD4 T cells.

1993 • 232 citations

Isolated human follicular dendritic cells display a unique antigenic phenotype.

1989 • 225 citations

Isolation and characterization of human tonsil dendritic cells.

1988 • 201 citations

Antibody to the ligand of CD40, gp39, blocks the occurrence of the acute and chronic forms of graft-vs-host disease.

1994 • 187 citations

THE CONTROL OF LEISHMANIASIS

1980 • 177 citations

Role of the CD40‐CD40 ligand interaction in CD4⁺ T cell contact‐dependent activation of monocyte interleukin‐1 synthesis

1994 • 174 citations

Reconstitution of Leishmania immunity in severe combined immunodeficient mice using Th1- and Th2-like cell lines.

1991 • 139 citations

Activated T cells enhance nitric oxide production by murine splenic macrophages through gp39 and LFA‐1

1995 • 132 citations

T-Cell Responses and Immunity to Experimental Infection with Leishmania Major

1989 • 125 citations

Patterns of cytokine secretion in murine leishmaniasis: correlation with disease progression or resolution

1990 • 86 citations

Reconstitution of C.B‐17 scid mice with BALB/c T cells initiates a T helper type‐1 response and renders them capable of healing Leishmania major infection

1993 • 78 citations

B7/BB-1 is a leucocyte differentiation antigen on human dendritic cells induced by activation.

1993 • 70 citations

Transfected Leishmania expressing biologically active IFN-gamma.

1993 • 44 citations