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MHC class II-associated invariant chain contains a sorting signal for endosomal compartments

Data up to Jan 2025

Published1990
Citations565
References54

Total Citations Per Year

Abstract

References (54)

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The membrane-spanning segment of invariant chain (Iγ) contains a potentially cleavable signal sequence

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Cell surface expression of class II histocompatibility antigens occurs in the absence of the invariant chain.

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Human major histocompatibility complex class II invariant chain is expressed on the cell surface.

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Intracellular class II HLA antigens are accessible to transferrin-neuraminidase conjugates internalized by receptor-mediated endocytosis.

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The human Ia-associated invariant chain is synthesized in Ia-negative B cell variants and is not expressed on the cell surface of both Ia-negative and Ia-positive parental cells.

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Sorting signals

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MHC class II-associated invariant chain contains a sorting signal for endosomal… (1990) – Cell | Metascience Observatory Explorer