Cell biology of antigen presentation

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

A hypothetical model of the foreign antigen binding site of Class II histocompatibility molecules

1988 • 1,161 citations

Empty MHC class I molecules come out in the cold

1990 • 933 citations

Crystal Structures of Two Viral Peptides in Complex with Murine MHC Class I H-2K ^b

1992 • 864 citations

Identification of self peptides bound to purified HLA-B27

1991 • 844 citations

Isolation of an endogenously processed immunodominant viral peptide from the class I H–2Kb molecule

1990 • 689 citations

The structure of HLA-B27 reveals nonamer self-peptides bound in an extended conformation

1991 • 687 citations

Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments

1991 • 663 citations

Proteolysis, proteasomes and antigen presentation

1992 • 576 citations

MHC class II-associated invariant chain contains a sorting signal for endosomal compartments

1990 • 565 citations

Intracellular transport of class II MHC molecules directed by invariant chain

1990 • 548 citations

HLA-A2.1-Associated Peptides from a Mutant Cell Line: A Second Pathway of Antigen Presentation

1992 • 522 citations

Major histocompatibility antigens: The human (HLA-A,-B,-C) and murine (H-2K, H-2D) class I molecules

1981 • 511 citations

HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides

1992 • 502 citations

Assembly of MHC class I molecules analyzed in vitro

1990 • 491 citations

Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding

1990 • 486 citations

The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route

1990 • 445 citations

Transport Protein Genes in the Murine MHC: Possible Implications for Antigen Processing

1990 • 438 citations

A proteasome-related gene between the two ABC transporter loci in the class II region of the human MHC

1991 • 427 citations

MHC class II region encoding proteins related to the muKidrug resistance family of transmembrane transporters

1990 • 426 citations

Direct binding of peptide to empty MHC class I molecules on intact cells and in vitro

1990 • 418 citations

Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex

1992 • 407 citations

Presentation of viral antigen controlled by a gene in the major histocompatibility complex

1990 • 381 citations

Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule

1992 • 344 citations

Role for intracellular proteases in the processing and transport of class II HLA antigens.

1988 • 336 citations

Defective presentation to class I-restricted cytotoxic T lymphocytes in vaccinia-infected cells is overcome by enhanced degradation of antigen.

1988 • 331 citations

Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain

1991 • 326 citations

Maternally transmitted histocompatibility antigen of mice: A hydrophobic peptide of a mitochondrially encoded protein

1990 • 324 citations

Presentation of viral antigen by MHC class I molecules is dependent on a putative peptide transporter heterodimer

1992 • 322 citations

Participation of a novel 88-kD protein in the biogenesis of murine class I histocompatibility molecules.

1991 • 312 citations

The human class II MHC protein HLA-DR1 assembles as empty αβ heterodimers in the absence of antigenic peptide

1992 • 306 citations

Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways

1990 • 303 citations

Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein

1991 • 303 citations

A role for peptide in determining MHC class II structure

1991 • 275 citations

Subunit of the '20S' proteasome (multicatalytic proteinase) encoded by the major histocompatibility complex

1991 • 262 citations

MHC class II—Restricted presentation of intracellular antigen

1991 • 260 citations

Homology of proteasome subunits to a major histocompatibility complex-linked LMP gene

1991 • 256 citations

Liposome-encapsulated antigens are processed in lysosomes, recycled, and presented to T cells

1991 • 250 citations

Proteasome subunits encoded by the major histocompatibility complex are not essential for antigen presentation

1992 • 250 citations

Reduction of disulfide bonds within lysosomes is a key step in antigen processing.

1991 • 245 citations

Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes

1990 • 236 citations

Proteolysis of the class II-associated invariant chain generates a peptide binding site in intracellular HLA-DR molecules.

1991 • 234 citations

Efficient cell surface expression of class II MHC molecules in the absence of associated invariant chain.

1986 • 226 citations

Allele and locus‐specific differences in cell surface expression and the association of HLA class I heavy chain with β₂‐microglobulin: differential effects of inhibition of glycosylation on class I subunit association

1988 • 224 citations

Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes.

1992 • 219 citations

Beta 2-microglobulin is not required for cell surface expression of the murine class I histocompatibility antigen H-2Db or of a truncated H-2Db.

1986 • 212 citations

Antigen processing for presentation by class II major histocompatibility complex requires cleavage by cathepsin E

1992 • 207 citations

Invariant chain can function as a chaperone protein for class II major histocompatibility complex molecules.

1992 • 197 citations

Assembly and transport properties of invariant chain trimers and HLA-DR-invariant chain complexes.

1992 • 189 citations

An endogenous processing pathway in vaccinia virus-infected cells for presentation of cytoplasmic antigens to class II-restricted T cells.

1990 • 188 citations

Processed antigen binds to newly synthesized mhc class II molecules in antigen-specific B lymphocytes

1991 • 188 citations

Efficient dissociation of the p88 chaperone from major histocompatibility complex class I molecules requires both beta 2-microglobulin and peptide.

1992 • 184 citations

Flanking sequences influence the presentation of an endogenously synthesized peptide to cytotoxic T lymphocytes.

1992 • 184 citations

Irreversible association of peptides with class II MHC molecules in living cells

1992 • 173 citations

Epitope-directed processing of specific antigen by B lymphocytes.

1989 • 163 citations

Invariant chain targets HLA class II molecules to acidic endosomes containing internalized influenza virus.

1991 • 146 citations

Intracellular transport and localization of major histocompatibility complex class II molecules and associated invariant chain.

1991 • 145 citations

Cell surface expression of class II histocompatibility antigens occurs in the absence of the invariant chain.

1986 • 142 citations

Excess β2 microglobulin promoting functional peptide association with purified soluble class I MHC molecules

1991 • 129 citations

Binding to Ia protects an immunogenic peptide from proteolytic degradation.

1989 • 113 citations

A gene required for class II-restricted antigen presentation maps to the major histocompatibility complex.

1991 • 106 citations

Reassociation with beta 2-microglobulin is necessary for Kb class I major histocompatibility complex binding of exogenous peptides.

1990 • 95 citations

Stable surface expression of invariant chain prevents peptide presentation by HLA-DR.

1992 • 94 citations

Invariant chain promotes egress of poorly expressed, haplotype-mismatched class II major histocompatibility complex A alpha A beta dimers from the endoplasmic reticulum/cis-Golgi compartment.

1991 • 94 citations

A trans-acting major histocompatibility complex-linked gene whose alleles determine gain and loss changes in the antigenic structure of a classical class I molecule.

1989 • 94 citations

Surface appearance and instability of empty H-2 class I molecules under physiological conditions.

1991 • 93 citations

Class II-restricted presentation of an endogenously derived immunodominant T-cell determinant of hen egg lysozyme.

1991 • 89 citations

Induction of HLA expression in Daudi cells after cell fusion

1977 • 79 citations

pH dependence and exchange of high and low responder peptides binding to a class II MHC molecule.

1992 • 78 citations

Antigen processing by endosomal proteases determines which sites of sperm‐whale myoglobin are eventually recognized by T cells

1991 • 74 citations

Exogenous peptides compete for the presentation of endogenous antigens to major histocompatibility complex class II-restricted T cells.

1991 • 60 citations

The fate of the three subunits of major histocompatibility complex class I molecules

1992 • 45 citations

Clonal sketches of the immune response.

1988 • 28 citations

Association of the human invariant chain with H‐2 D^b class I molecules

1992 • 28 citations

Class II‐restricted IgG2a^b‐specific T cells recognize a signal‐minus form of the V‐CH3^b antigen

1991 • 22 citations

Processing without proteolytic cleavage is required for recognition of insulin by T cells

1990 • 7 citations

Invariant chain targets HLA class II molecules to acidic endosomes containing internalized influenza virus

1991 • 7 citations