Influenza virus-specific CD4+ T helper type 2 T lymphocytes do not promote recovery from experimental virus infection.

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system

1974 • 2,058 citations

Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones.

1987 • 966 citations

Tumour necrosis factors α and β inhibit virus replication and synergize with interferons

1986 • 726 citations

Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens.

1988 • 713 citations

Establishment and Characterization of BALB/c Lymphoma Lines with B Cell Properties

1979 • 677 citations

Differences in antigen presentation to MHC class I-and class II-restricted influenza virus-specific cytolytic T lymphocyte clones.

1986 • 513 citations

Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals.

1993 • 484 citations

In vivo effector function of influenza virus-specific cytotoxic T lymphocyte clones is highly specific.

1984 • 439 citations

Role of Cytokines and CD4+ T‐Cell Subsets in the Regulation of Parasite Immunity and Disease

1989 • 405 citations

Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge.

1992 • 381 citations

Primary respiratory syncytial virus infection in mice

1988 • 381 citations

Clearance of influenza virus respiratory infection in mice lacking class I major histocompatibility complex-restricted CD8+ T cells.

1991 • 372 citations

Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection.

1994 • 365 citations

Roles of alphabeta and gammadelta T Cell Subsets in Viral Immunity

1992 • 350 citations

Biological properties of an influenza A virus-specific killer T cell clone. Inhibition of virus replication in vivo and induction of delayed-type hypersensitivity reactions.

1981 • 345 citations

Adoptive transfer studies demonstrating the antiviral effect of natural killer cells in vivo.

1985 • 327 citations

The Immune Response to Influenza Infection

1986 • 321 citations

Distinct types of lung disease caused by functional subsets of antiviral T cells.

1994 • 318 citations

Response to influenza infection in mice with a targeted disruption in the interferon gamma gene.

1993 • 247 citations

Cytotoxic Effects of Antigen- and Mitogen-Induced T Cells on Various Targets

1975 • 224 citations

Functional analysis of influenza-specific helper T cell clones in vivo. T cells specific for internal viral proteins provide cognate help for B cell responses to hemagglutinin.

1986 • 199 citations

Heterogeneity of helper/inducer T lymphocytes. II. Effects of interleukin 4- and interleukin 2-producing T cell clones on resting B lymphocytes.

1988 • 198 citations

Mice can recover from pulmonary influenza virus infection in the absence of class I-restricted cytotoxic T cells.

1992 • 174 citations

Immunologic recognition of influenza virus-infected cells

1977 • 158 citations

Activation of cytokine genes in T cells during primary and secondary murine influenza pneumonia.

1993 • 150 citations

"Anergy" of TH0 helper T lymphocytes induces downregulation of TH1 characteristics and a transition to a TH2-like phenotype.

1994 • 134 citations

Heterogeneity and specificity of cloned lines of influenza-virus specific cytotoxic T lymphocytes.

1981 • 132 citations

Reversal of the Immunosenescent Phenotype by Dehydroepiandrosterone: Hormone Treatment Provides an Adjuvant Effect on the Immunization of Aged Mice with Recombinant Hepatitis B Surface Antigen

1993 • 124 citations

Resistance of Mice Deficient in IL-4 to Retrovirus-Induced Immunodeficiency Syndrome (MAIDS)

1993 • 112 citations

The Recovery of Mice from Influenza Virus Infection: Adoptive Transfer of Immunity with Immune T Lymphocytes

1978 • 81 citations

Role of T-cell function in recovery from murine influenza infection

1979 • 63 citations

Activity of CD4+ T-cell clones of type 1 and type 2 in generation of influenza virus-specific cytotoxic responses in vitro

1991 • 54 citations

Inability of interferon to protect virus-infected cells against lysis by natural killer (NK) cells correlates with NK cell-mediated antiviral effects in vivo.

1985 • 52 citations

Diversity in the biological properties of anti‐influenza cytotoxic T cell clones

1983 • 42 citations

Establishment and characterization of BALB/c lymphoma lines with B cell properties

1980 • 40 citations

Murine CD4⁺ T cell clones vary in function in vitro and in influenza infection in vivo

1990 • 24 citations

Influenza viruses as lymphocyte mitogens. I. B cell mitogenesis by influenza A viruses of the H2 and H6 subtypes is controlled by the I-E/C subregion of the major histocompatibility complex.

1985 • 21 citations

Antigen-dependent proliferation of cloned continuous lines of H-2-restricted influenza virus-specific cytotoxic T lymphocytes.

1981 • 21 citations