Article

Two populations of Ia-like molecules on a human B cell line.

1980 • 1,112 citations

Sequence analysis of peptides bound to MHC class II molecules

1991 • 1,071 citations

Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size

1992 • 763 citations

Peptides Presented to the Immune System by the Murine Class II Major Histocompatibility Complex Molecule I-A _d

1992 • 654 citations

Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids

1985 • 580 citations

MHC class II-associated invariant chain contains a sorting signal for endosomal compartments

1990 • 565 citations

Intracellular transport of class II MHC molecules directed by invariant chain

1990 • 548 citations

Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding

1990 • 486 citations

Isolation and characterization of antigen-la complexes involved in T cell recognition

1986 • 470 citations

The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route

1990 • 445 citations

Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes

1994 • 442 citations

Isolation and characterization of the intracellular MHC class II compartment

1994 • 426 citations

MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding

1991 • 394 citations

HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides

1992 • 380 citations

An essential role for HLA–DM in antigen presentation by class II major histocompatibility molecules

1994 • 378 citations

Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment

1990 • 377 citations

Antigen processing and class II MHC peptide-loading compartments in human B-lymphoblastoid cells

1994 • 349 citations

Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain

1991 • 326 citations

The human class II MHC protein HLA-DR1 assembles as empty αβ heterodimers in the absence of antigenic peptide

1992 • 306 citations

Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways

1990 • 303 citations

A role for peptide in determining MHC class II structure

1991 • 275 citations

Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells

1994 • 247 citations

HLA-DMA and DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells

1994 • 247 citations

Accumulation of HLA-DM, a regulator of antigen presentation, in MHC class II compartments

1994 • 244 citations

Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes

1990 • 236 citations

Proteolysis of the class II-associated invariant chain generates a peptide binding site in intracellular HLA-DR molecules.

1991 • 234 citations

Separation of subcellular compartments containing distinct functional forms of MHC class II.

1994 • 221 citations

Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple compartments

1995 • 198 citations

Invariant chain can function as a chaperone protein for class II major histocompatibility complex molecules.

1992 • 197 citations

Processed antigen binds to newly synthesized mhc class II molecules in antigen-specific B lymphocytes

1991 • 188 citations

Homozygous deletions that simultaneously eliminate expressions of class I and class II antigens of EBV-transformed B-lymphoblastoid cells. I. Reduced proliferative responses of autologous and allogeneic T cells to mutant cells that have decreased expression of class II antigens

1984 • 187 citations

Binding of major histocompatibility complex class II to the invariant chain-derived peptide, CLIP, is regulated by allelic polymorphism in class II.

1995 • 186 citations

In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides

1994 • 185 citations

The CLIP region of invariant chain plays a critical role in regulating major histocompatibility complex class II folding, transport, and peptide occupancy.

1994 • 184 citations

Class II MHC molecules are present in macrophage lysosomes and phagolysosomes that function in the phagocytic processing of Listeria monocytogenes for presentation to T cells.

1992 • 167 citations

Invariant chain trimers are sequestered in the rough endoplasmic reticulum in the absence of association with HLA class II antigens.

1990 • 149 citations

High-affinity binding of an influenza hemagglutinin-derived peptide to purified HLA-DR.

1990 • 148 citations

Characterization of endogenous peptides bound to purified HLA-DR molecules and their absence from invariant chain-associated alpha beta dimers.

1993 • 145 citations

Reconstitution of an operational MHC class II compartment in nonantigen-presenting cells

1994 • 135 citations

Invariant chain influences the immunological recognition of MHC class II molecules

1990 • 127 citations

Regulation of antigen presentation by acidic pH.

1990 • 127 citations

The antigen-processing mutant T2 suggests a role for MHC-linked genes in class II antigen presentation.

1992 • 125 citations

Mapping functional regions in the lumenal domain of the class II-associated invariant chain.

1994 • 122 citations

Supermotifs enable natural invariant chain-derived peptides to interact with many major histocompatibility complex-class II molecules.

1995 • 121 citations

A gene required for class II-restricted antigen presentation maps to the major histocompatibility complex.

1991 • 106 citations

Stable surface expression of invariant chain prevents peptide presentation by HLA-DR.

1992 • 94 citations

Enhanced binding of peptide antigen to purified class II major histocompatibility glycoproteins at acidic pH.

1991 • 94 citations

Binding of labelled influenza matrix peptide to HLA DR in living B lymphoid cells

1989 • 85 citations

Acidification and disulfide reduction can be sufficient to allow intact proteins to bind class II MHC.

1993 • 79 citations

pH dependence and exchange of high and low responder peptides binding to a class II MHC molecule.

1992 • 78 citations

MHC class II deletion mutant expresses normal levels of transgene encoded class II molecules that have abnormal conformation and impaired antigen presentation ability.

1992 • 72 citations

Kinetics of MHC-antigen complex formation on antigen-presenting cells.

1988 • 63 citations

Molecular analysis of HLA class I and class II antigen loss mutants reveals a homozygous deletion of the DR, DQ, and part of the DP region: Implications for class II gene order

1986 • 59 citations

Motifs and supermotifs for MHC class II binding peptides.

1995 • 57 citations

Selective release of some invariant chain-derived peptides from HLA-DR1 molecules at endosomal pH.

1994 • 48 citations

Membrane interactions influence the peptide binding behavior of DR1.

1994 • 31 citations

Biochemical evidence for the rapid assembly and disassembly of processed antigen-major histocompatibility complex class II complexes in acidic vesicles of B cells.

1992 • 27 citations

Invariant chain targets HLA class II molecules to acidic endosomes containing internalized influenza virus

1991 • 7 citations