Requirement for CD40 Ligand in Costimulation Induction, T Cell Activation, and Experimental Allergic Encephalomyelitis

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.

1995 • 2,531 citations

Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells.

1995 • 1,560 citations

Activation of human dendritic cells through CD40 cross-linking.

1994 • 1,351 citations

The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation

1994 • 1,099 citations

Mice deficient for the CD40 ligand

1994 • 753 citations

Interleukin‐12 is produced by dendritic cells and mediates T helper 1 development as well as interferon‐γ production by T helper 1 cells

1996 • 676 citations

The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro.

1994 • 607 citations

CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis.

1996 • 492 citations

Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand

1995 • 476 citations

Activated T cells induce interleukin‐12 production by monocytes via CD40‐CD40 ligand interaction

1995 • 427 citations

Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion.

1996 • 349 citations

CD40 Ligand Is Required for Protective Cell-Mediated Immunity to Leishmania major

1996 • 332 citations

CD40 and its ligand, an essential ligand-receptor pair for thymus-dependent B-cell activation

1992 • 327 citations

Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4.

1995 • 323 citations

Protective Role of CD40 in Leishmania major Infection at Two Distinct Phases of Cell-Mediated Immunity

1996 • 302 citations

Impaired T cell-mediated macrophage activation in CD40 ligand-deficient mice.

1996 • 237 citations

Studies on the interdependence of gp39 and B7 expression and function during antigen‐specific immune responses

1995 • 225 citations

CD40/CD40 ligand interactions are required for T cell‐dependent production of interleukin‐12 by mouse macrophages

1996 • 184 citations

Co‐stimulation of murine CD4 T cell growth: cooperation between B7 and heat‐stable antigen

1992 • 135 citations

T cells with two functional antigen-specific receptors.

1995 • 119 citations

Functional expression of CD40 antigen on human epidermal Langerhans cells.

1995 • 108 citations

The relative contribution of the CD28 and gp39 costimulatory pathways in the clonal expansion and pathogenic acquisition of self-reactive T cells.

1996 • 104 citations

Uptake of microparticle‐adsorbed protein antigen by bone marrow‐derived dendritic cells results in up‐regulation of interleukin‐1α and interleukin‐12 p40/p35 and triggers prolonged, efficient antigen presentation

1995 • 98 citations

Dominant determinants in hen eggwhite lysozyme correspond to the cryptic determinants within its self-homologue, mouse lysozyme: implications in shaping of the T cell repertoire and autoimmunity.

1993 • 84 citations

Regulation of CD40 ligand expression on naive CD4 T cells: a role for TCR but not co-stimulatory signals

1996 • 83 citations

A negative regulatory function of B7 revealed in B7-1 transgenic mice

1994 • 82 citations

Rapid induction of a novel costimulatory activity on B cells by CD40 ligand

1995 • 55 citations

T cell receptor (TCR) usage determines disease susceptibility in experimental autoimmune encephalomyelitis: studies with TCR V beta 8.2 transgenic mice.

1994 • 32 citations