Interleukin-11: Review of Molecular, Cell Biology, and Clinical Use

Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand

1994 • 1,328 citations

Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo

1994 • 1,138 citations

Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin

1994 • 1,081 citations

Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor MpI

1994 • 987 citations

Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine.

1990 • 649 citations

LIFRβ and gp130 as Heterodimerizing Signal Transducers of the Tripartite CNTF Receptor

1993 • 632 citations

Neuroendocrine-Immune Interactions

1993 • 571 citations

Aromatase expression in endometriosis.

1996 • 520 citations

The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet production.

1994 • 443 citations

Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro

1995 • 416 citations

Interleukin-11: a new cytokine critical for osteoclast development.

1994 • 408 citations

Thrombopoietin, the Mp1 ligand, is essential for full megakaryocyte development.

1995 • 333 citations

Ex vivo expansion of murine marrow cells with interleukin-3 (IL-3), IL- 6, IL-11, and stem cell factor leads to impaired engraftment in irradiated hosts

1996 • 326 citations

Cytokine regulation of neuronal differentiation of hippocampal progenitor cells

1993 • 307 citations

A randomized placebo-controlled trial of recombinant human interleukin-11 in cancer patients with severe thrombocytopenia due to chemotherapy

1996 • 299 citations

Thrombopoietin, the ligand for the Mpl receptor, synergizes with steel factor and other early acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice

1996 • 278 citations

Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction.

1994 • 275 citations

Involvement of IL-6 signal transducer gp130 in IL-11-mediated signal transduction.

1993 • 267 citations

The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transducer and activator of transcription (STAT) family.

1994 • 251 citations

Ciliary neurotropic factor, interleukin 11, leukemia inhibitory factor, and oncostatin M are growth factors for human myeloma cell lines using the interleukin 6 signal transducer gp130.

1994 • 239 citations

Aromatase expression in endometriosis

1996 • 235 citations

Direct and synergistic effects of interleukin 11 on murine hemopoiesis in culture.

1991 • 234 citations

Growth factor requirements for survival in G0 and entry into the cell cycle of primitive human hemopoietic progenitors.

1992 • 224 citations

A phase I trial of recombinant human interleukin-11 (neumega rhIL-11 growth factor) in women with breast cancer receiving chemotherapy

1996 • 216 citations

Interleukin-11 regulates the hepatic expression of the same plasma protein genes as interleukin-6.

1991 • 207 citations

Interleukin-11 enhances human megakaryocytopoiesis in vitro

1992 • 203 citations

Molecular anatomy of the neuro-immune connection

1991 • 202 citations

The role of gp130-mediated signals in osteoclast development: regulation of interleukin 11 production by osteoblasts and distribution of its receptor in bone marrow cultures.

1996 • 200 citations

Interleukin-11: a multifunctional growth factor derived from the hematopoietic microenvironment

1994 • 190 citations

Interleukin-11 prevents apoptosis and accelerates recovery of small intestinal mucosa in mice treated with combined chemotherapy and radiation.

1996 • 186 citations

Interleukin-11: a multifunctional growth factor derived from the hematopoietic microenvironment

1994 • 184 citations

The FLT3 ligand potently and directly stimulates the growth and expansion of primitive murine bone marrow progenitor cells in vitro: synergistic interactions with interleukin (IL) 11, IL-12, and other hematopoietic growth factors.

1995 • 175 citations

Murine marrow cells expanded in culture with IL-3, IL-6, IL-11, and SCF acquire an engraftment defect in normal hosts.

1995 • 173 citations

Enhancement of murine hematopoiesis by synergistic interactions between steel factor (ligand for c-kit), interleukin-11, and other early acting factors in culture

1992 • 167 citations

Neuropoietic cytokines and activin A differentially regulate the phenotype of cultured sympathetic neurons.

1994 • 167 citations

Clonal proliferation of murine lymphohemopoietic progenitors in culture.

1992 • 163 citations

Recombinant human interleukin-11 stimulates megakaryocytopoiesis and increases peripheral platelets in normal and splenectomized mice

1993 • 162 citations

A bone marrow stromal-derived growth factor, interleukin-11, stimulates recovery of small intestinal mucosal cells after cytoablative therapy

1994 • 161 citations

Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin‐11

1991 • 156 citations

Leukemia inhibitory factor and interleukin‐11 promote maturation of murine and human megakaryocytes in vitro

1992 • 154 citations

Epithelial interleukin-11. Regulation by cytokines, respiratory syncytial virus, and retinoic acid.

1994 • 152 citations

Effects of recombinant interleukin 11 on human megakaryocyte progenitor cells.

1991 • 151 citations

Effects of recombinant human interleukin-11 on hematopoietic reconstitution in transplant mice: acceleration of recovery of peripheral blood neutrophils and platelets

1993 • 139 citations

Substance P (SP) mediates production of stem cell factor and interleukin-1 in bone marrow stroma: potential autoregulatory role for these cytokines in SP receptor expression and induction

1995 • 136 citations

Interleukin-11, an inducible cytokine in human articular chondrocytes and synoviocytes, stimulates the production of the tissue inhibitor of metalloproteinases.

1993 • 133 citations

Oncostatin M, leukemia inhibitory factor, and interleukin 6 induce the proliferation of human plasmacytoma cells via the common signal transducer, gp130.

1994 • 131 citations

IL-11, a pleiotropic cytokine: exciting new effects of IL-11 on gastrointestinal mucosal biology.

1994 • 127 citations

Interleukin-11, an inducible cytokine in human articular chondrocytes and synoviocytes, stimulates the production of the tissue inhibitor of metalloproteinases.

1993 • 124 citations

Synergistic interactions between interleukin-11 and interleukin-4 in support of proliferation of primitive hematopoietic progenitors of mice

1991 • 118 citations

In vitro stimulatory effect of substance P on hematopoiesis

1993 • 116 citations

Enhancement of in vitro and in vivo antigen-specific antibody responses by interleukin 11.

1992 • 115 citations

Cytokine and hormonal stimulation of human osteosarcoma interleukin-11 production.

1995 • 114 citations

Interleukin‐11 protects the clonogenic stem cells in murine small‐intestinal crypts from impairment of their reproductive capacity by radiation

1995 • 108 citations

In vitro expansion of human peripheral blood CD34+ cells

1993 • 105 citations

Mitogen-activated protein kinases and ribosomal S6 protein kinases are involved in signaling pathways shared by interleukin-11, interleukin-6, leukemia inhibitory factor, and oncostatin M in mouse 3T3-L1 cells.

1994 • 105 citations

Interleukin-11 inhibits adipogenesis and stimulates myelopoiesis in human long-term marrow cultures

1993 • 100 citations

IL-1 and transforming growth factor-beta regulation of fibroblast-derived IL-11.

1994 • 99 citations

Interleukins 6 and 11 protect mice from mortality in a staphylococcal enterotoxin-induced toxic shock model

1996 • 99 citations

Interleukin-11 stimulates multiple phases of erythropoiesis in vitro

1992 • 95 citations

In vivo effects of recombinant interleukin-11 on myelopoiesis in mice

1993 • 95 citations

The Plasmacytoma Growth Inhibitor Restrictin-P Is an Antagonist of Interleukin 6 and Interleukin 11

1995 • 94 citations

Interleukin-11 acts as an autocrine growth factor for human megakaryoblastic cell lines

1993 • 94 citations

Constitutive and modulated cytokine expression in two permanent human bone marrow stromal cell lines.

1996 • 90 citations

Altered interleukin-6 production by peritoneal leukocytes from patients with endometriosis

1994 • 89 citations

Negative regulation of early B lymphopoiesis by interleukin 3 and interleukin 1 alpha.

1994 • 88 citations

Ex vivo expansion with stem cell factor and interleukin-11 augments both short-term recovery posttransplant and the ability to serially transplant marrow

1996 • 87 citations

Genomic sequence and chromosomal location of human interleukin-11 gene (IL11)

1992 • 86 citations

Synergistic interaction between interleukin-12 and steel factor in support of proliferation of murine lymphohematopoietic progenitors in culture

1994 • 86 citations

Regulation of tissue inhibitor of metalloproteinases-1 gene expression by cytokines and dexamethasone in rat hepatocyte primary cultures

1993 • 85 citations

Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin-11

1995 • 79 citations

Interleukin-11 inhibits bone formation in vitro

1993 • 79 citations

Substance P gene expression is regulated by interleukin‐1 in cultured sympathetic ganglia

1991 • 78 citations

Stromal cell-associated hematopoiesis: immortalization and characterization of a primate bone marrow-derived stromal cell line

1991 • 77 citations

Synergistic effects of interleukin 3 and interleukin 11 on murine megakaryopoiesis in serum-free culture.

1992 • 74 citations

The human IL-11 receptor requires gp130 for signalling: demonstration by molecular cloning of the receptor.

1996 • 72 citations

Characterization of interleukin-11 receptor and protein tyrosine phosphorylation induced by interleukin-11 in mouse 3T3-L1 cells.

1992 • 69 citations

Stromal cell independent growth of bipotent B cell – macrophage precursors from murine fetal liver

1994 • 67 citations

Effect of recombinant human interleukin‐11 on rat megakaryopoiesis and thrombopoiesis in vivo: comparative study with interleukin‐6

1993 • 65 citations

Trophic effects of interleukin-11 in rats with experimental short bowel syndrome

1996 • 65 citations

Progenitor cell hyperplasia with rare development of myeloid leukemia in interleukin 11 bone marrow chimeras.

1993 • 65 citations

Induction of IL-3 and granulocyte-macrophage colony-stimulating factor by substance P in bone marrow cells is partially mediated through the release of IL-1 and IL-6.

1994 • 63 citations

Syp Associates with gp130 and Janus Kinase 2 in Response to Interleukin-11 in 3T3-L1 Mouse Preadipocytes

1995 • 63 citations

Interleukin-11 promotes accessory cell-dependent B-cell differentiation in humans

1992 • 63 citations

Detection and quantification of transforming growth factor beta (TGF-beta) and platelet-derived growth factor (PDGF) release by normal human megakaryocytes.

1995 • 62 citations

Thrombopoietic potential and serial repopulating ability of murine hematopoietic stem cells constitutively expressing interleukin 11.

1996 • 62 citations

Interleukin-11 stimulates the proliferation of human hematopoietic CD34+ and CD34+CD33-DR- cells and synergizes with stem cell factor, interleukin-3, and granulocyte-macrophage colony-stimulating factor.

1993 • 61 citations

Synergistic effects of interleukin-11 with other growth factors on the expansion of murine hematopoietic progenitors and maintenance of stem cells in liquid culture.

1994 • 60 citations

Preclinical biology of interleukin 11: A multifunctional hematopoietic cytokine with potent thrombopoietic activity

1995 • 60 citations

Structural Analysis of the Gene Encoding the Murine Interleukin-11 Receptor α-Chain and a Related Locus

1996 • 58 citations

Interleukin 13: novel role in direct regulation of proliferation and differentiation of primitive hematopoietic progenitor cells.

1994 • 56 citations

Interleukin-11 induces intestinal epithelial cell growth arrest through effects on retinoblastoma protein phosphorylation.

1996 • 54 citations

Murine interleukin-11 (IL-11) is expressed at high levels in the hippocampus and expression is developmentally regulated in the testis

1996 • 54 citations

Interleukin-12 synergizes with interleukin-3 and steel factor to enhance recovery of murine hemopoietic stem cells in liquid culture.

1993 • 53 citations

Identification of a 130-kilodalton tyrosine-phosphorylated protein induced by interleukin-11 as JAK2 tyrosine kinase, which associates with gp130 signal transducer.

1994 • 52 citations

Involvement of gp130/interleukin‐6 receptor transducing component in interleukin‐11 receptor

1994 • 51 citations

Effect of interleukin-11 on cycling status and clonogenic maturation of fetal and adult hematopoietic progenitors

1992 • 51 citations

Tyrosine Phosphorylation of Jak-Tyk Kinases in Malignant Plasma Cell Lines Growth Stimulated by Interleukins 6 and 11

1994 • 51 citations

Interleukin-12 enhances interleukin-3 dependent multilineage hematopoietic colony formation stimulated by interleukin-11 or steel factor.

1993 • 50 citations

Histamine augments cytokine-stimulated IL-11 production by human lung fibroblasts.

1994 • 49 citations

Structure-Function Relationships in Human Interleukin-11

1995 • 49 citations

Interleukin-11 Induces Complex Formation of Grb2, Fyn, and JAK2 in 3T3L1 Cells

1995 • 48 citations

Hematopoietic stem cells in the blood after stem cell factor and interleukin-11 administration: evidence for different mechanisms of mobilization

1995 • 48 citations

Regulation of interleukin (IL)-11 gene expression in IL-1 induced primate bone marrow stromal cells

1994 • 48 citations

Effects of IL‐11 on the growth of intestinal epithelial cells in vitro

1995 • 46 citations

Comparative effects of in vivo treatment using interleukin-11 and stem cell factor on reconstitution in mice after bone marrow transplantation

1993 • 45 citations

Interleukin (IL)‐11‐mediated Signal Transductiona

1995 • 45 citations

Lack of a role of interleukin 11 in the growth of multiple myeloma

1992 • 43 citations

IL-11 in combination with SLF and G-CSF or GM-CSF significantly increases expansion of isolated CD34+ cell population from cord blood vs. adult bone marrow.

1995 • 42 citations

Increased survival and multilineage hematopoietic protection from delayed and severe myelosuppressive effects of a nitrosourea with recombinant interleukin-11.

1994 • 40 citations

Interleukin-11 and its receptor.

1992 • 39 citations

Adipogenesis inhibitory factor A novel inhibitory regulator of adipose conversion in bone marrow

1991 • 39 citations

Accelerated cell-cycling of hematopoietic progenitor cells by growth factors

1995 • 37 citations

Effects of rhIL-11 on normal dogs and after sublethal radiation.

1995 • 37 citations

Interleukin-11 induces phosphatidic acid formation and activates map kinase in mouse 3T3-L1 cells

1995 • 35 citations

Effect of Interleukin-11 on the Levels of mRNAs Encoding Heme Oxygenase and Haptoglobin in Human HepG2 Hepatoma Cells

1993 • 34 citations

Anti-gp130 transducer monoclonal antibodies specifically inhibiting ciliary neurotrophic factor, interleukin-6, interleukin-11, leukemia inhibitory factor or oncostatin M

1996 • 34 citations

Alanine‐scanning Mutagenesis of Human Interleulcin‐11: Identification of Regions Important for Biological Activity

1995 • 34 citations

Interleukin‐10 induces interleukin‐11 responsiveness in human myeloma cell lines

1995 • 33 citations

Activation of Src-family protein tyrosine kinases and phosphatidylinositol 3-kinase in 3T3-L1 mouse preadipocytes by interleukin-11.

1996 • 32 citations

Interleukin-11 improves survival and reduces bacterial translocation and bone marrow suppression in burned mice

1997 • 32 citations

Effect of Interleukin-11 with and without Granulocyte Colony-Stimulating Factor on In Vivo Neonatal Rat Hematopoiesis: Induction of Neonatal Thrombocytosis by Interleukin-11 and Synergistic Enhancement of Neutrophilia by Interleukin-11 + Granulocyte Colony-Stimulating Factor

1993 • 30 citations

Expression of Leukemia Inhibitory Factor and Interleukin-11 by Human Melanoma Cell Lines: LIF, IL-6, and IL-11 Are Not Coregulated

1995 • 30 citations

Molecular cloning and characterization of murine interleukin-11.

1996 • 29 citations

Heparin inhibits the expression of interleukin-11 and granulocyte- macrophage colony-stimulating factor in primate bone marrow stromal fibroblasts through mRNA destabilization

1995 • 28 citations

In vivo effects of interleukin‐11 and stem cell factor in combination with erythropoietin in the regulation of erythropoiesis

1995 • 27 citations

Prophylactic pretreatment of mice with hematopoietic growth factors induces expansion of primitive cell compartments and results in protection against 5-fluorouracil-induced toxicity

1996 • 27 citations

Interleukin-11 stimulates multilineage progenitors, but not stem cells, in murine and human long-term marrow cultures

1995 • 25 citations

Effects of interleukin-11 on the proliferation and cell cycle status of myeloid leukemic cells

1993 • 25 citations

Interleukin-11 mRNA Stabilization in Phorbol Ester-Stimulated Primate Bone Marrow Stromal Cells

1996 • 23 citations

A highly sensitive quantitative bioassay for human interleukin-11

1994 • 22 citations

Interleukin-11 expression in donor bone marrow cells improves hematological reconstitution in lethally irradiated recipient mice.

1994 • 22 citations

The combined effects of interleukin-11, stem cell factor, and granulocyte colony-stimulating factor on newborn rat hematopoiesis: significant enhancement of the absolute neutrophil count.

1994 • 22 citations

Cord blood plasma-mediated ex vivo expansion of hematopoietic progenitor cells.

1994 • 20 citations

Fever produced by interleukin-11 (IL-11) injected into the anterior hypothalamic pre-optic area of the rat is antagonized by indomethacin

1994 • 19 citations

Interleukin-4 (IL-4) in combination with IL-11 or IL-6 reverses the inhibitory effect of IL-3 on early B lymphocyte development.

1996 • 18 citations

Expression of interleukin-11 and its encoding mRNA by glioblastoma cells

1995 • 18 citations

Protein tyrosine phosphorylation and activation of primary response genes by interleukin 11 in B9-TY1 cells.

1993 • 18 citations

IL-11 directly stimulates murine and human erythroid burst formation in semisolid cultures.

1995 • 18 citations

Interleukin‐11 (IL‐11) acts as a synergistic factor for the proliferation of human myeloid leukaemic cells

1995 • 17 citations

Influence of cytokines (IL‐1α, IL‐3, IL‐11, GM‐CSF) on megakaryocyte‐fibroblast interactions in normal human bone marrow

1995 • 17 citations

Isolation and characterization of primitive hematopoietic progenitors of murine fetal liver.

1996 • 15 citations

Stem‐cell factor in aplastic anemia: in vitro expression in bone marrow stroma and fibroblast cultures

1995 • 15 citations

Regulation of lipoprotein lipase synthesis in 3T3-L1 adipocytes by interleukin-11/adipogenesis inhibitory factor.

1994 • 14 citations

Synergistic effects of stem cell factor and interleukin 6 or interleukin 11 on the expansion of murine hematopoietic progenitors in liquid suspension culture

1995 • 14 citations

Synergism between serum factor(s) and erythropoietin in inducing murine megakaryocyte colony formation: the synergistic factor in serum is distinct from interleukin-11 and stem cell factor (c-kit ligand) [letter]

1993 • 11 citations

Update on development of interleukin-11

1995 • 11 citations

The Human Interleukin-11 Receptor α Gene (IL11RA): Genomic Organization and Chromosome Mapping

1996 • 11 citations

Direct synergistic effects of IL-4 and IL-11 on proliferation of primitive hematopoietic progenitor cells.

1995 • 10 citations

GP130 in Human Myeloma/Plasmacytoma

1995 • 9 citations

Recombinant human interleukin-11 prevents hypotension in LPS-treated anesthetized rabbits

1996 • 9 citations

Interleukin‐11 enhances gastrointestinal absorption of iron in rats

1995 • 8 citations

Interleukin‐6‐Type Cytokines in Myeloproliferative Diseasea

1995 • 7 citations

SAFETY AND ACTIVITY EVALUATION OF rhlL-11 IN SUBJECTS WITH ACTIVE CROHNʼS DISEASE.

1997 • 6 citations

The T‐Cell Receptor in Multiple Sclerosis

1995 • 5 citations