Recombinant human interleukin-11 prevents hypotension in LPS-treated anesthetized rabbits

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

The Natural History of the Systemic Inflammatory Response Syndrome (SIRS)

1995 • 2,007 citations

Treatment of Gram-Negative Bacteremia and Septic Shock with HA-1A Human Monoclonal Antibody against Endotoxin

1991 • 1,611 citations

Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition.

1988 • 990 citations

Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock

1991 • 873 citations

Cytokine Serum Level During Severe Sepsis in Human IL-6 as a Marker of Severity

1992 • 799 citations

Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro

1991 • 729 citations

IL-6 inhibits lipopolysaccharide-induced tumor necrosis factor production in cultured human monocytes, U937 cells, and in mice.

1989 • 578 citations

Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo

1990 • 536 citations

Inhibition of nitric oxide synthesis by methylene blue

1993 • 519 citations

A specific receptor antagonist for interleukin 1 prevents Escherichia coli ‐induced shock in rabbits

1991 • 435 citations

Evidence that tumor necrosis factor has an important role in antibacterial resistance.

1989 • 422 citations

Divergent Efficacy of Antibody to Tumor Necrosis Factor- in Intravascular and Peritonitis Models of Sepsis

1991 • 275 citations

Staphylococcus epidermidis induces complement activation, tumor necrosis factor and interleukin-1, a shock-like state and tissue injury in rabbits without endotoxemia. Comparison to Escherichia coli.

1991 • 248 citations

Prophylactic and Therapeutic Effects of a Monoclonal Antibody to Tumor Necrosis Factor- in Experimental Gram-Negative Shock

1990 • 200 citations

Interleukin-11: a multifunctional growth factor derived from the hematopoietic microenvironment

1994 • 190 citations

Interleukin-11: a multifunctional growth factor derived from the hematopoietic microenvironment

1994 • 184 citations

Correlation of plasma cytokine elevations with mortality rate in children with sepsis

1992 • 176 citations

Interleukin-6 as an endogenous pyrogen: induction of prostaglandin E2 in brain but not in peripheral blood mononuclear cells

1991 • 164 citations

A bone marrow stromal-derived growth factor, interleukin-11, stimulates recovery of small intestinal mucosal cells after cytoablative therapy

1994 • 161 citations

Methylene blue reverses endotoxin-induced hypotension.

1994 • 110 citations

Effectiveness of a Human Monoclonal Anti-Endotoxin Antibody (HA-1A) in Gram-Negative Sepsis: Relationship to Endotoxin and Cytokine Levels

1992 • 109 citations

Interleukin-6 antagonizes tumor necrosis factor-mediated mycobacteriostatic and mycobactericidal activities in macrophages

1992 • 91 citations

Role of Interferon- in Experimental Gram-Negative Sepsis

1992 • 90 citations

Detection of interleukin 1 alpha and 1 beta in rabbit tissues during endotoxemia using sensitive radioimmunoassays

1991 • 78 citations

Alteration in the frequency, severity and duration of chemotherapy-induced mucositis in hamsters by interleukin-11

1995 • 69 citations

Nitric oxide from endothelium and smooth muscle modulates responses to sympathetic nerve stimulation: Implications for endotoxin shock

1992 • 52 citations

Experimental elimination of tumor necrosis factor in low-dose endotoxin models has variable effects on survival

1991 • 38 citations

Effect of Interleukin-11 on the Levels of mRNAs Encoding Heme Oxygenase and Haptoglobin in Human HepG2 Hepatoma Cells

1993 • 34 citations

Altered interleukin-1 and tumor necrosis factor production and secretion during pyrogenic tolerance to LPS in rabbits

1994 • 33 citations

Ciliary Neurotrophic Factor Combined with Soluble Receptor Inhibits Synthesis of Proinflammatory Cytokines and Prostaglandin-E2in Vitro

1994 • 30 citations

Ciliary Neurotrophic Factor Inhibits Brain and Peripheral Tumor Necrosis Factor Production and, When Coadministered with Its Soluble Receptor, Protects Mice From Lipopolysaccharide Toxicity

1995 • 28 citations

Utility of serum interleukin-6 for diagnosis of invasive bacterial disease in children

1992 • 23 citations

Interferons as inhibitors of interleukin 1 induced interleukin 1 synthesis.

1989 • 14 citations

The Systemic Inflammatory Response, Sepsis, and Multiple Organ Dysfunction: New Definitions for an Old Problem

1994 • 12 citations