Thrombopoietic potential and serial repopulating ability of murine hematopoietic stem cells constitutively expressing interleukin 11.

A safe packaging line for gene transfer: separating viral genes on two different plasmids

1988 • 1,118 citations

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1988 • 1,086 citations

Developmental potential and dynamic behavior of hematopoietic stem cells

1986 • 888 citations

Versatile retroviral vectors for potential use in gene therapy.

1994 • 690 citations

Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine.

1990 • 649 citations

Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo.

1995 • 606 citations

Expression of a foreign gene in myeloid and lymphoid cells derived from multipotent haematopoietic precursors

1985 • 598 citations

Effects of retroviral vector design on expression of human adenosine deaminase in murine bone marrow transplant recipients engrafted with genetically modified cells.

1995 • 357 citations

Ex vivo expansion of murine marrow cells with interleukin-3 (IL-3), IL- 6, IL-11, and stem cell factor leads to impaired engraftment in irradiated hosts

1996 • 326 citations

Combination of interleukins 3 and 6 preserves stem cell function in culture and enhances retrovirus-mediated gene transfer into hematopoietic stem cells.

1989 • 316 citations

Loss of stem cell repopulating ability upon transplantation. Effects of donor age, cell number, and transplantation procedure.

1982 • 295 citations

Primitive hemopoietic stem cells: direct assay of most productive populations by competitive repopulation with simple binomial, correlation and covariance calculations.

1993 • 288 citations

5-Fluorouracil spares hemopoietic stem cells responsible for long-term repopulation.

1990 • 247 citations

Direct and synergistic effects of interleukin 11 on murine hemopoiesis in culture.

1991 • 234 citations

Life span of multipotential hematopoietic stem cells in vivo.

1990 • 228 citations

Efficient transfer and sustained high expression of the human glucocerebrosidase gene in mice and their functional macrophages following transplantation of bone marrow transduced by a retroviral vector.

1992 • 183 citations

Two phases of engraftment established by serial bone marrow transplantation in mice

1989 • 179 citations

Enhancement of murine hematopoiesis by synergistic interactions between steel factor (ligand for c-kit), interleukin-11, and other early acting factors in culture

1992 • 167 citations

Transplantable myeloproliferative disease induced in mice by an interleukin 6 retrovirus.

1992 • 167 citations

Recombinant human interleukin-11 stimulates megakaryocytopoiesis and increases peripheral platelets in normal and splenectomized mice

1993 • 162 citations

Chronic exposure to retroviral vector encoded MGDF (mpl-ligand) induces lineage-specific growth and differentiation of megakaryocytes in mice

1995 • 162 citations

Stem cell factor, interleukin-3, and interleukin-6 promote retroviral- mediated gene transfer into murine hematopoietic stem cells

1992 • 147 citations

Effects of recombinant human interleukin-11 on hematopoietic reconstitution in transplant mice: acceleration of recovery of peripheral blood neutrophils and platelets

1993 • 139 citations

Synergistic interactions between interleukin-11 and interleukin-4 in support of proliferation of primitive hematopoietic progenitors of mice

1991 • 118 citations

Evidence that retroviruses integrate into post-replication host DNA.

1993 • 110 citations

Long- and short-lived murine hematopoietic stem cell clones individually identified with retroviral integration markers

1990 • 101 citations

The HOX11 homeobox-containing gene of human leukemia immortalizes murine hematopoietic precursors.

1994 • 98 citations

Expression of human adenosine deaminase in mice after transplantation of genetically-modified bone marrow

1990 • 93 citations

Stem cell quiescence/activation is reversible by serial transplantation and is independent of stromal cell genotype in mouse aggregation chimeras.

1992 • 80 citations

Rapid and efficient selection of human hematopoietic cells expressing murine heat-stable antigen as an indicator of retroviral-mediated gene transfer

1996 • 78 citations

Retroviral gene transfer of human adenosine deaminase in murine hematopoietic cells: effect of selectable marker sequences on long-term expression

1991 • 77 citations

Handicapped retroviral vectors efficiently transduce foreign genes into hematopoietic stem cells.

1987 • 73 citations

Progenitor cell hyperplasia with rare development of myeloid leukemia in interleukin 11 bone marrow chimeras.

1993 • 65 citations

Expression of genes transferred to haemopoietic stem cells by recombinant retroviruses.

1987 • 62 citations

Preclinical biology of interleukin 11: A multifunctional hematopoietic cytokine with potent thrombopoietic activity

1995 • 60 citations

Synergistic effects of interleukin-11 with other growth factors on the expansion of murine hematopoietic progenitors and maintenance of stem cells in liquid culture.

1994 • 60 citations

Retroviral vector design for long-term expression in murine hematopoietic cells in vivo

1994 • 53 citations

Tyrosine Phosphorylation of Jak-Tyk Kinases in Malignant Plasma Cell Lines Growth Stimulated by Interleukins 6 and 11

1994 • 51 citations

Hematopoietic transforming potential of activated ras in chimeric mice.

1995 • 49 citations

Hematopoietic stem cells in the blood after stem cell factor and interleukin-11 administration: evidence for different mechanisms of mobilization

1995 • 48 citations

Increased frequency of both total and specific monoclonal antibody producing hybridomas using a fusion partner that constitutively expresses recombinant IL-6

1992 • 47 citations

Differential effects of microenvironmentally presented interleukin 3 versus soluble growth factor on primitive human hematopoietic cells.

1991 • 37 citations

Interleukin-11 stimulates multilineage progenitors, but not stem cells, in murine and human long-term marrow cultures

1995 • 25 citations

Interleukin-11 expression in donor bone marrow cells improves hematological reconstitution in lethally irradiated recipient mice.

1994 • 22 citations

Hematopathology of interleukin 6-type cytokines.

1994 • 20 citations