A randomized placebo-controlled trial of recombinant human interleukin-11 in cancer patients with severe thrombocytopenia due to chemotherapy

Safety of stringent prophylactic platelet transfusion policy for patients with acute leukaemia

1991 • 341 citations

Direct and synergistic effects of interleukin 11 on murine hemopoiesis in culture.

1991 • 234 citations

A phase I trial of recombinant human interleukin-11 (neumega rhIL-11 growth factor) in women with breast cancer receiving chemotherapy

1996 • 216 citations

Collection and transfusion of blood and blood components in the United States, 1992

1995 • 207 citations

Platelet transfusions: the 20,000/microL trigger [see comments]

1993 • 206 citations

Interleukin-11 enhances human megakaryocytopoiesis in vitro

1992 • 203 citations

Clonal proliferation of murine lymphohemopoietic progenitors in culture.

1992 • 163 citations

Recombinant human interleukin-11 stimulates megakaryocytopoiesis and increases peripheral platelets in normal and splenectomized mice

1993 • 162 citations

Effects of recombinant interleukin 11 on human megakaryocyte progenitor cells.

1991 • 151 citations

The Effects of Treatment with Interleukin-1α on Platelet Recovery after High-Dose Carboplatin

1993 • 143 citations

Effects of recombinant human interleukin-11 on hematopoietic reconstitution in transplant mice: acceleration of recovery of peripheral blood neutrophils and platelets

1993 • 139 citations

Prophylactic versus therapeutic platelet transfusion practices in hematology and/or oncology patients

1995 • 130 citations

Synergistic interactions between interleukin-11 and interleukin-4 in support of proliferation of primitive hematopoietic progenitors of mice

1991 • 118 citations

In vivo effects of recombinant interleukin-11 on myelopoiesis in mice

1993 • 95 citations

Recombinant human interleukin-11 stimulates multilineage hematopoietic recovery in mice after a myelosuppressive regimen of sublethal irradiation and carboplatin

1994 • 93 citations

Effects of interleukin-3 after chemotherapy for advanced ovarian cancer

1992 • 92 citations

Effects of recombinant human interleukin-3 in patients with relapsed small-cell lung cancer treated with chemotherapy: a dose-finding study.

1992 • 76 citations

Dose-dependent interleukin-3 stimulation of thrombopoiesis and neutropoiesis in patients with small-cell lung carcinoma before and following chemotherapy: a placebo-controlled randomized phase Ib study.

1993 • 71 citations

Effect of recombinant human interleukin‐11 on rat megakaryopoiesis and thrombopoiesis in vivo: comparative study with interleukin‐6

1993 • 65 citations

Changing patterns of blood transfusions in four sets of United States hospitals, 1980 to 1985

1988 • 62 citations

Effects of PIXY321, a granulocyte-macrophage colony-stimulating factor/interleukin-3 fusion protein, on chemotherapy-induced multilineage myelosuppression in patients with sarcoma.

1994 • 55 citations

Clinical impact of chemotherapy-induced thrombocytopenia in patients with gynecologic cancer.

1994 • 49 citations

Effects of recombinant human interleukin-11 (Neumega rhIL-11 growth factor) on megakaryocytopoiesis in human bone marrow.

1996 • 48 citations

Increased survival and multilineage hematopoietic protection from delayed and severe myelosuppressive effects of a nitrosourea with recombinant interleukin-11.

1994 • 40 citations