Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor MpI

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

A new method for predicting signal sequence cleavage sites

1986 • 4,629 citations

Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

1986 • 2,137 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs

1985 • 1,594 citations

Human GM-CSF: Molecular Cloning of the Complementary DNA and Purification of the Natural and Recombinant Proteins

1985 • 1,253 citations

Isolation and characterization of genomic and cDNA clones of human erythropoietin

1985 • 1,101 citations

Purification of human erythropoietin.

1977 • 893 citations

Interleukin 6 enhancement of interleukin 3-dependent proliferation of multipotential hemopoietic progenitors.

1987 • 847 citations

Human IL-3 (multi-CSF): Identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3

1986 • 823 citations

Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2).

1985 • 679 citations

Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine.

1990 • 649 citations

Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines.

1983 • 559 citations

Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily.

1992 • 525 citations

Human interleukin 6 is a direct promoter of maturation of megakaryocytes in vitro.

1989 • 430 citations

A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors

1990 • 404 citations

Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis

1993 • 359 citations

Packaging system for rapid production of murine leukemia virus vectors with variable tropism

1992 • 260 citations

Interleukin-11 enhances human megakaryocytopoiesis in vitro

1992 • 203 citations

Murine c-mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal.

1993 • 174 citations

Inhibition of autoproteolytic activation of interstitial procollagenase by recombinant metalloproteinase inhibitor MI/TIMP-2

1991 • 156 citations

MPLV: A retrovirus complex inducing an acute myeloproliferative leukemic disorder in adult mice

1986 • 140 citations

Leukemia inhibitory factor can potentiate murine megakaryocyte production in vitro

1991 • 117 citations

Mast cell growth factor (c-kit ligand) enhances cytokine stimulation of proliferation of the human factor-dependent cell line, M07e.

1991 • 106 citations

A novel cytokine exhibiting megakaryocyte potentiating activity from a human pancreatic tumor cell line HPC-Y5.

1994 • 92 citations

Stimulation of Platelet Production by Serum of Platelet-Depleted Rats

1961 • 88 citations

Thrombopoietin production by human embryonic kidney cells in culture.

1975 • 78 citations

Purification and partial biochemical characterization of normal human interleukin 1.

1984 • 68 citations

Purification and properties of a megakaryocyte stimulatory factor present both in the serum-free conditioned medium of human embryonic kidney cells and in thrombocytopenic plasma.

1987 • 67 citations

In vitro stimulation of megakaryocyte maturation by megakaryocyte stimulatory factor.

1987 • 63 citations

Thrombopoietic activity of fractions of rabbit plasma: studies in rabbits and mice.

1974 • 56 citations

Human megakaryocyte colony-stimulating factor in sera from aplastic dogs: partial purification, characterization, and determination of hematopoietic cell lineage specificity.

1985 • 50 citations

Isolation of large numbers of enriched human megakaryocytes from liquid cultures of normal peripheral blood progenitor cells

1990 • 42 citations

Factor-independent erythropoietic progenitor cells in leukemia induced by the myeloproliferative leukemia virus

1989 • 32 citations

Partial purification of thrombopoietin using lectin chromatography.

1986 • 30 citations

Assay of thrombopoietin utilizing human sera and urine fractions

1975 • 27 citations

Megakaryocyte colony‐stimulating factor (Meg‐CSF) is a unique cytokine specific for the megakaryocyte lineage

1993 • 23 citations

Correlation of in vitro and in vivo biological activities during the partial purification of thrombopoietin.

1992 • 20 citations

Partial purification and characterization of human megakaryocyte colony-stimulating factor (Meg-CSF)

1990 • 11 citations

Purification of human megakaryocyte colony-stimulating factor (Meg-CSF) from urine of aplastic anemia patients

1991 • 4 citations