Thrombopoietin, the ligand for the Mpl receptor, synergizes with steel factor and other early acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice

Differentiation and proliferation of hematopoietic stem cells

1993 • 1,417 citations

Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand

1994 • 1,328 citations

Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo

1994 • 1,138 citations

Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin

1994 • 1,081 citations

Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor MpI

1994 • 987 citations

Interleukin 6 enhancement of interleukin 3-dependent proliferation of multipotential hemopoietic progenitors.

1987 • 847 citations

c-Mpl ligand is a humoral regulator of megakaryocytopoiesis

1994 • 689 citations

In utero manipulation of coat color formation by a monoclonal anti-c-kit antibody: two distinct waves of c-kit-dependency during melanocyte development.

1991 • 479 citations

Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro

1995 • 416 citations

Functional Isolation and Characterization of Human Hematopoietic Stem Cells

1995 • 414 citations

Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis

1993 • 359 citations

Identification in culture of a class of hemopoietic colony-forming units with extensive capability to self-renew and generate multipotential hemopoietic colonies.

1982 • 317 citations

Granulocyte colony-stimulating factor enhances interleukin 3-dependent proliferation of multipotential hemopoietic progenitors.

1988 • 296 citations

Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy.

1995 • 269 citations

In vitro megakaryocytopoietic and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells

1994 • 268 citations

Direct and synergistic effects of interleukin 11 on murine hemopoiesis in culture.

1991 • 234 citations

Growth factor requirements for survival in G0 and entry into the cell cycle of primitive human hemopoietic progenitors.

1992 • 224 citations

Recombinant gibbon interleukin 3 supports formation of human multilineage colonies and blast cell colonies in culture: comparison with recombinant human granulocyte-macrophage colony-stimulating factor

1987 • 216 citations

Single-cell origin of mouse hemopoietic colonies expressing multiple lineages in variable combinations.

1983 • 209 citations

Enhancement of murine hematopoiesis by synergistic interactions between steel factor (ligand for c-kit), interleukin-11, and other early acting factors in culture

1992 • 167 citations

The flt3 ligand supports proliferation of lymphohematopoietic progenitors and early B-lymphoid progenitors

1995 • 162 citations

Recombinant human thrombopoietin (Mpl ligand) enhances proliferation of erythroid progenitors

1995 • 157 citations

Soluble stem cell factor in human serum

1993 • 151 citations

Constitutive expression of steel factor gene by human stromal cells

1993 • 148 citations

Human thrombopoietin: gene structure, cDNA sequence, expression, and chromosomal localization.

1994 • 147 citations

Proliferative kinetics and differentiation of murine blast cell colonies in culture: Evidence for variable G₀ periods and constant doubling rates of early pluripotent hemopoietic progenitors

1983 • 145 citations

Leukemia inhibitory factor differentiation-inhibiting activity/human interleukin for DA cells augments proliferation of human hematopoietic stem cells

1990 • 133 citations

Clonal origin of murine hemopoietic colonies with apparent restriction to granuclocyte‐macrophage‐megakaryocyte (GMM) differentiation

1982 • 128 citations

Stage-specific expression of c-kit protein by murine hematopoietic progenitors

1993 • 121 citations

Differentiation and proliferation of hematopoietic stem cells

1993 • 118 citations

Enhancement of murine blast cell colony formation in culture by recombinant rat stem cell factor, ligand for c-kit

1991 • 113 citations

Cytotoxic lymphocyte maturation factor (interleukin 12) is a synergistic growth factor for hematopoietic stem cells.

1993 • 111 citations

Synergistic interaction between interleukin-12 and steel factor in support of proliferation of murine lymphohematopoietic progenitors in culture

1994 • 86 citations

Growth factor requirement for survival in cell-cycle dormancy of primitive murine lymphohematopoietic progenitors

1993 • 81 citations

Recombinant murine granulocyte‐macrophage (GM) colony‐stimulating factor supports formation of GM and multipotential blast cell colonies in culture: Comparison with the effects of interleukin‐3

1987 • 77 citations

Role of Ly-6 in lymphocyte activation. I. Characterization of a monoclonal antibody to a nonpolymorphic Ly-6 specificity.

1986 • 69 citations

Murine B‐cell stimulatory factor‐1 (BSF‐1)/Interleukin‐4 (IL‐4) is a multilineage colony‐stimulating factor that acts directly on primitive hemopoietic progenitors

1989 • 47 citations

Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis

1993 • 31 citations

Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin

1995 • 22 citations

Soluble stem cell factor in human serum

1993 • 20 citations

Recombinant gibbon interleukin 3 supports formation of human multilineage colonies and blast cell colonies in culture: comparison with recombinant human granulocyte-macrophage colony-stimulating factor

1987 • 19 citations

Constitutive expression of steel factor gene by human stromal cells

1993 • 15 citations

Recombinant human thrombopoietin (Mpl ligand) enhances proliferation of erythroid progenitors

1995 • 14 citations

Stage-specific expression of c-kit protein by murine hematopoietic progenitors

1993 • 14 citations

Growth factor requirement for survival in cell-cycle dormancy of primitive murine lymphohematopoietic progenitors

1993 • 12 citations

Enhancement of murine blast cell colony formation in culture by recombinant rat stem cell factor, ligand for c-kit

1991 • 11 citations

Enhancement of murine hematopoiesis by synergistic interactions between steel factor (ligand for c-kit), interleukin-11, and other early acting factors in culture

1992 • 8 citations

Synergistic interaction between interleukin-12 and steel factor in support of proliferation of murine lymphohematopoietic progenitors in culture

1994 • 6 citations

Leukemia inhibitory factor differentiation-inhibiting activity/human interleukin for DA cells augments proliferation of human hematopoietic stem cells

1990 • 6 citations