TGFbeta signaling pathways and human diseases.

THE GENETICS OF CAENORHABDITIS ELEGANS

1974 • 14,589 citations

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Mutations affecting segment number and polarity in Drosophila

1980 • 4,280 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.

1994 • 1,950 citations

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

1997 • 1,905 citations

Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells

1985 • 1,687 citations

Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1

1994 • 1,452 citations

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

1997 • 1,023 citations

SARA, a FYVE Domain Protein that Recruits Smad2 to the TGFβ Receptor

1998 • 952 citations

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

1996 • 899 citations

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

1999 • 890 citations

Receptor-associated Mad homologues synergize as effectors of the TGF-β response

1996 • 874 citations

MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma

1996 • 855 citations

Limb alterations in brachypodism mice due to mutations in a new member of the TGFβ-superfamily

1994 • 855 citations

Cloning of a TGF$beta; type I receptor that forms a heteromeric complex with the TGF$beta; type II receptor

1993 • 779 citations

Expression cloning of an activin receptor, a predicted transmembrane serine kinase

1991 • 760 citations

A transcript from a Drosophila pattern gene predicts a protein homologous to the transforming growth factor-β family

1987 • 756 citations

Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.

1994 • 737 citations

Complementary DNA sequences of ovarian follicular fluid inhibin show precursor structure and homology with transforming growth factor-β

1985 • 722 citations

The transforming growth factor-β system, a complex pattern of cross-reactive ligands and receptors

1987 • 710 citations

MADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways

1996 • 710 citations

A transcriptional partner for MAD proteins in TGF-β signalling

1996 • 699 citations

DPC4 gene in various tumor types.

1996 • 680 citations

A human Mad protein acting as a BMP-regulated transcriptional activator

1996 • 674 citations

Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster.

1995 • 672 citations

Identification of human activin and TGFβ type I receptors that form heteromeric kinase complexes with type II receptors

1993 • 656 citations

Intestinal Tumorigenesis in Compound Mutant Mice of both Dpc4(Smad4) and Apc Genes

1998 • 603 citations

Human Type II Receptor for Bone Morphogenic Proteins (BMPs): Extension of the Two-Kinase Receptor Model to the BMPs

1995 • 602 citations

Smad2 role in mesoderm formation, left–right patterning and craniofacial development

1998 • 600 citations

The Caenorhabditis elegans male: Postembryonic development of nongonadal structures

1980 • 588 citations

Smad4 and FAST-1 in the assembly of activin-responsive factor

1997 • 567 citations

Cloning and characterization of a human type II receptor for bone morphogenetic proteins.

1995 • 551 citations

IDENTIFICATION AND CHARACTERIZATION OF 22 GENES THAT AFFECT THE VULVAL CELL LINEAGES OF THE NEMATODE CAENORHABDITIS ELEGANS

1985 • 531 citations

Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components.

1996 • 528 citations

Control of C. elegans Larval Development by Neuronal Expression of a TGF-β Homolog

1996 • 516 citations

Interacting genes in nematode dauer larva formation

1981 • 504 citations

The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo

1998 • 494 citations

Targeted Disruption of Smad3 Reveals an Essential Role in Transforming Growth Factor β-Mediated Signal Transduction

1999 • 475 citations

Smad2 Signaling in Extraembryonic Tissues Determines Anterior-Posterior Polarity of the Early Mouse Embryo

1998 • 469 citations

Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes

1997 • 439 citations

Xenopus Mad Proteins Transduce Distinct Subsets of Signals for the TGFβ Superfamily

1996 • 432 citations

Daughters against dpp modulates dpp organizing activity in Drosophila wing development

1997 • 426 citations

Tumor suppressor activity of the TGF-β pathway in human cancers

1996 • 412 citations

A human chondrodysplasia due to a mutation in a TGF-β superfamily member

1996 • 412 citations

Cloning of a Type I TGF-β Receptor and Its Effect on TGF-β Binding to the Type II Receptor

1993 • 401 citations

Inactivation of the Type II Receptor Reveals Two Receptor Pathways for the Diverse TGF-β Activities

1993 • 388 citations

Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family

1996 • 387 citations

The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice

1998 • 368 citations

The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development

1993 • 368 citations

Characterization and Cloning of a Receptor for BMP-2 and BMP-4 from NIH 3T3 Cells

1994 • 368 citations

Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity.

1993 • 354 citations

Genetic analysis of the Müllerian-inhibiting substance signal transduction pathway in mammalian sexual differentiation.

1996 • 354 citations

A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway.

1996 • 351 citations

Decapentaplegic: A gene complex affecting morphogenesis in Drosophila melanogaster

1982 • 345 citations

Sensory regulation of male mating behavior in caenorhabditis elegans

1995 • 341 citations

Identification of Type I and Type II Serine/Threonine Kinase Receptors for Growth/Differentiation Factor-5

1996 • 336 citations

Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-beta.

1994 • 324 citations

Characterization and relationship of dpp receptors encoded by the saxophone and thick veins genes in Drosophila

1994 • 317 citations

An absolute requirement for both the type II and type I receptors, punt and thick veins, for Dpp signaling in vivo

1995 • 312 citations

A Transforming Growth Factor β Type I Receptor that Signals to Activate Gene Expression

1994 • 296 citations

Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2

1998 • 295 citations

daf-1, a C. elegans gene controlling dauer larva development, encodes a novel receptor protein kinase

1990 • 293 citations

The decapentaplegic gene is required for dorsal-ventral patterning of the Drosophila embryo.

1987 • 288 citations

Human BMP sequences can confer normal dorsal-ventral patterning in the Drosophila embryo.

1993 • 283 citations

Drosophila Dpp signaling is mediated by the punt gene product: A dual ligand-binding type II receptor of the TGFβ receptor family

1995 • 275 citations

Receptor serine/threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic

1994 • 275 citations

Tumor Suppressor Smad4 Is a Transforming Growth Factor β-Inducible DNA Binding Protein

1997 • 275 citations

The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-beta receptors

1998 • 265 citations

Somatic alterations of the DPC4 gene in human colorectal cancers in vivo

1996 • 259 citations

Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor

1994 • 254 citations

A BMP homolog acts as a dose-dependent regulator of body size and male tail patterning inCaenorhabditis elegans

1999 • 242 citations

Identification of a Human Type II Receptor for Bone Morphogenetic Protein-4 That Forms Differential Heteromeric Complexes with Bone Morphogenetic Protein Type I Receptors

1995 • 238 citations

Insensitivity to anti–Müllerian hormone due to a mutation in the human anti–Müllerian hormone receptor

1995 • 228 citations

Drosophila transforming growth factor beta superfamily proteins induce endochondral bone formation in mammals.

1993 • 227 citations

Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye

1996 • 223 citations

The screw gene encodes a ubiquitously expressed member of the TGF-beta family required for specification of dorsal cell fates in the Drosophila embryo.

1994 • 199 citations

The DAF-3 Smad protein antagonizes TGF-β-related receptor signaling in the Caenorhabditis elegansdauer pathway

1997 • 197 citations

The smad5 mutation somitabun blocks Bmp2b signaling during early dorsoventral patterning of the zebrafish embryo

1999 • 193 citations

The Drosophila Activin receptor Baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development

1999 • 190 citations

Suppressors of Ectopic UNC-5 Growth Cone Steering Identify Eight Genes Involved in Axon Guidance inCaenorhabditis elegans

1998 • 175 citations

lin-31, a Caenorhabditis elegans HNF-3/fork head transcription factor homolog, specifies three alternative cell fates in vulval development.

1993 • 167 citations

DPC4, a candidate tumor suppressor gene, is altered infrequently in head and neck squamous cell carcinoma.

1996 • 164 citations

Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-β family

1999 • 158 citations

Smad5 Induces Ventral Fates inXenopusEmbryo

1997 • 157 citations

TGF-β/BMP superfamily members, Gbb-60A and Dpp, cooperate to provide pattern information and establish cell identity in the Drosophila wing

1998 • 156 citations

Two distinct transmembrane serine/threonine kinases from Drosophila melanogaster form an activin receptor complex.

1994 • 153 citations

Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses

1998 • 153 citations

Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth.

1996 • 146 citations

Specificity of TGFβ signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans

1999 • 139 citations

Anti-Müllerian hormone Bruxelles: a nonsense mutation associated with the persistent Müllerian duct syndrome.

1991 • 132 citations

The Drosophila saxophone Gene: a Serine-Threonine Kinase Receptor of the TGF-β Superfamily

1994 • 131 citations

The Persistent Mullerian Duct Syndrome: A Molecular Approach*

1989 • 131 citations

Comparative mutational analysis of DPC4 (Smad4) in prostatic and colorectal carcinomas

1997 • 126 citations

Expression of ALK-1, a type 1 serine/threonine kinase receptor, coincides with sites of vasculogenesis and angiogenesis in early mouse development

1997 • 121 citations

The Drosophila Medea gene is required downstream of dpp and encodes a functional homolog of human Smad4

1998 • 113 citations

The Drosophila gene Medea demonstrates the requirement for different classes of Smads in dpp signaling

1998 • 112 citations

Molecular genetics of the persistent Mullerian duct syndrome: a study of 19 families

1994 • 111 citations

Pattern formation in the nematode epidermis: determination of the arrangement of peripheral sense organs in the C. elegans male tail

1991 • 98 citations

Serine Phosphorylation, Chromosomal Localization, and Transforming Growth Factor-β Signal Transduction by Human

1996 • 89 citations

HOM-C/Hox genes and four interacting loci determine the morphogenetic properties of single cells in the nematode male tail

1994 • 88 citations

The Caenorhabditis elegans gene lin-10 is broadly expressed while required specifically for the determination of vulval cell fates.

1990 • 71 citations

Variants of the anti-M�llerian hormone gene in a compound heterozygote with the persistent M�llerian duct syndrome and his family

1992 • 66 citations

Infrequent DPC4 gene mutation in esophageal cancer, gastric cancer and ulcerative colitis-associated neoplasms.

1996 • 66 citations

A genetic screen for modifiers of Drosophila decapentaplegic signaling identifies mutations in punt, Mothers against dpp and the BMP-7 homologue, 60A

1998 • 62 citations

Mutant Isoforms of the Anti-Müllerian Hormone Type II Receptor Are Not Expressed at the Cell Membrane

1996 • 51 citations

zALK-8, a novel type I serine/threonine kinase receptor, is expressed throughout early zebrafish development

1998 • 46 citations

Drosophila dSmad2 and Atr‐I transmit activin/TGFβ signals

1999 • 42 citations

The MH1 Domains of Smad2 and Smad3 Are Involved in the Regulation of the ALK7 Signals

1999 • 40 citations

TGFβ-like Signaling and Spicule Development in Caenorhabditis elegans

1999 • 23 citations

A Short Loop on the ALK-2 and ALK-4 Activin Receptors Regulates Signaling Specificity but Cannot Account for All Their Effects on EarlyXenopus Development

1999 • 14 citations