The Drosophila Activin receptor Baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

Analysis of genetic mosaics in developing and adult Drosophila tissues

1993 • 2,029 citations

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.

1994 • 1,950 citations

TGFβ signals through a heteromeric protein kinase receptor complex

1992 • 1,519 citations

The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling

1997 • 1,328 citations

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

1996 • 899 citations

Direct and Long-Range Action of a DPP Morphogen Gradient

1996 • 896 citations

Coordination of Growth and Cell Division in the Drosophila Wing

1998 • 760 citations

A transcript from a Drosophila pattern gene predicts a protein homologous to the transforming growth factor-β family

1987 • 756 citations

MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling

1996 • 740 citations

MADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways

1996 • 710 citations

Programmed cell death during Drosophila embryogenesis

1993 • 710 citations

A transcriptional partner for MAD proteins in TGF-β signalling

1996 • 699 citations

GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex.

1995 • 682 citations

Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster.

1995 • 672 citations

Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing

1996 • 629 citations

The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.

1997 • 569 citations

The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-β-induced transcriptional activation

1998 • 527 citations

Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic

1997 • 524 citations

Smad2 and Smad3 Positively and Negatively Regulate TGFβ-Dependent Transcription through the Forkhead DNA-Binding Protein FAST2

1998 • 513 citations

TGF-β-stimulated cooperation of Smad proteins with the coactivators CBP/p300

1998 • 503 citations

The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth.

1996 • 492 citations

TβRI Phosphorylation of Smad2 on Ser465 and Ser467 Is Required for Smad2-Smad4 Complex Formation and Signaling

1997 • 470 citations

Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes

1997 • 439 citations

Daughters against dpp modulates dpp organizing activity in Drosophila wing development

1997 • 426 citations

TGF-β receptor signaling

1997 • 417 citations

Phosphorylation of Ser465 and Ser467 in the C Terminus of Smad2 Mediates Interaction with Smad4 and Is Required for Transforming Growth Factor-β Signaling

1997 • 383 citations

Transforming growth factor β-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells

1997 • 357 citations

Characterization and relationship of dpp receptors encoded by the saxophone and thick veins genes in Drosophila

1994 • 317 citations

The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function

1997 • 317 citations

Activation of Signalling by the Activin Receptor Complex

1996 • 317 citations

Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila.

1995 • 306 citations

Autosomal P[ovo D1 ] dominant female-sterile insertions in Drosophila and their use in generating germ-line chimeras

1993 • 302 citations

Human BMP sequences can confer normal dorsal-ventral patterning in the Drosophila embryo.

1993 • 283 citations

Determinants of heat shock-induced chromosome puffing

1985 • 281 citations

The optic lobe of Drosophila melanogaster

1992 • 244 citations

Cell cycling and patterned cell proliferation in the wing primordium of Drosophila.

1996 • 231 citations

Synergistic signaling by two BMP ligands through the SAX and TKV receptors controls wing growth and patterning in Drosophila

1998 • 218 citations

The TGF-β signaling pathway is essential for Drosophila oogenesis

1996 • 218 citations

The screw gene encodes a ubiquitously expressed member of the TGF-beta family required for specification of dorsal cell fates in the Drosophila embryo.

1994 • 199 citations

Mads and Smads in TGFβ signalling

1998 • 194 citations

Cell cycle progression, growth and patterning in imaginal discs despite inhibition of cell division after inactivation of Drosophila Cdc2 kinase

1997 • 192 citations

P-lacW insertional mutagenesis on the second chromosome of Drosophila melanogaster: isolation of lethals with different overgrowth phenotypes.

1993 • 185 citations

Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-β responsive cells

1996 • 174 citations

TGF-β/BMP superfamily members, Gbb-60A and Dpp, cooperate to provide pattern information and establish cell identity in the Drosophila wing

1998 • 156 citations

Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses

1998 • 153 citations

Two distinct transmembrane serine/threonine kinases from Drosophila melanogaster form an activin receptor complex.

1994 • 153 citations

The decapentaplegic gene: a TGF-β homologue controlling pattern formation in Drosophila

1989 • 144 citations

Developmental territories created by mutual antagonism between Wingless and Decapentaplegic

1996 • 139 citations

Conservation of dorsal-ventral patterning in arthropods and chordates

1996 • 116 citations

Identification of a Drosophila activin receptor.

1993 • 114 citations

The Drosophila Medea gene is required downstream of dpp and encodes a functional homolog of human Smad4

1998 • 113 citations

The Drosophila gene Medea demonstrates the requirement for different classes of Smads in dpp signaling

1998 • 112 citations

The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development

1998 • 106 citations

Signaling Activity of Homologous and Heterologous Transforming Growth Factor-β Receptor Kinase Complexes

1995 • 78 citations

Signaling through both type I DPP receptors is required for anterior-posterior patterning of the entire Drosophila wing

1997 • 75 citations

TGF-β1 modulates EGF-stimulated phosphatidylinositol 3-kinase activity in human airway smooth muscle cells

1997 • 63 citations

A genetic screen for modifiers of Drosophila decapentaplegic signaling identifies mutations in punt, Mothers against dpp and the BMP-7 homologue, 60A

1998 • 62 citations

Transforming Growth Factor-β1 Stimulates or Inhibits Cell Growth via Down- or Up-Regulation of p21/Waf1

1998 • 61 citations

Glia in the chiasms and medulla of the Drosophila melanogaster optic lobes

1997 • 55 citations

Mechanisms of TGF-β-Induced Cell Cycle Arrest

1998 • 52 citations

Identification of a New Member of Transforming Growth Factor-Beta Superfamily inDrosophila:The First Invertebrate Activin Gene

1998 • 40 citations

Two Distinct Transmembrane Serine/Threonine Kinases from Drosophila melanogaster Form an Activin Receptor Complex

1994 • 24 citations

A transcriptional partner for MAD proteins in TGF-β signalling

1997 • 19 citations

[Cytogenetic analysis of the chromosome region containing the Drosophila radiosensitivity gene. II. The vitally important loci of the 44F-45C region of chromosome 2].

1994 • 8 citations

Untersuchungen über die Feinstruktur und Funktion des Analorgans normaler und letaler (l(3)tr) Larven von Drosophila melanogaster

1974 • 3 citations