The Drosophila Medea gene is required downstream of dpp and encodes a functional homolog of human Smad4

Molecular cloning: A laboratory manual

1990 • 85,659 citations

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

Drosophila — A Practical Approach

1987 • 1,888 citations

Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

1997 • 1,774 citations

The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling

1997 • 1,328 citations

Smad6 inhibits signalling by the TGF-β superfamily

1997 • 1,026 citations

brahma: A regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2SWI2

1992 • 951 citations

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

1996 • 899 citations

Receptor-associated Mad homologues synergize as effectors of the TGF-β response

1996 • 874 citations

MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma

1996 • 855 citations

TGFβ Signaling: Receptors, Transducers, and Mad Proteins

1996 • 840 citations

MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling

1996 • 740 citations

MADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways

1996 • 710 citations

A transcriptional partner for MAD proteins in TGF-β signalling

1996 • 699 citations

DPC4 gene in various tumor types.

1996 • 680 citations

A human Mad protein acting as a BMP-regulated transcriptional activator

1996 • 674 citations

Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster.

1995 • 672 citations

The Autosomal FLP-DFS Technique for Generating Germline Mosaics in Drosophila melanogaster

1996 • 652 citations

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

1996 • 614 citations

Functional cDNA libraries from Drosophila embryos

1988 • 604 citations

Eukaryotic start and stop translation sites

1991 • 602 citations

Bone morphogenetic protein 4: a ventralizing factor in early Xenopus development

1992 • 573 citations

Smad4 and FAST-1 in the assembly of activin-responsive factor

1997 • 567 citations

Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components.

1996 • 528 citations

Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic

1997 • 524 citations

DVR-4 (Bone Morphogenetic Protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction

1992 • 488 citations

decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo

1992 • 480 citations

A structural basis for mutational inactivation of the tumour suppressor Smad4

1997 • 459 citations

Xenopus Mad Proteins Transduce Distinct Subsets of Signals for the TGFβ Superfamily

1996 • 432 citations

Daughters against dpp modulates dpp organizing activity in Drosophila wing development

1997 • 426 citations

Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes

1996 • 408 citations

Transforming growth factor β-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells

1997 • 357 citations

Concentration-dependent patterning of the Xenopus ectoderm by BMP4 and its signal transducer Smad1

1997 • 354 citations

A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway.

1996 • 351 citations

Drosophila: A laboratory manual

1990 • 350 citations

Decapentaplegic: A gene complex affecting morphogenesis in Drosophila melanogaster

1982 • 345 citations

Bmp-4 acts as a morphogen in dorsoventral mesoderm patterning in Xenopus

1997 • 332 citations

Dosage-dependent modifiers of position effect variegation in Drosophila and a mass action model that explains their effect.

1988 • 320 citations

The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function

1997 • 317 citations

Characterization and relationship of dpp receptors encoded by the saxophone and thick veins genes in Drosophila

1994 • 317 citations

An absolute requirement for both the type II and type I receptors, punt and thick veins, for Dpp signaling in vivo

1995 • 312 citations

Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila.

1995 • 306 citations

The decapentaplegic gene is required for dorsal-ventral patterning of the Drosophila embryo.

1987 • 288 citations

An activity gradient of decapentaplegic is necessary for the specification of dorsal pattern elements in the Drosophila embryo

1993 • 283 citations

Drosophila Dpp signaling is mediated by the punt gene product: A dual ligand-binding type II receptor of the TGFβ receptor family

1995 • 275 citations

Receptor serine/threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic

1994 • 275 citations

Tumor Suppressor Smad4 Is a Transforming Growth Factor β-Inducible DNA Binding Protein

1997 • 275 citations

Defects in embryogenesis in mutants associated with the antennapedia gene complex of Drosophila melanogaster

1984 • 259 citations

Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor

1994 • 254 citations

Decapentaplegic transcripts are localized along the dorsal-ventral axis of the Drosophila embryo.

1987 • 247 citations

The Xenopus Dorsalizing Factor noggin Ventralizes Drosophila Embryos by Preventing DPP from Activating Its Receptor

1996 • 242 citations

Localized enhancement and repression of the activity of the TGF-P family member, decapentaplegic, is necessary for dorsal-ventral pattern formation in the Drosophila embryo

1992 • 222 citations

The TGF-β signaling pathway is essential for Drosophila oogenesis

1996 • 218 citations

Genetic analysis of dorsoventral pattern formation in the zebrafish: requirement of a BMP-like ventralizing activity and its dorsal repressor.

1996 • 213 citations

The drosophila schnurri gene acts in the Dpp/TGFβ signaling pathway and encodes a transcription factor homologous to the human MBP family

1995 • 212 citations

schnurri is required for drosophila Dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1

1995 • 200 citations

Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-β responsive cells

1996 • 174 citations

Xenopus mothers against decapentaplegic is an embryonic ventralizing agent that acts downstream of the BMP-2/4 receptor

1996 • 172 citations

Regulation of transforming growth factor β- and activin-induced transcription by mammalian Mad proteins

1996 • 162 citations

Developmental consequences of awdb3, a cell-autonomous lethal mutation of Drosophila induced by hybrid dysgenesis

1988 • 162 citations

Smad5 Induces Ventral Fates inXenopusEmbryo

1997 • 157 citations

tramtrack is a transcriptional repressor required for cell fate determination in the Drosophila eye.

1993 • 157 citations

Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses

1998 • 153 citations

Maternal regulation of zerknüllt: a homoeobox gene controlling differentiation of dorsal tissues in Drosophila

1987 • 143 citations

Multiple requirements for the receptor serine/threonine kinase thick veins reveal novel functions of TGF beta homologs during Drosophila embryogenesis.

1994 • 137 citations

The Drosophila saxophone Gene: a Serine-Threonine Kinase Receptor of the TGF-β Superfamily

1994 • 131 citations

FlyBase: a Drosophila database

1997 • 126 citations

Altered mitotic domains reveal fate map changes in Drosophila embryos mutant for zygotic dorsoventral patterning genes

1992 • 119 citations

Molecular consequences of awdb3, a cell-autonomous lethal mutation of Drosophila induced by hybrid dysgenesis

1988 • 98 citations

Mothers against dpp participates in a DPP/TGF-β responsive serine-threonine kinase signal transduction cascade

1997 • 88 citations

Role Of The zerknüllt Gene In Dorsal-Ventral Pattern Formation In Drosophila

1990 • 65 citations

The thick veins gene of Drosophila is required for dorsoventral polarity of the embryo.

1994 • 59 citations

Formation of the drosophila larval photoreceptor organ and its neuronal differentiation require continuous Krüppel gene activity

1992 • 57 citations

Deleted Work

1955 • 0 citations