A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 4,548 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.

1994 • 1,950 citations

Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse.

1995 • 1,782 citations

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.

1995 • 1,739 citations

Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos

1992 • 1,176 citations

Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos.

1986 • 1,118 citations

Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in xenopus embryos

1991 • 1,103 citations

Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate.

1994 • 1,032 citations

Teratocarcinomas and embryonic stem cells : a practical approach

1987 • 878 citations

Cloning of the T gene required in mesoderm formation in the mouse

1990 • 847 citations

TGFβ Signaling: Receptors, Transducers, and Mad Proteins

1996 • 840 citations

fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation.

1994 • 784 citations

Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis.

1995 • 784 citations

Induction of epidermis and inhibition of neural fate by Bmp-4

1995 • 782 citations

A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse

1994 • 769 citations

Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus

1995 • 758 citations

Physiological Actions and Clinical Applications of Transforming Growth Factor-β (TGF-β)

1993 • 755 citations

Murine FGFR-1 is required for early postimplantation growth and axial organization.

1994 • 748 citations

Requirement of FGF-4 for Postimplantation Mouse Development

1995 • 743 citations

Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus

1995 • 731 citations

MADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways

1996 • 710 citations

Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster.

1995 • 672 citations

Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center

1991 • 651 citations

Xenopus embryos regulate the nuclear localization of XMyoD.

1994 • 648 citations

Nodal is a novel TGF-β-like gene expressed in the mouse node during gastrulation

1993 • 606 citations

Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures

1990 • 600 citations

An assessment of the developmental potential of embryonic stem cells in the midgestation mouse embryo

1989 • 596 citations

A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos

1992 • 538 citations

Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components.

1996 • 528 citations

Expression cloning of Siamois, a xenopus homeobox gene expressed in dorsal-vegetal cells of blastulae and able to induce a complete secondary axis

1995 • 521 citations

Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate

1990 • 508 citations

Injected Wnt RNA induces a complete body axis in Xenopus embryos

1991 • 501 citations

Responses of embryonic xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm

1992 • 486 citations

Evidence for Involvement of Activin A and Bone Morphogenetic Protein 4 in Mammalian Mesoderm and Hematopoietic Development

1995 • 464 citations

Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo

1994 • 463 citations

Xenopus Mad Proteins Transduce Distinct Subsets of Signals for the TGFβ Superfamily

1996 • 432 citations

Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation

1995 • 415 citations

Activin/inhibin beta B subunit gene disruption leads to defects in eyelid development and female reproduction.

1994 • 395 citations

Monoclonal antibodies identify blastemal cells derived from dedifferentiating muscle in newt limb regeneration

1984 • 353 citations

SIGNALING PATHWAYS THAT ESTABLISH THE DORSAL-VENTRAL PATTERN OF THE DROSOPHILA EMBRYO

1995 • 348 citations

A nodal-related gene defines a physical and functional domain within the Spemann organizer

1995 • 332 citations

Vertebrate Embryonic Induction: Mesodermal and Neural Patterning

1994 • 286 citations

The eed mutation disrupts anterior mesoderm production in mice

1995 • 284 citations

Mesodermal patterning by an inducer gradient depends on secondary cell–cell communication

1994 • 267 citations

Inducing factors in Xenopus early embryos

1994 • 234 citations

Dorsal-ventral patterning and differentiation of noggin-induced neural tissue in the absence of mesoderm

1995 • 215 citations

The homeobox gene goosecoid controls cell migration in Xenopus embryos

1993 • 186 citations

Xenopus mothers against decapentaplegic is an embryonic ventralizing agent that acts downstream of the BMP-2/4 receptor

1996 • 172 citations

The DVR gene family in embryonic development

1991 • 159 citations

A novel retrovirally induced embryonic lethal mutation in the mouse: assessment of the developmental fate of embryonic stem cells homozygous for the 413.d proviral integration

1991 • 147 citations

The transforming growth factor beta family and induction of the vertebrate mesoderm: bone morphogenetic proteins are ventral inducers.

1994 • 145 citations

Posterior expression of a homeobox gene in early Xenopus embryos

1987 • 117 citations

ventral ectoderm of Xenopus forms neural tissue, including hindbrain, in response to activin

1992 • 105 citations

Morphological differences in Xenopus embryonic mesodermal cells are specified as an early response to distinct threshold concentrations of activin

1994 • 52 citations

Mesoderm-inducing factors and Spemann’s organiser phenomenon in amphibian development

1989 • 45 citations

msd is required for mesoderm induction in mice

1994 • 39 citations

Structure of repeated sequences in the centromeric region of the human Y chromosome

1987 • 34 citations