Smad2 Signaling in Extraembryonic Tissues Determines Anterior-Posterior Polarity of the Early Mouse Embryo

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse.

1995 • 1,782 citations

Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

1997 • 1,774 citations

TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes

1997 • 1,404 citations

The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling

1997 • 1,328 citations

The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo

1995 • 1,175 citations

Abnormal lung development and cleft palate in mice lacking TGF–β3 indicates defects of epithelial–mesenchymal interaction

1995 • 1,027 citations

Smad6 inhibits signalling by the TGF-β superfamily

1997 • 1,026 citations

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

1997 • 1,023 citations

Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development

1996 • 959 citations

A Requirement for Flk1 in Primitive and Definitive Hematopoiesis and Vasculogenesis

1997 • 938 citations

A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo

1990 • 924 citations

Transforming growth factor–β3 is required for secondary palate fusion

1995 • 895 citations

Teratocarcinomas and embryonic stem cells : a practical approach

1987 • 878 citations

Clonal analysis of epiblast fate during germ layer formation in the mouse embryo

1991 • 865 citations

Expression pattern of the mouse T gene and its role in mesoderm formation

1990 • 854 citations

TGFβ Signaling: Receptors, Transducers, and Mad Proteins

1996 • 840 citations

Requirement for LIml in head-organizer function

1995 • 801 citations

A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse

1994 • 769 citations

Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer

1996 • 757 citations

MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling

1996 • 740 citations

MADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways

1996 • 710 citations

flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors

1993 • 707 citations

A transcriptional partner for MAD proteins in TGF-β signalling

1996 • 699 citations

Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse

1991 • 646 citations

The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins

1993 • 619 citations

Nodal is a novel TGF-β-like gene expressed in the mouse node during gastrulation

1993 • 606 citations

Different phenotypes for mice deficient in either activins or activin receptor type II

1995 • 598 citations

An assessment of the developmental potential of embryonic stem cells in the midgestation mouse embryo

1989 • 596 citations

Mouse gastrulation: the formation of a mammalian body plan

1997 • 595 citations

Functional analysis of activins during mammalian development

1995 • 579 citations

The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.

1997 • 569 citations

Smad4 and FAST-1 in the assembly of activin-responsive factor

1997 • 567 citations

Anterior primitive endoderm may be responsible for patterning the anterior neural plate in the mouse embryo

1996 • 548 citations

Relationship between asymmetric nodal expression and the direction of embryonic turning

1996 • 547 citations

Hex: a homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors

1998 • 520 citations

Cerberus-like is a secreted factor with neuralizing activity expressed in the anterior primitive endoderm of the mouse gastrula

1997 • 452 citations

Xenopus Mad Proteins Transduce Distinct Subsets of Signals for the TGFβ Superfamily

1996 • 432 citations

Processed Vg1 protein is an axial mesoderm inducer in xenopus

1993 • 417 citations

nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation

1997 • 384 citations

Transforming growth factor β-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells

1997 • 357 citations

A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway.

1996 • 351 citations

Positive and negative signals from mesoderm regulate the expression of mouse Otx2 in ectoderm explants

1994 • 333 citations

[51] Gene targeting in embryonic stem cells

1993 • 320 citations

HNF-3β as a regulator of floor plate development

1994 • 287 citations

Vertebrate Embryonic Induction: Mesodermal and Neural Patterning

1994 • 286 citations

Rpx: a novel anterior-restricted homeobox gene progressively activated in the prechordal plate, anterior neural plate and Rathke’s pouch of the mouse embryo

1996 • 286 citations

The generation of diversity and pattern in animal development

1992 • 284 citations

Cell fate, morphogenetic movement and population kinetics of embryonic endoderm at the time of germ layer formation in the mouse

1987 • 275 citations

TGF-β signalling through the Smad pathway

1997 • 265 citations

Patterning the Xenopus blastula

1997 • 234 citations

Embryonic Patterning: To BMP or Not to BMP, That Is the Question

1997 • 221 citations

Embryonic Expression of Lim-1, the Mouse Homolog of Xenopus XLim-1, Suggests a Role in Lateral Mesoderm Differentiation and Neurogenesis

1994 • 215 citations

Production and analysis of chimeric mice

1987 • 175 citations

Xenopus mothers against decapentaplegic is an embryonic ventralizing agent that acts downstream of the BMP-2/4 receptor

1996 • 172 citations

Smad5 Induces Ventral Fates inXenopusEmbryo

1997 • 157 citations

Induction of dorsal mesoderm by soluble, mature Vg1 protein

1995 • 150 citations

A novel retrovirally induced embryonic lethal mutation in the mouse: assessment of the developmental fate of embryonic stem cells homozygous for the 413.d proviral integration

1991 • 147 citations

Misexpression of Cwnt8C in the mouse induces an ectopic embryonic axis and causes a truncation of the anterior neuroectoderm

1997 • 145 citations

The transforming growth factor beta family and induction of the vertebrate mesoderm: bone morphogenetic proteins are ventral inducers.

1994 • 145 citations

From receptor to nucleus: the Smad pathway

1997 • 110 citations

Development of the extraembryonic lineages

1995 • 71 citations

Modulation of alphafetoprotein synthesis in the early postimplantation mouse embryo

1978 • 65 citations

Visceral endoderm-1 (VE-1): an antigen marker that distinguishes anterior from posterior embryonic visceral endoderm in the early post-implantation mouse embryo

1995 • 46 citations

Axis duplication and anterior identity in the mouse embryo.

1997 • 36 citations

Positive regulators of the lineage-specific transcription factor GATA-1 in differentiating erythroid cells.

1994 • 28 citations

Vertebrate embryonic inductions

1994 • 24 citations