Specificity of TGFβ signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans

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Novel Regulators of Bone Formation: Molecular Clones and Activities

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TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

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1991 • 3,108 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

1997 • 1,774 citations

The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling

1997 • 1,328 citations

Smad6 inhibits signalling by the TGF-β superfamily

1997 • 1,026 citations

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

1996 • 899 citations

Receptor-associated Mad homologues synergize as effectors of the TGF-β response

1996 • 874 citations

MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma

1996 • 855 citations

A transcript from a Drosophila pattern gene predicts a protein homologous to the transforming growth factor-β family

1987 • 756 citations

MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling

1996 • 740 citations

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

1998 • 714 citations

MADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways

1996 • 710 citations

A transcriptional partner for MAD proteins in TGF-β signalling

1996 • 699 citations

GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex.

1995 • 682 citations

A human Mad protein acting as a BMP-regulated transcriptional activator

1996 • 674 citations

Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster.

1995 • 672 citations

A modular set of lacZ fusion vectors for studying gene expression in Caenorhabditis elegans

1990 • 618 citations

Human Type II Receptor for Bone Morphogenic Proteins (BMPs): Extension of the Two-Kinase Receptor Model to the BMPs

1995 • 602 citations

The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.

1997 • 569 citations

Smad4 and FAST-1 in the assembly of activin-responsive factor

1997 • 567 citations

Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components.

1996 • 528 citations

The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-β-induced transcriptional activation

1998 • 527 citations

Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic

1997 • 524 citations

Control of C. elegans Larval Development by Neuronal Expression of a TGF-β Homolog

1996 • 516 citations

Interacting genes in nematode dauer larva formation

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Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage

1997 • 504 citations

TGF-β-stimulated cooperation of Smad proteins with the coactivators CBP/p300

1998 • 503 citations

cul-1 Is Required for Cell Cycle Exit in C. elegans and Identifies a Novel Gene Family

1996 • 448 citations

Daughters against dpp modulates dpp organizing activity in Drosophila wing development

1997 • 426 citations

A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways

1994 • 417 citations

The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development

1993 • 368 citations

A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway.

1996 • 351 citations

Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-beta.

1994 • 324 citations

The riddle of MAP kinase signaling specificity

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daf-1, a C. elegans gene controlling dauer larva development, encodes a novel receptor protein kinase

1990 • 293 citations

The Drosophila dorsal-ventral patterning gene tolloid is related to human bone morphogenetic protein 1

1991 • 292 citations

The decapentaplegic gene is required for dorsal-ventral patterning of the Drosophila embryo.

1987 • 288 citations

A Drosophila growth factor homolog, decapentaplegic, regulates homeotic gene expression within and across germ layers during midgut morphogenesis

1990 • 251 citations

A BMP homolog acts as a dose-dependent regulator of body size and male tail patterning inCaenorhabditis elegans

1999 • 242 citations

Pioneer Axon Guidance by UNC-129, a C. elegans TGF-β

1998 • 229 citations

Heteromeric and Homomeric Interactions Correlate with Signaling Activity and Functional Cooperativity of Smad3 and Smad4/DPC4

1997 • 207 citations

The screw gene encodes a ubiquitously expressed member of the TGF-beta family required for specification of dorsal cell fates in the Drosophila embryo.

1994 • 199 citations

The DAF-3 Smad protein antagonizes TGF-β-related receptor signaling in the Caenorhabditis elegansdauer pathway

1997 • 197 citations

Mads and Smads in TGFβ signalling

1998 • 194 citations

Receptors for Transforming Growth Factor-β

1993 • 181 citations

Complementation between kinase-defective and activation-defective TGF-beta receptors reveals a novel form of receptor cooperativity essential for signaling.

1996 • 158 citations

TGF-β/BMP superfamily members, Gbb-60A and Dpp, cooperate to provide pattern information and establish cell identity in the Drosophila wing

1998 • 156 citations

Control of cell fate in the tail region of C. elegans by the gene egl-5

1991 • 136 citations

The Drosophila saxophone Gene: a Serine-Threonine Kinase Receptor of the TGF-β Superfamily

1994 • 131 citations

Histochemical techniques for locating Escherichia coli β-galactosidase activity in transgenic organisms

1992 • 103 citations

TGF-β signaling, Smads, and tumor suppressors

1998 • 100 citations

Pattern formation in the nematode epidermis: determination of the arrangement of peripheral sense organs in the C. elegans male tail

1991 • 98 citations

Functional intertwining of Dpp and EGFR signaling during Drosophilaendoderm induction

1998 • 95 citations

HOM-C/Hox genes and four interacting loci determine the morphogenetic properties of single cells in the nematode male tail

1994 • 88 citations

Reconstitution and transphosphorylation of TGF-beta receptor complexes.

1994 • 81 citations

Mutational analysis of the Drosophila tolloid gene, a human BMP-1 homolog

1994 • 71 citations

Two Domains of the tolloid Protein Contribute to Its Unusual Genetic Interaction with decapentaplegic

1994 • 65 citations

A genetic screen for modifiers of Drosophila decapentaplegic signaling identifies mutations in punt, Mothers against dpp and the BMP-7 homologue, 60A

1998 • 62 citations

The expression of the C. elegans labial-like Hox gene ceh-13 during early embryogenesis relies on cell fate and on anteroposterior cell polarity

1997 • 42 citations

The Astacins: structure and function of a new protein family

1997 • 19 citations