The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.

1994 • 1,950 citations

Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse.

1995 • 1,782 citations

Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

1997 • 1,774 citations

The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling

1997 • 1,328 citations

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

1991 • 1,317 citations

Fibroblast Growth Factor Receptor 3 Is a Negative Regulator of Bone Growth

1996 • 1,062 citations

Smad6 inhibits signalling by the TGF-β superfamily

1997 • 1,026 citations

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

1996 • 899 citations

Receptor-associated Mad homologues synergize as effectors of the TGF-β response

1996 • 874 citations

TGFβ Signaling: Receptors, Transducers, and Mad Proteins

1996 • 840 citations

fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation.

1994 • 784 citations

Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis.

1995 • 784 citations

Murine FGFR-1 is required for early postimplantation growth and axial organization.

1994 • 748 citations

MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling

1996 • 740 citations

DPC4 gene in various tumor types.

1996 • 680 citations

A human Mad protein acting as a BMP-regulated transcriptional activator

1996 • 674 citations

The Tumor Suppressor Gene Brca1 Is Required for Embryonic Cellular Proliferation in the Mouse

1996 • 652 citations

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

1996 • 614 citations

Essential role of Mash-2 in extraembryonic development

1994 • 612 citations

The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.

1997 • 569 citations

A structural basis for mutational inactivation of the tumour suppressor Smad4

1997 • 459 citations

Xenopus Mad Proteins Transduce Distinct Subsets of Signals for the TGFβ Superfamily

1996 • 432 citations

Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4

1997 • 365 citations

Gastrulation in the mouse : Growth and regionalization of the epiblast

1977 • 340 citations

The murine H19 gene is activated during embryonic stem cell differentiation in vitro and at the time of implantation in the developing embryo

1991 • 312 citations

An absolute requirement for both the type II and type I receptors, punt and thick veins, for Dpp signaling in vivo

1995 • 312 citations

Drosophila Dpp signaling is mediated by the punt gene product: A dual ligand-binding type II receptor of the TGFβ receptor family

1995 • 275 citations

Somatic in vivo alterations of the DPC4 gene at 18q21 in human lung cancers.

1996 • 242 citations

Embryonic Expression of Lim-1, the Mouse Homolog of Xenopus XLim-1, Suggests a Role in Lateral Mesoderm Differentiation and Neurogenesis

1994 • 215 citations

The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation.

1997 • 202 citations

DPC4, a candidate tumor suppressor gene, is altered infrequently in head and neck squamous cell carcinoma.

1996 • 164 citations

Smad5 Induces Ventral Fates inXenopusEmbryo

1997 • 157 citations

Smad8 mediates the signaling of the receptor serine kinase

1997 • 155 citations

From receptor to nucleus: the Smad pathway

1997 • 110 citations

Onset of gastrulation, morphogenesis and somitogenesis in mouse embryos displaying compensatory growth

1993 • 97 citations

Infrequent DPC4 gene mutation in esophageal cancer, gastric cancer and ulcerative colitis-associated neoplasms.

1996 • 66 citations

Cloning and Characterization of a Novel Member of the Human Mad Gene Family (MADH6)

1997 • 53 citations

The Type II TGF- Receptor Signals Diverse Responses in Cooperation with the Type I Receptor

1992 • 32 citations

Sequence and chromosomal mapping of the mouse homolog (Madh4) of the human DPC4/MADH4 gene

1997 • 16 citations