Characterization and Cloning of a Receptor for BMP-2 and BMP-4 from NIH 3T3 Cells

A general method applicable to the search for similarities in the amino acid sequence of two proteins

1970 • 11,049 citations

The protein data bank: A computer-based archival file for macromolecular structures

1977 • 8,627 citations

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs

1987 • 5,139 citations

A new method for predicting signal sequence cleavage sites

1986 • 4,629 citations

Novel Regulators of Bone Formation: Molecular Clones and Activities

1988 • 3,919 citations

Recombinant human bone morphogenetic protein induces bone formation.

1990 • 1,538 citations

TGFβ signals through a heteromeric protein kinase receptor complex

1992 • 1,519 citations

SRα Promoter: an Efficient and Versatile Mammalian cDNA Expression System Composed of the Simian Virus 40 Early Promoter and the R-U5 Segment of Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat

1988 • 1,351 citations

Analysis of radioligand binding experiments

1985 • 1,247 citations

[2] Protein kinase catalytic domain sequence database: Identification of conserved features of primary structure and classification of family members

1991 • 1,225 citations

Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase

1992 • 1,071 citations

Crystal structure of cyclin-dependent kinase 2

1993 • 946 citations

Biostatistics -- An Introductory Text

1965 • 830 citations

Biochemical Sequences in the Transformation of Normal Fibroblasts in Adolescent Rats

1972 • 815 citations

Cloning of a TGF$beta; type I receptor that forms a heteromeric complex with the TGF$beta; type II receptor

1993 • 779 citations

Expression cloning of an activin receptor, a predicted transmembrane serine kinase

1991 • 760 citations

Molecular cloning of a putative receptor protein kinase gene encoded at the self-incompatibility locus of Brassica oleracea.

1991 • 757 citations

The bone morphogenetic protein family and osteogenesis

1992 • 686 citations

Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro.

1992 • 680 citations

Identification of human activin and TGFβ type I receptors that form heteromeric kinase complexes with type II receptors

1993 • 656 citations

SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat.

1988 • 638 citations

Receptors for the TGF-β family

1992 • 638 citations

Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with magnesium-ATP and peptide inhibitor

1993 • 593 citations

Characterization of Type I Receptors for Transforming Growth Factor-β and Activin

1994 • 558 citations

Novel activin receptors: Distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors

1992 • 495 citations

Characterization of a membrane receptor for transforming growth factor-beta in normal rat kidney fibroblasts.

1984 • 477 citations

Crystal Structure of Transforming Growth Factor-β2: an Unusual Fold for the Superfamily

1992 • 446 citations

The alphas, betas, and kinases of cytokine receptor complexes

1993 • 418 citations

Cloning of a Type I TGF-β Receptor and Its Effect on TGF-β Binding to the Type II Receptor

1993 • 401 citations

Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin.

1994 • 377 citations

The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development

1993 • 368 citations

Relationship of a putative receptor protein kinase from maize to the S-locus glycoproteins of Brassica

1990 • 359 citations

Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity.

1993 • 354 citations

Transforming growth factor β type 1 binds to collagen IV of basement membrane matrix: Implications for development

1991 • 350 citations

Structural Framework for the Protein Kinase Family

1992 • 333 citations

Bone Morphogenetic Proteins

1989 • 326 citations

Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-beta.

1994 • 324 citations

Control of cell pattern in the neural tube: Regulation of cell differentiation by dorsalin-1, a novel TGFβ family member

1993 • 320 citations

A Transforming Growth Factor β Type I Receptor that Signals to Activate Gene Expression

1994 • 296 citations

daf-1, a C. elegans gene controlling dauer larva development, encodes a novel receptor protein kinase

1990 • 293 citations

A novel member of the transmembrane serine/threonine kinase receptor family is specifically expressed in the gonads and in mesenchymal cells adjacent to the müllerian duct

1994 • 290 citations

Determination of Type I Receptor Specificity by the Type II Receptors for TGF-β or Activin

1993 • 261 citations

5462925 Transforming growth factor beta2,3

1996 • 255 citations

Osteogenin and recombinant bone morphogenetic protein 2B are chemotactic for human monocytes and stimulate transforming growth factor beta 1 mRNA expression.

1992 • 240 citations

Effect of gamma rays at the dihydrofolate reductase locus: Deletions and inversions

1986 • 233 citations

The complete coding sequence of the human raf oncogene and the corresponding structure of the c-raf-1 gene

1986 • 225 citations

Transforming growth factor-beta and remodeling of bone.

1991 • 216 citations

Growth inhibition by transforming growth factor beta (TGF-beta) type I is restored in TGF-beta-resistant hepatoma cells after expression of TGF-beta receptor type II cDNA.

1993 • 192 citations

Nonreceptor tyrosine protein kinases.

1993 • 183 citations

Receptor‐like protein kinase genes of Arabidopsis thaliana

1993 • 182 citations

The myoglobin protein radical. Coupling of Tyr-103 to Tyr-151 in the H2O2-mediated cross-linking of sperm whale myoglobin.

1988 • 180 citations

Bone-Inducing Activity of Mature BMP-2b Produced from a Hybrid BMP-2a/2b Precursor

1991 • 172 citations

Developmental expression of four novel serine/threonine kinase receptors homologous to the activin/transforming growth factor‐β type II receptor family

1993 • 164 citations

Recombinant human bone morphogenetic protein 2B stimulates PC12 cell differentiation: potentiation and binding to type IV collagen.

1992 • 162 citations

Two distinct transmembrane serine/threonine kinases from Drosophila melanogaster form an activin receptor complex.

1994 • 153 citations

[17] Identification of receptor for type-β transforming growth factor

1987 • 134 citations

Erks: their fifteen minutes has arrived.

1992 • 133 citations

Recombinant Bone Morphogenetic Protein-4, Transforming Growth Factor-β1, and Activin A Enhance the Cartilage Phenotype of Articular Chondrocytes in Vitro

1994 • 132 citations

Proliferation of both somatic and germ cells is affected in the Drosophila mutants of raf proto-oncogene.

1988 • 131 citations

Cloning and characterization of a transmembrane serine kinase that acts as an activin type I receptor.

1993 • 125 citations

Flexible protein sequence patterns

1990 • 120 citations

Identification of a Drosophila activin receptor.

1993 • 114 citations

Five novel avian Eph-related tyrosine kinases are differentially expressed.

1993 • 112 citations

Sequence, biochemical characterization, and developmental expression of a new member of the TGF-β superfamily in Drosophila melanogaster

1992 • 111 citations

An Arabidopsis thaliana Gene with Sequence Similarity to the S-Locus Receptor Kinase of Brassica oleracea : Sequence and Expression

1992 • 97 citations

A widely expressed transmembrane serine/threonine kinase that does not bind activin, inhibin, transforming growth factor beta, or bone morphogenic factor

1993 • 91 citations

Molecular Characterization of Rat Transforming Growth Factor-β Type II Receptor

1993 • 74 citations

Identification and characterization of cellular binding proteins (receptors) for recombinant human bone morphogenetic protein 2B, an initiator of bone differentiation cascade.

1991 • 63 citations

Expression and amplification of engineered mouse dihydrofolate reductase minigenes.

1983 • 51 citations

Identification of a soluble receptor for platelet-derived growth factor in cell-conditioned medium and human plasma

1993 • 49 citations

Probing structure and function of the raf protein kinase domain with monoclonal antibodies.

1990 • 35 citations

Genomic structure and cloned cDNAs predict that four variants in the kinase domain of serine/threonine kinase receptors arise by alternative splicing and poly(A) addition.

1994 • 35 citations

A Mouse TGFβType I Receptor That Requires Type II Receptor for Ligand Binding

1994 • 34 citations

Effect of protein and steroidal osteotropic agents on differentiation and epidermal growth factor‐mediated growth of the CFK1 osseous cell line

1992 • 29 citations

Structure of the mouse activin receptor type II gene

1992 • 29 citations

A new receptor protein kinase from chick embryo related to type II receptor for TGF-β

1993 • 17 citations

Identification of a receptor for human müllerian inhibiting substance.

1993 • 12 citations

Characteristics of binding of human seminal alpha-inhibin-92 to human pituitary membranes.

1987 • 4 citations