Natural Substrates of the Proteasome and Their Recognition by the Ubiquitin System

THE UBIQUITIN SYSTEM

1998 • 8,360 citations

Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity

2000 • 4,644 citations

Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis

1986 • 2,566 citations

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1993 • 2,329 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

Functional and Genomic Analyses Reveal an Essential Coordination between the Unfolded Protein Response and ER-Associated Degradation

2000 • 1,939 citations

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1997 • 1,906 citations

Recognition of the polyubiquitin proteolytic signal

2000 • 1,651 citations

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

1999 • 1,521 citations

The ancient regulatory-protein family of WD-repeat proteins

1994 • 1,478 citations

A Multiubiquitin Chain Is Confined to Specific Lysine in a Targeted Short-Lived Protein

1989 • 1,463 citations

SCF and Cullin/RING H2-Based Ubiquitin Ligases

1999 • 1,249 citations

The leucine-rich repeat: a versatile binding motif

1994 • 1,209 citations

F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex

1997 • 1,208 citations

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

1999 • 1,134 citations

Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown.

1983 • 1,105 citations

Signal transduction through NF-κB

1998 • 1,103 citations

The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase

1999 • 1,045 citations

A Novel Ubiquitination Factor, E4, Is Involved in Multiubiquitin Chain Assembly

1999 • 1,031 citations

Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53

2000 • 1,026 citations

Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein

2000 • 1,018 citations

Ubiquitin Ligase Activity and Tyrosine Phosphorylation Underlie Suppression of Growth Factor Signaling by c-Cbl/Sli-1

1999 • 1,000 citations

Ubiquitin Protein Ligase Activity of IAPs and Their Degradation in Proteasomes in Response to Apoptotic Stimuli

2000 • 989 citations

Protein ubiquitination involving an E1–E2–E3 enzyme ubiquitin thioester cascade

1995 • 960 citations

Ubiquitin-dependent c-Jun degradation in vivo is mediated by the δ domain

1994 • 930 citations

The SCFbeta -TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in Ikappa Balpha and beta -catenin and stimulates Ikappa Balpha ubiquitination in vitro

1999 • 914 citations

A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18.

1991 • 872 citations

Ubiquitin, proteasomes, and the regulation of intracellular protein degradation

1995 • 862 citations

The N-end rule: functions, mysteries, uses.

1996 • 859 citations

Structure of the VHL-ElonginC-ElonginB Complex: Implications for VHL Tumor Suppressor Function

1999 • 834 citations

WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome.

1996 • 828 citations

Noncanonical MMS2-Encoded Ubiquitin-Conjugating Enzyme Functions in Assembly of Novel Polyubiquitin Chains for DNA Repair

1999 • 814 citations

CDC20 and CDH1 : A Family of Substrate-Specific Activators of APC-Dependent Proteolysis

1997 • 809 citations

A Complex of Cdc4p, Skp1p, and Cdc53p/Cullin Catalyzes Ubiquitination of the Phosphorylated CDK Inhibitor Sic1p

1997 • 806 citations

A Proteolytic Pathway That Recognizes Ubiquitin as a Degradation Signal

1995 • 804 citations

p27Kip1 ubiquitination and degradation is regulated by the SCFSkp2 complex through phosphorylated Thr187 in p27

1999 • 787 citations

Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination

1992 • 780 citations

Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p.

1996 • 777 citations

Rbx1, a Component of the VHL Tumor Suppressor Complex and SCF Ubiquitin Ligase

1999 • 771 citations

A 26 S protease subunit that binds ubiquitin conjugates.

1994 • 759 citations

The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.

1995 • 745 citations

The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1

2000 • 713 citations

BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression

1998 • 688 citations

A Novel Human WD Protein, h-βTrCP, that Interacts with HIV-1 Vpu Connects CD4 to the ER Degradation Pathway through an F-Box Motif

1998 • 656 citations

Identification of the receptor component of the IκBα–ubiquitin ligase

1998 • 648 citations

Does this have a familiar RING?

1996 • 632 citations

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

1998 • 596 citations

Regulation of ubiquitin‐dependent processes by deubiquitinating enzymes

1997 • 576 citations

Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein.

1996 • 571 citations

Genes involved in sister chromatid separation are needed for b-type cyclin proteolysis in budding yeast

1995 • 561 citations

Activation of a Membrane-Bound Transcription Factor by Regulated Ubiquitin/Proteasome-Dependent Processing

2000 • 561 citations

Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation

1997 • 556 citations

A Ubiquitin Mutant with Specific Defects in DNA Repair and Multiubiquitination

1995 • 547 citations

Structure of an E6AP-UbcH7 Complex: Insights into Ubiquitination by the E2-E3 Enzyme Cascade

1999 • 539 citations

ER Quality Control: The Cytoplasmic Connection

1997 • 528 citations

Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85

1984 • 522 citations

Control of Cyclin Ubiquitination by CDK-Regulated Binding of Hct1 to the Anaphase Promoting Complex

1998 • 521 citations

Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins.

1990 • 520 citations

Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis

1998 • 512 citations

Ubiquitination: RING for destruction?

2000 • 496 citations

The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae

1998 • 488 citations

Direct Binding of CDC20 Protein Family Members Activates the Anaphase-Promoting Complex in Mitosis and G1

1998 • 484 citations

Yeast Hct1 Is a Regulator of Clb2 Cyclin Proteolysis

1997 • 479 citations

The Ubiquitin-related BAG-1 Provides a Link between the Molecular Chaperones Hsc70/Hsp70 and the Proteasome

2000 • 478 citations

The RING finger domain: a recent example of a sequence—structure family

1996 • 464 citations

A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matα2 repressor degradation

2001 • 463 citations

Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation

2000 • 462 citations

Gettin’ down with ubiquitin: turning off cell-surface receptors, transporters and channels

1999 • 461 citations

The Ubiquitin-Proteasome Pathway and Pathogenesis of Human Diseases

1999 • 459 citations

A regulatory link between ER-associated protein degradation and the unfolded-protein response.

2000 • 459 citations

ROC1, a Homolog of APC11, Represents a Family of Cullin Partners with an Associated Ubiquitin Ligase Activity

1999 • 457 citations

Rad23 links DNA repair to the ubiquitin/proteasome pathway

1998 • 452 citations

The TPR snap helix: a novel protein repeat motif from mitosis to transcription

1991 • 452 citations

Substrate Targeting in the Ubiquitin System

1999 • 447 citations

A complex of mammalian Ufd1 and Npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways

2000 • 438 citations

The Yeast Cell Cycle Gene CDC34 Encodes a Ubiquitin-Conjugating Enzyme

1988 • 435 citations

Disjunction of Homologous Chromosomes in Meiosis I Depends on Proteolytic Cleavage of the Meiotic Cohesin Rec8 by Separin

2000 • 425 citations

Two RING finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair

2000 • 425 citations

Signal-induced ubiquitination of Ikappa Balpha by the F-box protein Slimb/beta -TrCP

1999 • 424 citations

Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34

1999 • 406 citations

Ubiquitin Lys63 is involved in ubiquitination of a yeast plasma membrane protein

1997 • 398 citations

Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MATα2 repressor

1993 • 397 citations

The Multiubiquitin-Chain-Binding Protein Mcb1 Is a Component of the 26S Proteasome in Saccharomyces cerevisiae and Plays a Nonessential, Substrate-Specific Role in Protein Turnover

1996 • 393 citations

The recognition component of the N-end rule pathway.

1990 • 388 citations

Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells

1999 • 388 citations

Reconstitution of G ₁ Cyclin Ubiquitination with Complexes Containing SCF ^Grr1 and Rbx1

1999 • 385 citations

β-Trcp couples β-catenin phosphorylation-degradation and regulates Xenopus axis formation

1999 • 385 citations

Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase

2000 • 378 citations

At the heart of the budding yeast cell cycle

1996 • 367 citations

Targeting of substrates to the 26S proteasome

1997 • 362 citations

A novel protein modification pathway related to the ubiquitin system

1998 • 361 citations

Nedd8 Modification of Cul-1 Activates SCF^βTrCP-Dependent Ubiquitination of IκBα

2000 • 359 citations

Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome

1999 • 358 citations

The N‐end rule pathway of protein degradation

1997 • 354 citations

Inhibition of proteolysis and cell cycle progression in a multiubiquitination-deficient yeast mutant.

1994 • 347 citations

APCCdc20 promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5

1999 • 346 citations

Mass Spectrometric Analysis of the Anaphase-Promoting Complex from Yeast: Identification of a Subunit Related to Cullins

1998 • 330 citations

Ligand-induced Ubiquitination of the Epidermal Growth Factor Receptor Involves the Interaction of the c-Cbl RING Finger and UbcH7

1999 • 328 citations

The mechanism of ubiquitin activating enzyme. A kinetic and equilibrium analysis.

1982 • 324 citations

Interaction between ubiquitin–protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation

1999 • 317 citations

Involvement of Valosin-containing Protein, an ATPase Co-purified with IκBα and 26 S Proteasome, in Ubiquitin-Proteasome-mediated Degradation of IκBα

1998 • 317 citations

Modification of yeast Cdc53p by the ubiquitin-related protein Rub1p affects function of the SCFCdc4 complex

1998 • 317 citations

"Covalent affinity" purification of ubiquitin-activating enzyme.

1982 • 310 citations

Pathways of ubiquitin conjugation

1997 • 309 citations

Proteolysis and the cell cycle: with this RING I do thee destroy

2000 • 308 citations

Covalent modification of all members of human cullin family proteins by NEDD8

1999 • 295 citations

p34^Cdc28-Mediated Control of Cln3 Cyclin Degradation

1995 • 293 citations

Structure and function of the WW domain

1996 • 290 citations

The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast

1997 • 287 citations

Degradation of a cohesin subunit by the N-end rule pathway is essential for chromosome stability

2001 • 284 citations

The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme.

1991 • 268 citations

Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism

1999 • 265 citations

Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box protein complexes that regulate cell division and methionine biosynthesis in yeast

1998 • 263 citations

Identification of Subunits of the Anaphase-Promoting Complex of Saccharomyces cerevisiae

1996 • 263 citations

Resistance to cadmium mediated by ubiquitin-dependent proteolysis

1993 • 261 citations

Cdc48p interacts with Ufd3p, a WD repeat protein required for ubiquitin-mediated proteolysis in Saccharomyces cerevisiae.

1996 • 261 citations

Interaction of hHR23 with S5a

1999 • 261 citations

Modes of regulation of ubiquitin-mediated protein degradation

2000 • 259 citations

Ubiquitination and Degradation of the Substrate Recognition Subunits of SCF Ubiquitin–Protein Ligases

1998 • 259 citations

INTRACELLULAR SIGNALING FROM THE ENDOPLASMIC RETICULUM TO THE NUCLEUS

1998 • 258 citations

Endoplasmic reticulum degradation: reverse protein flow of no return

1997 • 256 citations

In Vitro Assembly and Recognition of Lys-63 Polyubiquitin Chains

2001 • 253 citations

A Giant Ubiquitin-conjugating Enzyme Related to IAP Apoptosis Inhibitors

1998 • 248 citations

A Nedd8 conjugation pathway is essential for proteolytic targeting of p27 ^Kip1 by ubiquitination

2000 • 245 citations

APC-Mediated Proteolysis of Ase1 and the Morphogenesis of the Mitotic Spindle

1997 • 243 citations

Surface hydrophobic residues of multiubiquitin chains essential for proteolytic targeting.

1996 • 240 citations

Components of a system that ligates cyclin to ubiquitin and their regulation by the protein kinase cdc2.

1994 • 235 citations

Effect of heat shock on protein degradation in mammalian cells: involvement of the ubiquitin system.

1987 • 235 citations

The regulation of Cdc20 proteolysis reveals a role for the APC components Cdc23 and Cdc27 during S phase and early mitosis

1998 • 235 citations

Siah-1 N-Terminal RING Domain Is Required for Proteolysis Function, and C-Terminal Sequences Regulate Oligomerization and Binding to Target Proteins

1999 • 234 citations

PHYL Acts to Down-Regulate TTK88, a Transcriptional Repressor of Neuronal Cell Fates, by a SINA-Dependent Mechanism

1997 • 233 citations

Germ-line mutations in the von Hippel-Lindau tumor-suppressor gene are similar to somatic von Hippel-Lindau aberrations in sporadic renal cell carcinoma.

1994 • 232 citations

Inhibition of the 26 S Proteasome by Polyubiquitin Chains Synthesized to Have Defined Lengths

1997 • 229 citations

Rapid Degradation of the G ₁ Cyclin Cln2 Induced by CDK-Dependent Phosphorylation

1996 • 227 citations

Degradation signals for ubiquitin system proteolysis in Saccharomyces cerevisiae

1998 • 224 citations

Novel Multiubiquitin Chain Linkages Catalyzed by the Conjugating Enzymes E2EPF and RAD6 Are Recognized by 26 S Proteasome Subunit 5

1996 • 221 citations

Photoreceptor Cell Differentiation Requires Regulated Proteolysis of the Transcriptional Repressor Tramtrack

1997 • 219 citations

A Human IAP-Family Gene, Apollon, Expressed in Human Brain Cancer Cells

1999 • 217 citations

Phosphorylation- and ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor Far1p in budding yeast

1997 • 207 citations

Role of the proteasome in membrane extraction of a short-lived ER-transmembrane protein

1998 • 206 citations

The large subunit of RNA polymerase II is a substrate of the Rsp5 ubiquitin-protein ligase

1997 • 206 citations

The 19S Regulatory Complex of the Proteasome Functions Independently of Proteolysis in Nucleotide Excision Repair

1999 • 203 citations

p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1

1998 • 203 citations

Degradation Signal Masking by Heterodimerization of MATα2 and MATa1 Blocks Their Mutual Destruction by the Ubiquitin-Proteasome Pathway

1998 • 201 citations

Nedd4-like proteins: an emerging family of ubiquitin-protein ligases implicated in diverse cellular functions

1999 • 199 citations

The C2 Domain of the Ubiquitin Protein Ligase Nedd4 Mediates Ca2+-dependent Plasma Membrane Localization

1997 • 199 citations

Identification of HHR23A as a Substrate for E6-associated Protein-mediated Ubiquitination

1999 • 198 citations

Reconstitution of the KRAB-KAP-1 repressor complex: a model system for defining the molecular anatomy of RING-B box-coiled-coil domain-mediated protein-protein interactions

2000 • 196 citations

A Glycine-Rich Region in NF-κB p105 Functions as a Processing Signal for the Generation of the p50 Subunit

1996 • 196 citations

Mammalian homologs of seven in absentia regulate DCC via the ubiquitin–proteasome pathway

1997 • 189 citations

The DNA repair protein Rad23 is a negative regulator of multi-ubiquitin chain assembly

2000 • 184 citations

E3-Ubiquitin Ligase/E6-AP Links Multicopy Maintenance Protein 7 to the Ubiquitination Pathway by a Novel Motif, the L2G Box

1998 • 180 citations

Physical association of ubiquitin ligases and the 26S proteasome

2000 • 178 citations

A Role for Ubiquitination in Mitochondrial Inheritance in Saccharomyces cerevisiae

1999 • 177 citations

The mouse and human genes encoding the recognition component of the N-end rule pathway

1998 • 175 citations

Functional Domains of the Rsp5 Ubiquitin-Protein Ligase

1999 • 174 citations

A Chinese hamster cell cycle mutant arrested at G2 phase has a temperature-sensitive ubiquitin-activating enzyme, E1.

1988 • 173 citations

Characterization of Human hect Domain Family Members and Their Interaction with UbcH5 and UbcH7

1998 • 172 citations

Suppressor of Cytokine Signaling-1 Inhibits VAV Function through Protein Degradation

2000 • 168 citations

Control of Enzyme Levels in Mammalian Tissues

1973 • 166 citations

Feedback-regulated degradation of the transcriptional activator Met4 is triggered by the SCFMet30 complex

2000 • 164 citations

11 Mating-type Determination and Mating-type Interconversion in Saccharomyces cerevisiae

1992 • 162 citations

UBC1 encodes a novel member of an essential subfamily of yeast ubiquitin-conjugating enzymes involved in protein degradation.

1990 • 160 citations

The Anaphase-Promoting Complex: New Subunits and Regulators

1999 • 160 citations

The E2-E3 interaction in the N-end rule pathway: the RING-H2 finger of E3 is required for the synthesis of multiubiquitin chain

1999 • 160 citations

The Conserved Npl4 Protein Complex Mediates Proteasome-dependent Membrane-bound Transcription Factor Activation

2001 • 157 citations

Pleiotropic Defects Caused by Loss of the Proteasome-Interacting Factors Rad23 and Rpn10 of Saccharomyces cerevisiae

1999 • 155 citations

Degradation of G alpha by the N-end rule pathway

1994 • 154 citations

Fission yeast WD-repeat protein pop1 regulates genome ploidy through ubiquitin-proteasome-mediated degradation of the CDK inhibitor Rum1 and the S-phase initiator Cdc18.

1997 • 152 citations

Cloning of Human Ubiquitin-conjugating Enzymes UbcH6 and UbcH7 (E2-F1) and Characterization of Their Interaction with E6-AP and RSP5

1996 • 151 citations

Structure of Tetraubiquitin Shows How Multiubiquitin Chains Can Be Formed

1994 • 151 citations

MUF1, A Novel Elongin BC-interacting Leucine-rich Repeat Protein That Can Assemble with Cul5 and Rbx1 to Reconstitute a Ubiquitin Ligase

2001 • 150 citations

RGS4 Is Arginylated and Degraded by the N-end Rule Pathway in Vitro

2000 • 150 citations

Cis-trans recognition and subunit-specific degradation of short-lived proteins

1990 • 150 citations

Ubiquitinylation Is Not an Absolute Requirement for Degradation of c-Jun Protein by the 26 S Proteasome

1995 • 150 citations

Physical Interaction between Specific E2 and Hect E3 Enzymes Determines Functional Cooperativity

1997 • 150 citations

In vivo function of the proteasome in the ubiquitin pathway.

1992 • 144 citations

Specificity of binding of NH2-terminal residue of proteins to ubiquitin-protein ligase. Use of amino acid derivatives to characterize specific binding sites.

1988 • 144 citations

Role of UEV-1, an Inactive Variant of the E2 UbiquitinConjugating Enzymes, in In Vitro Differentiation and Cell Cycle Behavior of HT-29-M6 Intestinal Mucosecretory Cells

1998 • 143 citations

E2-C, a cyclin-selective ubiquitin carrier protein required for the destruction of mitotic cyclins.

1996 • 141 citations

Cdc34 and the F-box protein Met30 are required for degradation of the Cdk-inhibitory kinase Swe1

1998 • 140 citations

Modification of Cullin-1 by Ubiquitin-like Protein Nedd8 Enhances the Activity of SCFskp2 toward p27kip1

2000 • 134 citations

The N-end rule pathway controls the import of peptides through degradation of a transcriptional repressor

1998 • 126 citations

Degradation of the Transcription Factor Gcn4 Requires the Kinase Pho85 and the SCF^CDC4Ubiquitin–Ligase Complex

2000 • 126 citations

All Three WW Domains of Murine Nedd4 Are Involved in the Regulation of Epithelial Sodium Channels by Intracellular Na+

1999 • 123 citations

The ubiquitin‐protein ligase E6‐associated protein (E6‐AP) serves as its own substrate

1998 • 122 citations

Herpes Simplex Virus Type 1 Immediate-Early Protein Vmw110 Inhibits Progression of Cells through Mitosis and from G ₁ into S Phase of the Cell Cycle

1999 • 122 citations

Subunits and Substrates of the Anaphase-Promoting Complex

1999 • 119 citations

PRT1 of Arabidopsis thaliana encodes a component of the plant N-end rule pathway

1998 • 119 citations

The Ubiquitin-conjugating Enzymes UbcH7 and UbcH8 Interact with RING Finger/IBR Motif-containing Domains of HHARI and H7-AP1

1999 • 114 citations

Pub1 acts as an E6-AP-like protein ubiquitiin ligase in the degradation of cdc25.

1996 • 110 citations

G₁ Cyclin Degradation: the PEST Motif of Yeast Cln2 Is Necessary, but Not Sufficient, for Rapid Protein Turnover

1994 • 108 citations

Domains Required for Dimerization of Yeast Rad6 Ubiquitin-Conjugating Enzyme and Rad18 DNA Binding Protein

1997 • 108 citations

HRDGene Dependence of Endoplasmic Reticulum-associated Degradation

2000 • 106 citations

Evidence for an Interaction between Ubiquitin-Conjugating Enzymes and the 26S Proteasome

2000 • 106 citations

Bul1, a New Protein That Binds to the Rsp5 Ubiquitin Ligase in Saccharomyces cerevisiae

1996 • 106 citations

A Zinc-binding Domain Involved in the Dimerization of RAG1

1996 • 100 citations

The Ligation Systems for Ubiquitin and Ubiquitin-like Proteins

1998 • 97 citations

Degradation of Ornithine Decarboxylase by the 26S Proteasome

2000 • 93 citations

Cell Cycle Regulation of DNA Replication Initiator Factor Dbf4p

1999 • 92 citations

Identification of a Novel Family of Ubiquitin-conjugating Enzymes with Distinct Amino-terminal Extensions

1996 • 91 citations

A family of ubiquitin‐like proteins binds the ATPase domain of Hsp70‐like Stch

2000 • 91 citations

Identification of homer as a homologue of the Wiskott-Aldrich Syndrome protein suggests a receptor-binding function for WH1 domains

1997 • 89 citations

The breast cancer gene product TSG101: a regulator of ubiquitination?

1997 • 89 citations

A Novel Yeast Screen for Mitotic Arrest Mutants IdentifiesDOC1, a New Gene Involved in Cyclin Proteolysis

1997 • 85 citations

The Cancer-predisposing Mutation C61G Disrupts Homodimer Formation in the NH2-terminal BRCA1 RING Finger Domain

1998 • 84 citations

Rsp5 WW Domains Interact Directly with the Carboxyl-terminal Domain of RNA Polymerase II

2000 • 82 citations

E2/E3-mediated Assembly of Lysine 29-linked Polyubiquitin Chains

1999 • 79 citations

G1 cyclin degradation: the PEST motif of yeast Cln2 is necessary, but not sufficient, for rapid protein turnover.

1994 • 74 citations

Synthetic Signals for Ubiquitin-Dependent Proteolysis

1995 • 65 citations

A ubiquitin-protein ligase specific for type III protein substrates.

1990 • 62 citations

Mechanism of Ubiquitin Conjugating Enzyme E2-230K: Catalysis Involving a Thiol Relay?

1996 • 59 citations

The PY-motif of Bul1 protein is essential for growth of Saccharomyces cerevisiae under various stress conditions

1998 • 58 citations

A RING‐H2 finger motif is essential for the function of Der3/Hrd1 in endoplasmic reticulum associated protein degradation in the yeast Saccharomyces cerevisiae

1999 • 57 citations

Are there multiple proteolytic pathways contributing to c-Fos, c-Jun and p53 protein degradation in vivo?

1999 • 57 citations

The Abundance of Cell Cycle Regulatory Protein Cdc4p Is Controlled by Interactions between Its F Box and Skp1p

1999 • 52 citations

A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4¹

1999 • 50 citations

ATP-Dependent Inactivation and Sequestration of Ornithine Decarboxylase by the 26S Proteasome Are Prerequisites for Degradation

1999 • 47 citations

CROC-1 encodes a protein which mediates transcriptional activation of the human FOS promoter

1997 • 47 citations

Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast (vol 81, pg 269, 1995)

1998 • 39 citations

The N Terminus of Antizyme Promotes Degradation of Heterologous Proteins

1996 • 34 citations

In vitro ubiquitination of cyclin D1 by ROC1–CUL1 and ROC1–CUL3

2001 • 27 citations

The Yeast UBC4 Ubiquitin Conjugating Enzyme Monoubiquitinates Itself in Vivo: Evidence for an E2-E2 Homointeraction

1995 • 25 citations

Sequence elements that contribute to the degradation of yeast Gα

1998 • 21 citations

Role of the conserved carboxy‐terminal α‐helix of Rad6p in ubiquitination and DNA repair

1996 • 16 citations

Molecular Cloning of a 1α,25-Dihydroxyvitamin D3-Inducible Transcript (DDVit 1)1in Human Blood Monocytes

1997 • 13 citations

p75, a Polypeptide Component of Karyoskeletal Protein-Enriched Fractions Associated with Transcriptionally Active Loci of Drosophila melanogaster Polytene Chromosomes

1988 • 5 citations

Deleted Work

1955 • 0 citations