Nedd4-like proteins: an emerging family of ubiquitin-protein ligases implicated in diverse cellular functions

THE UBIQUITIN SYSTEM

1998 • 8,360 citations

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1993 • 2,329 citations

Liddle's syndrome: Heritable human hypertension caused by mutations in the β subunit of the epithelial sodium channel

1994 • 1,238 citations

Protein ubiquitination involving an E1–E2–E3 enzyme ubiquitin thioester cascade

1995 • 960 citations

WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome.

1996 • 828 citations

Cloning and expression of multiple protein kinase C cDNAs

1986 • 683 citations

Function of WW Domains as Phosphoserine- or Phosphothreonine-Binding Modules

1999 • 663 citations

Identification of a set of genes with developmentally down-regulated expression in the mouse brain

1992 • 537 citations

Gettin’ down with ubiquitin: turning off cell-surface receptors, transporters and channels

1999 • 461 citations

Ubiquitin Lys63 is involved in ubiquitination of a yeast plasma membrane protein

1997 • 398 citations

NPI1, an essential yeast gene involved in induced degradation of Gap1 and Fur4 permeases, encodes the Rsp5 ubiquitin—protein ligase

1995 • 331 citations

The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice

1998 • 328 citations

Ubiquitination Mediated by the Npi1p/Rsp5p Ubiquitin-protein Ligase Is Required for Endocytosis of the Yeast Uracil Permease

1996 • 316 citations

Structure and function of the WW domain

1996 • 290 citations

SPT3 interacts with TFIID to allow normal transcription in Saccharomyces cerevisiae.

1992 • 217 citations

Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains.

1996 • 213 citations

The large subunit of RNA polymerase II is a substrate of the Rsp5 ubiquitin-protein ligase

1997 • 206 citations

Inhibition of the Epithelial Na+ Channel by Interaction of Nedd4 with a PY Motif Deleted in Liddle's Syndrome

1998 • 178 citations

Functional Domains of the Rsp5 Ubiquitin-Protein Ligase

1999 • 174 citations

Atrophin-1, the DRPLA Gene Product, Interacts with Two Families of WW Domain-Containing Proteins

1998 • 165 citations

Identification of Novel Human WW Domain-containing Proteins by Cloning of Ligand Targets

1997 • 163 citations

Yeast RSP5 and Its Human Homolog hRPF1 Potentiate Hormone-Dependent Activation of Transcription by Human Progesterone and Glucocorticoid Receptors

1996 • 160 citations

cDNA Cloning, Expression Analysis, and Mapping of the MouseNedd4Gene

1997 • 142 citations

Nedd4 mediates control of an epithelial Na ⁺ channel in salivary duct cells by cytosolic Na ⁺

1998 • 140 citations

Pub1 acts as an E6-AP-like protein ubiquitiin ligase in the degradation of cdc25.

1996 • 110 citations

Bul1, a New Protein That Binds to the Rsp5 Ubiquitin Ligase in Saccharomyces cerevisiae

1996 • 106 citations

MDP1, a Saccharomyces cerevisiae Gene Involved in Mitochondrial/Cytoplasmic Protein Distribution, Is Identical to the Ubiquitin-Protein Ligase Gene RSP5

1997 • 70 citations

Caspase-mediated Cleavage of the Ubiquitin-protein Ligase Nedd4 during Apoptosis

1998 • 68 citations

Catabolite inactivation of the yeast maltose transporter requires ubiquitin-ligase npi1/rsp5 and ubiquitin-hydrolase npi2/doa4

2006 • 64 citations

Interaction of WW Domains with Hematopoietic Transcription Factor p45/NF-E2 and RNA Polymerase II

1997 • 62 citations

Tolerance of low pH in Schizosaccharomyces pombe requires a functioning pub1 ubiquitin ligase

1997 • 14 citations

A ubiquitin-protein ligase (E3) mutation of Saccharomyces cerevisiae suppressed by co-overexpression of two ubiquitin-specific processing proteases.

1996 • 12 citations