Endoplasmic reticulum degradation: reverse protein flow of no return

Identification of the Cystic Fibrosis Gene: Genetic Analysis

1989 • 4,105 citations

The ubiquitin-proteasome proteolytic pathway

1994 • 1,778 citations

Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis

1990 • 1,756 citations

UBIQUITIN-DEPENDENT PROTEIN DEGRADATION

1996 • 1,680 citations

Degradation of CFTR by the ubiquitin-proteasome pathway

1995 • 1,285 citations

Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

1996 • 1,101 citations

The Human Cytomegalovirus US11 Gene Product Dislocates MHC Class I Heavy Chains from the Endoplasmic Reticulum to the Cytosol

1996 • 1,083 citations

Multiple proteolytic systems, including the proteasome, contribute to CFTR processing

1995 • 885 citations

Ubiquitin, proteasomes, and the regulation of intracellular protein degradation

1995 • 862 citations

Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination

1992 • 780 citations

ER Degradation of a Misfolded Luminal Protein by the Cytosolic Ubiquitin-Proteasome Pathway

1996 • 704 citations

Protein degradation in the endoplasmic reticulum

1990 • 659 citations

Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein.

1996 • 571 citations

PROTEIN TRANSPORT ACROSS THE EUKARYOTIC ENDOPLASMIC RETICULUM AND BACTERIAL INNER MEMBRANES

1996 • 560 citations

Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation

1997 • 556 citations

Identification of the cystic fibrosis gene.

1990 • 509 citations

Degradation from the endoplasmic reticulum: Disposing of newly synthesized proteins

1988 • 488 citations

Proteasome-dependent endoplasmic reticulum-associated protein degradation: An unconventional route to a familiar fate

1996 • 451 citations

Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation

1997 • 412 citations

Assembly of ER-associated protein degradation in vitro: dependence on cytosol, calnexin, and ATP.

1996 • 400 citations

Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast.

1996 • 385 citations

Proteasomes: destruction as a programme

1996 • 373 citations

Degradation of a Mutant Secretory Protein, α1-Antitrypsin Z, in the Endoplasmic Reticulum Requires Proteasome Activity

1996 • 362 citations

Protein translocation mutants defective in the insertion of integral membrane proteins into the endoplasmic reticulum.

1992 • 352 citations

Inhibition of proteolysis and cell cycle progression in a multiubiquitination-deficient yeast mutant.

1994 • 347 citations

Secretory proteins move through the endoplasmic reticulum membrane via an aqueous, gated pore

1994 • 338 citations

A protein translocation defect linked to ubiquitin conjugation at the endoplasmic reticulum

1993 • 326 citations

Misfolded major histocompatibility complex class I heavy chains are translocated into the cytoplasm and degraded by the proteasome

1997 • 295 citations

The Aqueous Pore through the Translocon Has a Diameter of 40–60 Å during Cotranslational Protein Translocation at the ER Membrane

1997 • 279 citations

Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway.

1996 • 273 citations

Aberrant retention of tyrosinase in the endoplasmic reticulum mediates accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of amelanotic melanoma cells

1997 • 255 citations

Pre-Golgi degradation of newly synthesized T-cell antigen receptor chains: intrinsic sensitivity and the role of subunit assembly.

1989 • 228 citations

Analysis of two mutated vacuolar proteins reveals a degradation pathway in the endoplasmic reticulum or a related compartment of yeast

1993 • 205 citations

The Human Immunodeficiency Virus Type 1 (HIV-1) Vpu Protein Interferes with an Early Step in the Biosynthesis of Major Histocompatibility Complex (MHC) Class I Molecules

1997 • 193 citations

Interaction of BiP with newly synthesized immunoglobulin light chain molecules: cycles of sequential binding and release.

1992 • 187 citations

The modification and assembly of proteins in the endoplasmic reticulum

1993 • 156 citations

Intracellular degradation of unassembled asialoglycoprotein receptor subunits: a pre-Golgi, nonlysosomal endoproteolytic cleavage.

1989 • 146 citations

Selective degradation of T cell antigen receptor chains retained in a pre-Golgi compartment.

1988 • 139 citations

N-glycosylation affects endoplasmic reticulum degradation of a mutated derivative of carboxypeptidase yscY in yeast

1996 • 139 citations

Soluble aggregates of the human PiZ alpha 1-antitrypsin variant are degraded within the endoplasmic reticulum by a mechanism sensitive to inhibitors of protein synthesis.

1992 • 123 citations

Signal Sequence Processing in Rough Microsomes

1995 • 111 citations

AUT1, a gene essential for autophagocytosis in the yeast Saccharomyces cerevisiae

1997 • 97 citations

Bidirectional movement of a nascent polypeptide across microsomal membranes reveals requirements for vectorial translocation of proteins

1992 • 93 citations

Proteinase C (carboxypeptidase Y) mutant of yeast

1975 • 91 citations

Distinct processes mediate glycoprotein and glycopeptide export from the endoplasmic reticulum in Saccharomyces cerevisiae.

1992 • 52 citations

Autophosphorylation of 70 kDa heat shock proteins.

1992 • 37 citations