The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.

Checkpoints: Controls That Ensure the Order of Cell Cycle Events

1989 • 3,036 citations

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1993 • 2,329 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

Cyclin: A protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division

1983 • 1,506 citations

THE UBIQUITIN SYSTEM FOR PROTEIN DEGRADATION

1992 • 1,402 citations

Cyclin synthesis drives the early embryonic cell cycle

1989 • 1,223 citations

The role of cyclin synthesis and degradation in the control of maturation promoting factor activity

1989 • 1,114 citations

Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown.

1983 • 1,105 citations

Ubiquitin-dependent c-Jun degradation in vivo is mediated by the δ domain

1994 • 930 citations

The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae

1994 • 902 citations

Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor

1993 • 569 citations

THE UBIQUITIN-CONJUGATION SYSTEM

1992 • 561 citations

The clam embryo protein cyclin A induces entry into M phase and the resumption of meiosis in Xenopus oocytes

1986 • 534 citations

Ubiquitination

1991 • 430 citations

The recognition component of the N-end rule pathway.

1990 • 388 citations

Degradation of nuclear oncoproteins by the ubiquitin system in vitro.

1991 • 345 citations

A cyclin B homolog in S. cerevisiae: Chronic activation of the Cdc28 protein kinase by cyclin prevents exit from mitosis

1991 • 310 citations

Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when expressed as a non-destructible mutant, causes mitotic arrest in HeLa cells

1992 • 298 citations

The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme.

1991 • 268 citations

Methylated ubiquitin inhibits cyclin degradation in clam embryo extracts.

1991 • 246 citations

The role of cyclin B in meiosis I.

1989 • 241 citations

The requirements for protein synthesis and degradation, and the control of destruction of cyclins A and B in the meiotic and mitotic cell cycles of the clam embryo.

1992 • 236 citations

Components of a system that ligates cyclin to ubiquitin and their regulation by the protein kinase cdc2.

1994 • 235 citations

Red light-induced formation of ubiquitin-phytochrome conjugates: Identification of possible intermediates of phytochrome degradation

1987 • 224 citations

Triggering of cyclin degradation in interphase extracts of amphibian eggs by cdc2 kinase

1990 • 222 citations

Both cyclin A delta 60 and B delta 97 are stable and arrest cells in M-phase, but only cyclin B delta 97 turns on cyclin destruction.

1991 • 196 citations

Ubiquitin-aldehyde: a general inhibitor of ubiquitin-recycling processes.

1987 • 189 citations

The protein substrate binding site of the ubiquitin-protein ligase system.

1986 • 178 citations

Specificity of binding of NH2-terminal residue of proteins to ubiquitin-protein ligase. Use of amino acid derivatives to characterize specific binding sites.

1988 • 144 citations

Control of programmed cyclin destruction in a cell-free system.

1989 • 138 citations

Detection, resolution and nomenclature of multiple ubiquitin carboxyl-terminal esterases from bovine calf thymus

1989 • 129 citations

Degradation of Mos by the N-terminal proline (Pro2)-dependent ubiquitin pathway on fertilization of Xenopus eggs: possible significance of natural selection for Pro2 in Mos.

1993 • 127 citations

Mechanism of ubiquitin carboxyl-terminal hydrolase. Borohydride and hydroxylamine inactivate in the presence of ubiquitin.

1986 • 102 citations

The Ubiquitin System for Protein Degradation

1992 • 97 citations

Affinity purification of ubiquitin-protein ligase on immobilized protein substrates. Evidence for the existence of separate NH2-terminal binding sites on a single enzyme.

1990 • 73 citations

Binding Sites of Ubiquitin-Protein Ligase

1989 • 70 citations

An okadaic acid-sensitive phosphatase negatively controls the cyclin degradation pathway in amphibian eggs.

1991 • 65 citations

A ubiquitin-protein ligase specific for type III protein substrates.

1990 • 62 citations

Mitotic arrest caused by the amino terminus of Xenopus cyclin B2.

1993 • 48 citations

Cyclin A-cdc2 kinase does not trigger but delays cyclin degradation in interphase extracts of amphibian eggs

1992 • 47 citations

The Ubiquitin-Conjugation System

1992 • 35 citations

Ubiquitin metabolism in cycling Xenopus egg extracts.

1993 • 31 citations

An Okadaic Acid-Sensitive Phosphatase Negatively Controls the Cyclin Degradation Pathway in Amphibian Eggs

1991 • 13 citations

Mitotic Arrest Caused by the Amino Terminus of Xenopus Cyclin B2

1993 • 11 citations