Nedd8 Modification of Cul-1 Activates SCF^βTrCP-Dependent Ubiquitination of IκBα

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases

1997 • 4,661 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

NF-κB: Ten Years After

1996 • 3,008 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

Suppression of TNF-α-Induced Apoptosis by NF-κB

1996 • 2,623 citations

β-catenin is a target for the ubiquitin–proteasome pathway

1997 • 2,461 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

The ubiquitin-proteasome pathway: on protein death and cell life

1998 • 1,401 citations

SKP1 Connects Cell Cycle Regulators to the Ubiquitin Proteolysis Machinery through a Novel Motif, the F-Box

1996 • 1,386 citations

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.

1995 • 1,296 citations

F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex

1997 • 1,208 citations

Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown.

1983 • 1,105 citations

The SCFbeta -TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in Ikappa Balpha and beta -catenin and stimulates Ikappa Balpha ubiquitination in vitro

1999 • 914 citations

A Complex of Cdc4p, Skp1p, and Cdc53p/Cullin Catalyzes Ubiquitination of the Phosphorylated CDK Inhibitor Sic1p

1997 • 806 citations

Structure of an IκBα/NF-κB Complex

1998 • 792 citations

Rbx1, a Component of the VHL Tumor Suppressor Complex and SCF Ubiquitin Ligase

1999 • 771 citations

A Novel Human WD Protein, h-βTrCP, that Interacts with HIV-1 Vpu Connects CD4 to the ER Degradation Pathway through an F-Box Motif

1998 • 656 citations

The F-box protein β-TrCP associates with phosphorylated β-catenin and regulates its activity in the cell

1999 • 650 citations

Identification of the receptor component of the IκBα–ubiquitin ligase

1998 • 648 citations

The Crystal Structure of the IκBα/NF-κB Complex Reveals Mechanisms of NF-κB Inactivation

1998 • 563 citations

Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination.

1995 • 558 citations

Identification of a set of genes with developmentally down-regulated expression in the mouse brain

1992 • 537 citations

Identification of an SCF ubiquitin-ligase complex required for auxin response in Arabidopsis thaliana

1999 • 520 citations

Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis

1998 • 512 citations

Structure of a Fibronectin Type III Domain from Tenascin Phased by MAD Analysis of the Selenomethionyl Protein

1992 • 500 citations

NF-κB Activation: The IκB Kinase Revealed?

1997 • 492 citations

Characterization of NEDD8, a Developmentally Down-regulated Ubiquitin-like Protein

1997 • 484 citations

ROC1, a Homolog of APC11, Represents a Family of Cullin Partners with an Associated Ubiquitin Ligase Activity

1999 • 457 citations

Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.

1995 • 438 citations

The human F box protein β-Trcp associates with the Cul1/Skp1 complex and regulates the stability of β-catenin

1999 • 432 citations

A ubiquitin ligase complex essential for the NF-kappa B, Wnt/Wingless, and Hedgehog signaling pathways

1999 • 427 citations

Signal-induced ubiquitination of Ikappa Balpha by the F-box protein Slimb/beta -TrCP

1999 • 424 citations

Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34

1999 • 406 citations

Reconstitution of G ₁ Cyclin Ubiquitination with Complexes Containing SCF ^Grr1 and Rbx1

1999 • 385 citations

β-Trcp couples β-catenin phosphorylation-degradation and regulates Xenopus axis formation

1999 • 385 citations

MEKK1 activates both IκB kinase α and IκB kinase β

1998 • 382 citations

SGT1 Encodes an Essential Component of the Yeast Kinetochore Assembly Pathway and a Novel Subunit of the SCF Ubiquitin Ligase Complex

1999 • 376 citations

Recruitment of a ROC1–CUL1 Ubiquitin Ligase by Skp1 and HOS to Catalyze the Ubiquitination of IκBα

1999 • 348 citations

Modification of yeast Cdc53p by the ubiquitin-related protein Rub1p affects function of the SCFCdc4 complex

1998 • 317 citations

The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2

1999 • 269 citations

Identification of the Activating and Conjugating Enzymes of the NEDD8 Conjugation Pathway

1999 • 267 citations

Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box protein complexes that regulate cell division and methionine biosynthesis in yeast

1998 • 263 citations

Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53.

1994 • 259 citations

A new NEDD8-ligating system for cullin-4A

1998 • 249 citations

Inhibition of NF-kappa B cellular function via specific targeting of the Ikappa B-ubiquitin ligase

1997 • 238 citations

Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase

1997 • 220 citations

Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45SKP2: evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway

1998 • 204 citations

Ubiquitin-dependent degradation of IκBα is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1

1999 • 197 citations

Ubiquitin-aldehyde: a general inhibitor of ubiquitin-recycling processes.

1987 • 189 citations

HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IκB and β-catenin

1999 • 172 citations

Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A.

1998 • 130 citations

Inducible Degradation of IκBα by the Proteasome Requires Interaction with the F-box Protein h-βTrCP

1999 • 126 citations

Identification of the Ubiquitin Carrier Proteins, E2s, Involved in Signal-induced Conjugation and Subsequent Degradation of IκBα

1999 • 122 citations

There's the Rub: a novel ubiquitin-like modification linked to cell cycle regulation

1998 • 122 citations

Identification of a Family of Closely Related Human Ubiquitin Conjugating Enzymes

1995 • 119 citations

IκBα Ubiquitination Is Catalyzed by an SCF-like Complex Containing Skp1, Cullin-1, and Two F-Box/WD40-Repeat Proteins, βTrCP1 and βTrCP2

1999 • 117 citations

Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel–Lindau tumor suppressor function

1999 • 113 citations

Inhibition of NF-κB activation in vitro and in vivo: Role of 26S proteasome

1999 • 89 citations

Identification of NEDD8-Conjugation Site in Human Cullin-2

1999 • 87 citations

Kinetic Studies on the Inhibition of Isopeptidase T by Ubiquitin Aldehyde

1996 • 32 citations

The von Hippel-Lindau Tumor Suppressor Gene Product Promotes, but Is Not Essential for, NEDD8 Conjugation to Cullin-2

1999 • 28 citations

Deleted Work

1955 • 0 citations