SCF and Cullin/RING H2-Based Ubiquitin Ligases

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1997 • 1,906 citations

Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27

1995 • 1,848 citations

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

1998 • 1,740 citations

COI1 : An Arabidopsis Gene Required for Jasmonate-Regulated Defense and Fertility

1998 • 1,576 citations

SKP1 Connects Cell Cycle Regulators to the Ubiquitin Proteolysis Machinery through a Novel Motif, the F-Box

1996 • 1,386 citations

F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex

1997 • 1,208 citations

The 2.0 Å crystal structure of a heterotrimeric G protein

1996 • 1,118 citations

The structure of the G protein heterotrimer Giα1β1γ2

1995 • 1,091 citations

Protein ubiquitination involving an E1–E2–E3 enzyme ubiquitin thioester cascade

1995 • 960 citations

Cyclin E-CDK2 is a regulator of p27Kip1.

1997 • 915 citations

The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae

1994 • 902 citations

Ubiquitin, proteasomes, and the regulation of intracellular protein degradation

1995 • 862 citations

Structure of the VHL-ElonginC-ElonginB Complex: Implications for VHL Tumor Suppressor Function

1999 • 834 citations

A Complex of Cdc4p, Skp1p, and Cdc53p/Cullin Catalyzes Ubiquitination of the Phosphorylated CDK Inhibitor Sic1p

1997 • 806 citations

Rbx1, a Component of the VHL Tumor Suppressor Complex and SCF Ubiquitin Ligase

1999 • 771 citations

Crystal structure of a GA protein βγdimer at 2.1 Å resolution

1996 • 741 citations

Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and C

1995 • 672 citations

The TIR1 protein of Arabidopsis functions in auxin response and is related to human SKP2 and yeast Grr1p

1998 • 663 citations

A Novel Human WD Protein, h-βTrCP, that Interacts with HIV-1 Vpu Connects CD4 to the ER Degradation Pathway through an F-Box Motif

1998 • 656 citations

The F-box protein β-TrCP associates with phosphorylated β-catenin and regulates its activity in the cell

1999 • 650 citations

Identification of the receptor component of the IκBα–ubiquitin ligase

1998 • 648 citations

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

1999 • 620 citations

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

1998 • 596 citations

Know Your Neighbors: Three Phenotypes in Null Mutants of the Myogenic bHLH Gene MRF4

1996 • 572 citations

Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein.

1996 • 571 citations

Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis

1998 • 512 citations

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

1997 • 490 citations

pl9skp1 and p45skp2 are essential elements of the cyclin A-CDK2 S phase kinase

1995 • 460 citations

ROC1, a Homolog of APC11, Represents a Family of Cullin Partners with an Associated Ubiquitin Ligase Activity

1999 • 457 citations

Phosphorylation of Sic1p by G ₁ Cdk Required for Its Degradation and Entry into S Phase

1997 • 454 citations

cul-1 Is Required for Cell Cycle Exit in C. elegans and Identifies a Novel Gene Family

1996 • 448 citations

Molecular Basis for Interactions of G Protein βγ Subunits with Effectors

1998 • 440 citations

The Yeast Cell Cycle Gene CDC34 Encodes a Ubiquitin-Conjugating Enzyme

1988 • 435 citations

The human F box protein β-Trcp associates with the Cul1/Skp1 complex and regulates the stability of β-catenin

1999 • 432 citations

Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34

1999 • 406 citations

Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21 ^CIP1/WAF1 and cyclin D proteins

1998 • 401 citations

Reconstitution of G ₁ Cyclin Ubiquitination with Complexes Containing SCF ^Grr1 and Rbx1

1999 • 385 citations

Regulation of Hypoxia-Inducible mRNAs by the von Hippel-Lindau Tumor Suppressor Protein Requires Binding to Complexes Containing Elongins B/C and Cul2

1998 • 377 citations

Der3p/Hrd1p Is Required for Endoplasmic Reticulum-associated Degradation of Misfolded Lumenal and Integral Membrane Proteins

1998 • 365 citations

A novel protein modification pathway related to the ubiquitin system

1998 • 361 citations

Recruitment of a ROC1–CUL1 Ubiquitin Ligase by Skp1 and HOS to Catalyze the Ubiquitination of IκBα

1999 • 348 citations

Mass Spectrometric Analysis of the Anaphase-Promoting Complex from Yeast: Identification of a Subunit Related to Cullins

1998 • 330 citations

Modification of yeast Cdc53p by the ubiquitin-related protein Rub1p affects function of the SCFCdc4 complex

1998 • 317 citations

Interaction between ubiquitin–protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation

1999 • 317 citations

Cdc53 Targets Phosphorylated G1 Cyclins for Degradation by the Ubiquitin Proteolytic Pathway

1996 • 306 citations

Yeast DNA Repair Proteins Rad6 and Rad18 Form a Heterodimer That Has Ubiquitin Conjugating, DNA Binding, and ATP Hydrolytic Activities

1997 • 297 citations

p34^Cdc28-Mediated Control of Cln3 Cyclin Degradation

1995 • 293 citations

The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast

1997 • 287 citations

Budding Yeast SKP1 Encodes an Evolutionarily Conserved Kinetochore Protein Required for Cell Cycle Progression

1996 • 284 citations

A LEAFY co-regulator encoded by UNUSUAL FLORAL ORGANS

1997 • 279 citations

Regulated degradation of the transcription factor Gcn4.

1994 • 271 citations

Identification of the Activating and Conjugating Enzymes of the NEDD8 Conjugation Pathway

1999 • 267 citations

Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism

1999 • 265 citations

Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box protein complexes that regulate cell division and methionine biosynthesis in yeast

1998 • 263 citations

Ubiquitination and Degradation of the Substrate Recognition Subunits of SCF Ubiquitin–Protein Ligases

1998 • 259 citations

Identification of a Cullin Homology Region in a Subunit of the Anaphase-Promoting Complex

1998 • 253 citations

A new NEDD8-ligating system for cullin-4A

1998 • 249 citations

Siah-1 N-Terminal RING Domain Is Required for Proteolysis Function, and C-Terminal Sequences Regulate Oligomerization and Binding to Target Proteins

1999 • 234 citations

sel-10, a negative regulator of lin-12 activity inCaenorhabditis elegans, encodes a member of the CDC4 family of proteins

1997 • 234 citations

Linkage of Replication to Start by the Cdk Inhibitor Sic1

1996 • 230 citations

Inhibition of the 26 S Proteasome by Polyubiquitin Chains Synthesized to Have Defined Lengths

1997 • 229 citations

Rapid Degradation of the G ₁ Cyclin Cln2 Induced by CDK-Dependent Phosphorylation

1996 • 227 citations

Grr1 of Saccharomyces cerevisiae is connected to the ubiquitin proteolysis machinery through Skp1: coupling glucose sensing to gene expression and the cell cycle

1997 • 215 citations

Ubiquitination of the G1 cyclin Cln2p by a Cdc34p-dependent pathway.

1995 • 213 citations

Phosphorylation- and ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor Far1p in budding yeast

1997 • 207 citations

Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45SKP2: evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway

1998 • 204 citations

G1 cyclin turnover and nutrient uptake are controlled by a common pathway in yeast.

1995 • 204 citations

Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle

1999 • 201 citations

Ubiquitin-dependent degradation of IκBα is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1

1999 • 197 citations

Cdc53p Acts in Concert with Cdc4p and Cdc34p To Control the G₁-to-S-Phase Transition and Identifies a Conserved Family of Proteins

1996 • 195 citations

Human cyclin F.

1994 • 175 citations

The mouse and human genes encoding the recognition component of the N-end rule pathway

1998 • 175 citations

HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IκB and β-catenin

1999 • 172 citations

SIC1 is ubiquitinated in vitro by a pathway that requires CDC4, CDC34, and cyclin/CDK activities.

1997 • 171 citations

Dual role for fimbriata in regulating floral homeotic genes and cell division in Antirrhinum

1997 • 165 citations

Proteolysis and the G1-S transition: the SCF connection

1998 • 156 citations

Phosphorylation Controls Timing of Cdc6p Destruction: A Biochemical Analysis

1999 • 155 citations

The human homologue for the Caenorhabditis elegans cul-4 gene is amplified and overexpressed in primary breast cancers.

1998 • 153 citations

β-TrCP is a negative regulator of the Wnt/β-catenin signaling pathway and dorsal axis formation in Xenopus embryos

1998 • 152 citations

Fission yeast WD-repeat protein pop1 regulates genome ploidy through ubiquitin-proteasome-mediated degradation of the CDK inhibitor Rum1 and the S-phase initiator Cdc18.

1997 • 152 citations

Regulating the Yeast Kinetochore by Ubiquitin-Dependent Degradation and Skp1p-Mediated Phosphorylation

1997 • 141 citations

Cdc34 and the F-box protein Met30 are required for degradation of the Cdk-inhibitory kinase Swe1

1998 • 140 citations

Coupling of Mitosis to the Completion of S Phase Through Cdc34-Mediated Degradation of Wee1

1998 • 138 citations

Human CUL1 forms an evolutionarily conserved ubiquitin ligase complex (SCF) with SKP1 and an F-box protein

1998 • 138 citations

Control of Swe1p degradation by the morphogenesis checkpoint

1998 • 138 citations

Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A.

1998 • 130 citations

Inducible Degradation of IκBα by the Proteasome Requires Interaction with the F-box Protein h-βTrCP

1999 • 126 citations

IκBα Ubiquitination Is Catalyzed by an SCF-like Complex Containing Skp1, Cullin-1, and Two F-Box/WD40-Repeat Proteins, βTrCP1 and βTrCP2

1999 • 117 citations

The B-type cyclin kinase inhibitor p40(SiC1) Controls the G1 to S transition in S-cerevisiae (vol 79, pg 233, 1994)

1996 • 111 citations

Two F‐box/WD‐repeat proteins Pop1 and Pop2 form hetero‐ and homo‐complexes together with cullin‐1 in the fission yeast SCF (Skp1‐Cullin‐1‐F‐box) ubiquitin ligase

1998 • 105 citations

A chimeric ubiquitin conjugating enzyme that combines the cell cycle properties of CDC34 (UBC3) and the DNA repair properties of RAD6 (UBC2): implications for the structure, function and evolution of the E2s.

1992 • 104 citations

The bacterially expressed yeast CDC34 gene product can undergo autoubiquitination to form a multiubiquitin chain-linked protein.

1993 • 96 citations

The Cdc42p effector Gic2p is targeted for ubiquitin-dependent degradation by the SCFGrr1 complex

1998 • 92 citations

Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast.

1993 • 90 citations

Identification of NEDD8-Conjugation Site in Human Cullin-2

1999 • 87 citations

The role of protein stability in the cell cycle and cancer

1998 • 87 citations

Regulation of Cyclin A-Cdk2 by SCF Component Skp1 and F-Box Protein Skp2

1999 • 78 citations

Identification of a portable determinant of cell cycle function within the carboxyl-terminal domain of the yeast CDC34 (UBC3) ubiquitin conjugating (E2) enzyme.

1992 • 78 citations

The Saccharomyces cerevisiae kinetochore contains a cyclin-CDK complexing homologue, as identified by in vitro reconstitution.

1996 • 76 citations

The Ubc3 (Cdc34) ubiquitin-conjugating enzyme is ubiquitinated and phosphorylated in vivo.

1994 • 73 citations

The Cytoplasmic F-box Binding Protein SKP1 Contains a Novel Pentasaccharide Linked to Hydroxyproline inDictyostelium

1998 • 73 citations

Yeast G1 cyclins are unstable in G1 phase

1998 • 72 citations

F-box/WD-repeat proteins Pop1p and Sud1p/Pop2p form complexes that bind and direct the proteolysis of Cdc18p

1999 • 72 citations

Proteolysis and DNA Replication: The CDC34 Requirement in the Xenopus Egg Cell Cycle

1997 • 67 citations

slimb coordinates wg and dpp expression in the dorsal-ventral and anterior-posterior axes during limb development

1998 • 64 citations

A Novel F Box Protein, NFB42, Is Highly Enriched in Neurons and Induces Growth Arrest

1998 • 63 citations

Functional and physical characterization of the cell cycle ubiquitin-conjugating enzyme CDC34 (UBC3). Identification of a functional determinant within the tail that facilitates CDC34 self-association

1994 • 61 citations

Expression cloning of an AVP-activated, calcium-mobilizing receptor from rabbit kidney medulla

1995 • 59 citations

sud1 ⁺ targets cyclin-dependent kinase-phosphorylated Cdc18 and Rum1 proteins for degradation and stops unwanted diploidization in fission yeast

1998 • 59 citations

An Essential Domain within Cdc34p Is Required for Binding to a Complex Containing Cdc4p and Cdc53p in Saccharomyces cerevisiae

1998 • 58 citations

A novel, putative MEK kinase controls developmental timing and spatial patterning in Dictyostelium and is regulated by ubiquitin-mediated protein degradation

1998 • 54 citations

The Abundance of Cell Cycle Regulatory Protein Cdc4p Is Controlled by Interactions between Its F Box and Skp1p

1999 • 52 citations

The Aspergillus nidulans sulphur regulatory gene sconB encodes a protein with WD40 repeats and an F-box

1998 • 51 citations

A relationship between the yeast cell cycle genes CDC4 and CDC36 and the ets sequence of oncogenic virus E26

1984 • 51 citations

Association of Human SCFSKP2Subunit p19SKP1with Interphase Centrosomes and Mitotic Spindle Poles

1999 • 50 citations

An additional role for the F-box motif: Gene regulation within the Neurospora crassa sulfur control network

1998 • 46 citations

Cloning and Expression Analysis of a Novel Salicylate Suppressible Gene, Hs-CUL-3, a Member of Cullin/Cdc53 Family

1998 • 33 citations

Grr1 functions in the ubiquitin pathway in Saccharomyces cerevisiae through association with Skp1

1998 • 27 citations

Cocaine addiction: Clues from Drosophila on drugs

1999 • 26 citations

Characterization of Elongin C Functional Domains Required for Interaction with Elongin B and Activation of Elongin A

1996 • 21 citations

Identification of Elongin C Sequences Required for Interaction with the von Hippel-Lindau Tumor Suppressor Protein

1997 • 18 citations

Characterization of the cullin and F‐box protein partner Skp1

1998 • 12 citations

Correction

1999 • 11 citations