Molecular Determinants of Cardiac Development and Congenital Disease

The incidence of congenital heart disease

2002 • 5,652 citations

The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression

2000 • 3,504 citations

A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy

1998 • 2,570 citations

WT-1 is required for early kidney development

1993 • 1,976 citations

PPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development

1999 • 1,904 citations

Promotion of Trophoblast Stem Cell Proliferation by FGF4

1998 • 1,340 citations

Congenital Heart Disease Caused by Mutations in the Transcription Factor NKX2-5

1998 • 1,284 citations

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1

1997 • 1,239 citations

Multiple essential functions of neuregulin in development

1995 • 1,236 citations

Targeted Disruption of the Mouse Caspase 8 Gene Ablates Cell Death Induction by the TNF Receptors, Fas/Apo1, and DR3 and Is Lethal Prenatally

1998 • 1,224 citations

The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo

1995 • 1,175 citations

Correlation of Terminal Cell Cycle Arrest of Skeletal Muscle with Induction of p21 by MyoD

1995 • 1,154 citations

Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis.

1997 • 1,138 citations

Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5.

1995 • 1,130 citations

Fate of the mammalian cardiac neural crest

2000 • 1,123 citations

Mutations in the human Jagged1 gene are responsible for Alagille syndrome

1997 • 1,121 citations

Mutations in human cause limb and cardiac malformation in Holt-Oram syndrome

1997 • 1,066 citations

DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1

2001 • 1,062 citations

Embryonic retinoic acid synthesis is essential for early mouse post-implantation development

1999 • 1,051 citations

An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination

1998 • 1,048 citations

GATA4 transcription factor is required for ventral morphogenesis and heart tube formation.

1997 • 1,031 citations

TRANSCRIPTIONAL CONTROL OF MUSCLE DEVELOPMENT BY MYOCYTE ENHANCER FACTOR-2 (MEF2) PROTEINS

1998 • 1,026 citations

Control of Mouse Cardiac Morphogenesis and Myogenesis by Transcription Factor MEF2C

1997 • 1,024 citations

Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation

2000 • 1,024 citations

A Murine Model of Holt-Oram Syndrome Defines Roles of the T-Box Transcription Factor Tbx5 in Cardiogenesis and Disease

2001 • 1,022 citations

Tbx1 haploinsufficiency in the DiGeorge syndrome region causes aortic arch defects in mice

2001 • 996 citations

TBX1 Is Responsible for Cardiovascular Defects in Velo-Cardio-Facial/DiGeorge Syndrome

2001 • 963 citations

Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development

1996 • 959 citations

Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family

1997 • 909 citations

FADD: Essential for Embryo Development and Signaling from Some, But Not All, Inducers of Apoptosis

1998 • 893 citations

Clonal analysis of epiblast fate during germ layer formation in the mouse embryo

1991 • 865 citations

Retinoids in Embryonal Development

2000 • 859 citations

The Zinc Finger-containing Transcription Factors GATA-4, -5, and -6

2000 • 854 citations

The Wnt/Ca2+ pathway

2000 • 843 citations

The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals

1999 • 823 citations

Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins

1995 • 817 citations

The gene tinman is required for specification of the heart and visceral muscles in Drosophila

1993 • 790 citations

Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis.

1995 • 784 citations

A molecular pathway determining left-right asymmetry in chick embryogenesis

1995 • 781 citations

Incidence of congenital heart disease: I. Postnatal incidence

1995 • 780 citations

A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse

1994 • 769 citations

Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer

1996 • 757 citations

Axis Development and Early Asymmetry in Mammals

1999 • 740 citations

tinman and bagpipe: two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila.

1993 • 719 citations

Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND

1997 • 716 citations

Developmental Defects in Mouse Embryos Lacking N-Cadherin

1997 • 712 citations

The EGF-CFC Protein One-Eyed Pinhead Is Essential for Nodal Signaling

1999 • 710 citations

A role for bone morphogenetic proteins in the induction of cardiac myogenesis.

1997 • 687 citations

Asymmetric redirection of flow through the heart

2000 • 681 citations

Xwnt11is a target ofXenopusBrachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway

2000 • 677 citations

Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways

1999 • 667 citations

Loss of a gp130 Cardiac Muscle Cell Survival Pathway Is a Critical Event in the Onset of Heart Failure during Biomechanical Stress

1999 • 666 citations

The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors

1997 • 660 citations

Identification of a New Family of Tissue-Specific Basic Helix-Loop-Helix Proteins with a Two-Hybrid System

1995 • 655 citations

The Xenopus Dorsalizing Factor Gremlin Identifies a Novel Family of Secreted Proteins that Antagonize BMP Activities

1998 • 649 citations

Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo

1999 • 644 citations

Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders.

1996 • 635 citations

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues.

1994 • 634 citations

RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis.

1994 • 632 citations

Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis

1999 • 608 citations

Nodal is a novel TGF-β-like gene expressed in the mouse node during gastrulation

1993 • 606 citations

A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genes.

1989 • 605 citations

Smad2 role in mesoderm formation, left–right patterning and craniofacial development

1998 • 600 citations

MesP1 is expressed in the heart precursor cells and required for the formation of a single heart tube

1999 • 586 citations

Dosage requirement of Pitx2 for development of multiple organs

1999 • 586 citations

Inhibition of Wnt activity induces heart formation from posterior mesoderm

2001 • 581 citations

NK-2Homeobox Genes and Heart Development

1996 • 574 citations

Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis

1994 • 553 citations

The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development

1999 • 552 citations

Mutation of an axonemal dynein affects left–right asymmetry in inversus viscerum mice

1997 • 549 citations

Relationship between asymmetric nodal expression and the direction of embryonic turning

1996 • 547 citations

A Subclass of bHLH Proteins Required for Cardiac Morphogenesis

1995 • 544 citations

lefty-1 Is Required for Left-Right Determination as a Regulator of lefty-2 and nodal

1998 • 539 citations

Common Epicardial Origin of Coronary Vascular Smooth Muscle, Perivascular Fibroblasts, and Intermyocardial Fibroblasts in the Avian Heart

1998 • 535 citations

Csx: a murine homeobox-containing gene specifically expressed in the developing heart.

1993 • 533 citations

Restricted expression and retinoic acid-induced downregulation of the retinaldehyde dehydrogenase type 2 (RALDH-2) gene during mouse development

1997 • 527 citations

YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis

1999 • 525 citations

The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis

1998 • 524 citations

The entire mesodermal mantle behaves as Spemann's organizer in dorsoanterior enhanced Xenopus laevis embryos

1988 • 521 citations

The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning

1997 • 518 citations

Pitx2 determines left–right asymmetry of internal organs in vertebrates

1998 • 512 citations

Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases

2000 • 511 citations

Function of Rieger syndrome gene in left–right asymmetry and craniofacial development

1999 • 502 citations

The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development

1999 • 502 citations

Requirement of MADS Domain Transcription Factor D-MEF2 for Muscle Formation in Drosophila

1995 • 502 citations

Chamber-Specific Cardiac Expression of Tbx5 and Heart Defects in Holt–Oram Syndrome

1999 • 501 citations

The 22q11 deletion syndromes

2000 • 492 citations

Fashioning the vertebrate heart: earliest embryonic decisions

1997 • 490 citations

Cripto is required for correct orientation of the anterior–posterior axis in the mouse embryo

1998 • 483 citations

Chamber Formation and Morphogenesis in the Developing Mammalian Heart

2000 • 483 citations

Wnt antagonism initiates cardiogenesis in Xenopus laevis

2001 • 479 citations

Induction of avian cardiac myogenesis by anterior endoderm

1995 • 475 citations

GATA-6: A Zinc Finger Transcription Factor That Is Expressed in Multiple Cell Lineages Derived from Lateral Mesoderm

1996 • 469 citations

Mice lacking both presenilin genes exhibitearlyembryonic patterningdefects

1999 • 462 citations

Conserved left–right asymmetry of nodal expression and alterations in murine situs inversus

1996 • 459 citations

Mouse Pitx2 deficiency leads to anomalies of the ventral body wall, heart, extra- and periocular mesoderm and right pulmonary isomerism

1999 • 458 citations

MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type

2000 • 455 citations

The Transcription Factor Pitx2 Mediates Situs-Specific Morphogenesis in Response to Left-Right Asymmetric Signals

1998 • 445 citations

Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects

1999 • 436 citations

Drosophila MEF2, a transcription factor that is essential for myogenesis.

1995 • 426 citations

Gata5 is required for the development of the heart and endoderm in zebrafish

1999 • 421 citations

Induction of visceral and cardiac mesoderm by ectodermal Dpp in the early Drosophila embryo

1995 • 419 citations

On the biological basis of human laterality: I. Evidence for a maturational left–right gradient

1978 • 412 citations

FOG-2, a Cofactor for GATA Transcription Factors, Is Essential for Heart Morphogenesis and Development of Coronary Vessels from Epicardium

2000 • 409 citations

X-linked situs abnormalities result from mutations in ZIC3

1997 • 408 citations

The development of handedness in left/right asymmetry

1990 • 402 citations

A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development

2000 • 401 citations

Embryonic retinoic acid synthesis is essential for heart morphogenesis in the mouse

2001 • 400 citations

Incidence of congenital heart disease: II. Prenatal incidence

1995 • 390 citations

The cell surface in animal embryogenesis and development

1977 • 389 citations

The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse.

1997 • 387 citations

Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1

1998 • 375 citations

Pitx2, a Bicoid-Type Homeobox Gene, Is Involved in a Lefty-Signaling Pathway in Determination of Left-Right Asymmetry

1998 • 371 citations

Cardiovascular development in the zebrafish I. Myocardial fate map and heart tube formation

1993 • 365 citations

Serum response factor is essential for mesoderm formation during mouse embryogenesis

1998 • 364 citations

Different TBX5 interactions in heart and limb defined by Holt–Oram syndrome mutations

1999 • 362 citations

Primitive-Streak Origin of the Cardiovascular System in Avian Embryos

1993 • 362 citations

Targeted disruption of the Wnt2 gene results in placentation defects

1996 • 357 citations

Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG

1998 • 352 citations

Head induction by simultaneous repression of Bmp and Wnt signalling in Xenopus

1997 • 351 citations

The homeobox gene Pitx2: mediator of asymmetric left-right signaling in vertebrate heart and gut looping

1999 • 344 citations

Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup

1999 • 343 citations

Cardiac Septal and Valvular Dysmorphogenesis in Mice Heterozygous for Mutations in the Homeobox Gene Nkx2-5

2000 • 340 citations

GATA-dependent recruitment of MEF2 proteins to target promoters

2000 • 339 citations

Retrotransposons as epigenetic mediators of phenotypic variation in mammals

2001 • 339 citations

Loss-of-function mutations in the EGF-CFC gene CFC1 are associated with human left-right laterality defects

2000 • 337 citations

Essential role of β-adrenergic receptor kinase 1 in cardiac development and function

1996 • 336 citations

The bHLH transcription factor Hand2 plays parallel roles in zebrafish heart and pectoral fin development

2000 • 330 citations

Pitx2 Participates in the Late Phase of the Pathway Controlling Left-Right Asymmetry

1998 • 330 citations

Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice.

1994 • 325 citations

Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish

1997 • 324 citations

Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHand during murine heart development.

1997 • 323 citations

Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development

1995 • 321 citations

Genetic dissection ofnodalfunction in patterning the mouse embryo

2001 • 320 citations

TheCspg2Gene, Disrupted in thehdfMutant, Is Required for Right Cardiac Chamber and Endocardial Cushion Formation

1998 • 318 citations

Mechanisms of Left–Right Determination in Vertebrates

2000 • 314 citations

Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tips

1996 • 312 citations

Transcription factor GATA-4 regulates cardiac muscle-specific expression of the alpha-myosin heavy-chain gene.

1994 • 310 citations

Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors

2001 • 309 citations

GATA-4 and Nkx-2.5 Coactivate Nkx-2 DNA Binding Targets: Role for Regulating Early Cardiac Gene Expression

1998 • 303 citations

Heartless, a Drosophila FGF receptor homolog, is essential for cell migration and establishment of several mesodermal lineages.

1996 • 303 citations

Mice lacking the homologue of the human 22q11.2 gene CRKL phenocopy neurocristopathies of DiGeorge syndrome

2001 • 301 citations

Drosophila NK-homeobox genes.

1989 • 300 citations

Localization of transcription factor GATA-4 to regions of the mouse embryo involved in cardiac development

1994 • 299 citations

heartless encodes a fibroblast growth factor receptor (DFR1/DFGF-R2) involved in the directional migration of early mesodermal cells in the Drosophila embryo.

1996 • 298 citations

Interrelations of the proliferation and differentiation processes during cardiact myogenesis and regeneration.

1977 • 296 citations

Conserved and divergent roles for members of the Snail family of transcription factors in the chick and mouse embryo

1998 • 295 citations

Anterior patterning in mouse

1998 • 287 citations

Fibronectins Are Essential for Heart and Blood Vessel Morphogenesis But Are Dispensable for Initial Specification of Precursor Cells

1997 • 286 citations

Ventricular muscle-restricted targeting of the RXRα gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis

1998 • 285 citations

Familial Tetralogy of Fallot caused by mutation in the jagged1 gene

2001 • 285 citations

Enhanced cardiogenesis in embryonic stem cells overexpressing the GATA-4 transcription factor

1997 • 283 citations

Development of the Cardiac Conduction System

1998 • 282 citations

Molecular cloning of FOG-2: A modulator of transcription factor GATA-4 in cardiomyocytes

1999 • 279 citations

Etiology and Morphogenesis of Congenital Heart Disease

1981 • 277 citations

HRT1, HRT2, and HRT3: A New Subclass of bHLH Transcription Factors Marking Specific Cardiac, Somitic, and Pharyngeal Arch Segments

1999 • 276 citations

Cell fate, morphogenetic movement and population kinetics of embryonic endoderm at the time of germ layer formation in the mouse

1987 • 275 citations

The Cardiac Tissue-Restricted Homeobox Protein Csx/Nkx2.5 Physically Associates with the Zinc Finger Protein GATA4 and Cooperatively Activates Atrial Natriuretic Factor Gene Expression

1998 • 274 citations

A signaling cascade involving endothelin-1, dHAND and Msx1 regulates development of neural-crest-derived branchial arch mesenchyme

1998 • 271 citations

Features of embryonic induction

1988 • 271 citations

MesP1 and MesP2 are essential for the development of cardiac mesoderm

2000 • 270 citations

Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer

1999 • 266 citations

Myogenin induces the myocyte-specific enhancer binding factor MEF-2 independently of other muscle-specific gene products.

1991 • 264 citations

Visualization and functional characterization of the developing murine cardiac conduction system

2001 • 262 citations

Growth of the heart in health and disease

1985 • 262 citations

Induction and differentiation of the zebrafish heart requires fibroblast growth factor 8 (fgf8/acerebellar)

2000 • 262 citations

Cloning of inv, a gene that controls left/right asymmetry and kidney development

1998 • 261 citations

GATA transcription factors and cardiac development

1999 • 259 citations

Expression of the atrial-specific myosin heavy chain AMHC1 and the establishment of anteroposterior polarity in the developing chicken heart

1994 • 254 citations

Aortic‐arch and cardiac anomalies in the offspring of vitamin A deficient rats

1949 • 254 citations

GATA-5: A Transcriptional Activator Expressed in a Novel Temporally and Spatially-Restricted Pattern during Embryonic Development

1997 • 253 citations

Wnt signals from the neural tube block ectopic cardiogenesis

2001 • 250 citations

Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to theDrosophila mesoderm

1998 • 250 citations

Hey genes: a novel subfamily of hairy - and Enhancer of split related genes specifically expressed during mouse embryogenesis

1999 • 249 citations

Expression of the Novel Basic Helix-Loop-Helix Gene eHAND in Neural Crest Derivatives and Extraembryonic Membranes during Mouse Development

1995 • 248 citations

The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development

2000 • 246 citations

Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation

1999 • 245 citations

Regulation of Chamber-Specific Gene Expression in the Developing Heart by Irx4

1999 • 245 citations

Modeling stochastic gene expression: Implications for haploinsufficiency

1998 • 244 citations

Cooperative Interaction between GATA-4 and GATA-6 Regulates Myocardial Gene Expression

1999 • 242 citations

Positional specification of ventricular myosin light chain 2 expression in the primitive murine heart tube.

1993 • 242 citations

Inversin, a novel gene in the vertebrate left-right axis pathway, is partially deleted in the inv mouse

1998 • 241 citations

Formation of the Tricuspid Valve in the Human Heart

1995 • 241 citations

Binding of a Large Chondroitin Sulfate/Dermatan Sulfate Proteoglycan, Versican, to L-selectin, P-selectin, and CD44

2000 • 241 citations

Developmental cardiology : morphogenesis and function

1990 • 240 citations

Persisting zones of slow impulse conduction in developing chicken hearts.

1992 • 238 citations

A new homeobox-containing gene, msh-2, is transiently expressed early during mesoderm formation of Drosophila

1990 • 237 citations

Bone Morphogenetic Proteins Induce Cardiomyocyte Differentiation through the Mitogen-Activated Protein Kinase Kinase Kinase TAK1 and Cardiac Transcription Factors Csx/Nkx-2.5 and GATA-4

1999 • 237 citations

Left–Right Asymmetric Expression of lefty2 and nodal Is Induced by a Signaling Pathway that Includes the Transcription Factor FAST2

2000 • 236 citations

Congenital heart disease : causes and processes

1984 • 234 citations

An inductive role for the endoderm in Xenopus cardiogenesis

1995 • 234 citations

Members of the HRT family of basic helix–loop–helix proteins act as transcriptional repressors downstream of Notch signaling

2000 • 231 citations

The HAND1 Basic Helix-Loop-Helix Transcription Factor Regulates Trophoblast Differentiation via Multiple Mechanisms

2000 • 227 citations

Two novel nodal-related genes initiate early inductive events in Xenopus Nieuwkoop center

2000 • 226 citations

Combined BMP-2 and FGF-4, but Neither Factor Alone, Induces Cardiogenesis in Non-Precardiac Embryonic Mesoderm

1996 • 224 citations

Dynamic Patterns of Retinoic Acid Synthesis and Response in the Developing Mammalian Heart

1998 • 223 citations

FOG-2, a Heart- and Brain-Enriched Cofactor for GATA Transcription Factors

1999 • 222 citations

The EGF-CFC gene family in vertebrate development

2000 • 221 citations

Heart Development in Drosophila Requires the Segment Polarity Gene wingless

1995 • 221 citations

XNkx-2.5, a Xenopus Gene Related to Nkx-2.5 and tinman: Evidence for a Conserved Role in Cardiac Development

1994 • 219 citations

Expression Pattern of Connexin Gene Products at the Early Developmental Stages of the Mouse Cardiovascular System

1997 • 219 citations

Patterning the zebrafish heart tube: Acquisition of anteroposterior polarity

1992 • 217 citations

Regulation of left-right patterning in mice by growth/differentiation factor-1

2000 • 216 citations

Endoderm and heart development

2000 • 215 citations

Optical approaches to ontogeny of electrical activity and related functional organization during early heart development

1991 • 214 citations

Wild-Type Endoderm Abrogates the Ventral Developmental Defects Associated with GATA-4 Deficiency in the Mouse

1997 • 211 citations

Association of COOH-terminal-binding Protein (CtBP) and MEF2-interacting Transcription Repressor (MITR) Contributes to Transcriptional Repression of the MEF2 Transcription Factor

2001 • 210 citations

FOG-2: A novel GATA-family cofactor related to multitype zinc-finger proteins Friend of GATA-1 and U-shaped

1999 • 209 citations

A Series of Mutations in the D-MEF2 Transcription Factor Reveal Multiple Functions in Larval and Adult Myogenesis in Drosophila

1995 • 209 citations

Left/Right Patterning Signals and the Independent Regulation of Different Aspects ofSitusin the Chick Embryo

1997 • 206 citations

Characterization and Mutation Analysis of Human LEFTY A and LEFTY B, Homologues of Murine Genes Implicated in Left-Right Axis Development

1999 • 206 citations

Cardiac Expression of the Ventricle-Specific Homeobox Gene Irx4 Is Modulated by Nkx2-5 and dHand

2000 • 205 citations

The bHLH Factors, dHAND and eHAND, Specify Pulmonary and Systemic Cardiac Ventricles Independent of Left–Right Sidedness

1998 • 205 citations

BMP2 is required for early heart development during a distinct time period

2000 • 204 citations

Complete Repair of Tetralogy of Fallot in the Neonate

2000 • 200 citations

Left-right axis malformations associated with mutations inACVR2B, the gene for human activin receptor type IIB

1999 • 199 citations

Cardiac Tissue Enriched Factors Serum Response Factor and GATA-4 Are Mutual Coregulators

2000 • 197 citations

BMP-2 induces ectopic expression of cardiac lineage markers and interferes with somite formation in chicken embryos

1998 • 197 citations

Versican Interacts with Chemokines and Modulates Cellular Responses

2001 • 197 citations

Ventricular Expression of tbx5 Inhibits Normal Heart Chamber Development

2000 • 196 citations

Control of Vertebrate Left-Right Asymmetry by a Snail -Related Zinc Finger Gene

1997 • 194 citations

MEF-2 function is modified by a novel co-repressor, MITR

1999 • 194 citations

The Wingless Signaling Pathway Is Directly Involved inDrosophilaHeart Development

1996 • 193 citations

Defects in heart and lung development in compound heterozygotes for two different targeted mutations at the N-myc locus

1993 • 193 citations

Conserved and divergent mechanisms in left–right axis formation

2000 • 192 citations

Genomic circuits and the integrative biology of cardiac diseases

2000 • 192 citations

Temporal summation in frogs and men

1979 • 191 citations

Spatial distribution of “tissue‐specific” antigens in the developing human heart and skeletal muscle III. An immunohistochemical analysis of the distribution of the neural tissue antigen G1N2 in the embryonic heart; implications for the development of the atrioventricular conduction system

1992 • 191 citations

Vitamin A and Embryonic Development: An Overview ,

1998 • 190 citations

Transcriptional activity of Pannier is regulated negatively by heterodimerization of the GATA DNA-binding domain with a cofactor encoded by the u-shaped gene of Drosophila

1997 • 189 citations

Divergent roles for NK-2 class homeobox genes in cardiogenesis in flies and mice

1998 • 188 citations

A role for the COUP-TF-related gene seven-up in the diversification of cardioblast identities in the dorsal vessel of Drosophila

2001 • 188 citations

Origin and differentiation of cardiac muscle cells in the mouse

1973 • 186 citations

Avian Serum Response Factor Expression Restricted Primarily to Muscle Cell Lineages Is Required for α-Actin Gene Transcription

1996 • 186 citations

Murine Cerberus Homologue mCer-1: A Candidate Anterior Patterning Molecule

1998 • 185 citations

Building the heart piece by piece: modularity of cis-elements regulating Nkx2-5 transcription

1999 • 184 citations

The Combinatorial Activities of Nkx2.5 and dHAND Are Essential for Cardiac Ventricle Formation

2001 • 181 citations

The development of the myocardium and endocardium in mouse embryos

1992 • 179 citations

Overexpression of the tinman-related genes XNkx-2.5 and XNkx-2.3 in Xenopus embryos results in myocardial hyperplasia

1996 • 178 citations

Cell death in the morphogenesis and teratogenesis of the heart

1975 • 178 citations

A syndrome of tricuspid atresia in mice with a targeted mutation of the gene encoding Fog-2

2000 • 177 citations

WNT11 promotes cardiac tissue formation of early mesoderm

1999 • 176 citations

Regulation of Avian Cardiac Myogenesis by Activin/TGFβ and Bone Morphogenetic Proteins

1998 • 176 citations

Retinoid X receptors are essential for early mouse development and placentogenesis

1999 • 176 citations

Interrelations of the Proliferation and Differentiation Processes during Cardiac Myogenesis and Regeneration

1977 • 173 citations

Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathway

2000 • 172 citations

Msg1 and Mrg1, founding members of a gene family, show distinct patterns of gene expression during mouse embryogenesis

1998 • 172 citations

A GATA-dependent nkx-2.5 regulatory element activates early cardiac gene expression in transgenic mice

1998 • 171 citations

Vitamin A deficiency and mutations of RXRα, RXRβ and RARα lead to early differentiation of embryonic ventricular cardiomyocytes

1997 • 171 citations

A genomewide survey of basic helix–loop–helix factors in Drosophila

2000 • 169 citations

Location of pacemaker in chick embryo heart at the time of initiation of heartbeat

1967 • 167 citations

Regionalisation of cell fate and morphogenetic movement of the mesoderm during mouse gastrulation

1995 • 164 citations

Left-right asymmetry of a nodal-related gene is regulated by dorsoanterior midline structures during Xenopus development

1997 • 164 citations

Parsing the Heart: Genetic Modules for Organ Assembly

1997 • 163 citations

Abrogation of the Cripto gene in mouse leads to failure of postgastrulation morphogenesis and lack of differentiation of cardiomyocytes

1999 • 163 citations

RhoA Signaling via Serum Response Factor Plays an Obligatory Role in Myogenic Differentiation

1998 • 163 citations

Asymmetric Nodal signaling in the zebrafish diencephalon positions the pineal organ

2000 • 161 citations

The basic helix-loop-helix transcription factor, dHAND, is required for vascular development

2000 • 160 citations

Formation of the Atrioventricular Septal Structures in the Normal Mouse

1998 • 159 citations

Cardiomyopathy in Irx4-Deficient Mice Is Preceded by Abnormal Ventricular Gene Expression

2001 • 159 citations

BMP Signaling Is Required for Heart Formation in Vertebrates

2000 • 157 citations

The zinc finger proteins Pannier and GATA4 function as cardiogenic factors in Drosophila

1999 • 156 citations

Cardiovascular Basic Helix Loop Helix Factor 1, a Novel Transcriptional Repressor Expressed Preferentially in the Developing and Adult Cardiovascular System

2000 • 155 citations

Patterning the Embryonic Heart: Identification of Five Mouse Iroquois Homeobox Genes in the Developing Heart

2000 • 155 citations

Apoptosis During Cardiovascular Development

2000 • 154 citations

The G3 Domain of Versican Enhances Cell Proliferation via Epidermial Growth Factor-like Motifs

1998 • 154 citations

A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart

2000 • 151 citations

A Subpopulation of Apoptosis-Prone Cardiac Neural Crest Cells Targets to the Venous Pole: Multiple Functions in Heart Development?

1999 • 150 citations

Control of cell fates and segmentation in the Drosophila mesoderm

1997 • 148 citations

Pitx2 Expression Defines a Left Cardiac Lineage of Cells: Evidence for Atrial and Ventricular Molecular Isomerism in the iv/iv Mice

2001 • 148 citations

The identification of two novel ligands of the fgf receptor by a yeast screening method and their activity in xenopus development

1995 • 146 citations

Anterior endoderm is a specific effector of terminal cardiac myocyte differentiation of cells from the embryonic heart forming region

1994 • 145 citations

N-Cadherin, a Cell Adhesion Molecule Involved in Establishment of Embryonic Left-Right Asymmetry

2000 • 144 citations

Living Morphogenesis of the Heart

1998 • 143 citations

Myocyte Enhancer Factor 2C and Nkx2–5 Up-regulate Each Other's Expression and Initiate Cardiomyogenesis in P19 Cells

1998 • 143 citations

The steroid receptor coactivator, GRIP-1, is necessary for MEF-2C-dependent gene expression and skeletal muscle differentiation

2000 • 142 citations

An early marker of axial pattern in the chick embryo and its respecification by retinoic acid

1992 • 142 citations

To be or not to be active: the stochastic nature of enhancer action

2000 • 141 citations

A retinoic acid-inducible transgenic marker of sino-atrial development in the mouse heart

1999 • 140 citations

u-shaped encodes a zinc finger protein that regulates the proneural genesachaete and scute during the formation of bristles in Drosophila

1997 • 139 citations

Toward a Molecular Understanding of Congenital Heart Disease

1995 • 139 citations

Transcriptional activating activity of Smad4: Roles of SMAD hetero-oligomerization and enhancement by an associating transactivator

1998 • 139 citations

N-Cadherin–Catenin Interaction: Necessary Component of Cardiac Cell Compartmentalization during Early Vertebrate Heart Development

1997 • 135 citations

MEF2B Is a Potent Transactivator Expressed in Early Myogenic Lineages

1996 • 135 citations

Patterns of expression in the developing myocardium: towards a morphologically integrated transcriptional model

1998 • 134 citations

Induction of cardiac myogenesis in avian pregastrula epiblast: the role of the hypoblast and activin

1997 • 134 citations

A role of the cryptic gene in the correct establishment of the left–right axis

1999 • 133 citations

Atrial development in the human heart: An immunohistochemical study with emphasis on the role of mesenchymal tissues

2000 • 132 citations

A heart segmental defect in the anterior-posterior axis of a transgenic mutant mouse

1997 • 131 citations

Retinoic acid is required in the mouse embryo for left-right asymmetry determination and heart morphogenesis

1999 • 131 citations

Vertebrate tinman homologues XNkx2-3 and XNkx2-5 are required for heart formation in a functionally redundant manner

1998 • 131 citations

Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency.

1996 • 131 citations

The Morphology of Heart Development in Xenopus laevis

2000 • 130 citations

Modular regulation of muscle gene transcription: a mechanism for muscle cell diversity

1997 • 130 citations

Specific Arrest of Cardiogenesis in Cultured Embryonic Stem Cells Lacking Cripto-1

1998 • 128 citations

An HF-1a/ HF-1b/MEF-2 combinatorial element confers cardiac ventricular specificity and establishes an anterior-posterior gradient of expression

1996 • 128 citations

Serrate and Notch specify cell fates in the heart field by suppressing cardiomyogenesis

2000 • 127 citations

Formation and Early Morphogenesis of Endocardial Endothelial Precursor Cells and the Role of Endoderm

1996 • 126 citations

Developmental Mechanisms of Heart Disease

1996 • 126 citations

Control of segmental expression of the cardiac-restricted ankyrin repeat protein gene by distinct regulatory pathways in murine cardiogenesis

1999 • 125 citations

TBX5 Transcription Factor Regulates Cell Proliferation during Cardiogenesis

2001 • 124 citations

The formation of the cardiac loop in the chick

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The primitive cardiac regions in the straight tube heart (Stage 9) and their anatomical expression in the mature heart: An experimental study in the chick embryo.

1989 • 123 citations

The murine cripto gene: expression during mesoderm induction and early heart morphogenesis

1993 • 122 citations

A differential display strategy identifies Cryptic, a novel EGF-related gene expressed in the axial and lateral mesoderm during mouse gastrulation

1997 • 122 citations

Regulation in the heart field of zebrafish

1998 • 121 citations

Activation of the cardiac α-actin promoter depends upon serum response factor,Tinman homologue, Nkx-2.5, and intact serum response elements

1996 • 120 citations

Tinman Function Is Essential for Vertebrate Heart Development: Elimination of Cardiac Differentiation by Dominant Inhibitory Mutants of thetinman-Related Genes,XNkx2-3andXNkx2-5

1998 • 120 citations

Context-dependent Transcriptional Cooperation Mediated by Cardiac Transcription Factors Csx/Nkx-2.5 and GATA-4

1999 • 119 citations

Sequential Programs of Retinoic Acid Synthesis in the Myocardial and Epicardial Layers of the Developing Avian Heart

2000 • 119 citations

Developmental remodeling and shortening of the cardiac outflow tract involves myocyte programmed cell death

1998 • 118 citations

Actin bundles on the right side in the caudal part of the heart tube play a role in dextro-looping in the embryonic chick heart

1991 • 116 citations

Direct Activation of a GATA6 Cardiac Enhancer by Nkx2.5: Evidence for a Reinforcing Regulatory Network of Nkx2.5 and GATA Transcription Factors in the Developing Heart

2000 • 116 citations

Congenital Heart Surgery Nomenclature and Database Project: hypoplastic left heart syndrome

2000 • 115 citations

Nodal Signaling Uses Activin and Transforming Growth Factor-β Receptor-regulated Smads

2001 • 114 citations

Congenital Heart Disease and Genetic Syndromes

2000 • 112 citations

Versican Expression Is Associated With Chamber Specification, Septation, and Valvulogenesis in the Developing Mouse Heart

1998 • 112 citations

In vivo induction of cardiac Purkinje fiber differentiation by coexpression of preproendothelin-1 and endothelin converting enzyme-1

2000 • 112 citations

Over-expression of GATA-6 in Xenopus embryos blocks differentiation of heart precursors

1997 • 112 citations

Orphan Receptor COUP-TF Is Required for Induction of Retinoic Acid Receptor β, Growth Inhibition, and Apoptosis by Retinoic Acid in Cancer Cells

2000 • 111 citations

The compulsion of chirality: toward an understanding of left-right asymmetry

1998 • 110 citations

Spatial distribution of “tissue‐specific” antigens in the developing human heart and skeletal muscle. I. An immunohistochemical analysis of creatine kinase isoenzyme expression patterns

1990 • 110 citations

Wnt-11 is expressed in early avian mesoderm and required for the differentiation of the quail mesoderm cell line QCE-6

1997 • 109 citations

Identification and characterization of a ventricular-specific avian myosin heavy chain, VMHC1: Expression in differentiating cardiac and skeletal muscle

1991 • 107 citations

The role of the dorsal lip in the induction of heart mesoderm in Xenopus laevis

1990 • 106 citations

Patterns of Expression of Sarcoplasmic Reticulum Ca ²⁺ -ATPase and Phospholamban mRNAs During Rat Heart Development

1995 • 105 citations

Expression of sarcomeric myosin in the presumptive myocardium of chicken embryos occurs within six hours of myocyte commitment

1992 • 104 citations

Spectrum of heart malformations in mice with situs solitus, situs inversus, and associated visceral heterotaxy.

1991 • 103 citations

Origins and patterning of avian outflow tract endocardium

1991 • 103 citations

In vitro analysis of cardiac progenitor cell differentiation

1990 • 102 citations

Serum Response Factor Mediates AP-1-dependent Induction of the Skeletal α-Actin Promoter in Ventricular Myocytes

1996 • 102 citations

Retinoid Signaling Required for Normal Heart Development Regulates GATA-4 in a Pathway Distinct from Cardiomyocyte Differentiation

1999 • 99 citations

Wingless effects mesoderm patterning and ectoderm segmentation events via induction of its downstream target sloppy paired

2000 • 98 citations

Reduced Penetrance, Variable Expressivity, and Genetic Heterogeneity of Familial Atrial Septal Defects

1998 • 98 citations

HAND Proteins Molecular Mediators of Cardiac Development and Congenital Heart Disease

1999 • 97 citations

Multiple Transcriptional Domains, With Distinct Left and Right Components, in the Atrial Chambers of the Developing Heart

2000 • 97 citations

Murine cardiac progenitor cells require visceral embryonic endoderm and primitive streak for terminal differentiation

1997 • 96 citations

Opioid Peptide Gene Expression Primes Cardiogenesis in Embryonal Pluripotent Stem Cells

2000 • 96 citations

Abnormal laterality and congenital cardiac anomalies. Relations of visceral and cardiac morphologies in the iv/iv mouse.

1992 • 96 citations

Induction of cardiac muscle differentiation in isolated animal pole explants of Xenopus laevis embryos

1993 • 96 citations

Regulation and function oftinman during dorsal mesoderm induction and heart specification inDrosophila

1998 • 95 citations

The Basic Helix-Loop-Helix Transcription factorsdHAND and eHAND Exhibit Dimerization Characteristics That Suggest Complex Regulation of Function

2000 • 95 citations

Development of cardiovascular systems: Molecules to organisms

1998 • 94 citations

Left–Right Asymmetric Localization of Flectin in the Extracellular Matrix during Heart Looping

1996 • 94 citations

Development of the Myocardium of the Atrioventricular Canal and the Vestibular Spine in the Human Heart

2001 • 93 citations

Retinoic Acid Directs Cardiac Laterality and the Expression of Early Markers of Precardiac Asymmetry

1997 • 92 citations

Early heart development: Dynamics of endocardial cell sorting suggests a common origin with cardiomyocytes

1993 • 92 citations

Adult Presentation of Heterotaxic Syndromes and Related Complexes

1995 • 92 citations

Conversion of zebrafish blastomeres to an endodermal fate by TGF-β-related signalling

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An anterior signalling centre in Xenopus revealed by the homeobox gene XHex

1999 • 91 citations

Development of cardiac beat rate in early chick embryos is regulated by regional cues

1988 • 91 citations

Conservation of sequence and expression of Xenopus and zebrafish dHAND during cardiac, branchial arch and lateral mesoderm development

2000 • 91 citations

Spatially distinct head and heart inducers within the Xenopus organizer region

1999 • 90 citations

Presence of Functional Sarcoplasmic Reticulum in the Developing Heart and Its Confinement to Chamber Myocardium

2000 • 90 citations

The role of tinman, a mesodermal cell fate gene, in axon pathfinding during the development of the transverse nerve in Drosophila

1994 • 90 citations

The Small Muscle-Specific Protein Csl Modifies Cell Shape and Promotes Myocyte Fusion in an Insulin-like Growth Factor 1–Dependent Manner

2001 • 90 citations

Early differentiation of the heart in mouse embryos.

1981 • 89 citations

Expression of HAND Gene Products May Be Sufficient for the Differentiation of Avian Neural Crest-Derived Cells into Catecholaminergic Neurons in Culture

1999 • 89 citations

The origin of heart asymmetry: Right and left contributions to the early chick embryo heart

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The restriction of the heart morphogenetic field in Xenopus laevis

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Genetically distinct cardial cells within theDrosophila heart

2000 • 86 citations

The role of the brachyury gene in heart development and left–right specification in the mouse

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In situ analysis of the cardiac muscle gene program during embryogenesis

1994 • 85 citations

Common role for each of the cGATA-4/5/6 genes in the regulation of cardiac morphogenesis

1998 • 83 citations

Evidence for a Role of Smad6 in Chick Cardiac Development

1999 • 81 citations

Genetic Determination of Drosophila Heart Development

1999 • 80 citations

Cripto: a novel epidermal growth factor (EGF)-related peptide in mammary gland development and neoplasia

1999 • 80 citations

A Conserved Role for H15-Related T-Box Transcription Factors in Zebrafish and Drosophila Heart Formation

2000 • 80 citations

Regulative ability of the prospective cardiogenic and vasculogenic areas of the primitive streak during avian gastrulation

1993 • 79 citations

Lack of Regulation in the Heart Forming Region of Avian Embryos

1999 • 79 citations

Thyroid Hormone Influences Beta Myosin Heavy Chain (βMHC) Expression

1994 • 78 citations

Compartment-Selective Sensitivity of Cardiovascular Morphogenesis to Combinations of Retinoic Acid Receptor Gene Mutations

1997 • 76 citations

Regulation of SRF Activity by Rho Family GTPases

1998 • 76 citations

Cell Multiplication Rates During Development of the Primitive Cardiac Tube in the Chick Embryo

1966 • 76 citations

A Role for BMP Signalling in Heart Looping Morphogenesis in Xenopus

2001 • 76 citations

Mechanism of dextral looping of the embryonic heart

1970 • 75 citations

An Intrinsic Timer That Controls Cell-Cycle Withdrawal in Cultured Cardiac Myocytes

1999 • 75 citations

A heparin‐binding growth factor, midkine, binds to a chondroitin sulfate proteoglycan, PG‐M/versican

2000 • 74 citations

A Role for GATA-4/5/6 in the Regulation of Nkx2.5 Expression with Implications for Patterning of the Precardiac Field

1999 • 73 citations

The RXRα gene functions in a non-cell-autonomous manner during mouse cardiac morphogenesis

1998 • 73 citations

The level of the tissue‐specific factor GATA‐1 affects the cell‐cycle machinery

1997 • 71 citations

Subdivision of the Cardiac Nkx2.5 Expression Domain into Myogenic and Nonmyogenic Compartments

2000 • 70 citations

Vertebrate tinman homologues and cardiac differentiation

1999 • 68 citations

Staging of Commitment and Differentiation of Avian Cardiac Myocytes

1994 • 67 citations

Regional mitotic activity in the precardiac mesoderm and differentiating heart tube in the chick embryo

1969 • 67 citations

Nodal signalling and the roles of the transcription factors SnR and Pitx2 in vertebrate left–right asymmetry

1999 • 66 citations

Energy deprivation and a deficiency in downstream metabolic target genes during the onset of embryonic heart failure in RXRα−/− embryos

1998 • 65 citations

Regionalized Transcriptional Domains of Myosin Light Chain 3f Transgenes in the Embryonic Mouse Heart: Morphogenetic Implications

1997 • 65 citations

A Positive GATA Element and a Negative Vitamin D Receptor-Like Element Control Atrial Chamber-Specific Expression of a Slow Myosin Heavy-Chain Gene during Cardiac Morphogenesis

1998 • 64 citations

RXRα overexpression in cardiomyocytes causes dilated cardiomyopathy but fails to rescue myocardial hypoplasia in RXRα-null fetuses

2000 • 63 citations

Cell fate choices in Drosophila tracheal morphogenesis

2000 • 62 citations

Retinoic Acid Can Block Differentiation of the Myocardium after Heart Specification

1997 • 62 citations

Notochord Regulates Cardiac Lineage in Zebrafish Embryos

1998 • 61 citations

Early Exclusion of Hand1-Deficient Cells from Distinct Regions of the Left Ventricular Myocardium in Chimeric Mouse Embryos

2000 • 60 citations

Zic3 is involved in the left-right specification of the Xenopus embryo

2000 • 60 citations

Anterior Endoderm Is Sufficient to Rescue Foregut Apoptosis and Heart Tube Morphogenesis in an Embryo Lacking Retinoic Acid

2000 • 59 citations

Negative regulation of the human atrial natriuretic peptide gene by 1,25-dihydroxyvitamin D3.

1994 • 58 citations

COUP-TF1 Antagonizes Nkx2.5-mediated Activation of the Calreticulin Gene during Cardiac Development

2001 • 58 citations

Expression of NK-2 class homeobox gene Nkx2–6 in foregut endoderm and heart

1998 • 58 citations

Conotruncal anomalies in the trisomy 16 mouse: An immunohistochemical analysis with emphasis on the involvement of the neural crest

2000 • 58 citations

From the bottom of the heart: anteroposterior decisions in cardiac muscle differentiation

2000 • 57 citations

Primitive interventricular septum, its primordium, and its contribution in the definitive interventricular septum: In vivo labelling study in the chick embryo heart

1997 • 56 citations

Contribution of Neural Crest to Heart and Vessel Morphology

1999 • 55 citations

Control of cell migration during Caenorhabditis elegans development

1999 • 55 citations

Distinct spatial and temporal distributions of aggrecan and versican in the embryonic chick heart

1999 • 54 citations

Regulation of the tinman Homologues in Xenopus Embryos

2000 • 54 citations

Zinc 65 metabolism: gastrointestinal secretion by the pig

1966 • 54 citations

An Nkx-Dependent Enhancer Regulates cGATA-6 Gene Expression during Early Stages of Heart Development

2000 • 53 citations

SITUS INVERSUS AND CARDIAC DEFECTS

1963 • 53 citations

The multitype zinc-finger protein U-shaped functions in heart cell specification in the Drosophila embryo

2000 • 53 citations

Xenopus eHAND: a marker for the developing cardiovascular system of the embryo that is regulated by bone morphogenetic proteins

1998 • 52 citations

Nuclear Opioid Receptors Activate Opioid Peptide Gene Transcription in Isolated Myocardial Nuclei

1998 • 50 citations

Distinct spatial and temporal distributions of aggrecan and versican in the embryonic chick heart

1999 • 48 citations

Characterization of the Human TBX20 Gene, a New Member of the T-Box Gene Family Closely Related to the Drosophila H15 Gene

2000 • 47 citations

Activated Raf kinase inhibits muscle cell differentiation through a MEF2-dependent mechanism

2000 • 47 citations

Cardiac looping — an uneasy deal with laterality

1998 • 45 citations

GATA Transcription Factors and Cardiac Development

1999 • 45 citations

Analysis ofHox gene expression during early avian heart development

1998 • 44 citations

Commitment and differentiation of cardiac myocytes

1992 • 44 citations

The MADS-Box Factor CeMEF2 Is Not Essential for Caenorhabditis elegans Myogenesis and Development

2000 • 42 citations

Cardiac development: a morphologically integrated molecular approach

1997 • 40 citations

Tinman Regulates the Transcription of the β3 tubulin Gene (βTub60D) in the Dorsal Vessel of Drosophila

1999 • 40 citations

Correlated heart/limb anomalies in Mendelian syndromes provide evidence for a cardiomelic developmental field

1998 • 40 citations

Dextrocardia and isolated laevocardia. II. Situs inversus and isolated dextrocardia.

1966 • 39 citations

Transcriptional Control and Pattern Formation in the Developing Vertebrate Heart

1999 • 38 citations

Straight Tube Heart. Primitive Cardiac Cavities vs. Primitive Cardiac Segments

1998 • 38 citations

Staging of the Commitment of Murine Cardiac Cell Progenitors

2000 • 38 citations

Correlated heart/limb anomalies in Mendelian syndromes provide evidence for a cardiomelic developmental field.

1998 • 38 citations

Seeking a regulatory roadmap for heart morphogenesis

1999 • 37 citations

Endoderm and Cardiogenesis

1996 • 37 citations

Embryology of the heart

1999 • 36 citations

Symmetry and Laterality in the Human Heart

1999 • 36 citations

β₁-Integrin and PI 3-kinase regulate RhoA-dependent activation of skeletal α-actin promoter in myoblasts

2000 • 35 citations

The Chicken GATA-6 Locus Contains Multiple Control Regions That Confer Distinct Patterns of Heart Region-specific Expression in Transgenic Mouse Embryos

1997 • 34 citations

Homeobox genes and heart development

1995 • 33 citations

Neurogenic Cells Inhibit the Differentiation of Cardiogenic Cells

1995 • 32 citations

Hypoblastic tissue and fibroblast growth factor induce blood tissue (haemoglobin) in the early chick embryo

1994 • 31 citations

Reconstitution of the organizer is both sufficient and required to re-establish a fully patterned body plan in avian embryos

1999 • 30 citations

Cardiac Fate Maps

1999 • 30 citations

Cardiac myogenesis: overexpression of XCsx2 or XMEF2A in whole Xenopus embryos induces the precocious expression of XMHC? gene

1995 • 29 citations

Development of the Conduction System of the Vertebrate Heart

1999 • 27 citations

Dynamic Left/Right Regionalisation of Endogenous Myosin Light Chain 3F Transcripts in the Developing Mouse Heart

1998 • 25 citations

Regionalization of Transcriptional Potential in the Myocardium

1999 • 23 citations

Negative Regulation of Selected bHLH Proteins by eHAND

2000 • 22 citations

Downregulation of atrial markers during cardiac chamber morphogenesis is irreversible in murine embryos

1998 • 22 citations

Evidence that FGF receptor signaling is necessary for endoderm-regulated development of precardiac mesoderm

1999 • 21 citations

Torsion and Looping of the Cardiac Tube and Primitive Cardiac Segments. Anatomical Manifestations

1998 • 21 citations

Laterality disturbances

1996 • 21 citations

Phenotypic effects in Xenopus and zebrafish suggest that one-eyed pinhead functions as antagonist of BMP signalling

2000 • 20 citations

Right-left asymmetry of cell proliferation predominates in mouse embryos undergoing clockwise axial rotation

1998 • 19 citations

Retinoids in Heart Development

1999 • 18 citations

Vertebrate segmentation: is cycling the rule?

2000 • 17 citations

RESEARCH ON HEART DEVELOPMENT IN CHICK EMBRYO UNDER NORMAL AND EXPERIMENTAL CONDITIONS

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The Serum Response Factor (SRF) Is Needed for Muscle-Specific Activation of CArG Boxes

1996 • 17 citations

Control of Early Embryonic Heart Morphogenesis: A Hypothesis

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Homeobox genes and heart development.

1997 • 14 citations

Morphoregulatory Mechanisms Underlying Early Heart Development: Precardiac Stages to the Looping, Tubular Heart

1998 • 14 citations

Control of Cardiac Development by the MEF2 Family of Transcription Factors

1999 • 14 citations

Arrangement of the systemic and pulmonary venous components of the atrial chambers in hearts with isomeric atrial appendages

2000 • 13 citations

The Cardiac Cell Cycle

1999 • 13 citations

Morphogenesis of vertebrate hearts

1998 • 9 citations

Evolution of cardiovascular systems: Insights into ontogeny

1998 • 9 citations

Heart Formation and the Heart Field in Amphibian Embryos

1999 • 8 citations

Analysis of Hox gene expression during early avian heart development

1998 • 1 citations

Unravelling Knotted1 gene function

1998 • 1 citations