TBX5 Transcription Factor Regulates Cell Proliferation during Cardiogenesis

A series of normal stages in the development of the chick embryo

1951 • 12,226 citations

Mutations in human cause limb and cardiac malformation in Holt-Oram syndrome

1997 • 1,066 citations

Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family

1997 • 909 citations

Expression of the T-box family genes,Tbx1-Tbx5, during early mouse development

1996 • 654 citations

Developmental patterning of the myocardium

2000 • 607 citations

Chamber-Specific Cardiac Expression of Tbx5 and Heart Defects in Holt–Oram Syndrome

1999 • 501 citations

The Brachyury gene encodes a novel DNA binding protein.

1993 • 406 citations

The Clinical and Genetic Spectrum of the Holt-Oram Syndrome (Heart-Hand Syndrome)

1994 • 383 citations

Different TBX5 interactions in heart and limb defined by Holt–Oram syndrome mutations

1999 • 362 citations

Crystallographic structure of the T domain–DNA complex of the Brachyury transcription factor

1997 • 327 citations

The Brachyury gene encodes a novel DNA binding protein.

1993 • 308 citations

The T-box genes Tbx4 and Tbx5 regulate limb outgrowth and identity

1999 • 293 citations

The T protein encoded by Brachyury is a tissue-specific transcription factor.

1995 • 287 citations

Tbx5 and Tbx4 genes determine the wing/leg identity of limb buds

1999 • 264 citations

Tbx5 and the Retinotectum Projection

2000 • 234 citations

Tbx5 is essential for heart development

1999 • 219 citations

The T genes in embryogenesis

1994 • 215 citations

Ventricular Expression of tbx5 Inhibits Normal Heart Chamber Development

2000 • 196 citations

Fibroblast growth factor receptor is required for in vivo cardiac myocyte proliferation at early embryonic stages of heart development.

1995 • 186 citations

Clonal analysis of cardiac morphogenesis in the chicken embryo using a replication‐defective retrovirus: I. Formation of the ventricular myocardium

1992 • 180 citations

In vivo induction of cardiac Purkinje fiber differentiation by coexpression of preproendothelin-1 and endothelin converting enzyme-1

2000 • 112 citations

Clonal analysis of cardiac morphogenesis in the chicken embryo using a replication‐defective retrovirus. III: Polyclonal origin of adjacent ventricular myocytes

1992 • 102 citations

Cardiac compartment-specific overexpression of a modified retinoic acid receptor produces dilated cardiomyopathy and congestive heart failure in transgenic mice.

1997 • 100 citations

Formation of the avian primitive streak from spatially restricted blastoderm: evidence for polarized cell division in the elongating streak

2000 • 97 citations

Identification and localization of TBX5 transcription factor during human cardiac morphogenesis

2000 • 95 citations

Basic Fibroblast Growth Factor in Retinal Development: Differential Levels of bFGF Expression and Content in Normal and Retinal Degeneration (rd) Mutant Mice

1995 • 92 citations

A novel family of T-box genes in urodele amphibian limb development and regeneration: candidate genes involved in vertebrate forelimb/hindlimb patterning

1997 • 86 citations

The Holt-Oram syndrome.

1991 • 72 citations

Holt-Oram syndrome: clinical and genetic study of a large family.

1966 • 69 citations

Retroviral Targeting of FGF and FGFR in Cardiomyocytes and Coronary Vascular Cells during Heart Development^a

1995 • 66 citations

Three novel TBX5 mutations in Chinese patients with Holt-Oram syndrome

2000 • 48 citations

Doxorubicin induced expression of P-glycoprotein in a canine osteosarcoma cell line

1998 • 46 citations

Selective disruption of neuregulin-1 function in vertebrate embryos using ribozyme-tRNA transgenes

1998 • 44 citations

The local expression of adult chicken heart myosins during development

1984 • 39 citations

Malformation syndrome of duplication 12q24.1→qter

1981 • 39 citations

Mosaicism for duplication 12q (12q13-->q24.2) in a dysmorphic male infant.

1993 • 38 citations

MC29-immortalized clonal avian heart cell lines can partially differentiate in vitro

1991 • 33 citations

Forced expression of the homeodomain protein Gax inhibits cardiomyocyte proliferation and perturbs heart morphogenesis

1997 • 33 citations

Duplication (12q) syndrome in female cousins, resulting from maternal (11;12) (p15.5;q24.2) translocations

1986 • 28 citations

An in vivo/in vitro experimental model system for the study of human osteosarcoma: canine osteosarcoma cells (COS31) which retain osteoblastic and metastatic properties in nude mice.

1998 • 24 citations

Cross-sectional Echocardiographic Imaging of Supracardiac Total Anomalous Pulmonary Venous Drainage to a Vertical Vein in a Patient With Holt-Oram Syndrome:

1981 • 22 citations

[An unusual type of congenital heart disease associated with the Holt-Oram-syndrome (author's transl)].

1981 • 10 citations

Holt-Oram Syndrome and the TBX5 Transcription Factor in Cardiogenesis

2000 • 3 citations

Lung Immobilization Chamber Therapy in Chronic Pulmonary Tuberculosis

1952 • 1 citations