Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins

Expression of a single transfected cDNA converts fibroblasts to myoblasts

1987 • 3,373 citations

Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence

1989 • 1,876 citations

Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo

1991 • 874 citations

A gene with homology to the myc similarity region of MyoD1 is expressed during myogenesis and is sufficient to activate the muscle differentiation program.

1989 • 863 citations

The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation

1990 • 794 citations

The MADS-Box Family of Transcription Factors

1995 • 780 citations

MyoD family: a paradigm for development?

1990 • 776 citations

The MADS-Box Family of Transcription Factors

1995 • 645 citations

A regulatory hierarchy for cell specialization in yeast

1989 • 612 citations

A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genes.

1989 • 605 citations

Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis

1994 • 553 citations

Requirement of MADS Domain Transcription Factor D-MEF2 for Muscle Formation in Drosophila

1995 • 502 citations

Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors.

1992 • 491 citations

Crystal structure of MyoD bHLH domain-DNA complex: Perspectives on DNA recognition and implications for transcriptional activation

1994 • 448 citations

Human SRF-related proteins: DNA-binding properties and potential regulatory targets.

1991 • 446 citations

Drosophila MEF2, a transcription factor that is essential for myogenesis.

1995 • 426 citations

The regulation of myogenin gene expression during the embryonic development of the mouse.

1993 • 419 citations

Regulation of Muscle Differentiation by the MEF2 Family of MADS Box Transcription Factors

1995 • 348 citations

Muscle-specific transcriptional activation by MyoD.

1991 • 347 citations

Muscle-specific expression of the cardiac alpha-actin gene requires MyoD1, CArG-box binding factor, and Sp1.

1990 • 334 citations

FGF inactivates myogenic helix-loop-helix proteins through phosphorylation of a conserved protein kinase C site in their DNA-binding domains

1992 • 333 citations

HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors.

1992 • 312 citations

Analysis of the myogenin promoter reveals an indirect pathway for positive autoregulation mediated by the muscle-specific enhancer factor MEF-2.

1992 • 302 citations

MyoD binds cooperatively to two sites in a target enhancer sequence: occupancy of two sites is required for activation.

1990 • 294 citations

Myogenin resides in the nucleus and acquires high affinity for a conserved enhancer element on heterodimerization.

1990 • 278 citations

Expression of mef2 genes in the mouse central nervous system suggests a role in neuronal maturation

1995 • 274 citations

Myocyte enhancer factor (MEF) 2C: a tissue-restricted member of the MEF-2 family of transcription factors.

1993 • 267 citations

Myogenin induces the myocyte-specific enhancer binding factor MEF-2 independently of other muscle-specific gene products.

1991 • 264 citations

Separable Regulatory Elements Governing myogenin Transcription in Mouse Embryogenesis

1993 • 258 citations

Expression of a MyoD family member prefigures muscle pattern in Drosophila embryos.

1990 • 243 citations

hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors.

1993 • 234 citations

MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex.

1993 • 234 citations

A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage

1993 • 224 citations

Activation of the Myogenic Lineage by MEF2A, a Factor that Induces and Cooperates with MyoD

1994 • 223 citations

Displacement of BrdUrd-induced YY1 by serum response factor activates skeletal alpha-actin transcription in embryonic myoblasts.

1992 • 221 citations

A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing.

1994 • 218 citations

A Series of Mutations in the D-MEF2 Transcription Factor Reveal Multiple Functions in Larval and Adult Myogenesis in Drosophila

1995 • 209 citations

D-mef2: a Drosophila mesoderm-specific MADS box-containing gene with a biphasic expression profile during embryogenesis.

1994 • 171 citations

Mutagenesis of the myogenin basic region identifies an ancient protein motif critical for activation of myogenesis.

1991 • 159 citations

Wiring diagrams: regulatory circuits and the control of skeletal myogenesis

1994 • 154 citations

Myogenin and MEF2 Function Synergistically To Activate the MRF4 Promoter during Myogenesis

1995 • 151 citations

Acquisition of myogenic specificity by replacement of three amino acid residues from MyoD into E12

1992 • 147 citations

The Drosophila homologue of vertebrate myogenic-determination genes encodes a transiently expressed nuclear protein marking primary myogenic cells.

1991 • 136 citations

Cross-Binding of Factors to Functionally Different Promoter Elements in c-fos and Skeletal Actin Genes

1989 • 135 citations

Drosophila MEF2 is regulated by twist and is expressed in both the primordia and differentiated cells of the embryonic somatic, visceral and heart musculature

1995 • 113 citations

The basic region of myogenin cooperates with two transcription activation domains to induce muscle-specific transcription.

1992 • 110 citations

Skeletal myogenesis: genetics and embryology to the fore

1993 • 103 citations

Cyclic amplification and selection of targets for multicomponent complexes: myogenin interacts with factors recognizing binding sites for basic helix-loop-helix, nuclear factor 1, myocyte-specific enhancer-binding factor 2, and COMP1 factor.

1992 • 100 citations

Muscle-specific expression of SRF-related genes in the early embryo of Xenopus laevis.

1992 • 98 citations

The RSRF/MEF2 protein SL1 regulates cardiac muscle-specific transcription of a myosin light-chain gene in Xenopus embryos.

1994 • 94 citations

The Mouse MRF4 Promoter Is trans-Activated Directly and Indirectly by Muscle-specific Transcription Factors

1995 • 93 citations

Muscle basic helix-loop-helix proteins and the regulation of myogenesis

1992 • 69 citations

Binding of TFIID and MEF2 to the TATA element activates transcription of the Xenopus MyoDa promoter.

1994 • 66 citations

Cross-binding of factors to functionally different promoter elements in c-fos and skeletal actin genes.

1989 • 64 citations

Synergistic Interactions between Heterologous Upstream Activation Elements and Specific TATA Sequences in a Muscle-Specific Promoter

1995 • 63 citations

The myogenin gene is activated during myocyte differentiation by pre-existing, not newly synthesized transcription factor MEF-2.

1994 • 63 citations

Activation of Xenopus MyoD Transcription by Members of the MEF2 Protein Family

1994 • 40 citations

Analysis of the oligomerization of myogenin and E2A products in vivo using a two-hybrid assay system.

1992 • 17 citations