Loss of a gp130 Cardiac Muscle Cell Survival Pathway Is a Critical Event in the Onset of Heart Failure during Biomechanical Stress

Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor

1992 • 2,004 citations

Impaired immune and acute-phase responses in interleukin-6-deficient mice

1994 • 1,776 citations

Apoptosis in the Failing Human Heart

1997 • 1,690 citations

Liver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice

1996 • 1,498 citations

<scp>gp</scp>130 AND THE INTERLEUKIN-6 FAMILY OF CYTOKINES

1997 • 1,468 citations

Cytokine signal transduction

1994 • 1,358 citations

Role of IL-6 and Its Soluble Receptor in Induction of Chemokines and Leukocyte Recruitment

1997 • 1,091 citations

Cardiac Muscle Cell Hypertrophy and Apoptosis Induced by Distinct Members of the p38 Mitogen-activated Protein Kinase Family

1998 • 855 citations

MLP-Deficient Mice Exhibit a Disruption of Cardiac Cytoarchitectural Organization, Dilated Cardiomyopathy, and Heart Failure

1997 • 831 citations

Apoptosis

1998 • 806 citations

Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response

1991 • 798 citations

RETRACTED: Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy.

1991 • 769 citations

Sequence identification of 2,375 human brain genes

1992 • 764 citations

Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion.

1994 • 738 citations

Genetic analysis of RXRα developmental function: Convergence of RXR and RAR signaling pathways in heart and eye morphogenesis

1994 • 684 citations

Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy

1990 • 641 citations

Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders.

1996 • 635 citations

RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis.

1994 • 632 citations

Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death

1995 • 583 citations

Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy.

1995 • 548 citations

Analysis of FBJ-MuSV provirus and c-fos (mouse) gene reveals that viral and cellular fos gene products have different carboxy termini

1983 • 532 citations

Enhanced Gαq signaling: A common pathway mediates cardiac hypertrophy and apoptotic heart failure

1998 • 528 citations

Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice.

1995 • 504 citations

Fashioning the vertebrate heart: earliest embryonic decisions

1997 • 490 citations

Conditional gene targeting.

1996 • 462 citations

The Role of Interleukin-6 in Mucosal IgA Antibody Responses in Vivo

1994 • 460 citations

Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes. Characterization and regulation of iNOS expression and detection of iNOS activity in single cardiac myocytes in vitro.

1994 • 436 citations

Apoptosis in pressure overload-induced heart hypertrophy in the rat.

1996 • 416 citations

Cardiotrophin 1 (CT-1) Inhibition of Cardiac Myocyte Apoptosis via a Mitogen-activated Protein Kinase-dependent Pathway

1997 • 399 citations

Transthoracic Echocardiography in Models of Cardiac Disease in the Mouse

1996 • 372 citations

Cardiotrophin-1 Activates a Distinct Form of Cardiac Muscle Cell Hypertrophy

1996 • 364 citations

Cardiac Hypertrophy Induced by Mitogen-activated Protein Kinase Kinase 7, a Specific Activator for c-Jun NH2-terminal Kinase in Ventricular Muscle Cells

1998 • 335 citations

Impaired neutrophil response and CD4+ T helper cell 1 development in interleukin 6-deficient mice infected with Candida albicans.

1996 • 319 citations

Essential function of LIF receptor in motor neurons

1995 • 318 citations

Ventricular muscle-restricted targeting of the RXRα gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis

1998 • 285 citations

Impaired neuroglial activation in interleukin-6 deficient mice

1997 • 284 citations

Positional specification of ventricular myosin light chain 2 expression in the primitive murine heart tube.

1993 • 242 citations

Interleukin-6 is required in vivo for the regulation of stem cells and committed progenitors of the hematopoietic system

1994 • 234 citations

HRas-dependent pathways can activate morphological and genetic markers of cardiac muscle cell hypertrophy.

1993 • 228 citations

Postnatally Induced Inactivation of gp130 in Mice Results in Neurological, Cardiac, Hematopoietic, Immunological, Hepatic, and Pulmonary Defects

1998 • 218 citations

Gq- and ras-dependent pathways mediate hypertrophy of neonatal rat ventricular myocytes following alpha 1-adrenergic stimulation.

1994 • 189 citations

RXR alpha deficiency confers genetic susceptibility for aortic sac, conotruncal, atrioventricular cushion, and ventricular muscle defects in mice.

1996 • 189 citations

Cardiotrophin-1 displays early expression in the murine heart tube and promotes cardiac myocyte survivals

1996 • 183 citations

Mouse embryonic stem cells express the cardiac myosin heavy chain genes during development in vitro.

1990 • 175 citations

Selective Requirement of Myosin Light Chain 2v in Embryonic Heart Function

1998 • 172 citations

In vitro chamber specification during embryonic stem cell cardiogenesis. Expression of the ventricular myosin light chain-2 gene is independent of heart tube formation.

1993 • 171 citations

Adult Mice With Targeted Mutation of the Interleukin-11 Receptor (IL11Ra) Display Normal Hematopoiesis

1997 • 167 citations

Atrial-like phenotype is associated with embryonic ventricular failure in retinoid X receptor alpha -/- mice.

1995 • 166 citations

Method for isolation of adult mouse cardiac myocytes for studies of contraction and microfluorimetry

1996 • 137 citations

An HF-1a/ HF-1b/MEF-2 combinatorial element confers cardiac ventricular specificity and establishes an anterior-posterior gradient of expression

1996 • 128 citations

Cardiotrophin-1 and the role of gp130-dependent signaling pathways in cardiac growth and development

1997 • 98 citations

Molecular Advances in Cardiovascular Biology

1993 • 71 citations

Force-frequency effect is a powerful determinant of myocardial contractility in the mouse

1997 • 65 citations

Energy deprivation and a deficiency in downstream metabolic target genes during the onset of embryonic heart failure in RXRα−/− embryos

1998 • 65 citations

Molecular Basis of Cardiovascular Disease

2010 • 64 citations

Ras-dependent pathways induce obstructive hypertrophy in echo-selected transgenic mice

1997 • 63 citations

Downregulation of atrial markers during cardiac chamber morphogenesis is irreversible in murine embryos

1998 • 22 citations

[26]Molecular analysis of cardiac muscle diseases based on mouse genetics

1996 • 19 citations